Click here to switch to the map view.

The map label for this gene is lvr [H]

Identifier: 158318126

GI number: 158318126

Start: 7757450

End: 7758211

Strand: Reverse

Name: lvr [H]

Synonym: Franean1_6390

Alternate gene names: 158318126

Gene position: 7758211-7757450 (Counterclockwise)

Preceding gene: 158318127

Following gene: 158318124

Centisome position: 86.37

GC content: 71.78

Gene sequence:

>762_bases
GTGAAACTCGCCGGCAGGGTCGTCGTGATCACCGGCTCGGGGGGTGGTCTCGGCGAGGCCTGCGCGCGCCGGTTCACCGC
CGAGGGCGCGAAGGTCGTCGTGACGGACGTCGACCCCGCCGGCGTCGAGCGGGTGTCGAGCGCGATCGGCGGTGTCGGCC
TGGCGGCCGACATCACGGTCGAGGACAACGTCCGCGCCGTCGCCGACCTCGCTCGCCGCGCCTACGGCGAGATCGACGTC
TGGTTCAGCAACGCCGGGGCCGCCGGCCCCCGCCAGCCCGGCGACGTCCAGGCGAACCCCCTGTGGGATTCGTCCTGGCA
GCTGCACGTGATGTCACACGTGTACGCGGTCCGCGAGGTTCTGCCGGCGATGCTCGAACGGGGCGACGGGTATCTGCTGC
AGACGGCGTCGGTCGTCGCGCTGTCGACGCAGGCGGAGAAGGCGGCGTACTCGGTGACGAAACACGCGGCGCTCGCGCTC
TCCGAGTGGCTGGCGGCCGCGTACCGCCCGCGCGGCATCAAGGTCTCCTGTTTCTGCCCCGGCGCGATGCTGACACCGAT
GCTCCTCGCGAACGGCCTGCCCGCCGACCATCCGGTGCTCCGCTCCGCGCCGACACCGGACGCGCAGGCCGACCTGCTCA
TACGGGCGATCGACGAGGAGCGGTTCCTCATCGTCGACTCGGAGCAGGGGCCGGACGCGATGCTGGCCAAGCTGACCGAC
TACGACCGCTGGATCGACGGCATCGCGCCTCCGTTCGGCTGA

Upstream 100 bases:

>100_bases
AACGAACCCAACCCCTACCTCCCCGACCTCCTCATCTGCCGCCCCGAACTCACCGACACAGTCCTGACCGCGCTGAGAGA
CTCGTGAGGGGAACCGCGCT

Downstream 100 bases:

>100_bases
GATCGCCTGAGATCCCGCCCCGCCGCGGCCCTGACACACGCCCCGTCGTGACCCCACCACCCGGCCCGGCGGGCCTTCCC
CGACCGCGCGGTCAGGCGTC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKLAGRVVVITGSGGGLGEACARRFTAEGAKVVVTDVDPAGVERVSSAIGGVGLAADITVEDNVRAVADLARRAYGEIDV
WFSNAGAAGPRQPGDVQANPLWDSSWQLHVMSHVYAVREVLPAMLERGDGYLLQTASVVALSTQAEKAAYSVTKHAALAL
SEWLAAAYRPRGIKVSCFCPGAMLTPMLLANGLPADHPVLRSAPTPDAQADLLIRAIDEERFLIVDSEQGPDAMLAKLTD
YDRWIDGIAPPFG

Sequences:

>Translated_253_residues
MKLAGRVVVITGSGGGLGEACARRFTAEGAKVVVTDVDPAGVERVSSAIGGVGLAADITVEDNVRAVADLARRAYGEIDV
WFSNAGAAGPRQPGDVQANPLWDSSWQLHVMSHVYAVREVLPAMLERGDGYLLQTASVVALSTQAEKAAYSVTKHAALAL
SEWLAAAYRPRGIKVSCFCPGAMLTPMLLANGLPADHPVLRSAPTPDAQADLLIRAIDEERFLIVDSEQGPDAMLAKLTD
YDRWIDGIAPPFG
>Mature_253_residues
MKLAGRVVVITGSGGGLGEACARRFTAEGAKVVVTDVDPAGVERVSSAIGGVGLAADITVEDNVRAVADLARRAYGEIDV
WFSNAGAAGPRQPGDVQANPLWDSSWQLHVMSHVYAVREVLPAMLERGDGYLLQTASVVALSTQAEKAAYSVTKHAALAL
SEWLAAAYRPRGIKVSCFCPGAMLTPMLLANGLPADHPVLRSAPTPDAQADLLIRAIDEERFLIVDSEQGPDAMLAKLTD
YDRWIDGIAPPFG

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=34.0314136125654, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI40807363, Length=230, Percent_Identity=26.5217391304348, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI142976729, Length=254, Percent_Identity=23.6220472440945, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI66933014, Length=188, Percent_Identity=30.3191489361702, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=33.1521739130435, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758504, Length=238, Percent_Identity=31.5126050420168, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI59889578, Length=166, Percent_Identity=28.9156626506024, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI210032110, Length=186, Percent_Identity=24.1935483870968, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI5031737, Length=189, Percent_Identity=31.2169312169312, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=31.2169312169312, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310128830, Length=235, Percent_Identity=25.531914893617, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI310115468, Length=235, Percent_Identity=25.531914893617, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4504505, Length=194, Percent_Identity=30.9278350515464, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI126723750, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI83715985, Length=232, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=31.1224489795918, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=220, Percent_Identity=31.3636363636364, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786701, Length=200, Percent_Identity=29, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789208, Length=189, Percent_Identity=24.8677248677249, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787820, Length=177, Percent_Identity=25.9887005649718, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=231, Percent_Identity=29.4372294372294, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17564282, Length=208, Percent_Identity=27.4038461538462, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=229, Percent_Identity=25.3275109170306, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193203115, Length=225, Percent_Identity=25.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=27.4111675126904, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=196, Percent_Identity=29.0816326530612, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=205, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=192, Percent_Identity=25.5208333333333, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=203, Percent_Identity=26.1083743842365, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=207, Percent_Identity=26.5700483091787, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=190, Percent_Identity=30, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=211, Percent_Identity=28.436018957346, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=27.6041666666667, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358495, Length=200, Percent_Identity=27.5, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=28.9017341040462, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24663911, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221510726, Length=234, Percent_Identity=29.0598290598291, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI23397609, Length=190, Percent_Identity=25.7894736842105, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26720; Mature: 26720

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAGRVVVITGSGGGLGEACARRFTAEGAKVVVTDVDPAGVERVSSAIGGVGLAADITV
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEE
EDNVRAVADLARRAYGEIDVWFSNAGAAGPRQPGDVQANPLWDSSWQLHVMSHVYAVREV
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LPAMLERGDGYLLQTASVVALSTQAEKAAYSVTKHAALALSEWLAAAYRPRGIKVSCFCP
HHHHHHCCCCEEEEECEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GAMLTPMLLANGLPADHPVLRSAPTPDAQADLLIRAIDEERFLIVDSEQGPDAMLAKLTD
CHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEECCCEEEEEECCCCCHHHHHHHHH
YDRWIDGIAPPFG
HHHHHHCCCCCCC
>Mature Secondary Structure
MKLAGRVVVITGSGGGLGEACARRFTAEGAKVVVTDVDPAGVERVSSAIGGVGLAADITV
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEE
EDNVRAVADLARRAYGEIDVWFSNAGAAGPRQPGDVQANPLWDSSWQLHVMSHVYAVREV
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LPAMLERGDGYLLQTASVVALSTQAEKAAYSVTKHAALALSEWLAAAYRPRGIKVSCFCP
HHHHHHCCCCEEEEECEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GAMLTPMLLANGLPADHPVLRSAPTPDAQADLLIRAIDEERFLIVDSEQGPDAMLAKLTD
CHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEECCCEEEEEECCCCCHHHHHHHHH
YDRWIDGIAPPFG
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]