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The map label for this gene is adhB [H]

Identifier: 158423599

GI number: 158423599

Start: 2277999

End: 2279198

Strand: Direct

Name: adhB [H]

Synonym: AZC_1975

Alternate gene names: 158423599

Gene position: 2277999-2279198 (Clockwise)

Preceding gene: 158423597

Following gene: 158423600

Centisome position: 42.42

GC content: 69.17

Gene sequence:

>1200_bases
ATGAGCGGCCCGGTCCTGCGCCTGCGGGCCGATGATCCGGGCGCCGGCGTCCCGCCGTCTCCCGTCTCCCGCGCAAGCCT
CGCGACGCCGCTTGCGCTGCAGCGCCCACGGGTGATCGAGTTCGGCGCCGGAACGGCGCCCATCGCCGGCCGCTGGGCCG
CCGCGCAAGGCTTCTCGCGCATACTGGTCGTGGCCGACGCCTTCAACGCCGCCCGCATCGATGTGCTGGAACTGAATGGC
GCGGTGACCGTCTTCGGCACGGTGAAGCCGGAACCGGATGTTCCCAATCTCGAAGCCGCCCTTGCCCTCGCCGAGGCGAC
CAAGCCGGATCTCGTGATCGGCTTCGGCGGCGGCAGTGCCATGGATCTCGCCAAGCTGGTGGCGGTGCTGCCGGGAAGCG
GGCAGACGCTGGCCGAGGTCGTGGGCCCGGAGAAGGTGAGAGTCAAGGGCCCGGCGCTCATGCAGGTGCCGACCACCTCC
GGAACGGGCAGCGAGGCGGGGACGCGCGCGCTGATCACCGATCCGCAGACGCAGAACAAGCTCGCGGTTCAGAGCCTCCA
TATGCTGGCGGACATCGCCATCATCGATCCGGCGCTGACCCTGACCGTGCCGCCCGCTGTGACGGCGGCGACGGGCGTGG
ATGCTCTTGCCCATTGCGTCGAGGCCTACACCAGCCGCAAAGCCCATCCGCTCATCGACATGTATGCGCTCGAGGGCGTG
CGGCTTGTTGGCGCCTTTCTCGCTCGCGCCGTGGCGGACGGCAGCGATGTCGAGGCGCGGGCGGGTCTATCTCTCGCCTC
GCTCTATGGCGGTTTCTGCCTCGGGCCAGTGAACACGACGGCGGGCCACGCCGTGGCCTATCCGCTGGGCACCCGTCATC
ACATCGCCCATGGCGCGGCCAATGCGCTGATCTTTCCGCACACGCTGGCCTTCAACGCCCCGGCCATGCCGGAGAAGACT
GCCGCCGTCATCGCGGCGCTGGGCCTCGGCGCGGCGTCGCGGCAGGCGGACGTGTTCGAGGCCGCCCATCGCTATTGCGC
CGGCCTCGGCTGCGAGATGCGTCTGTCCGCGCTTGATGTGCCACGCGACGACCTGCCTGTCATGGCGACCGAGGCCCATG
CCATTCGCCGCCTGCTCGACAACAACCCGCGCGACATCAGCCGGGACGATATCCTCGCGATCTATGAAAAGGCTTATTGA

Upstream 100 bases:

>100_bases
CTCGCCCGCCGAGCAACAGACATGGGTGGACAATGCACAAGGTTTGGCTTGACGCTTTGCGTCCGGTGGCCGGGCGCGCG
CCCGAACATGGACGGGTCCG

Downstream 100 bases:

>100_bases
GATGGGCAGCCACCCCACCGCCATCGAGCCCGCGGGCCTGACGGAGCGCACCGGCATCCTTCATCCGCGCGAGGGTGATC
CGGCGCGGACGGAGGCCTAT

Product: iron alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSGPVLRLRADDPGAGVPPSPVSRASLATPLALQRPRVIEFGAGTAPIAGRWAAAQGFSRILVVADAFNAARIDVLELNG
AVTVFGTVKPEPDVPNLEAALALAEATKPDLVIGFGGGSAMDLAKLVAVLPGSGQTLAEVVGPEKVRVKGPALMQVPTTS
GTGSEAGTRALITDPQTQNKLAVQSLHMLADIAIIDPALTLTVPPAVTAATGVDALAHCVEAYTSRKAHPLIDMYALEGV
RLVGAFLARAVADGSDVEARAGLSLASLYGGFCLGPVNTTAGHAVAYPLGTRHHIAHGAANALIFPHTLAFNAPAMPEKT
AAVIAALGLGAASRQADVFEAAHRYCAGLGCEMRLSALDVPRDDLPVMATEAHAIRRLLDNNPRDISRDDILAIYEKAY

Sequences:

>Translated_399_residues
MSGPVLRLRADDPGAGVPPSPVSRASLATPLALQRPRVIEFGAGTAPIAGRWAAAQGFSRILVVADAFNAARIDVLELNG
AVTVFGTVKPEPDVPNLEAALALAEATKPDLVIGFGGGSAMDLAKLVAVLPGSGQTLAEVVGPEKVRVKGPALMQVPTTS
GTGSEAGTRALITDPQTQNKLAVQSLHMLADIAIIDPALTLTVPPAVTAATGVDALAHCVEAYTSRKAHPLIDMYALEGV
RLVGAFLARAVADGSDVEARAGLSLASLYGGFCLGPVNTTAGHAVAYPLGTRHHIAHGAANALIFPHTLAFNAPAMPEKT
AAVIAALGLGAASRQADVFEAAHRYCAGLGCEMRLSALDVPRDDLPVMATEAHAIRRLLDNNPRDISRDDILAIYEKAY
>Mature_398_residues
SGPVLRLRADDPGAGVPPSPVSRASLATPLALQRPRVIEFGAGTAPIAGRWAAAQGFSRILVVADAFNAARIDVLELNGA
VTVFGTVKPEPDVPNLEAALALAEATKPDLVIGFGGGSAMDLAKLVAVLPGSGQTLAEVVGPEKVRVKGPALMQVPTTSG
TGSEAGTRALITDPQTQNKLAVQSLHMLADIAIIDPALTLTVPPAVTAATGVDALAHCVEAYTSRKAHPLIDMYALEGVR
LVGAFLARAVADGSDVEARAGLSLASLYGGFCLGPVNTTAGHAVAYPLGTRHHIAHGAANALIFPHTLAFNAPAMPEKTA
AVIAALGLGAASRQADVFEAAHRYCAGLGCEMRLSALDVPRDDLPVMATEAHAIRRLLDNNPRDISRDDILAIYEKAY

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=411, Percent_Identity=26.7639902676399, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI87082107, Length=383, Percent_Identity=33.420365535248, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=30.0791556728232, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789163, Length=365, Percent_Identity=27.9452054794521, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787493, Length=316, Percent_Identity=32.9113924050633, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789386, Length=399, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=416, Percent_Identity=25.4807692307692, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=373, Percent_Identity=29.4906166219839, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24657991, Length=413, Percent_Identity=24.6973365617433, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41129; Mature: 40997

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPVLRLRADDPGAGVPPSPVSRASLATPLALQRPRVIEFGAGTAPIAGRWAAAQGFSR
CCCCEEEEEECCCCCCCCCCCCCHHHHCCCHHHCCCCEEEECCCCCCCCCCHHHHCCCEE
ILVVADAFNAARIDVLELNGAVTVFGTVKPEPDVPNLEAALALAEATKPDLVIGFGGGSA
EEEEEECCCCCEEEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCH
MDLAKLVAVLPGSGQTLAEVVGPEKVRVKGPALMQVPTTSGTGSEAGTRALITDPQTQNK
HHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCCCH
LAVQSLHMLADIAIIDPALTLTVPPAVTAATGVDALAHCVEAYTSRKAHPLIDMYALEGV
HHHHHHHHHHHHHEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RLVGAFLARAVADGSDVEARAGLSLASLYGGFCLGPVNTTAGHAVAYPLGTRHHIAHGAA
HHHHHHHHHHHCCCCCCHHHCCCHHHHHHCCEEECCCCCCCCCEEEECCCCCHHHHHCCC
NALIFPHTLAFNAPAMPEKTAAVIAALGLGAASRQADVFEAAHRYCAGLGCEMRLSALDV
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC
PRDDLPVMATEAHAIRRLLDNNPRDISRDDILAIYEKAY
CCCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SGPVLRLRADDPGAGVPPSPVSRASLATPLALQRPRVIEFGAGTAPIAGRWAAAQGFSR
CCCEEEEEECCCCCCCCCCCCCHHHHCCCHHHCCCCEEEECCCCCCCCCCHHHHCCCEE
ILVVADAFNAARIDVLELNGAVTVFGTVKPEPDVPNLEAALALAEATKPDLVIGFGGGSA
EEEEEECCCCCEEEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCH
MDLAKLVAVLPGSGQTLAEVVGPEKVRVKGPALMQVPTTSGTGSEAGTRALITDPQTQNK
HHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCCCH
LAVQSLHMLADIAIIDPALTLTVPPAVTAATGVDALAHCVEAYTSRKAHPLIDMYALEGV
HHHHHHHHHHHHHEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RLVGAFLARAVADGSDVEARAGLSLASLYGGFCLGPVNTTAGHAVAYPLGTRHHIAHGAA
HHHHHHHHHHHCCCCCCHHHCCCHHHHHHCCEEECCCCCCCCCEEEECCCCCHHHHHCCC
NALIFPHTLAFNAPAMPEKTAAVIAALGLGAASRQADVFEAAHRYCAGLGCEMRLSALDV
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC
PRDDLPVMATEAHAIRRLLDNNPRDISRDDILAIYEKAY
CCCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]