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The map label for this gene is hutH [H]

Identifier: 157963184

GI number: 157963184

Start: 4116764

End: 4118449

Strand: Direct

Name: hutH [H]

Synonym: Spea_3369

Alternate gene names: 157963184

Gene position: 4116764-4118449 (Clockwise)

Preceding gene: 157963183

Following gene: 157963185

Centisome position: 79.56

GC content: 47.69

Gene sequence:

>1686_bases
GTGCCCTGCACTGAGCAGCAAAAAATTATGGAATTGATCAAGATGAAAACAACTAAAAATGCTGTATTAACATCACTCGC
ACTTGCATTAACTGCGACTCATGCCATGGCTGCAGACACTGTGGTACTCGACGGTAAACACTTTACCCAAGATCAAGCTT
GGGCGATTGCCGATGGCGCTAAAGTAAAAATCGCACCGCAATCAGCGACAACCTTAGTCAAAGCCCATGAGTTATTAATG
GAAGCCGCTCGTCTAGGCAAGCCAGTTTATGGACTAACAGTTGGTGTAGGTCTAAACAAAGATCATAAACTATTCGATGC
TAACGGTGAGCTAAGCGCTGAAGTATTAAAGGCTTCTGAGTCGTTCAACTACAGCACGCTTCGCGCTCACAGCGCTGGTG
TAGGTGAAGCCATGCCAGTGCGTTTAACTCGTGTTGCGCTAGCCGTACGCTTAAACACCATCTTGTCTGGTCACACAGGC
GTACAGCCTTATGTTGCCGAGATTTACCAAGCTTACCTAAATAACGATATCTCACCAATTATCCCATCTAAGGGCACGGT
AGGCGAAGCGGACATCCTACTGGCTTCTCATGTTGGCCTAGCCATGATTGGTGAATGGGATGTGATCTACAAAGGCAAGC
GCATGAACAGCGCCGAAGCGATGAAAAAAGCGGGGATCAAGCCGCTAGCCCCTGTAGGTAAAGATGCGCTGTCGATTCTG
TCCAACAACTCTGTTGGCGTGGCTTACGCGATGAAGGGTTACCGCGATGCTAAGCATTTACTAGAGGTCTCACCAACGGT
ATTTAGCCTAAGCCTTGAAGGCCTAAACGGTAACGTGTCGCCATTCTTGCCACAGACCAATGACATTCGCCCTTTCCCAT
ACCTAAAAGAAGCGACAGCCGATGTGCGTAATACCCTATCTGGAAGCTACTTATGGGATGCCAATAGCGAACGTCCACTG
CAAGATCCACTCAGCTACCGCACCACAGCCTATACGTTTGCTAGCGCCTACAAGGCACTAGCAGATCTTGGACAGATGAT
TGATATCCAGATCAACCATTCAGACGACAACCCAGGTGTGATATTAGGTGCGGGTAAAGACTACGGTAACAACTCTCAGG
TCTCTAAGTATTTAGTTGAAGGCAAAGGCGGTGTGTTCCCAACTACCAACTTTGAACCACTCCCTGTCGCACTTGCCGTA
CAACAACTAAGCATCGCGCTGACTCACGTTTCACATAACAGTGCCATGCGTACTATCCACCTATCGGATGACCACTTTAC
TCGTCTACCGCGTTTCTTAAGCGCACCGGGTAACAATGGCCACGCATTCGGTGCAATCCAGAAGAGCTTCGTTGATATGC
AGGTTCGTAATAAAGCCTTAGCAAACCCTGTTTCATTCGACGGTATCCAAATTGCTGGTAACATCGAAGACACCTTCACT
AACTTGAAATTGGCGTCTGACAGACTTATCCAAATCGTTGATAACACAAACGTAATGTACGGCCTAGAGCTGATGCACTC
GACTCAAGCTATCGACCTACGCAAACTTGCAGACAAGAACATCAAGCAAGGCGAAGCGACTAAAGCCATGTATGAAGCTT
TCCGTAAGCAAGTGCCATTTGTTGAAGTTGACCGTCCATTCACACCAGACATTCAGGCTGCATACGAGTTTGTGACTAAG
CTCTAG

Upstream 100 bases:

>100_bases
AGTAGTAACTGGACGTAATGCTGGTCGTCATTGTTCACAGAGCCAGCCAGTGAAACTGAATCTCGCTTAGCTCAAATAAA
AATCAAATTCGCTTAGCTAA

Downstream 100 bases:

>100_bases
CTCATAAGTTAGGGGGGCGATACGAGTCCCCCACGCTCTACTGGCTGCGATAGGTACCACTCCCGCCTATTGCAGCAAAT
CGAGTCACAAGGCTAAGGAA

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MPCTEQQKIMELIKMKTTKNAVLTSLALALTATHAMAADTVVLDGKHFTQDQAWAIADGAKVKIAPQSATTLVKAHELLM
EAARLGKPVYGLTVGVGLNKDHKLFDANGELSAEVLKASESFNYSTLRAHSAGVGEAMPVRLTRVALAVRLNTILSGHTG
VQPYVAEIYQAYLNNDISPIIPSKGTVGEADILLASHVGLAMIGEWDVIYKGKRMNSAEAMKKAGIKPLAPVGKDALSIL
SNNSVGVAYAMKGYRDAKHLLEVSPTVFSLSLEGLNGNVSPFLPQTNDIRPFPYLKEATADVRNTLSGSYLWDANSERPL
QDPLSYRTTAYTFASAYKALADLGQMIDIQINHSDDNPGVILGAGKDYGNNSQVSKYLVEGKGGVFPTTNFEPLPVALAV
QQLSIALTHVSHNSAMRTIHLSDDHFTRLPRFLSAPGNNGHAFGAIQKSFVDMQVRNKALANPVSFDGIQIAGNIEDTFT
NLKLASDRLIQIVDNTNVMYGLELMHSTQAIDLRKLADKNIKQGEATKAMYEAFRKQVPFVEVDRPFTPDIQAAYEFVTK
L

Sequences:

>Translated_561_residues
MPCTEQQKIMELIKMKTTKNAVLTSLALALTATHAMAADTVVLDGKHFTQDQAWAIADGAKVKIAPQSATTLVKAHELLM
EAARLGKPVYGLTVGVGLNKDHKLFDANGELSAEVLKASESFNYSTLRAHSAGVGEAMPVRLTRVALAVRLNTILSGHTG
VQPYVAEIYQAYLNNDISPIIPSKGTVGEADILLASHVGLAMIGEWDVIYKGKRMNSAEAMKKAGIKPLAPVGKDALSIL
SNNSVGVAYAMKGYRDAKHLLEVSPTVFSLSLEGLNGNVSPFLPQTNDIRPFPYLKEATADVRNTLSGSYLWDANSERPL
QDPLSYRTTAYTFASAYKALADLGQMIDIQINHSDDNPGVILGAGKDYGNNSQVSKYLVEGKGGVFPTTNFEPLPVALAV
QQLSIALTHVSHNSAMRTIHLSDDHFTRLPRFLSAPGNNGHAFGAIQKSFVDMQVRNKALANPVSFDGIQIAGNIEDTFT
NLKLASDRLIQIVDNTNVMYGLELMHSTQAIDLRKLADKNIKQGEATKAMYEAFRKQVPFVEVDRPFTPDIQAAYEFVTK
L
>Mature_560_residues
PCTEQQKIMELIKMKTTKNAVLTSLALALTATHAMAADTVVLDGKHFTQDQAWAIADGAKVKIAPQSATTLVKAHELLME
AARLGKPVYGLTVGVGLNKDHKLFDANGELSAEVLKASESFNYSTLRAHSAGVGEAMPVRLTRVALAVRLNTILSGHTGV
QPYVAEIYQAYLNNDISPIIPSKGTVGEADILLASHVGLAMIGEWDVIYKGKRMNSAEAMKKAGIKPLAPVGKDALSILS
NNSVGVAYAMKGYRDAKHLLEVSPTVFSLSLEGLNGNVSPFLPQTNDIRPFPYLKEATADVRNTLSGSYLWDANSERPLQ
DPLSYRTTAYTFASAYKALADLGQMIDIQINHSDDNPGVILGAGKDYGNNSQVSKYLVEGKGGVFPTTNFEPLPVALAVQ
QLSIALTHVSHNSAMRTIHLSDDHFTRLPRFLSAPGNNGHAFGAIQKSFVDMQVRNKALANPVSFDGIQIAGNIEDTFTN
LKLASDRLIQIVDNTNVMYGLELMHSTQAIDLRKLADKNIKQGEATKAMYEAFRKQVPFVEVDRPFTPDIQAAYEFVTKL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=531, Percent_Identity=22.9755178907721, Blast_Score=128, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17567831, Length=530, Percent_Identity=22.8301886792453, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 60870; Mature: 60739

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCTEQQKIMELIKMKTTKNAVLTSLALALTATHAMAADTVVLDGKHFTQDQAWAIADGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEECCC
KVKIAPQSATTLVKAHELLMEAARLGKPVYGLTVGVGLNKDHKLFDANGELSAEVLKASE
EEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCHHHHHHHHCC
SFNYSTLRAHSAGVGEAMPVRLTRVALAVRLNTILSGHTGVQPYVAEIYQAYLNNDISPI
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
IPSKGTVGEADILLASHVGLAMIGEWDVIYKGKRMNSAEAMKKAGIKPLAPVGKDALSIL
CCCCCCCCCHHEEEECCCCEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHH
SNNSVGVAYAMKGYRDAKHLLEVSPTVFSLSLEGLNGNVSPFLPQTNDIRPFPYLKEATA
CCCCCEEEEEHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
DVRNTLSGSYLWDANSERPLQDPLSYRTTAYTFASAYKALADLGQMIDIQINHSDDNPGV
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCE
ILGAGKDYGNNSQVSKYLVEGKGGVFPTTNFEPLPVALAVQQLSIALTHVSHNSAMRTIH
EEECCCCCCCCHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCEEEEE
LSDDHFTRLPRFLSAPGNNGHAFGAIQKSFVDMQVRNKALANPVSFDGIQIAGNIEDTFT
ECCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
NLKLASDRLIQIVDNTNVMYGLELMHSTQAIDLRKLADKNIKQGEATKAMYEAFRKQVPF
HHEECCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCE
VEVDRPFTPDIQAAYEFVTKL
EEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PCTEQQKIMELIKMKTTKNAVLTSLALALTATHAMAADTVVLDGKHFTQDQAWAIADGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEECCC
KVKIAPQSATTLVKAHELLMEAARLGKPVYGLTVGVGLNKDHKLFDANGELSAEVLKASE
EEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCHHHHHHHHCC
SFNYSTLRAHSAGVGEAMPVRLTRVALAVRLNTILSGHTGVQPYVAEIYQAYLNNDISPI
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
IPSKGTVGEADILLASHVGLAMIGEWDVIYKGKRMNSAEAMKKAGIKPLAPVGKDALSIL
CCCCCCCCCHHEEEECCCCEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHH
SNNSVGVAYAMKGYRDAKHLLEVSPTVFSLSLEGLNGNVSPFLPQTNDIRPFPYLKEATA
CCCCCEEEEEHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
DVRNTLSGSYLWDANSERPLQDPLSYRTTAYTFASAYKALADLGQMIDIQINHSDDNPGV
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCE
ILGAGKDYGNNSQVSKYLVEGKGGVFPTTNFEPLPVALAVQQLSIALTHVSHNSAMRTIH
EEECCCCCCCCHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCEEEEE
LSDDHFTRLPRFLSAPGNNGHAFGAIQKSFVDMQVRNKALANPVSFDGIQIAGNIEDTFT
ECCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
NLKLASDRLIQIVDNTNVMYGLELMHSTQAIDLRKLADKNIKQGEATKAMYEAFRKQVPF
HHEECCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCE
VEVDRPFTPDIQAAYEFVTKL
EEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA