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Identifier: 15834768

GI number: 15834768

Start: 179834

End: 180898

Strand: Reverse

Name: Not Available

Synonym: TC0148

Alternate gene names: 15834768

Gene position: 180898-179834 (Counterclockwise)

Preceding gene: 15834773

Following gene: 15834765

Centisome position: 16.86

GC content: 43.38

Gene sequence:

>1065_bases
ATGGGATCTCCATCAAGAATTTCACTCCAAGAAGGGCTCCAACTTTTTCTCTCCTCCCCCTTAGAAGAACTTCGAATCCG
CGCAGACTCATTACGAAGAGATCGCTACCCTCAAAATACTATTACCTATGTTCTAGATGCCAATCCCAATTACACGAATG
TTTGTAAAATAGATTGTTCTTTCTGTGCCTTTTACAGAAAGCCTAATTCTTCGGATTCCTATTTACTTTCATTCAATGAA
TTTCGCGAGTGGATGCACCGCTACGTAGAATTAGGTATCAAAACAGTACTACTACAGGGAGGCGTTCATCCAAAAATCGG
CATTGATTACTTGGAGACTTTAGTTTCCATTACAAAACAAGAGTTCCCCTCTCTACACCCACATTTTTTTTCTGCGGTAG
AAATTTCCCATGCGGCTCAGGTATCAGGAATTTCTACTGAACAAGCACTAAAACGTCTCTGGGATGCGGGTCAACGTACA
GTCCCTGGGGGAGGCGCAGAAATATTATCTGAAAAAATTCGTAAACGCATATCGCCAAAAAAAATGTATCCCGATGGCTG
GATACAATTCCATAAGCTAGCGCATCGACTAGGGTTTCGTTCAACAGCAACCATGATGTTTGGTCATTTGGAAAGCGCGG
AAGATATTCTCTTACATCTACAAACTCTTCGTGATGCTCAGGATGAAAATCCAGGATTTTTTAGCTTCATCCCTTGGAGC
TACAAACCCAATAACACAGCACTGGGCCGACGCGTCACTCAGCAAGCATCTCCTGAGCTCTATTATCGCATTCTGGCAAT
CGCAAGAATCTTTTTAGACAATTTCGATCACATTGCAGCTTCTTGGTTTGGTGAAGGAAAAGAAGAGGGACTACAAGGGC
TTTTCTATGGCGCTGATGACTTTGGAGGGACTATTCTCGATGAAAGCGTTCACAAATGCACGGGATGGGACTTGCAAAGT
TCTGAGCAAGAAATTCGTATGATGCTTAGCCGCGCAGGATTTACTCCTGTGGAACGAGATACCTTCTATCTCCCAGTTTC
TCCTGCCTTCTCAACGAAGATCTAG

Upstream 100 bases:

>100_bases
GAATATCCATATAATAAACTGCTGGTTAGTGTGAGTCTTGACAAAAAAAACAATTGGTAGTCAAAGTTTGCTCTGGCAAT
GCATTATCGTCAACGGTTTT

Downstream 100 bases:

>100_bases
CCACATAGAAAGTAGTCCTGCGCTATCTTTCTTGCGATATCACCAAGAGTCATGCCCATAGGGCTCAGTTCTCTAAATAG
TGGATAACGTTTAAACCAAG

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 1 [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MGSPSRISLQEGLQLFLSSPLEELRIRADSLRRDRYPQNTITYVLDANPNYTNVCKIDCSFCAFYRKPNSSDSYLLSFNE
FREWMHRYVELGIKTVLLQGGVHPKIGIDYLETLVSITKQEFPSLHPHFFSAVEISHAAQVSGISTEQALKRLWDAGQRT
VPGGGAEILSEKIRKRISPKKMYPDGWIQFHKLAHRLGFRSTATMMFGHLESAEDILLHLQTLRDAQDENPGFFSFIPWS
YKPNNTALGRRVTQQASPELYYRILAIARIFLDNFDHIAASWFGEGKEEGLQGLFYGADDFGGTILDESVHKCTGWDLQS
SEQEIRMMLSRAGFTPVERDTFYLPVSPAFSTKI

Sequences:

>Translated_354_residues
MGSPSRISLQEGLQLFLSSPLEELRIRADSLRRDRYPQNTITYVLDANPNYTNVCKIDCSFCAFYRKPNSSDSYLLSFNE
FREWMHRYVELGIKTVLLQGGVHPKIGIDYLETLVSITKQEFPSLHPHFFSAVEISHAAQVSGISTEQALKRLWDAGQRT
VPGGGAEILSEKIRKRISPKKMYPDGWIQFHKLAHRLGFRSTATMMFGHLESAEDILLHLQTLRDAQDENPGFFSFIPWS
YKPNNTALGRRVTQQASPELYYRILAIARIFLDNFDHIAASWFGEGKEEGLQGLFYGADDFGGTILDESVHKCTGWDLQS
SEQEIRMMLSRAGFTPVERDTFYLPVSPAFSTKI
>Mature_353_residues
GSPSRISLQEGLQLFLSSPLEELRIRADSLRRDRYPQNTITYVLDANPNYTNVCKIDCSFCAFYRKPNSSDSYLLSFNEF
REWMHRYVELGIKTVLLQGGVHPKIGIDYLETLVSITKQEFPSLHPHFFSAVEISHAAQVSGISTEQALKRLWDAGQRTV
PGGGAEILSEKIRKRISPKKMYPDGWIQFHKLAHRLGFRSTATMMFGHLESAEDILLHLQTLRDAQDENPGFFSFIPWSY
KPNNTALGRRVTQQASPELYYRILAIARIFLDNFDHIAASWFGEGKEEGLQGLFYGADDFGGTILDESVHKCTGWDLQSS
EQEIRMMLSRAGFTPVERDTFYLPVSPAFSTKI

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40304; Mature: 40173

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPSRISLQEGLQLFLSSPLEELRIRADSLRRDRYPQNTITYVLDANPNYTNVCKIDCS
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEHH
FCAFYRKPNSSDSYLLSFNEFREWMHRYVELGIKTVLLQGGVHPKIGIDYLETLVSITKQ
HHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EFPSLHPHFFSAVEISHAAQVSGISTEQALKRLWDAGQRTVPGGGAEILSEKIRKRISPK
HCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
KMYPDGWIQFHKLAHRLGFRSTATMMFGHLESAEDILLHLQTLRDAQDENPGFFSFIPWS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEECCC
YKPNNTALGRRVTQQASPELYYRILAIARIFLDNFDHIAASWFGEGKEEGLQGLFYGADD
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHCCCEEEECCCC
FGGTILDESVHKCTGWDLQSSEQEIRMMLSRAGFTPVERDTFYLPVSPAFSTKI
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
GSPSRISLQEGLQLFLSSPLEELRIRADSLRRDRYPQNTITYVLDANPNYTNVCKIDCS
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEHH
FCAFYRKPNSSDSYLLSFNEFREWMHRYVELGIKTVLLQGGVHPKIGIDYLETLVSITKQ
HHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EFPSLHPHFFSAVEISHAAQVSGISTEQALKRLWDAGQRTVPGGGAEILSEKIRKRISPK
HCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
KMYPDGWIQFHKLAHRLGFRSTATMMFGHLESAEDILLHLQTLRDAQDENPGFFSFIPWS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEECCC
YKPNNTALGRRVTQQASPELYYRILAIARIFLDNFDHIAASWFGEGKEEGLQGLFYGADD
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHCCCEEEECCCC
FGGTILDESVHKCTGWDLQSSEQEIRMMLSRAGFTPVERDTFYLPVSPAFSTKI
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA