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The map label for this gene is mtrB [H]

Identifier: 157963443

GI number: 157963443

Start: 4420213

End: 4421562

Strand: Direct

Name: mtrB [H]

Synonym: Spea_3631

Alternate gene names: 157963443

Gene position: 4420213-4421562 (Clockwise)

Preceding gene: 157963442

Following gene: 157963445

Centisome position: 85.42

GC content: 46.07

Gene sequence:

>1350_bases
TTGCTAAAGCGCTTACTCAACCGTGTGCCATCGGCATCTAAATTACCGCAAAAGCTGCTGATCTATTTCAGCAGTATTGC
CTTAATGATAGGTCTGACTCTCTATATCTCTATGCTAAGTCTAATGCAGTGGATTGAAGATGAGGTCAACCAACATGAAC
TCGAGTCCAGCGCTCCCTTTGCCATTAGTCTATTTCAGCAAGGTGCAAAACAGCCATTACAGATAGGTCTGCATGTTGAG
GCCTACTATTCAGCAGAGCTCATTCCAGAACAGTATGGTGACTTAAGCCAATTTCCAAACGGGTTTTCAGGAGAAGTTGT
CGATCGTGGTGAGAGTGGGCTACTGCACGAGATCTTCAACTTTAACTTGTTAGTTAACGATACCCTTGGTGTCAACAATG
AGTTATTCCTCTATCGCAGCGAATTTGAACTCAACGGCACCATGCAGCCTCTCTACCTTATCATGCCATCAGAGAACGTG
GAGCTAAGCGATAGTGAATGGCGATCGATAAACCTATTCGTTCTCGGCTTCATCGGAATGCTATTCCTGCTTTTTGGCTT
CGCCATTCATAAGCTAAGCCGCAGATTAGTCGAACCTGTGGAGCAACTCAGCAAACAGTTACAATCGCCCGAGATGCACA
AGACCTTTAATGTACCGCCACAGTCAGCCGCCGAATTTAGTGAGCTTGCCAATAGCCTCAATGATTATCGCCAACAAAAT
GAGCAGATGATAAAGCAAGAGCAGGCCTTTGCTCGCTATGCCAGCCACGAGCTGCGCACCCCCATTACCGTCATTAGTGG
AGCAGCTAAACTGCAAGAGCACAATAATGCCCCTGAGTTTCAGGCTCGCCAGCGAGATAGGATCCAGCGTGCCGCCTTTG
AGATGCAACATACCGTCGATGCATTGCTGAGCATAGTTAAACAGGAAAAAGGCACAGAAAATAATGACTATAGAGCCCTA
GAACTCAAAGAAATCGAACAGATAATCGCACCATTATTGCTGTTAGCTAATGCTAAAAATATCCACATTATCCTAGACTT
CAAACAAGCGCCGCTAATTAAACCGAGTCCCGCCGTACTCAGGATGCTGCTCAGCAATGTCATTAGCAATGCAATCAATG
CCAGTGACTCGGGCGAAATAGCCATCCGCATAGATAAAGAACAGATAGAGATTATCGATATGGGGCGTGGGCTTAGCTCG
TCGGAAAACAGGAATGAAGAGGGTCACGGCCTTGGACTGCTGATTGTCGATAGCCTATGTCAGCGTTATCAATGGCAATT
TAGCCTTATTGAGATCGCCCCTAAGGGGTGTTGTGCTCGACTCACTTTACCTGTAACCGAAAACAATTAA

Upstream 100 bases:

>100_bases
ATATGTACCAGCTTCGCAATCAGCTCGATAAACCCTTTAAGCAGCCAATGCTTGCCACAGTACCTAAAATTGGCTTTAGG
CTACAGCTGGGAGAATAGAT

Downstream 100 bases:

>100_bases
ACACGCCTAAGGTACTCCCCGTTAGTCAGCCCTCAATCTCATTATTGATGGCCTTAGCAATGCGTCGACTGAAAATCACC
GACAGATGCAAAATAATGAT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLKRLLNRVPSASKLPQKLLIYFSSIALMIGLTLYISMLSLMQWIEDEVNQHELESSAPFAISLFQQGAKQPLQIGLHVE
AYYSAELIPEQYGDLSQFPNGFSGEVVDRGESGLLHEIFNFNLLVNDTLGVNNELFLYRSEFELNGTMQPLYLIMPSENV
ELSDSEWRSINLFVLGFIGMLFLLFGFAIHKLSRRLVEPVEQLSKQLQSPEMHKTFNVPPQSAAEFSELANSLNDYRQQN
EQMIKQEQAFARYASHELRTPITVISGAAKLQEHNNAPEFQARQRDRIQRAAFEMQHTVDALLSIVKQEKGTENNDYRAL
ELKEIEQIIAPLLLLANAKNIHIILDFKQAPLIKPSPAVLRMLLSNVISNAINASDSGEIAIRIDKEQIEIIDMGRGLSS
SENRNEEGHGLGLLIVDSLCQRYQWQFSLIEIAPKGCCARLTLPVTENN

Sequences:

>Translated_449_residues
MLKRLLNRVPSASKLPQKLLIYFSSIALMIGLTLYISMLSLMQWIEDEVNQHELESSAPFAISLFQQGAKQPLQIGLHVE
AYYSAELIPEQYGDLSQFPNGFSGEVVDRGESGLLHEIFNFNLLVNDTLGVNNELFLYRSEFELNGTMQPLYLIMPSENV
ELSDSEWRSINLFVLGFIGMLFLLFGFAIHKLSRRLVEPVEQLSKQLQSPEMHKTFNVPPQSAAEFSELANSLNDYRQQN
EQMIKQEQAFARYASHELRTPITVISGAAKLQEHNNAPEFQARQRDRIQRAAFEMQHTVDALLSIVKQEKGTENNDYRAL
ELKEIEQIIAPLLLLANAKNIHIILDFKQAPLIKPSPAVLRMLLSNVISNAINASDSGEIAIRIDKEQIEIIDMGRGLSS
SENRNEEGHGLGLLIVDSLCQRYQWQFSLIEIAPKGCCARLTLPVTENN
>Mature_449_residues
MLKRLLNRVPSASKLPQKLLIYFSSIALMIGLTLYISMLSLMQWIEDEVNQHELESSAPFAISLFQQGAKQPLQIGLHVE
AYYSAELIPEQYGDLSQFPNGFSGEVVDRGESGLLHEIFNFNLLVNDTLGVNNELFLYRSEFELNGTMQPLYLIMPSENV
ELSDSEWRSINLFVLGFIGMLFLLFGFAIHKLSRRLVEPVEQLSKQLQSPEMHKTFNVPPQSAAEFSELANSLNDYRQQN
EQMIKQEQAFARYASHELRTPITVISGAAKLQEHNNAPEFQARQRDRIQRAAFEMQHTVDALLSIVKQEKGTENNDYRAL
ELKEIEQIIAPLLLLANAKNIHIILDFKQAPLIKPSPAVLRMLLSNVISNAINASDSGEIAIRIDKEQIEIIDMGRGLSS
SENRNEEGHGLGLLIVDSLCQRYQWQFSLIEIAPKGCCARLTLPVTENN

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=316, Percent_Identity=21.8354430379747, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50798; Mature: 50798

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRLLNRVPSASKLPQKLLIYFSSIALMIGLTLYISMLSLMQWIEDEVNQHELESSAPF
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AISLFQQGAKQPLQIGLHVEAYYSAELIPEQYGDLSQFPNGFSGEVVDRGESGLLHEIFN
HHHHHHHCCCCCEEEEEEEEEEHHHHHCHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHC
FNLLVNDTLGVNNELFLYRSEFELNGTMQPLYLIMPSENVELSDSEWRSINLFVLGFIGM
CEEEEECCCCCCCEEEEEEECEEECCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHH
LFLLFGFAIHKLSRRLVEPVEQLSKQLQSPEMHKTFNVPPQSAAEFSELANSLNDYRQQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EQMIKQEQAFARYASHELRTPITVISGAAKLQEHNNAPEFQARQRDRIQRAAFEMQHTVD
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALLSIVKQEKGTENNDYRALELKEIEQIIAPLLLLANAKNIHIILDFKQAPLIKPSPAVL
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHH
RMLLSNVISNAINASDSGEIAIRIDKEQIEIIDMGRGLSSSENRNEEGHGLGLLIVDSLC
HHHHHHHHHHHCCCCCCCCEEEEEEHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
QRYQWQFSLIEIAPKGCCARLTLPVTENN
HHHHCCEEEEEECCCCCEEEEEEEECCCC
>Mature Secondary Structure
MLKRLLNRVPSASKLPQKLLIYFSSIALMIGLTLYISMLSLMQWIEDEVNQHELESSAPF
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AISLFQQGAKQPLQIGLHVEAYYSAELIPEQYGDLSQFPNGFSGEVVDRGESGLLHEIFN
HHHHHHHCCCCCEEEEEEEEEEHHHHHCHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHC
FNLLVNDTLGVNNELFLYRSEFELNGTMQPLYLIMPSENVELSDSEWRSINLFVLGFIGM
CEEEEECCCCCCCEEEEEEECEEECCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHH
LFLLFGFAIHKLSRRLVEPVEQLSKQLQSPEMHKTFNVPPQSAAEFSELANSLNDYRQQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EQMIKQEQAFARYASHELRTPITVISGAAKLQEHNNAPEFQARQRDRIQRAAFEMQHTVD
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALLSIVKQEKGTENNDYRALELKEIEQIIAPLLLLANAKNIHIILDFKQAPLIKPSPAVL
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHH
RMLLSNVISNAINASDSGEIAIRIDKEQIEIIDMGRGLSSSENRNEEGHGLGLLIVDSLC
HHHHHHHHHHHCCCCCCCCEEEEEEHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
QRYQWQFSLIEIAPKGCCARLTLPVTENN
HHHHCCEEEEEECCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]