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The map label for this gene is uvrC

Identifier: 15834793

GI number: 15834793

Start: 203306

End: 205111

Strand: Reverse

Name: uvrC

Synonym: TC0173

Alternate gene names: 15834793

Gene position: 205111-203306 (Counterclockwise)

Preceding gene: 15834794

Following gene: 15834791

Centisome position: 19.12

GC content: 40.2

Gene sequence:

>1806_bases
TTGATTGGCGTGCGCATAGAAGATTTTTCTCTAAAAAACGTTTCTTCCTCCCCAGGGGTCTATCTTATGAAAGACTCTCA
AGGAGTGGTGCTTTACGTTGGCAAAGCCAAAAATTTGCGTAATCGCCTCTCCTCATATCTTCAAAAAAACGGGGACTCTC
GCGAGCGCATTCCCTTTCTGATGAAACGAACTGCTGATATAGATACTATTGTTGTTTCAAATGAAACAGAAGCTCTTCTC
TTAGAAAATAATTTAATAAAAAAATACCAGCCTCGCTACAACGTCCTTCTAAAAGACGATAAGACTTTTTTTTGTTTATC
GATATCTCTTCAACATCCGTGGCCTAAAATTGAAGCGATACGGACACGAGCGCTCTCACCAAGCAAAAAAAAACAATTAT
TATTTGGGCCTTATGTTAGTGCTGAAGCCTGCTATGCCCTACTCGAAGTAATTAGCCATTGGTTCCCTCTTAGAACCTGC
TCCGATCGAGAATTTTCAACTCGACAACGTCCTTGTGTTCTTTATGAAATGAAGAGATGTTTAGCTCCTTGTGTAGGTTT
TTGTTCCCAAACGGAATATCAGGAAACTTTAGAGAAAGCTATTCTTTTCCTTAAAGGAGAAGTGGACACTACGATAGCTA
ATTTAGAGGAAGCTATCAAAAAGGCTTCTCAAGAACATAAATTCGAACACGCCGCAGCTTTATATCGCACGCTCACACTC
ATCCGTCAAACAATGGCGAAACAACATGTTGAGAAATTTCAAGCGTACGATATTGATGTACTCGGACTCTATAGAAAAGG
CCCTCTTGCTATTATTTCTGTACTCTCTGTCTATTCCGGCAAATTACTCGGGGCTCGTCATTTCACCTTCCCAGAAAATG
CTCAGGAAGACTCTTCTCTATTTTCTTCTTTCATCCTGCAATATTATGCAGAGAATACTCGTATTCCCAAGCAGATATTC
GTTCCCGTATCTCCAGATAGCCCAGAACTCCCCTACCTATTAAATGCTGCCGAACCACCAAAAATCCGCTGTCCTAAAAC
GGAATATGGAAAAGAGCTTCTTGCTCTTGCTCATAAAAATGCCGCGGAGCAAGCTAAACCCTTAAATTCCATCACTCTTC
CCTACGAAGAACTGCAACAACTTTTTAAATTCAGCCAATATCCGAATCGCATCGAATGCTATGACAATGCTCACTTACAA
GGAGAACACAATGTAGGTGTCTATATTGTATTTGAAAAAGGGAGTTTCTCTCCTAAACAGTATCGCACTTTCTCTATCAC
TTCTCATGGTGATGATTTAGCAGCATTTGAAGAGGTACTTACACGACGTTTCCGCTCTCTTACTACAGAACTTCCTGATC
TTATCGTGATTGATGGCGGACGTAATCAGTTCAGACGAGCACAGCACATTTTGGAGAAACTTAATTTAACAGGAATCGCT
GTAGTTTCTATTGCTAAAGAATCGGGAAACCACAGCAGAGGCTTACAACAAGAGAAACTGTTTTGTGAAGCTTTCCCTCA
GGGGATACTCCTTAATCCTACCTCAGAAATTCTTCAATTCTTCCAACTATTACGCGATGAAGCACACCGTTTCGCGATCA
ACCGTTACCGGAATAAACATTCTAAAGCCATTCTAACCACAAAAAAAATTCCAGGAATTGGAAAGACAAAAACTACACAT
CTACTTCAAAAATTCAAAAGCTGGAAACGTATACTCTCAGCTTCAGAAGAAGAACTAAAAACAGTTCAAGGACTAACCAA
AAAAGACATCCAACGAATTCAGGAAGAGGGAAAAAGAGCAGAATAA

Upstream 100 bases:

>100_bases
TATCAAGAGCGCAGCAGATCTTGCATCAATTCGAAGGGCCTGATCTACGTCCAGAACCTGAGAAGGCTCAACAGCTGGTC
ATGTTTTAATTCTATTTTTT

Downstream 100 bases:

>100_bases
AAGCTTTCTGCTCTAATTACAGAATTTTATGAAGAGCTTTCCTATTCTTCTGTTTTGACCAAAGAAACTTCCTCTAAATG
TGCCTCTGTGGAAGGCAATG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MIGVRIEDFSLKNVSSSPGVYLMKDSQGVVLYVGKAKNLRNRLSSYLQKNGDSRERIPFLMKRTADIDTIVVSNETEALL
LENNLIKKYQPRYNVLLKDDKTFFCLSISLQHPWPKIEAIRTRALSPSKKKQLLFGPYVSAEACYALLEVISHWFPLRTC
SDREFSTRQRPCVLYEMKRCLAPCVGFCSQTEYQETLEKAILFLKGEVDTTIANLEEAIKKASQEHKFEHAAALYRTLTL
IRQTMAKQHVEKFQAYDIDVLGLYRKGPLAIISVLSVYSGKLLGARHFTFPENAQEDSSLFSSFILQYYAENTRIPKQIF
VPVSPDSPELPYLLNAAEPPKIRCPKTEYGKELLALAHKNAAEQAKPLNSITLPYEELQQLFKFSQYPNRIECYDNAHLQ
GEHNVGVYIVFEKGSFSPKQYRTFSITSHGDDLAAFEEVLTRRFRSLTTELPDLIVIDGGRNQFRRAQHILEKLNLTGIA
VVSIAKESGNHSRGLQQEKLFCEAFPQGILLNPTSEILQFFQLLRDEAHRFAINRYRNKHSKAILTTKKIPGIGKTKTTH
LLQKFKSWKRILSASEEELKTVQGLTKKDIQRIQEEGKRAE

Sequences:

>Translated_601_residues
MIGVRIEDFSLKNVSSSPGVYLMKDSQGVVLYVGKAKNLRNRLSSYLQKNGDSRERIPFLMKRTADIDTIVVSNETEALL
LENNLIKKYQPRYNVLLKDDKTFFCLSISLQHPWPKIEAIRTRALSPSKKKQLLFGPYVSAEACYALLEVISHWFPLRTC
SDREFSTRQRPCVLYEMKRCLAPCVGFCSQTEYQETLEKAILFLKGEVDTTIANLEEAIKKASQEHKFEHAAALYRTLTL
IRQTMAKQHVEKFQAYDIDVLGLYRKGPLAIISVLSVYSGKLLGARHFTFPENAQEDSSLFSSFILQYYAENTRIPKQIF
VPVSPDSPELPYLLNAAEPPKIRCPKTEYGKELLALAHKNAAEQAKPLNSITLPYEELQQLFKFSQYPNRIECYDNAHLQ
GEHNVGVYIVFEKGSFSPKQYRTFSITSHGDDLAAFEEVLTRRFRSLTTELPDLIVIDGGRNQFRRAQHILEKLNLTGIA
VVSIAKESGNHSRGLQQEKLFCEAFPQGILLNPTSEILQFFQLLRDEAHRFAINRYRNKHSKAILTTKKIPGIGKTKTTH
LLQKFKSWKRILSASEEELKTVQGLTKKDIQRIQEEGKRAE
>Mature_601_residues
MIGVRIEDFSLKNVSSSPGVYLMKDSQGVVLYVGKAKNLRNRLSSYLQKNGDSRERIPFLMKRTADIDTIVVSNETEALL
LENNLIKKYQPRYNVLLKDDKTFFCLSISLQHPWPKIEAIRTRALSPSKKKQLLFGPYVSAEACYALLEVISHWFPLRTC
SDREFSTRQRPCVLYEMKRCLAPCVGFCSQTEYQETLEKAILFLKGEVDTTIANLEEAIKKASQEHKFEHAAALYRTLTL
IRQTMAKQHVEKFQAYDIDVLGLYRKGPLAIISVLSVYSGKLLGARHFTFPENAQEDSSLFSSFILQYYAENTRIPKQIF
VPVSPDSPELPYLLNAAEPPKIRCPKTEYGKELLALAHKNAAEQAKPLNSITLPYEELQQLFKFSQYPNRIECYDNAHLQ
GEHNVGVYIVFEKGSFSPKQYRTFSITSHGDDLAAFEEVLTRRFRSLTTELPDLIVIDGGRNQFRRAQHILEKLNLTGIA
VVSIAKESGNHSRGLQQEKLFCEAFPQGILLNPTSEILQFFQLLRDEAHRFAINRYRNKHSKAILTTKKIPGIGKTKTTH
LLQKFKSWKRILSASEEELKTVQGLTKKDIQRIQEEGKRAE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=605, Percent_Identity=34.0495867768595, Blast_Score=299, Evalue=4e-82,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68752; Mature: 68752

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVRIEDFSLKNVSSSPGVYLMKDSQGVVLYVGKAKNLRNRLSSYLQKNGDSRERIPFL
CCCEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
MKRTADIDTIVVSNETEALLLENNLIKKYQPRYNVLLKDDKTFFCLSISLQHPWPKIEAI
HHHCCCCEEEEECCCCCEEEEECCHHHHCCCCCCEEEECCCEEEEEEEEECCCCCHHHHH
RTRALSPSKKKQLLFGPYVSAEACYALLEVISHWFPLRTCSDREFSTRQRPCVLYEMKRC
HHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LAPCVGFCSQTEYQETLEKAILFLKGEVDTTIANLEEAIKKASQEHKFEHAAALYRTLTL
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQTMAKQHVEKFQAYDIDVLGLYRKGPLAIISVLSVYSGKLLGARHFTFPENAQEDSSL
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHH
FSSFILQYYAENTRIPKQIFVPVSPDSPELPYLLNAAEPPKIRCPKTEYGKELLALAHKN
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCC
AAEQAKPLNSITLPYEELQQLFKFSQYPNRIECYDNAHLQGEHNVGVYIVFEKGSFSPKQ
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCCEEEEEEECCCCCCCC
YRTFSITSHGDDLAAFEEVLTRRFRSLTTELPDLIVIDGGRNQFRRAQHILEKLNLTGIA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCEEE
VVSIAKESGNHSRGLQQEKLFCEAFPQGILLNPTSEILQFFQLLRDEAHRFAINRYRNKH
EEEEEHHCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SKAILTTKKIPGIGKTKTTHLLQKFKSWKRILSASEEELKTVQGLTKKDIQRIQEEGKRA
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCC
E
C
>Mature Secondary Structure
MIGVRIEDFSLKNVSSSPGVYLMKDSQGVVLYVGKAKNLRNRLSSYLQKNGDSRERIPFL
CCCEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
MKRTADIDTIVVSNETEALLLENNLIKKYQPRYNVLLKDDKTFFCLSISLQHPWPKIEAI
HHHCCCCEEEEECCCCCEEEEECCHHHHCCCCCCEEEECCCEEEEEEEEECCCCCHHHHH
RTRALSPSKKKQLLFGPYVSAEACYALLEVISHWFPLRTCSDREFSTRQRPCVLYEMKRC
HHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LAPCVGFCSQTEYQETLEKAILFLKGEVDTTIANLEEAIKKASQEHKFEHAAALYRTLTL
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQTMAKQHVEKFQAYDIDVLGLYRKGPLAIISVLSVYSGKLLGARHFTFPENAQEDSSL
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHH
FSSFILQYYAENTRIPKQIFVPVSPDSPELPYLLNAAEPPKIRCPKTEYGKELLALAHKN
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCC
AAEQAKPLNSITLPYEELQQLFKFSQYPNRIECYDNAHLQGEHNVGVYIVFEKGSFSPKQ
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCCEEEEEEECCCCCCCC
YRTFSITSHGDDLAAFEEVLTRRFRSLTTELPDLIVIDGGRNQFRRAQHILEKLNLTGIA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCEEE
VVSIAKESGNHSRGLQQEKLFCEAFPQGILLNPTSEILQFFQLLRDEAHRFAINRYRNKH
EEEEEHHCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SKAILTTKKIPGIGKTKTTHLLQKFKSWKRILSASEEELKTVQGLTKKDIQRIQEEGKRA
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]