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The map label for this gene is 157963093

Identifier: 157963093

GI number: 157963093

Start: 4020681

End: 4021115

Strand: Direct

Name: 157963093

Synonym: Spea_3277

Alternate gene names: NA

Gene position: 4020681-4021115 (Clockwise)

Preceding gene: 157963090

Following gene: 157963094

Centisome position: 77.7

GC content: 48.74

Gene sequence:

>435_bases
ATGATGACAAAATGGGCGACACGTTTTTTACAGATGGCCGAGCTCGTTGCATCTTGGAGTAAAGATCCCTCCACACAAGT
GGGCGCAGTGATCACCGAAGATAACCGAATTGTCTCATTAGGTTTTAACGGCTATCCCCATGGGATCTCCGATAGCGCCG
AAACCGACAACCGAGAGATGAAGCTACTCAAAACCCTGCATGCCGAAGAGAATGCCATTCTCTACGCTAAGCGCGATCTT
AGTGGCTGCGAGATCTGGGTGACGCATTTTCCCTGCCCTAACTGCGCCGCCAAGATAATCCAAACAGGATTAAGCACAGT
CCATAGTCCACAACCAAGCGAAGACTTTCTGTCACGCTGGGCGGATAAGATTAAAATAAGCCAAGATATGTTTGACCAAG
CAGGGGTTAAGGTTGATTGGATGCAGGCAGACTAA

Upstream 100 bases:

>100_bases
TATTGATGGGTTATATGTTGATTTATCATTGTTCTGCATAGAGAATAACAGCTAGTTTGAGCGGTTTATTCAATGGTATC
GATTTAGGAGTTTTAGTTAG

Downstream 100 bases:

>100_bases
TACAAGTGGACGAACAAAAGCACCGCTTAACATGATTAAAAAGGACGCTGATTAGCGTCCTTTTTAATATAATGAGCTTA
AACATAGTTAAACTAGGTTT

Product: zinc-binding CMP/dCMP deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MMTKWATRFLQMAELVASWSKDPSTQVGAVITEDNRIVSLGFNGYPHGISDSAETDNREMKLLKTLHAEENAILYAKRDL
SGCEIWVTHFPCPNCAAKIIQTGLSTVHSPQPSEDFLSRWADKIKISQDMFDQAGVKVDWMQAD

Sequences:

>Translated_144_residues
MMTKWATRFLQMAELVASWSKDPSTQVGAVITEDNRIVSLGFNGYPHGISDSAETDNREMKLLKTLHAEENAILYAKRDL
SGCEIWVTHFPCPNCAAKIIQTGLSTVHSPQPSEDFLSRWADKIKISQDMFDQAGVKVDWMQAD
>Mature_144_residues
MMTKWATRFLQMAELVASWSKDPSTQVGAVITEDNRIVSLGFNGYPHGISDSAETDNREMKLLKTLHAEENAILYAKRDL
SGCEIWVTHFPCPNCAAKIIQTGLSTVHSPQPSEDFLSRWADKIKISQDMFDQAGVKVDWMQAD

Specific function: Unknown

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742821, Length=144, Percent_Identity=36.1111111111111, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI61742819, Length=112, Percent_Identity=40.1785714285714, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17557019, Length=127, Percent_Identity=38.5826771653543, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321938, Length=117, Percent_Identity=35.8974358974359, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667298, Length=149, Percent_Identity=40.9395973154362, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667302, Length=149, Percent_Identity=40.9395973154362, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 16161; Mature: 16161

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTKWATRFLQMAELVASWSKDPSTQVGAVITEDNRIVSLGFNGYPHGISDSAETDNREM
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHH
KLLKTLHAEENAILYAKRDLSGCEIWVTHFPCPNCAAKIIQTGLSTVHSPQPSEDFLSRW
HHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
ADKIKISQDMFDQAGVKVDWMQAD
HHHHHHHHHHHHHCCCEEEEEECC
>Mature Secondary Structure
MMTKWATRFLQMAELVASWSKDPSTQVGAVITEDNRIVSLGFNGYPHGISDSAETDNREM
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHH
KLLKTLHAEENAILYAKRDLSGCEIWVTHFPCPNCAAKIIQTGLSTVHSPQPSEDFLSRW
HHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
ADKIKISQDMFDQAGVKVDWMQAD
HHHHHHHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8329441 [H]