Click here to switch to the map view.

The map label for this gene is cobB1 [H]

Identifier: 158423559

GI number: 158423559

Start: 2236599

End: 2237360

Strand: Direct

Name: cobB1 [H]

Synonym: AZC_1935

Alternate gene names: 158423559

Gene position: 2236599-2237360 (Clockwise)

Preceding gene: 158423554

Following gene: 158423560

Centisome position: 41.65

GC content: 67.72

Gene sequence:

>762_bases
ATGATTTTCGAAGCCGATCTCAAGACCGCCCAGCGTGAACTGGCGGACTTTCTCACCGCCGCCGACCGGGCGGTCGCCTT
TACCGGGGCTGGGCTCTCCACCGAATGCGGCATTCCCGATTTCCGGTCCCCCGGGGGCCTGTGGAGCCGGAACAAGCCCA
TCGCCTTCGGCGACTTCCGCGCCCATCCGGCGGCCCGAAACGAGGCCTGGCGGCGCAAGTTCGTGATGGACGCATCCTTT
GCGGGCGCGCAGCCGGGGCGGGGACACAGGGCGCTTGCGAACCTGCTGGCGCAGGGGCGGCTCTCGGGGATCATCACCCA
GAACATCGATGGGCTGCACCAGGCCTCTGGCGTGCCGGACATGGATCTGGTCGAACTGCACGGCAACGGCACCTATGCCA
CCTGCCTCGACTGCCGGCGGCGCTATGAGCTGGGATGGGTGAAGACCCGCTTCGAGGCGGCGGGTGGCATCGCGCCCGAT
TGCGAGGCTTGCGGCGGGCCGATCAAGTCGGCCACCATTTCGTTCGGCCAGGCCATGCCGGAGCGGGAGATGGCCCGCGC
GGCGGCGCTCACCGATACGTGCGACCTCTTCATCGTGCTGGGATCGTCGCTGGTGGTCTATCCTGCTGCCGGATTTCCGC
TCATGGCCCGGCGCAACGGCGCGCGGCTCGTCATCGTCAACCGCCAGCCCACCGACTTCGACGAGATGGCGGATCTGGTG
GTGCGGGACGATATCGGCGATGTGCTGGAGCCCTTCCTCTAG

Upstream 100 bases:

>100_bases
AGGCGTCGAGATCCGTGACGCGGACCATGGTGTGGAGATAGCGCATGGCTGATCCTTGGCGGGGAGGGAAAACCTGGCGG
GGCGCCGGCGGGGCAAAGGT

Downstream 100 bases:

>100_bases
CGCGCCGGCGGTCCCGCAGGTGCCGCAGCGGACGCGCGAGGGGAAGGAGCGGGGGGGGCCGAAAATGTCGCGTCGCGCTG
CAACGAAAGGGTGTGCGTCG

Product: silent information regulator protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIFEADLKTAQRELADFLTAADRAVAFTGAGLSTECGIPDFRSPGGLWSRNKPIAFGDFRAHPAARNEAWRRKFVMDASF
AGAQPGRGHRALANLLAQGRLSGIITQNIDGLHQASGVPDMDLVELHGNGTYATCLDCRRRYELGWVKTRFEAAGGIAPD
CEACGGPIKSATISFGQAMPEREMARAAALTDTCDLFIVLGSSLVVYPAAGFPLMARRNGARLVIVNRQPTDFDEMADLV
VRDDIGDVLEPFL

Sequences:

>Translated_253_residues
MIFEADLKTAQRELADFLTAADRAVAFTGAGLSTECGIPDFRSPGGLWSRNKPIAFGDFRAHPAARNEAWRRKFVMDASF
AGAQPGRGHRALANLLAQGRLSGIITQNIDGLHQASGVPDMDLVELHGNGTYATCLDCRRRYELGWVKTRFEAAGGIAPD
CEACGGPIKSATISFGQAMPEREMARAAALTDTCDLFIVLGSSLVVYPAAGFPLMARRNGARLVIVNRQPTDFDEMADLV
VRDDIGDVLEPFL
>Mature_253_residues
MIFEADLKTAQRELADFLTAADRAVAFTGAGLSTECGIPDFRSPGGLWSRNKPIAFGDFRAHPAARNEAWRRKFVMDASF
AGAQPGRGHRALANLLAQGRLSGIITQNIDGLHQASGVPDMDLVELHGNGTYATCLDCRRRYELGWVKTRFEAAGGIAPD
CEACGGPIKSATISFGQAMPEREMARAAALTDTCDLFIVLGSSLVVYPAAGFPLMARRNGARLVIVNRQPTDFDEMADLV
VRDDIGDVLEPFL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=244, Percent_Identity=34.4262295081967, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI6912662, Length=266, Percent_Identity=33.8345864661654, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI300797597, Length=237, Percent_Identity=33.7552742616034, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI6912660, Length=225, Percent_Identity=32.8888888888889, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI63054862, Length=203, Percent_Identity=33.9901477832512, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13775602, Length=219, Percent_Identity=32.4200913242009, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI13775600, Length=219, Percent_Identity=32.4200913242009, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI7657575, Length=226, Percent_Identity=30.5309734513274, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI300795542, Length=221, Percent_Identity=33.4841628959276, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI300797705, Length=198, Percent_Identity=31.3131313131313, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706712, Length=261, Percent_Identity=29.1187739463602, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI13787215, Length=237, Percent_Identity=31.6455696202532, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI6912664, Length=237, Percent_Identity=31.6455696202532, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI215982798, Length=163, Percent_Identity=29.4478527607362, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI308199517, Length=228, Percent_Identity=31.5789473684211, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71990482, Length=274, Percent_Identity=31.021897810219, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17567771, Length=270, Percent_Identity=29.6296296296296, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71990487, Length=276, Percent_Identity=30.7971014492754, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17541892, Length=226, Percent_Identity=30.9734513274336, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17505510, Length=260, Percent_Identity=25.7692307692308, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325242, Length=268, Percent_Identity=27.9850746268657, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645650, Length=257, Percent_Identity=30.3501945525292, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571445, Length=276, Percent_Identity=32.6086956521739, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24648389, Length=222, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17137536, Length=229, Percent_Identity=27.9475982532751, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650933, Length=253, Percent_Identity=26.8774703557312, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571443, Length=217, Percent_Identity=29.4930875576037, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571441, Length=217, Percent_Identity=29.4930875576037, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27302; Mature: 27302

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFEADLKTAQRELADFLTAADRAVAFTGAGLSTECGIPDFRSPGGLWSRNKPIAFGDFR
CEECHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC
AHPAARNEAWRRKFVMDASFAGAQPGRGHRALANLLAQGRLSGIITQNIDGLHQASGVPD
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
MDLVELHGNGTYATCLDCRRRYELGWVKTRFEAAGGIAPDCEACGGPIKSATISFGQAMP
CEEEEEECCCCEEHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHCCC
EREMARAAALTDTCDLFIVLGSSLVVYPAAGFPLMARRNGARLVIVNRQPTDFDEMADLV
HHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCEEEECCCCEEEEECCCCCCHHHHHHHH
VRDDIGDVLEPFL
HHHHHHHHHHHCC
>Mature Secondary Structure
MIFEADLKTAQRELADFLTAADRAVAFTGAGLSTECGIPDFRSPGGLWSRNKPIAFGDFR
CEECHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC
AHPAARNEAWRRKFVMDASFAGAQPGRGHRALANLLAQGRLSGIITQNIDGLHQASGVPD
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
MDLVELHGNGTYATCLDCRRRYELGWVKTRFEAAGGIAPDCEACGGPIKSATISFGQAMP
CEEEEEECCCCEEHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHCCC
EREMARAAALTDTCDLFIVLGSSLVVYPAAGFPLMARRNGARLVIVNRQPTDFDEMADLV
HHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCEEEECCCCEEEEECCCCCCHHHHHHHH
VRDDIGDVLEPFL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]