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The map label for this gene is cyp18 [H]

Identifier: 157962928

GI number: 157962928

Start: 3813481

End: 3814140

Strand: Direct

Name: cyp18 [H]

Synonym: Spea_3111

Alternate gene names: 157962928

Gene position: 3813481-3814140 (Clockwise)

Preceding gene: 157962927

Following gene: 157962929

Centisome position: 73.7

GC content: 44.7

Gene sequence:

>660_bases
ATGAAAACTTGGAAAACTTGGATAACTTATTTAACAAAAAGTTTAACGAAAAATTTAGCAAAAAAAACAACTAAGATAGC
CAAGACGCTCGCGTCACTGGTCCTGTTAACAACGAGCCAGCTCAGCTATGCCGTAGATATTCAGCCCAACACGCTTTACC
CTCTCGTTGAGCTAGACACCAGCATGGGCAAGATAGTGGTGGAGTTAGATAGAACTCGCTCGCCGATCACAGTTGATAAC
TTTCTAACCTATGTTGTAAAAGGTCACTATGACAACACACTATTTCACCGTGTGATTAGCGATTTCGTGGTGCAAGGTGG
CGGTTTAGACTTAAACAAAGAAGAGCGACCGACCGATAAACCTATCGTCAATGAATCGGGAAACGGCCTCTCTAACCTAA
CTGGCACCATTGCCATGGCTCGAGAAGCCGAGCCACATACCGCCACCAGCCAGTTCTACTTTAATGTAGTCGATAATGAG
AAGTTAGATCCCTCTTCGCGCCGCTGGGGCTATACGGTTTTTGGTGAGGTAACCTCAGGCATGGAAGTATTGCAAGCCAT
ATCGTTAGTGCCTACTGATTTCAATAGCCAAGTAGAGTGGCCTGACTTTCCAGTGCAAGATATTGTTCTTAAAAAGGCGA
CCTTGCTACCTCGAAATTAA

Upstream 100 bases:

>100_bases
ACCCGCGACATCATTAACGACCCAGAGCTGAATCAATTCATTCAGCAGTAAAGATTAAGGTTAGGTTTTCAGCATTCAAA
ATGCTATTAAAAGGAACATT

Downstream 100 bases:

>100_bases
GCCTTATCTATTTAGCCAATCTAAATCTTGAATTATTTTGAAATAATTTGAATTATTTTGAGCAATAGCCCTAATTTCCT
GCCTATACTTATTTCGTAAA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKTWKTWITYLTKSLTKNLAKKTTKIAKTLASLVLLTTSQLSYAVDIQPNTLYPLVELDTSMGKIVVELDRTRSPITVDN
FLTYVVKGHYDNTLFHRVISDFVVQGGGLDLNKEERPTDKPIVNESGNGLSNLTGTIAMAREAEPHTATSQFYFNVVDNE
KLDPSSRRWGYTVFGEVTSGMEVLQAISLVPTDFNSQVEWPDFPVQDIVLKKATLLPRN

Sequences:

>Translated_219_residues
MKTWKTWITYLTKSLTKNLAKKTTKIAKTLASLVLLTTSQLSYAVDIQPNTLYPLVELDTSMGKIVVELDRTRSPITVDN
FLTYVVKGHYDNTLFHRVISDFVVQGGGLDLNKEERPTDKPIVNESGNGLSNLTGTIAMAREAEPHTATSQFYFNVVDNE
KLDPSSRRWGYTVFGEVTSGMEVLQAISLVPTDFNSQVEWPDFPVQDIVLKKATLLPRN
>Mature_219_residues
MKTWKTWITYLTKSLTKNLAKKTTKIAKTLASLVLLTTSQLSYAVDIQPNTLYPLVELDTSMGKIVVELDRTRSPITVDN
FLTYVVKGHYDNTLFHRVISDFVVQGGGLDLNKEERPTDKPIVNESGNGLSNLTGTIAMAREAEPHTATSQFYFNVVDNE
KLDPSSRRWGYTVFGEVTSGMEVLQAISLVPTDFNSQVEWPDFPVQDIVLKKATLLPRN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=169, Percent_Identity=34.9112426035503, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19557636, Length=160, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.0975609756098, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.0975609756098, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=31.0975609756098, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=46.9512195121951, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=43.2926829268293, Blast_Score=143, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=34.6938775510204, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=151, Percent_Identity=33.112582781457, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=30.7228915662651, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17986117, Length=187, Percent_Identity=33.6898395721925, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922376, Length=209, Percent_Identity=26.7942583732057, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24543; Mature: 24543

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWKTWITYLTKSLTKNLAKKTTKIAKTLASLVLLTTSQLSYAVDIQPNTLYPLVELDT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECC
SMGKIVVELDRTRSPITVDNFLTYVVKGHYDNTLFHRVISDFVVQGGGLDLNKEERPTDK
CCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIVNESGNGLSNLTGTIAMAREAEPHTATSQFYFNVVDNEKLDPSSRRWGYTVFGEVTSG
CCCCCCCCCHHHHHHHEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
MEVLQAISLVPTDFNSQVEWPDFPVQDIVLKKATLLPRN
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTWKTWITYLTKSLTKNLAKKTTKIAKTLASLVLLTTSQLSYAVDIQPNTLYPLVELDT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECC
SMGKIVVELDRTRSPITVDNFLTYVVKGHYDNTLFHRVISDFVVQGGGLDLNKEERPTDK
CCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIVNESGNGLSNLTGTIAMAREAEPHTATSQFYFNVVDNEKLDPSSRRWGYTVFGEVTSG
CCCCCCCCCHHHHHHHEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
MEVLQAISLVPTDFNSQVEWPDFPVQDIVLKKATLLPRN
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]