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The map label for this gene is phoP [H]

Identifier: 157962753

GI number: 157962753

Start: 3595533

End: 3596222

Strand: Direct

Name: phoP [H]

Synonym: Spea_2935

Alternate gene names: 157962753

Gene position: 3595533-3596222 (Clockwise)

Preceding gene: 157962752

Following gene: 157962754

Centisome position: 69.48

GC content: 45.51

Gene sequence:

>690_bases
ATGAGATTGTTATTAGTTGAAGATGATTTAGAACTGCAATCTAACCTCAAACAGCACCTTATCGAGGCCAATTATACCGT
CGACACTGCAGATGATGGCGAAATAGGCCTGTTTCAGGGCCGTGAATACAATTACGATGCGGCGATTATCGATGTTGGCT
TACCCAAGCTTGATGGCATCGCCCTCATTAAAGAGCTTAGAGCGCTCGATATCGGCTTTCCTATTCTCATTTTGACTGCC
CGTGATAGCTGGCAAGATAAGGTCGAAGGACTAGACGCCGGCGCCGATGATTACCTCACGAAACCCTTTCATCCTGAGGA
ATTGGTCGCCAGATTAAAAGCCTTGATCCGCCGCTCTGCCGGTAAGGCGAGCCCAATTGTTAGCAATGGGCCTTTTAGCC
TAAACACCAGCAGTTTAGAGATCACCAAGTCTGGTGAAACCATCACCTTGAGTGGCTCAGAGTACAAGTTATTTGAGTAC
TTTATGCTGCATATCGGCGAGGTGAAATCGAAAACCGTGCTAACAGAACACATCTACGATCAAGATTTTGATTTGGACTC
CAACGTGATTGAGGTGTTTATCAGACGCTTACGCAAAAAACTCGACCCAGATAATCAACTCGGCCTTATCGAAACTCTTA
GAGGTCAAGGTTACCGTCTTGTCTCACTCGATAATGATGCTAAGAAATAA

Upstream 100 bases:

>100_bases
CCTTAATAGGCATAAATAAGCATAAGCGCTGACTTAGAAACAACACCAGTTCAGAATAACTGAACGCGCCTTACCAACAT
CCAATAACGAGGGCTTAAGC

Downstream 100 bases:

>100_bases
CCCGTTGATGATTCGCCTTAAGCACTTACCCAGATTATTACACTCGTTAAAGGCACGCCTCATCGTCAGTGCCATGTTGT
TGATCTTGGTCTTGCTGCCC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRLLLVEDDLELQSNLKQHLIEANYTVDTADDGEIGLFQGREYNYDAAIIDVGLPKLDGIALIKELRALDIGFPILILTA
RDSWQDKVEGLDAGADDYLTKPFHPEELVARLKALIRRSAGKASPIVSNGPFSLNTSSLEITKSGETITLSGSEYKLFEY
FMLHIGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNQLGLIETLRGQGYRLVSLDNDAKK

Sequences:

>Translated_229_residues
MRLLLVEDDLELQSNLKQHLIEANYTVDTADDGEIGLFQGREYNYDAAIIDVGLPKLDGIALIKELRALDIGFPILILTA
RDSWQDKVEGLDAGADDYLTKPFHPEELVARLKALIRRSAGKASPIVSNGPFSLNTSSLEITKSGETITLSGSEYKLFEY
FMLHIGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNQLGLIETLRGQGYRLVSLDNDAKK
>Mature_229_residues
MRLLLVEDDLELQSNLKQHLIEANYTVDTADDGEIGLFQGREYNYDAAIIDVGLPKLDGIALIKELRALDIGFPILILTA
RDSWQDKVEGLDAGADDYLTKPFHPEELVARLKALIRRSAGKASPIVSNGPFSLNTSSLEITKSGETITLSGSEYKLFEY
FMLHIGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNQLGLIETLRGQGYRLVSLDNDAKK

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=44.4954128440367, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=40.8071748878924, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=37.6681614349776, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.6846846846847, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=36.036036036036, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.070796460177, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=38.0952380952381, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=30.1310043668122, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.4675324675325, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=31.390134529148, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=38.0597014925373, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=25.764192139738, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25726; Mature: 25726

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDDLELQSNLKQHLIEANYTVDTADDGEIGLFQGREYNYDAAIIDVGLPKLDGI
CEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCHH
ALIKELRALDIGFPILILTARDSWQDKVEGLDAGADDYLTKPFHPEELVARLKALIRRSA
HHHHHHHHHCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPIVSNGPFSLNTSSLEITKSGETITLSGSEYKLFEYFMLHIGEVKSKTVLTEHIYD
CCCCCCCCCCCCEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNQLGLIETLRGQGYRLVSLDNDAKK
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure
MRLLLVEDDLELQSNLKQHLIEANYTVDTADDGEIGLFQGREYNYDAAIIDVGLPKLDGI
CEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCHH
ALIKELRALDIGFPILILTARDSWQDKVEGLDAGADDYLTKPFHPEELVARLKALIRRSA
HHHHHHHHHCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPIVSNGPFSLNTSSLEITKSGETITLSGSEYKLFEYFMLHIGEVKSKTVLTEHIYD
CCCCCCCCCCCCEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNQLGLIETLRGQGYRLVSLDNDAKK
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA