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The map label for this gene is mdtA [H]

Identifier: 157963507

GI number: 157963507

Start: 4494740

End: 4495822

Strand: Direct

Name: mdtA [H]

Synonym: Spea_3695

Alternate gene names: 157963507

Gene position: 4494740-4495822 (Clockwise)

Preceding gene: 157963505

Following gene: 157963508

Centisome position: 86.86

GC content: 50.97

Gene sequence:

>1083_bases
ATGAAAAACCTGACAACTACACTTTCACTCCTTATCTTGACTGCAGTCATTTCAGGTTGTAACGCAGAGTCTAGCGAGGC
TGTAAAGCCTAGCGTGCGCCCAGTTAAACTGCTTGAAATCACCGATATCAATGCGGGTTCGCTGCGAAGCTTCCCTGCAA
AAGTTGCTGCCACTAAGCAAGCAGAACTCGCCTTTCGGCTGTCGGGACACTTAGTAGAGTTTAATCTTGTTGAAGGTCAA
CAGGTAAATAAAGGCGCCGTATTAGCCCGCCTGGATAGACGTGATTCGCAAAACACCCTGCTTAACCGTGAGGCCGATTA
TGAATTAGCTAAGGCCGACTTTAAGCGTAAGGGCGAGCTGCTTCGCCGTGAGCTTATCTCACAGGCCGAATATGACTTAG
CCTCGGCGCAGTTAAAGTCGTCGAAAGCCAACCTTGCCAGCGCCCAAGATCAGCTCAGCTATACCGAGTTAACCGCTCCC
TATGACGGCACAGTCGCTAAGATCTCCATCGATAACTACCAGATGGTCCAAGCTAACCAGCCAGTGCTAGTGCTACAAAA
AGACAGCGACATAGATGTGGTGATCCAAGTGCCTGAATCCCTTGCGAGCAAGGTGACTCAATTTAATCCCAACGCCATTA
CTCAACCTGTAGTGCGATTCGCCAACGACCCAAGCAGCAGCTATGCCGCGCTATTAAAAGAGCATGCAACCCAAGTGACC
CCTGGCACCCAGAGCTATGAAGTGGTGTTTACCCTGCCCCGCCCTGCCAATATGACAGTGCTACCGGGTATGAGCGCCGA
GCTGACTATGGACATTACACAGCACAATTCTCAAACCCTGGCTGCGATTCTGCCTGCCAGTGCCATTAGTAAACGCGACC
AAGATGGCCAAACGGTTGTCTGGGCCTTTGACAGTAAACTAGGCAAGGTAACACAACAGATGGTGACCTTAGGTAAGGTG
ACAACCGATGGCATTGAGATTGTCGATGGCATCAAGGTGGGTGACCAAGTGGTTGTGGCTGGCGTGCAATATCTGTCTGA
AGGGCTTGAGGTTAAGCCACTGCGTTGGCAACGAGGCGTGTAG

Upstream 100 bases:

>100_bases
CGGAACTCATGATTCCACATAATTCCATTTTACTCAACTCAAAGTCCTGCTATCTTTGCTCCCCCTAAATATTGGCCTTT
CGTTATATGGAATTTGCGTT

Downstream 100 bases:

>100_bases
CGCACCGCCTCAGTTCACCGTCCCCCAACCTTTTTGCCCCTGCTTTACAAGAGAGTTAATTGATGAATTTTGCTGAATAT
TCCATCACCCACAAAGTCAT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKNLTTTLSLLILTAVISGCNAESSEAVKPSVRPVKLLEITDINAGSLRSFPAKVAATKQAELAFRLSGHLVEFNLVEGQ
QVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGELLRRELISQAEYDLASAQLKSSKANLASAQDQLSYTELTAP
YDGTVAKISIDNYQMVQANQPVLVLQKDSDIDVVIQVPESLASKVTQFNPNAITQPVVRFANDPSSSYAALLKEHATQVT
PGTQSYEVVFTLPRPANMTVLPGMSAELTMDITQHNSQTLAAILPASAISKRDQDGQTVVWAFDSKLGKVTQQMVTLGKV
TTDGIEIVDGIKVGDQVVVAGVQYLSEGLEVKPLRWQRGV

Sequences:

>Translated_360_residues
MKNLTTTLSLLILTAVISGCNAESSEAVKPSVRPVKLLEITDINAGSLRSFPAKVAATKQAELAFRLSGHLVEFNLVEGQ
QVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGELLRRELISQAEYDLASAQLKSSKANLASAQDQLSYTELTAP
YDGTVAKISIDNYQMVQANQPVLVLQKDSDIDVVIQVPESLASKVTQFNPNAITQPVVRFANDPSSSYAALLKEHATQVT
PGTQSYEVVFTLPRPANMTVLPGMSAELTMDITQHNSQTLAAILPASAISKRDQDGQTVVWAFDSKLGKVTQQMVTLGKV
TTDGIEIVDGIKVGDQVVVAGVQYLSEGLEVKPLRWQRGV
>Mature_360_residues
MKNLTTTLSLLILTAVISGCNAESSEAVKPSVRPVKLLEITDINAGSLRSFPAKVAATKQAELAFRLSGHLVEFNLVEGQ
QVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGELLRRELISQAEYDLASAQLKSSKANLASAQDQLSYTELTAP
YDGTVAKISIDNYQMVQANQPVLVLQKDSDIDVVIQVPESLASKVTQFNPNAITQPVVRFANDPSSSYAALLKEHATQVT
PGTQSYEVVFTLPRPANMTVLPGMSAELTMDITQHNSQTLAAILPASAISKRDQDGQTVVWAFDSKLGKVTQQMVTLGKV
TTDGIEIVDGIKVGDQVVVAGVQYLSEGLEVKPLRWQRGV

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=310, Percent_Identity=28.0645161290323, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789929, Length=374, Percent_Identity=24.0641711229947, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789665, Length=374, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786668, Length=340, Percent_Identity=25.2941176470588, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081796, Length=325, Percent_Identity=24.9230769230769, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39080; Mature: 39080

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTTTLSLLILTAVISGCNAESSEAVKPSVRPVKLLEITDINAGSLRSFPAKVAATKQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCH
AELAFRLSGHLVEFNLVEGQQVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGEL
HHEEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHHH
LRRELISQAEYDLASAQLKSSKANLASAQDQLSYTELTAPYDGTVAKISIDNYQMVQANQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEEEECCEEEEECCC
PVLVLQKDSDIDVVIQVPESLASKVTQFNPNAITQPVVRFANDPSSSYAALLKEHATQVT
CEEEEECCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
PGTQSYEVVFTLPRPANMTVLPGMSAELTMDITQHNSQTLAAILPASAISKRDQDGQTVV
CCCCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCEEEEHHCHHHHHCCCCCCCEEE
WAFDSKLGKVTQQMVTLGKVTTDGIEIVDGIKVGDQVVVAGVQYLSEGLEVKPLRWQRGV
EEECCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNLTTTLSLLILTAVISGCNAESSEAVKPSVRPVKLLEITDINAGSLRSFPAKVAATKQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCH
AELAFRLSGHLVEFNLVEGQQVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGEL
HHEEEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHHH
LRRELISQAEYDLASAQLKSSKANLASAQDQLSYTELTAPYDGTVAKISIDNYQMVQANQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEEEECCEEEEECCC
PVLVLQKDSDIDVVIQVPESLASKVTQFNPNAITQPVVRFANDPSSSYAALLKEHATQVT
CEEEEECCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
PGTQSYEVVFTLPRPANMTVLPGMSAELTMDITQHNSQTLAAILPASAISKRDQDGQTVV
CCCCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCEEEEHHCHHHHHCCCCCCCEEE
WAFDSKLGKVTQQMVTLGKVTTDGIEIVDGIKVGDQVVVAGVQYLSEGLEVKPLRWQRGV
EEECCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA