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The map label for this gene is gltP [H]

Identifier: 157962767

GI number: 157962767

Start: 3609712

End: 3610980

Strand: Direct

Name: gltP [H]

Synonym: Spea_2949

Alternate gene names: 157962767

Gene position: 3609712-3610980 (Clockwise)

Preceding gene: 157962764

Following gene: 157962772

Centisome position: 69.76

GC content: 47.6

Gene sequence:

>1269_bases
ATGTTCAAATCATTATCATCCCGTATATTCGTTGGCTTATTTGCCGGCTTATTACTGGGCACACTTTTCCAATATGGCTT
TAGCGAAAATAGCTTTGCCAATACCACACTTGTCGATATCGCATCAGGCGCTGGCAGCATGTTTGTCCAGCTCATCATGA
TGCTGGTTGTACCGCTAGTCTTTTTCAGTATCGTTAGCGGTATTATCGAGCTGAAAGATCTAAAGTCATTCGGCCGACTC
GGCAGTAAGACGTTTGGCTTGTACCTAGTCAATACCGTTATTGCGATTGCCGCAGCGATAGGTCTAGCACTACTGATAGC
TCCTGGGCAAGGCATGCAGCTAACCGGAGAAGATGGCGCAGCCCTTACCTCCACCAGCTTGCCTAGCTTTATCGATATGA
TTGTTAATATTATTCCAAGCAACCCTTTCCAGGCGTTTGCTGACGGCAATATGTTACAGATTATCTTTATGGCATTGCTC
ACTGGCGGCATCATTAAGGCCCTAGGCGAAGATGTAAAACCCATAGTCACCTTCTTCAAGTACGGCAATAAAGTCATGCT
TAAGGCGATTACCGTTGTTATGCAAGTCGCCCCTATTGGTGTGTTTGCGTTAATGGTAAAACTGGGTGCCACCTTCGAGC
CATCGGCATTTGTCAGCGTATTGAGCTACATGGCGGTGATCTTAAGCTTACTCGCTGTATGGGCGCTTGTGGTGTATCCG
GTAGTAGTTGGTATGACAACCAATATCTCCGCGGGTGAGTTTCGCCGTAAGACCCGCGAGCAGTTTCTGTTTGCCTTGTC
GACCGCGAGTTCAAATGCGACTATTCCCGTCACCATGCGCACCTTAACCGACAAGCTTGGCGTAAAACCTAGCGTTGCAG
GCTTTGGTGTACCTATGGGCGCGACCATGAATATGAGTGGTGTCGCGATATATATTACTGTCGCCGCTTTCTTTGTCGGT
AATGCCTTTGGCTACCCTATCACCACAGATCAAATTCCAGCACTCGCCTTTAGTGTATTCCTACTGTCTATTGGTGCCGG
TGGCGTTCCTGGTGGCGGTATTGTGATGATAGGTGTGCTTATTCATCAGATGGGCTTGCCTGTCGAAGCTATCGCATTAG
TTGCTGCACTGGATCGTATCATCGATATGTTCTGTACTAGCACCAATGTGGTTGGTGACTCTGCTGTCGTCAGTATTGTT
GATCACAGTGAGCAGCATGACTTATCTGCAGCAGCGTCACTGGATCTAAATACACAAACGCAAACTTAG

Upstream 100 bases:

>100_bases
ACTTGTGAACCACGTCTCTTTAGTTGAATACTTTTTATACCAATCAGGGAGCGTTTATCTAAGGAAGGAAGTAACCAACA
TCATTGAAGGCAGCAGACTT

Downstream 100 bases:

>100_bases
CCGCGTACATAATCAGCTAGCTCGTCAATAGTCACCTATCACGTTAATAAACACTGATACGAAAAAAGGCACCCTAAGGT
GCCTTTTTATTCGCTATCAC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFKSLSSRIFVGLFAGLLLGTLFQYGFSENSFANTTLVDIASGAGSMFVQLIMMLVVPLVFFSIVSGIIELKDLKSFGRL
GSKTFGLYLVNTVIAIAAAIGLALLIAPGQGMQLTGEDGAALTSTSLPSFIDMIVNIIPSNPFQAFADGNMLQIIFMALL
TGGIIKALGEDVKPIVTFFKYGNKVMLKAITVVMQVAPIGVFALMVKLGATFEPSAFVSVLSYMAVILSLLAVWALVVYP
VVVGMTTNISAGEFRRKTREQFLFALSTASSNATIPVTMRTLTDKLGVKPSVAGFGVPMGATMNMSGVAIYITVAAFFVG
NAFGYPITTDQIPALAFSVFLLSIGAGGVPGGGIVMIGVLIHQMGLPVEAIALVAALDRIIDMFCTSTNVVGDSAVVSIV
DHSEQHDLSAAASLDLNTQTQT

Sequences:

>Translated_422_residues
MFKSLSSRIFVGLFAGLLLGTLFQYGFSENSFANTTLVDIASGAGSMFVQLIMMLVVPLVFFSIVSGIIELKDLKSFGRL
GSKTFGLYLVNTVIAIAAAIGLALLIAPGQGMQLTGEDGAALTSTSLPSFIDMIVNIIPSNPFQAFADGNMLQIIFMALL
TGGIIKALGEDVKPIVTFFKYGNKVMLKAITVVMQVAPIGVFALMVKLGATFEPSAFVSVLSYMAVILSLLAVWALVVYP
VVVGMTTNISAGEFRRKTREQFLFALSTASSNATIPVTMRTLTDKLGVKPSVAGFGVPMGATMNMSGVAIYITVAAFFVG
NAFGYPITTDQIPALAFSVFLLSIGAGGVPGGGIVMIGVLIHQMGLPVEAIALVAALDRIIDMFCTSTNVVGDSAVVSIV
DHSEQHDLSAAASLDLNTQTQT
>Mature_422_residues
MFKSLSSRIFVGLFAGLLLGTLFQYGFSENSFANTTLVDIASGAGSMFVQLIMMLVVPLVFFSIVSGIIELKDLKSFGRL
GSKTFGLYLVNTVIAIAAAIGLALLIAPGQGMQLTGEDGAALTSTSLPSFIDMIVNIIPSNPFQAFADGNMLQIIFMALL
TGGIIKALGEDVKPIVTFFKYGNKVMLKAITVVMQVAPIGVFALMVKLGATFEPSAFVSVLSYMAVILSLLAVWALVVYP
VVVGMTTNISAGEFRRKTREQFLFALSTASSNATIPVTMRTLTDKLGVKPSVAGFGVPMGATMNMSGVAIYITVAAFFVG
NAFGYPITTDQIPALAFSVFLLSIGAGGVPGGGIVMIGVLIHQMGLPVEAIALVAALDRIIDMFCTSTNVVGDSAVVSIV
DHSEQHDLSAAASLDLNTQTQT

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=427, Percent_Identity=28.8056206088993, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI169790839, Length=420, Percent_Identity=26.9047619047619, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI21314632, Length=411, Percent_Identity=27.4939172749392, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI66773030, Length=409, Percent_Identity=26.8948655256724, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=28.030303030303, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI194239697, Length=266, Percent_Identity=31.203007518797, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4827012, Length=271, Percent_Identity=28.7822878228782, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=27.6752767527675, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=27.6752767527675, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI262359914, Length=420, Percent_Identity=23.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI301601644, Length=176, Percent_Identity=32.3863636363636, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1790514, Length=428, Percent_Identity=31.7757009345794, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789947, Length=437, Percent_Identity=27.0022883295195, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788024, Length=368, Percent_Identity=30.4347826086957, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1789473, Length=290, Percent_Identity=30, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71983106, Length=426, Percent_Identity=30.0469483568075, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71983099, Length=426, Percent_Identity=30.0469483568075, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17537407, Length=405, Percent_Identity=30.1234567901235, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=27.4004683840749, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=26.8018018018018, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=441, Percent_Identity=26.530612244898, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=425, Percent_Identity=26.3529411764706, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583025, Length=441, Percent_Identity=25.1700680272109, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137668, Length=441, Percent_Identity=25.1700680272109, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24583023, Length=441, Percent_Identity=25.1700680272109, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281360483, Length=469, Percent_Identity=23.454157782516, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137666, Length=469, Percent_Identity=23.454157782516, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360481, Length=469, Percent_Identity=23.454157782516, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44276; Mature: 44276

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSLSSRIFVGLFAGLLLGTLFQYGFSENSFANTTLVDIASGAGSMFVQLIMMLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHH
FFSIVSGIIELKDLKSFGRLGSKTFGLYLVNTVIAIAAAIGLALLIAPGQGMQLTGEDGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCC
ALTSTSLPSFIDMIVNIIPSNPFQAFADGNMLQIIFMALLTGGIIKALGEDVKPIVTFFK
EEECCCCHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YGNKVMLKAITVVMQVAPIGVFALMVKLGATFEPSAFVSVLSYMAVILSLLAVWALVVYP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVVGMTTNISAGEFRRKTREQFLFALSTASSNATIPVTMRTLTDKLGVKPSVAGFGVPMG
HHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCC
ATMNMSGVAIYITVAAFFVGNAFGYPITTDQIPALAFSVFLLSIGAGGVPGGGIVMIGVL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IHQMGLPVEAIALVAALDRIIDMFCTSTNVVGDSAVVSIVDHSEQHDLSAAASLDLNTQT
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCHHHHCCCCCCCC
QT
CC
>Mature Secondary Structure
MFKSLSSRIFVGLFAGLLLGTLFQYGFSENSFANTTLVDIASGAGSMFVQLIMMLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHH
FFSIVSGIIELKDLKSFGRLGSKTFGLYLVNTVIAIAAAIGLALLIAPGQGMQLTGEDGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCC
ALTSTSLPSFIDMIVNIIPSNPFQAFADGNMLQIIFMALLTGGIIKALGEDVKPIVTFFK
EEECCCCHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YGNKVMLKAITVVMQVAPIGVFALMVKLGATFEPSAFVSVLSYMAVILSLLAVWALVVYP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVVGMTTNISAGEFRRKTREQFLFALSTASSNATIPVTMRTLTDKLGVKPSVAGFGVPMG
HHHHCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCC
ATMNMSGVAIYITVAAFFVGNAFGYPITTDQIPALAFSVFLLSIGAGGVPGGGIVMIGVL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IHQMGLPVEAIALVAALDRIIDMFCTSTNVVGDSAVVSIVDHSEQHDLSAAASLDLNTQT
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCHHHHCCCCCCCC
QT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]