Click here to switch to the map view.

The map label for this gene is pcp [H]

Identifier: 158423158

GI number: 158423158

Start: 1747661

End: 1748284

Strand: Reverse

Name: pcp [H]

Synonym: AZC_1534

Alternate gene names: 158423158

Gene position: 1748284-1747661 (Counterclockwise)

Preceding gene: 158423159

Following gene: 158423157

Centisome position: 32.56

GC content: 72.44

Gene sequence:

>624_bases
ATGGCGCTGCCGCTCCGCGTGCTCATCTGCGGCTTCGGCCCCTTTCCCGGCGTGCCATCCAACCCCTCCGGACGCCTCGC
CGGCAAGCTCGCCCGGCTGCGACGCCCCGCGCTGGCGGGTCTCGACGTCCGCCTGAAGCTGCTGCCCACCACATGGGAGA
TGCTGCCGCAGGTGGCGGACTGGATTTCGGACGAAGCACCGGACGTGGTCCTCATGCTGGGTGTCGCCGCGCGCCGCAAA
CGCCTGTGCGTGGAAACGCGGGCCGTGAATGCCACGAAGGACGCGCCCGATGCCCTGCGCCGCCATCCGGTCGCCCGGCG
CCTCAGGTCCGACGCGCCCGGCGTGTTGCCGGCCCCAGTCCGGCCAAGGCATCTCCAGGCGGCGCTGGGCCGCCGGGTCC
CAAGCGCGCTCTCCCGCGACGCCGGCCGCTATCTGTGCAACGCGCTTTCCTTCGAGACATTCGCCGCCCTCAGGGCGCAT
CAGCGCGACACTCCGGCCGTGTTCATCCATCTGCCGGGCGTGCCGAAGGGGCGGCGGGCCGCTTATGACACAGCCCATCT
CGCCGCGCTGGGCGACCTGCTGGTGGCGCTGGTGGGCGCGGCGCGGAAAACCGCCCTCCCATGA

Upstream 100 bases:

>100_bases
AAGGCACGGCTCCCCGGCCTGGAACGCAGCGTCGCCGACGGCACGCTCGCCCCAACCCTCGCGGCGAACGAGATCGCCGC
CTTGCTGGGGCTTTGAGCCA

Downstream 100 bases:

>100_bases
CCATCTACCTGCCCATCGCCGAACTGCCCGTCGCCATGTTCACCCTGTTCGCGCTCGGGGCAGCGGTGGGCTTCGTCTCC
GGCATGTTCGGTGTGGGCGG

Product: pyroglutamyl peptidase I

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MALPLRVLICGFGPFPGVPSNPSGRLAGKLARLRRPALAGLDVRLKLLPTTWEMLPQVADWISDEAPDVVLMLGVAARRK
RLCVETRAVNATKDAPDALRRHPVARRLRSDAPGVLPAPVRPRHLQAALGRRVPSALSRDAGRYLCNALSFETFAALRAH
QRDTPAVFIHLPGVPKGRRAAYDTAHLAALGDLLVALVGAARKTALP

Sequences:

>Translated_207_residues
MALPLRVLICGFGPFPGVPSNPSGRLAGKLARLRRPALAGLDVRLKLLPTTWEMLPQVADWISDEAPDVVLMLGVAARRK
RLCVETRAVNATKDAPDALRRHPVARRLRSDAPGVLPAPVRPRHLQAALGRRVPSALSRDAGRYLCNALSFETFAALRAH
QRDTPAVFIHLPGVPKGRRAAYDTAHLAALGDLLVALVGAARKTALP
>Mature_206_residues
ALPLRVLICGFGPFPGVPSNPSGRLAGKLARLRRPALAGLDVRLKLLPTTWEMLPQVADWISDEAPDVVLMLGVAARRKR
LCVETRAVNATKDAPDALRRHPVARRLRSDAPGVLPAPVRPRHLQAALGRRVPSALSRDAGRYLCNALSFETFAALRAHQ
RDTPAVFIHLPGVPKGRRAAYDTAHLAALGDLLVALVGAARKTALP

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22290; Mature: 22158

Theoretical pI: Translated: 11.92; Mature: 11.92

Prosite motif: PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPLRVLICGFGPFPGVPSNPSGRLAGKLARLRRPALAGLDVRLKLLPTTWEMLPQVAD
CCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHH
WISDEAPDVVLMLGVAARRKRLCVETRAVNATKDAPDALRRHPVARRLRSDAPGVLPAPV
HHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCC
RPRHLQAALGRRVPSALSRDAGRYLCNALSFETFAALRAHQRDTPAVFIHLPGVPKGRRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
AYDTAHLAALGDLLVALVGAARKTALP
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALPLRVLICGFGPFPGVPSNPSGRLAGKLARLRRPALAGLDVRLKLLPTTWEMLPQVAD
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHH
WISDEAPDVVLMLGVAARRKRLCVETRAVNATKDAPDALRRHPVARRLRSDAPGVLPAPV
HHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCC
RPRHLQAALGRRVPSALSRDAGRYLCNALSFETFAALRAHQRDTPAVFIHLPGVPKGRRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
AYDTAHLAALGDLLVALVGAARKTALP
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11057915; 10089475; 10368293 [H]