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The map label for this gene is deoA

Identifier: 15887488

GI number: 15887488

Start: 136629

End: 137945

Strand: Direct

Name: deoA

Synonym: Atu0133

Alternate gene names: 15887488

Gene position: 136629-137945 (Clockwise)

Preceding gene: 159184174

Following gene: 15887498

Centisome position: 4.81

GC content: 62.57

Gene sequence:

>1317_bases
TTGAGCTTGATCCCGCAGGAAATCATCCGCCGCAAACGCGATGGCCTGTCGCTCGCGCCACAGGAGATTGCCGCTTTCAT
CGAAGCGCTGTCGAAAGACGGCATATCGGAAGGGCAGGCGGCCGCTTTTGCCATGGCGGTGTTTTTCCGTGGCATGAACC
GCGACGAAATGGTGGCGCTGACGCTTGCCATGCGCGACAGCGGCGATGTCCTCTCCTGGCGCGATATTGGCAGGCCGGTG
GCGGACAAGCATTCCACCGGCGGTGTCGGTGACAATGTCTCCCTGATGCTGGCTCCCATCGTTGCCGCCTGCGGTCTTGC
GGTGCCGATGATATCAGGCAGGGGCCTTGGCCACACCGGTGGCACGCTCGACAAGCTGGAAGCCATCCCCGGTTATGATG
TCATGCCGGATGAGGCTCTGTTTCGCCGGACGGTGCAGTCGGTGGGCTGCGCCATCATCGGCCAGACGGGCGATCTCGCC
CCCGCCGACAAACGCCTCTACGCTATCAGGGACGTGACGGCGACCGTCGATTCCATTCCGCTGATTACCGCTTCCATTCT
TTCGAAGAAGCTCGCGGCCGGGCTTGAGACGCTGGTTCTCGACGTGAAGGTCGGCAACGGCGCCTTCATGCAAAGCCTGG
AGGATGCCCGCATTCTCGCCCGCGCGCTGGTCGATGTGGCGAATGGCGCCGGCCTGCCGACGACGGCGCTGATCACCGAC
ATGAACCAGCCGCTCTGCGATGCAGCCGGCAATGCCGTCGAAATTGTCAACTGCCTGGAGTTTCTGGCCGGTGGAAAGGC
CGGCACCCGTCTGGAGAAGGTGGTCCTATCCTTCGCCGCAGAAATGCTGGTGCAGGCTCGCAAAGCCGCGACATTGGAGG
AAGGCGAGGCGCTGGCGTCGGCGGCTCTCTCCTCCGGCCGCGCCATGGAGATCTTCGCGCGGATGGTTTCGGTACTGGGC
GGCCCGTCGGATTTTATCGAGAATCCATCCCGTTACTTGGCCTGTGCACCGATCATCCTCCCGGTTCCCGCTGCACGAAG
CGGCTGGCTCGCATCCTGTGCAACGCGCGATCTCGGCATGGTTGTCGTCGAACTCGGCGGCGGCAGAACAAAACCCTCGG
ACACCATCAATCCGGCAGTCGGTATTTCGGATATTCTGCCGCTTGGCGTAAGGGTGGAGAAGGGCGAGCCGATCGCCGTC
GTTCACGCAGCCTCCAGCGAAGACGCGGAGCGTGCGGTCAAGAGAATAGAGGACTGTTTTGGGATTGCGGATAACGCTCC
GGAAATCGCGGCATCTGTCCTCGAGCGGATCACCTGA

Upstream 100 bases:

>100_bases
GGGCCATGCCGTCGACCTTCCGTTTCGGTGCCTCGGGCGTCCTCGATGATGTGCTGAACGTGCTGGCCGGCGGCGAACCG
GCCAAGGCCGCCAGCGGGTA

Downstream 100 bases:

>100_bases
CCAGCCGCATTTCGCCGCCCGATACCTTAAAGGACGATAGTTGCTTCAAAAAGCTCATGCCGACCAGCATGTTGCTCAGT
GCATTGTCCTTCAGCACCAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSLIPQEIIRRKRDGLSLAPQEIAAFIEALSKDGISEGQAAAFAMAVFFRGMNRDEMVALTLAMRDSGDVLSWRDIGRPV
ADKHSTGGVGDNVSLMLAPIVAACGLAVPMISGRGLGHTGGTLDKLEAIPGYDVMPDEALFRRTVQSVGCAIIGQTGDLA
PADKRLYAIRDVTATVDSIPLITASILSKKLAAGLETLVLDVKVGNGAFMQSLEDARILARALVDVANGAGLPTTALITD
MNQPLCDAAGNAVEIVNCLEFLAGGKAGTRLEKVVLSFAAEMLVQARKAATLEEGEALASAALSSGRAMEIFARMVSVLG
GPSDFIENPSRYLACAPIILPVPAARSGWLASCATRDLGMVVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAV
VHAASSEDAERAVKRIEDCFGIADNAPEIAASVLERIT

Sequences:

>Translated_438_residues
MSLIPQEIIRRKRDGLSLAPQEIAAFIEALSKDGISEGQAAAFAMAVFFRGMNRDEMVALTLAMRDSGDVLSWRDIGRPV
ADKHSTGGVGDNVSLMLAPIVAACGLAVPMISGRGLGHTGGTLDKLEAIPGYDVMPDEALFRRTVQSVGCAIIGQTGDLA
PADKRLYAIRDVTATVDSIPLITASILSKKLAAGLETLVLDVKVGNGAFMQSLEDARILARALVDVANGAGLPTTALITD
MNQPLCDAAGNAVEIVNCLEFLAGGKAGTRLEKVVLSFAAEMLVQARKAATLEEGEALASAALSSGRAMEIFARMVSVLG
GPSDFIENPSRYLACAPIILPVPAARSGWLASCATRDLGMVVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAV
VHAASSEDAERAVKRIEDCFGIADNAPEIAASVLERIT
>Mature_437_residues
SLIPQEIIRRKRDGLSLAPQEIAAFIEALSKDGISEGQAAAFAMAVFFRGMNRDEMVALTLAMRDSGDVLSWRDIGRPVA
DKHSTGGVGDNVSLMLAPIVAACGLAVPMISGRGLGHTGGTLDKLEAIPGYDVMPDEALFRRTVQSVGCAIIGQTGDLAP
ADKRLYAIRDVTATVDSIPLITASILSKKLAAGLETLVLDVKVGNGAFMQSLEDARILARALVDVANGAGLPTTALITDM
NQPLCDAAGNAVEIVNCLEFLAGGKAGTRLEKVVLSFAAEMLVQARKAATLEEGEALASAALSSGRAMEIFARMVSVLGG
PSDFIENPSRYLACAPIILPVPAARSGWLASCATRDLGMVVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAVV
HAASSEDAERAVKRIEDCFGIADNAPEIAASVLERIT

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=439, Percent_Identity=39.4077448747153, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI4503445, Length=439, Percent_Identity=39.4077448747153, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI166158922, Length=439, Percent_Identity=39.4077448747153, Blast_Score=258, Evalue=7e-69,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=53.4246575342466, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_AGRT5 (Q8UJ08)

Other databases:

- EMBL:   AE007869
- PIR:   A97375
- PIR:   AG2592
- RefSeq:   NP_353169.1
- ProteinModelPortal:   Q8UJ08
- SMR:   Q8UJ08
- STRING:   Q8UJ08
- GeneID:   1132171
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0133
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AIGNANE
- PhylomeDB:   Q8UJ08
- ProtClustDB:   PRK05820
- BioCyc:   ATUM176299-1:ATU0133-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 45638; Mature: 45507

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIPQEIIRRKRDGLSLAPQEIAAFIEALSKDGISEGQAAAFAMAVFFRGMNRDEMVAL
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEE
TLAMRDSGDVLSWRDIGRPVADKHSTGGVGDNVSLMLAPIVAACGLAVPMISGRGLGHTG
EEEECCCCCEECHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTLDKLEAIPGYDVMPDEALFRRTVQSVGCAIIGQTGDLAPADKRLYAIRDVTATVDSIP
CCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHEEEHHHHHHHHHHHH
LITASILSKKLAAGLETLVLDVKVGNGAFMQSLEDARILARALVDVANGAGLPTTALITD
HHHHHHHHHHHHHCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
MNQPLCDAAGNAVEIVNCLEFLAGGKAGTRLEKVVLSFAAEMLVQARKAATLEEGEALAS
CCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALSSGRAMEIFARMVSVLGGPSDFIENPSRYLACAPIILPVPAARSGWLASCATRDLGM
HHHHCCCHHHHHHHHHHHHCCCHHHHCCCCHHEEECCEEEECCCCCCCCHHHHHHCCCCE
VVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAVVHAASSEDAERAVKRIEDCF
EEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
GIADNAPEIAASVLERIT
CCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLIPQEIIRRKRDGLSLAPQEIAAFIEALSKDGISEGQAAAFAMAVFFRGMNRDEMVAL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEE
TLAMRDSGDVLSWRDIGRPVADKHSTGGVGDNVSLMLAPIVAACGLAVPMISGRGLGHTG
EEEECCCCCEECHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTLDKLEAIPGYDVMPDEALFRRTVQSVGCAIIGQTGDLAPADKRLYAIRDVTATVDSIP
CCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCHHHEEEHHHHHHHHHHHH
LITASILSKKLAAGLETLVLDVKVGNGAFMQSLEDARILARALVDVANGAGLPTTALITD
HHHHHHHHHHHHHCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
MNQPLCDAAGNAVEIVNCLEFLAGGKAGTRLEKVVLSFAAEMLVQARKAATLEEGEALAS
CCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALSSGRAMEIFARMVSVLGGPSDFIENPSRYLACAPIILPVPAARSGWLASCATRDLGM
HHHHCCCHHHHHHHHHHHHCCCHHHHCCCCHHEEECCEEEECCCCCCCCHHHHHHCCCCE
VVVELGGGRTKPSDTINPAVGISDILPLGVRVEKGEPIAVVHAASSEDAERAVKRIEDCF
EEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
GIADNAPEIAASVLERIT
CCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194