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The map label for this gene is pepA [H]

Identifier: 157962580

GI number: 157962580

Start: 3371557

End: 3372918

Strand: Direct

Name: pepA [H]

Synonym: Spea_2759

Alternate gene names: 157962580

Gene position: 3371557-3372918 (Clockwise)

Preceding gene: 157962579

Following gene: 157962581

Centisome position: 65.16

GC content: 48.46

Gene sequence:

>1362_bases
ATGAGCAACCTTATTATCTCTGGTGCTTCTGGCATCCCTTTATCCATTTTCAATAGCGGGTCTTTCAACATCTGGCGTGA
GCAACAAGCGCCACGCATTCAAAACTGGCTCAATACCACCCAATTTAAAGGCAAAGGCGCAAGTTTAATTCCTGGCGCAG
AGGGTGAATTAGAGCAGGTCATTTTTGTCAGCGATAGCGAAGATTCATACTGGCTTTGCGGTGACTTAGTCAATCAACTT
CCAGCAGGCCAATATGAGCTTAAAGGCGATGACCAGCTAATAAGAACGGCAGCATTTAGCTGGGGCTTAGGAGCATATCA
GTTCGACCGTTATAAAAAGAGCGAGAAACAACATCCAGTGTTAATCGTGCCAACTCAGGCGCAGGCCGATGAAGCCAATA
AGTTTATCCGCTCAGTGTCTTTGGTGCGTGATTTGGTAAACACTCCTGCTGCAGATATGATGCCGCAACACTTAGGTGAC
ATCATGCTGGCCATGGCGCAAGAGTTTGGCGCAAGCATAAACCAAATTGTAGGCGATGAACTACTGGAACAAAACTACCC
AACCATTCATATGGTCGGCCGCGCCAGTGAAAACCTGCCACGCTTAATCGATCTCACCTGGGGTGATGAATCGGCGCCAA
AACTAACCTTAGTCGGCAAAGGGGTATGCTTTGATTCAGGGGGACTGGATCTAAAACCCGGCTCAGGCATGCGCTTAATG
AAGAAAGATATGGGCGGCGCGGCTCATGTTATCGGCCTAGCTCAACTCATCATGGCCCATAACTTACCAGTACGATTACG
CGTACTGGTACCTGCCGTTGAAAACGCAGTTTCGGCCAATGCCTTCAGACCCGGTGACGTGATCACCACTCGTAAAGGCA
TAACTGTTGAAATTGACAATACCGATGCTGAGGGTCGTTTAGTCTTGTGTGATGCATTAGCTGAAGCCAACAATGATAAA
CCAGAACTGGTTATTGATTTTGCCACGCTCACAGGCGCTATGCGCATTGCATTAGGTACCGAGCTTCCAGGTTTTTTCAG
TAATGACGAAGAAGTCGCAGCGGGCTTTACCGCATCAGGCCTAAAGGTTGATGACCCTGTTTGGCGCATGCCACTACACA
AGCCCTATATGGCGCTCACAGGCAGCGATATTGCCGATATTGCCAACTGCGCAACCACACCATTTGGTGGCGCAATTACC
GCGGCTCTTTATTTAGAGGAATTTGTCGATAAAGATATCAGCTGGAGCCATTTCGATGTCATGGCCTACAATGTGCGTAA
ATTACCCGGCCGCCCAGTCGGCGGTGAAGCCTTCGGCATTCGTGCAGTATTTGATTATCTGCAAAATCGCTTTCATGCCT
AA

Upstream 100 bases:

>100_bases
CCTTGCTAAATTTCCGCCCTTGCCTTTCTCCTGAACGGTTTGCCTGATACTCTAAGTCCTAAGCTATCCTCATCTTTTAA
TAACAAAAAAGAGTCCTTAC

Downstream 100 bases:

>100_bases
TTAGTACTCTTCCATGAATAAGGTCCGTTTATACAGGCCTTATTCATGCTTTTTATCACTAAATATTCATCTGACTCTTT
TTCACAGATACCCCATAAGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSNLIISGASGIPLSIFNSGSFNIWREQQAPRIQNWLNTTQFKGKGASLIPGAEGELEQVIFVSDSEDSYWLCGDLVNQL
PAGQYELKGDDQLIRTAAFSWGLGAYQFDRYKKSEKQHPVLIVPTQAQADEANKFIRSVSLVRDLVNTPAADMMPQHLGD
IMLAMAQEFGASINQIVGDELLEQNYPTIHMVGRASENLPRLIDLTWGDESAPKLTLVGKGVCFDSGGLDLKPGSGMRLM
KKDMGGAAHVIGLAQLIMAHNLPVRLRVLVPAVENAVSANAFRPGDVITTRKGITVEIDNTDAEGRLVLCDALAEANNDK
PELVIDFATLTGAMRIALGTELPGFFSNDEEVAAGFTASGLKVDDPVWRMPLHKPYMALTGSDIADIANCATTPFGGAIT
AALYLEEFVDKDISWSHFDVMAYNVRKLPGRPVGGEAFGIRAVFDYLQNRFHA

Sequences:

>Translated_453_residues
MSNLIISGASGIPLSIFNSGSFNIWREQQAPRIQNWLNTTQFKGKGASLIPGAEGELEQVIFVSDSEDSYWLCGDLVNQL
PAGQYELKGDDQLIRTAAFSWGLGAYQFDRYKKSEKQHPVLIVPTQAQADEANKFIRSVSLVRDLVNTPAADMMPQHLGD
IMLAMAQEFGASINQIVGDELLEQNYPTIHMVGRASENLPRLIDLTWGDESAPKLTLVGKGVCFDSGGLDLKPGSGMRLM
KKDMGGAAHVIGLAQLIMAHNLPVRLRVLVPAVENAVSANAFRPGDVITTRKGITVEIDNTDAEGRLVLCDALAEANNDK
PELVIDFATLTGAMRIALGTELPGFFSNDEEVAAGFTASGLKVDDPVWRMPLHKPYMALTGSDIADIANCATTPFGGAIT
AALYLEEFVDKDISWSHFDVMAYNVRKLPGRPVGGEAFGIRAVFDYLQNRFHA
>Mature_452_residues
SNLIISGASGIPLSIFNSGSFNIWREQQAPRIQNWLNTTQFKGKGASLIPGAEGELEQVIFVSDSEDSYWLCGDLVNQLP
AGQYELKGDDQLIRTAAFSWGLGAYQFDRYKKSEKQHPVLIVPTQAQADEANKFIRSVSLVRDLVNTPAADMMPQHLGDI
MLAMAQEFGASINQIVGDELLEQNYPTIHMVGRASENLPRLIDLTWGDESAPKLTLVGKGVCFDSGGLDLKPGSGMRLMK
KDMGGAAHVIGLAQLIMAHNLPVRLRVLVPAVENAVSANAFRPGDVITTRKGITVEIDNTDAEGRLVLCDALAEANNDKP
ELVIDFATLTGAMRIALGTELPGFFSNDEEVAAGFTASGLKVDDPVWRMPLHKPYMALTGSDIADIANCATTPFGGAITA
ALYLEEFVDKDISWSHFDVMAYNVRKLPGRPVGGEAFGIRAVFDYLQNRFHA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=349, Percent_Identity=32.378223495702, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI47155554, Length=311, Percent_Identity=31.8327974276527, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI87082123, Length=332, Percent_Identity=37.9518072289157, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1790710, Length=375, Percent_Identity=34.6666666666667, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=294, Percent_Identity=34.0136054421769, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=214, Percent_Identity=30.8411214953271, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355725, Length=306, Percent_Identity=32.6797385620915, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24661038, Length=283, Percent_Identity=32.8621908127208, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379063, Length=297, Percent_Identity=35.016835016835, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI221379062, Length=297, Percent_Identity=35.016835016835, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21357381, Length=297, Percent_Identity=35.016835016835, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077148, Length=352, Percent_Identity=30.1136363636364, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20130057, Length=352, Percent_Identity=30.1136363636364, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662227, Length=286, Percent_Identity=29.020979020979, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI20129969, Length=286, Percent_Identity=29.7202797202797, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922386, Length=322, Percent_Identity=27.3291925465839, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20129963, Length=323, Percent_Identity=28.4829721362229, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355645, Length=286, Percent_Identity=26.2237762237762, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662223, Length=286, Percent_Identity=26.2237762237762, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646701, Length=284, Percent_Identity=29.9295774647887, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646703, Length=284, Percent_Identity=29.9295774647887, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358201, Length=284, Percent_Identity=29.9295774647887, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49228; Mature: 49096

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLIISGASGIPLSIFNSGSFNIWREQQAPRIQNWLNTTQFKGKGASLIPGAEGELEQV
CCCEEEECCCCCEEEEECCCCCEEEECCCCCHHHHHHCCCEECCCCCCCCCCCCCCCEEE
IFVSDSEDSYWLCGDLVNQLPAGQYELKGDDQLIRTAAFSWGLGAYQFDRYKKSEKQHPV
EEEECCCCCEEEHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCE
LIVPTQAQADEANKFIRSVSLVRDLVNTPAADMMPQHLGDIMLAMAQEFGASINQIVGDE
EEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLEQNYPTIHMVGRASENLPRLIDLTWGDESAPKLTLVGKGVCFDSGGLDLKPGSGMRLM
HHHCCCCEEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCHHH
KKDMGGAAHVIGLAQLIMAHNLPVRLRVLVPAVENAVSANAFRPGDVITTRKGITVEIDN
HHHCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEECCCEEEEECC
TDAEGRLVLCDALAEANNDKPELVIDFATLTGAMRIALGTELPGFFSNDEEVAAGFTASG
CCCCCCEEEEEEHHHCCCCCCEEEEEEHHHHCEEEEEECCCCCCCCCCCCHHHCCEEECC
LKVDDPVWRMPLHKPYMALTGSDIADIANCATTPFGGAITAALYLEEFVDKDISWSHFDV
CEECCCHHCCCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
MAYNVRKLPGRPVGGEAFGIRAVFDYLQNRFHA
EEEEHEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNLIISGASGIPLSIFNSGSFNIWREQQAPRIQNWLNTTQFKGKGASLIPGAEGELEQV
CCEEEECCCCCEEEEECCCCCEEEECCCCCHHHHHHCCCEECCCCCCCCCCCCCCCEEE
IFVSDSEDSYWLCGDLVNQLPAGQYELKGDDQLIRTAAFSWGLGAYQFDRYKKSEKQHPV
EEEECCCCCEEEHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCE
LIVPTQAQADEANKFIRSVSLVRDLVNTPAADMMPQHLGDIMLAMAQEFGASINQIVGDE
EEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLEQNYPTIHMVGRASENLPRLIDLTWGDESAPKLTLVGKGVCFDSGGLDLKPGSGMRLM
HHHCCCCEEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCHHH
KKDMGGAAHVIGLAQLIMAHNLPVRLRVLVPAVENAVSANAFRPGDVITTRKGITVEIDN
HHHCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEECCCEEEEECC
TDAEGRLVLCDALAEANNDKPELVIDFATLTGAMRIALGTELPGFFSNDEEVAAGFTASG
CCCCCCEEEEEEHHHCCCCCCEEEEEEHHHHCEEEEEECCCCCCCCCCCCHHHCCEEECC
LKVDDPVWRMPLHKPYMALTGSDIADIANCATTPFGGAITAALYLEEFVDKDISWSHFDV
CEECCCHHCCCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
MAYNVRKLPGRPVGGEAFGIRAVFDYLQNRFHA
EEEEHEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA