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The map label for this gene is hmuU [H]

Identifier: 157963148

GI number: 157963148

Start: 4075478

End: 4076494

Strand: Direct

Name: hmuU [H]

Synonym: Spea_3332

Alternate gene names: 157963148

Gene position: 4075478-4076494 (Clockwise)

Preceding gene: 157963147

Following gene: 157963149

Centisome position: 78.76

GC content: 52.02

Gene sequence:

>1017_bases
ATGGATAATCGTCGTTGGCTTTGGCCCAGTTTACTCGCCGCTCTGGTGATAACCAGCCTGATGTCTGTCAGCATAGGTCC
ACTACAAATTAGCCCATCGGTTAGCTTTCATGCCGTGATGAATTGGGCGATGCAGCTAGATATAGGCAGCGTGGCGCCCC
ATGAGCAGCTAGTGATCAATAATGTGCGTTTACCACGCACTTTATTGGCGCTTGCTGTGGGAGCAGTATTAGCCCAATGC
GGCGCGGTAATGCAGGGGTTATTTAGAAACCCGCTGGCAGATCCCGGCATTATCGGCGTTTCATCGGGTGCAGCCTTGGG
CGCAGCCATCTGTATTGTGCTAATTCCTCAAGGTGGCGAATACATGGTTGCACTTAGCGCCTTTATCGCCGGCCTAGCGA
CCACCTTAATAGTGTATCGCCTTGCTAGCAGTCCCAGTGGTACCTCTGTGGTATTACTACTGTTATCGGGTGTCGCCATT
GCAGCGCTTGCTGGTGCGGGGATCGGGCTATTAACTTATATGGCAGACGATATGGCACTTAGGGATCTGACACTATGGCA
GATGGGCTCAATTGCCGGAGCTCAGTGGCATTACGTGCTATTAAGCTTAGTCGCGCTGGCACTTGTCAGCTGGCAGTTTA
ACTCCAGCGCAAAGGCGCTTAATGCCCTGTTACTTGGAGAAGCTGAAGCCCGCCATTTAGGCCTAGATGTCGATAAACTA
AAGCTGAAACTCATCATACTGTGCGCTATTGGTGTGGGGATTTCGGTGGCGGCAACCGGGATTATTGGCTTTATTGGTTT
AGTGGTGCCGCATCTTGTACGCATGATGGTAGGGCCGGATCATAAACAACTATTGCCACTGAGCGCCATGCTAGGCGCTG
CAATGTTGGCACTTGCTGACATTGGCGCTCGCTCTTTAGTGGCGCCATCAGAGCTGCCCGTCGGCTTAGTCACCGCTTTG
CTCGGTGCGCCCTTCTTTATCGTGTTGCTGTTAAAGCAGCGCCACCGATTAATATAA

Upstream 100 bases:

>100_bases
GACAAGTTAGCTAGCGACTTTATTAACGTAAACCAGTACTAAGACAACCTCTTTAACTGAGCAATATCGCCCCCACTAAG
ATAAAGAGCAGGATACATAA

Downstream 100 bases:

>100_bases
GGTTGCAATAGCCATGATAAATCAACTAGAACAAGCTAATCAGAGCAGTACAACCGCGCTACAAGTGAGTGATTTATCGG
TGCGTATCGGCCATAAATCG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MDNRRWLWPSLLAALVITSLMSVSIGPLQISPSVSFHAVMNWAMQLDIGSVAPHEQLVINNVRLPRTLLALAVGAVLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLIPQGGEYMVALSAFIAGLATTLIVYRLASSPSGTSVVLLLLSGVAI
AALAGAGIGLLTYMADDMALRDLTLWQMGSIAGAQWHYVLLSLVALALVSWQFNSSAKALNALLLGEAEARHLGLDVDKL
KLKLIILCAIGVGISVAATGIIGFIGLVVPHLVRMMVGPDHKQLLPLSAMLGAAMLALADIGARSLVAPSELPVGLVTAL
LGAPFFIVLLLKQRHRLI

Sequences:

>Translated_338_residues
MDNRRWLWPSLLAALVITSLMSVSIGPLQISPSVSFHAVMNWAMQLDIGSVAPHEQLVINNVRLPRTLLALAVGAVLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLIPQGGEYMVALSAFIAGLATTLIVYRLASSPSGTSVVLLLLSGVAI
AALAGAGIGLLTYMADDMALRDLTLWQMGSIAGAQWHYVLLSLVALALVSWQFNSSAKALNALLLGEAEARHLGLDVDKL
KLKLIILCAIGVGISVAATGIIGFIGLVVPHLVRMMVGPDHKQLLPLSAMLGAAMLALADIGARSLVAPSELPVGLVTAL
LGAPFFIVLLLKQRHRLI
>Mature_338_residues
MDNRRWLWPSLLAALVITSLMSVSIGPLQISPSVSFHAVMNWAMQLDIGSVAPHEQLVINNVRLPRTLLALAVGAVLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLIPQGGEYMVALSAFIAGLATTLIVYRLASSPSGTSVVLLLLSGVAI
AALAGAGIGLLTYMADDMALRDLTLWQMGSIAGAQWHYVLLSLVALALVSWQFNSSAKALNALLLGEAEARHLGLDVDKL
KLKLIILCAIGVGISVAATGIIGFIGLVVPHLVRMMVGPDHKQLLPLSAMLGAAMLALADIGARSLVAPSELPVGLVTAL
LGAPFFIVLLLKQRHRLI

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=283, Percent_Identity=44.8763250883392, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1790740, Length=282, Percent_Identity=38.2978723404255, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=33.5714285714286, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=36.0824742268041, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786804, Length=334, Percent_Identity=31.1377245508982, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786347, Length=280, Percent_Identity=31.7857142857143, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35197; Mature: 35197

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRRWLWPSLLAALVITSLMSVSIGPLQISPSVSFHAVMNWAMQLDIGSVAPHEQLVIN
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHEECCCCCCCHHHHHC
NVRLPRTLLALAVGAVLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLIPQGGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHEEEEEEECCCCC
YMVALSAFIAGLATTLIVYRLASSPSGTSVVLLLLSGVAIAALAGAGIGLLTYMADDMAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWHYVLLSLVALALVSWQFNSSAKALNALLLGEAEARHLGLDVDKL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCHHHH
KLKLIILCAIGVGISVAATGIIGFIGLVVPHLVRMMVGPDHKQLLPLSAMLGAAMLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGARSLVAPSELPVGLVTALLGAPFFIVLLLKQRHRLI
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNRRWLWPSLLAALVITSLMSVSIGPLQISPSVSFHAVMNWAMQLDIGSVAPHEQLVIN
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHEECCCCCCCHHHHHC
NVRLPRTLLALAVGAVLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLIPQGGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHEEEEEEECCCCC
YMVALSAFIAGLATTLIVYRLASSPSGTSVVLLLLSGVAIAALAGAGIGLLTYMADDMAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWHYVLLSLVALALVSWQFNSSAKALNALLLGEAEARHLGLDVDKL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCHHHH
KLKLIILCAIGVGISVAATGIIGFIGLVVPHLVRMMVGPDHKQLLPLSAMLGAAMLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGARSLVAPSELPVGLVTALLGAPFFIVLLLKQRHRLI
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]