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The map label for this gene is metC [H]

Identifier: 158423208

GI number: 158423208

Start: 1807402

End: 1808634

Strand: Reverse

Name: metC [H]

Synonym: AZC_1584

Alternate gene names: 158423208

Gene position: 1808634-1807402 (Counterclockwise)

Preceding gene: 158423213

Following gene: 158423198

Centisome position: 33.68

GC content: 67.4

Gene sequence:

>1233_bases
GTGGCGCGACATTGCGCACGGTGCCGTTATAGGCAAATGGGAGAATTTTTCATGAGTCATGCCGGCGATGACGACGCCCT
CGCGCCCGAGACCCGTGTGGTCCATCTGGGGCTCGACCCCTTCCGCTTTGACGGCTTCGTCAATCCGCCCGTGGTGCGTG
GCTCCACCGTGCTCTCGCCGACCTACAAGGATCTCGTCGGCCATACCGGCCGCTACAGCTACGGCCGGCGCGGCAACCCG
ACCTCCGAGGCGCTTCAGAATGCCGTGACGGCCCTCGAAGGCGGCGACGGCACCGTGCTCACGCCGTCGGGCCTGTCTGC
CATCTCCGTCGCCCTGCTCTCGGTGGTGGGTGCCGGCGACCATCTGCTGATGGTGGACACGGCCTACAATCCCACCCGCC
AGTTCTGTACCCGCGTGCTGAAGCGCATGGGGGTGGAGACCACCCATTACGATCCGCTCGTGGGCGCCGGCATCGCCGAC
CTCATCCGCCCGAACACCCGCGCCATCTTCCTGGAATCCCCCGGCTCCCAGAGCTTCGAGATGCAGGACATCCCGGCCAT
CGTGGCGGTGGCGAAGGCCCGCGGCATCACCACCCTCATCGACAACACCTGGGCGACGCCGCTCTTCTTCAAGCCGCACG
CCTTCGGCATCGACCTCTCGATCCAGGCCGGCACCAAATATCTGGGCGGCCATGCGGACCTCAACCTCGGCACCGTCTCG
GCCAAGGGCGATGCGTGGAAGGGCCTCATCGCCACCCATGGCGACATGGGCATCTGCATCAGTCCGGACGATGCGGCGCT
CGGCCTGCGCGGCCTGCGCACGCTCGCCGTCCGCCTCGCCCGGCATCAGGCATCGGGCCTTGAGGTGGCGCGCTGGCTGG
AAGCTTCGCCTTATGTCTCGCGGGTCCTGCATCCGGCGCTGGAGAGCCACCCTGGCCATGCGGTCTGGAAGCGGGATTTC
ACCGGCGCCTGCGGCCTGTTCAGCCTGATCCTGAAGCCGGTGCCCGAGGCGGCGGTGGCCACTTTTTTCGACAGCCTGAA
GCTGTTCGGCATGGGCTATTCCTGGGGCGGCTTCGAATGCCTCGCCATCCCCTTCGACTGCTCCAGCTACCGCACCGCCA
CCAGGTGGCAGGCGGAAGGCCCGGCCGTGCGGCTCCACATCGGCCTCGAAGAGCCGGCGGACATCATCGCTGATCTCGAG
CAGGCGCTGGAGAAGATGGCCGCCGCCGCGTGA

Upstream 100 bases:

>100_bases
TTGGCCAACTCGGTCCCCGCCCCGCCAGGACGGAATAGACGCCCGTTTCCCCGGCGTCTATTCACCCCATCTCAAACACT
CGCACCGTCTTGGTCAATAG

Downstream 100 bases:

>100_bases
TGCCTTGCGCCGCCGTCCGGTCCGGCCGGGCGGCGGCCGCGCTCCGTATCAGGTGGTCGCGCGGTTGGCGCGCCGCTCGC
GGATCGCGAACTGCAGGTTG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MARHCARCRYRQMGEFFMSHAGDDDALAPETRVVHLGLDPFRFDGFVNPPVVRGSTVLSPTYKDLVGHTGRYSYGRRGNP
TSEALQNAVTALEGGDGTVLTPSGLSAISVALLSVVGAGDHLLMVDTAYNPTRQFCTRVLKRMGVETTHYDPLVGAGIAD
LIRPNTRAIFLESPGSQSFEMQDIPAIVAVAKARGITTLIDNTWATPLFFKPHAFGIDLSIQAGTKYLGGHADLNLGTVS
AKGDAWKGLIATHGDMGICISPDDAALGLRGLRTLAVRLARHQASGLEVARWLEASPYVSRVLHPALESHPGHAVWKRDF
TGACGLFSLILKPVPEAAVATFFDSLKLFGMGYSWGGFECLAIPFDCSSYRTATRWQAEGPAVRLHIGLEEPADIIADLE
QALEKMAAAA

Sequences:

>Translated_410_residues
MARHCARCRYRQMGEFFMSHAGDDDALAPETRVVHLGLDPFRFDGFVNPPVVRGSTVLSPTYKDLVGHTGRYSYGRRGNP
TSEALQNAVTALEGGDGTVLTPSGLSAISVALLSVVGAGDHLLMVDTAYNPTRQFCTRVLKRMGVETTHYDPLVGAGIAD
LIRPNTRAIFLESPGSQSFEMQDIPAIVAVAKARGITTLIDNTWATPLFFKPHAFGIDLSIQAGTKYLGGHADLNLGTVS
AKGDAWKGLIATHGDMGICISPDDAALGLRGLRTLAVRLARHQASGLEVARWLEASPYVSRVLHPALESHPGHAVWKRDF
TGACGLFSLILKPVPEAAVATFFDSLKLFGMGYSWGGFECLAIPFDCSSYRTATRWQAEGPAVRLHIGLEEPADIIADLE
QALEKMAAAA
>Mature_409_residues
ARHCARCRYRQMGEFFMSHAGDDDALAPETRVVHLGLDPFRFDGFVNPPVVRGSTVLSPTYKDLVGHTGRYSYGRRGNPT
SEALQNAVTALEGGDGTVLTPSGLSAISVALLSVVGAGDHLLMVDTAYNPTRQFCTRVLKRMGVETTHYDPLVGAGIADL
IRPNTRAIFLESPGSQSFEMQDIPAIVAVAKARGITTLIDNTWATPLFFKPHAFGIDLSIQAGTKYLGGHADLNLGTVSA
KGDAWKGLIATHGDMGICISPDDAALGLRGLRTLAVRLARHQASGLEVARWLEASPYVSRVLHPALESHPGHAVWKRDFT
GACGLFSLILKPVPEAAVATFFDSLKLFGMGYSWGGFECLAIPFDCSSYRTATRWQAEGPAVRLHIGLEEPADIIADLEQ
ALEKMAAAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=336, Percent_Identity=33.9285714285714, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI299473759, Length=336, Percent_Identity=31.25, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI25453487, Length=335, Percent_Identity=30.7462686567164, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789383, Length=388, Percent_Identity=42.5257731958763, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=30.4232804232804, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71980708, Length=352, Percent_Identity=35.5113636363636, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17538055, Length=388, Percent_Identity=34.5360824742268, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17560056, Length=385, Percent_Identity=35.5844155844156, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=328, Percent_Identity=49.390243902439, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6319307, Length=374, Percent_Identity=30.2139037433155, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323333, Length=387, Percent_Identity=27.906976744186, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6321254, Length=385, Percent_Identity=26.7532467532467, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321904, Length=381, Percent_Identity=24.6719160104987, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=392, Percent_Identity=34.6938775510204, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44044; Mature: 43913

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHCARCRYRQMGEFFMSHAGDDDALAPETRVVHLGLDPFRFDGFVNPPVVRGSTVLSP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECC
TYKDLVGHTGRYSYGRRGNPTSEALQNAVTALEGGDGTVLTPSGLSAISVALLSVVGAGD
CHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHCCCC
HLLMVDTAYNPTRQFCTRVLKRMGVETTHYDPLVGAGIADLIRPNTRAIFLESPGSQSFE
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHCCCCCEEEEECCCCCCCC
MQDIPAIVAVAKARGITTLIDNTWATPLFFKPHAFGIDLSIQAGTKYLGGHADLNLGTVS
HHCCHHHHHHHHHCCCEEECCCCCCCCEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEE
AKGDAWKGLIATHGDMGICISPDDAALGLRGLRTLAVRLARHQASGLEVARWLEASPYVS
CCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHH
RVLHPALESHPGHAVWKRDFTGACGLFSLILKPVPEAAVATFFDSLKLFGMGYSWGGFEC
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
LAIPFDCSSYRTATRWQAEGPAVRLHIGLEEPADIIADLEQALEKMAAAA
EEEECCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARHCARCRYRQMGEFFMSHAGDDDALAPETRVVHLGLDPFRFDGFVNPPVVRGSTVLSP
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECC
TYKDLVGHTGRYSYGRRGNPTSEALQNAVTALEGGDGTVLTPSGLSAISVALLSVVGAGD
CHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHCCCC
HLLMVDTAYNPTRQFCTRVLKRMGVETTHYDPLVGAGIADLIRPNTRAIFLESPGSQSFE
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHCCCCCEEEEECCCCCCCC
MQDIPAIVAVAKARGITTLIDNTWATPLFFKPHAFGIDLSIQAGTKYLGGHADLNLGTVS
HHCCHHHHHHHHHCCCEEECCCCCCCCEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEE
AKGDAWKGLIATHGDMGICISPDDAALGLRGLRTLAVRLARHQASGLEVARWLEASPYVS
CCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHH
RVLHPALESHPGHAVWKRDFTGACGLFSLILKPVPEAAVATFFDSLKLFGMGYSWGGFEC
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
LAIPFDCSSYRTATRWQAEGPAVRLHIGLEEPADIIADLEQALEKMAAAA
EEEECCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]