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The map label for this gene is lon [H]

Identifier: 157962500

GI number: 157962500

Start: 3263731

End: 3266088

Strand: Reverse

Name: lon [H]

Synonym: Spea_2679

Alternate gene names: 157962500

Gene position: 3266088-3263731 (Counterclockwise)

Preceding gene: 157962501

Following gene: 157962499

Centisome position: 63.12

GC content: 45.59

Gene sequence:

>2358_bases
ATGACCCTAGAGCGTGATGCGCGAATCGAACTACCCGTACTACCACTAAGAGATGTGGTGGTTTATCCCCACATGGTAAT
TCCGTTATTCGTCGGTCGAGAAAAATCTATTCGTTGCTTAGAAAAAGCGATGGATCAAGGTAAACAAATCATTTTAGTCG
CCCAGCGTGATGCTGAGTTAGACGACCCTACAAGCGATGACATTTTTGATGTAGGTACCGTTGCGTCAATTTTACAGTTA
TTAAAACTTCCTGATGGTACTGTAAAGGTATTGGTTGAAGGTGGGCAGAGAGTCTGCATCGATAACTATATCGAGCAAGA
AGATATCTTTCAGGCGACAGCTCACTACCTTGAGTCCGAGCCACTTTCAGAGAAAGAAGAGGAAGTCCTCGTTCGCTCAG
CCGTTGGCCAGTTTGAAGGTTACATCAAGCTGAACAAGAAGATCCCACCAGAGGTACTAACTTCACTGTCAGGGATCGAT
GAAGCGGCAAGACTTGCCGACACCATGGCCGCACATATGCCACTTAAGCTAGAAGACAAACAGTCTGTGCTTGAGATGGT
GAATGTTAGCGAGCGCATCGAATATTTAATGGCGATGATGGAATCGGAAATTGACCTACTTCAGGTCGAGAAGCGCATTC
GTGGCCGTGTTAAAAAGCAGATGGAGAAGAGTCAGCGCGAGTACTATTTGAATGAGCAGATGAAGGCTATTCAAAAAGAA
CTTGGCGATATTGATGAGTCTCATGATGAATTTGAAAGCTTAGCGAAGAAGATTGAAGAGGCACAAATGCCTGCTGAGGC
AAAAGAAAAAGCCTCTGCTGAGTTAAATAAGTTAAAGATGATGTCACCAATGTCTGCCGAGGCAACTGTGGTGAGAAGTT
ACGTTGAGTGGATGGTGTCAGTGCCTTGGCATAAGCGCTCTAAAATCAAACGTGACTTAGCTAAGGCGCAAGACGTCCTC
GATACCGATCATTTTGGTCTTGAGAAAGTCAAAGAGCGAATCTTGGAATATCTAGCGGTTCAAAGCCGAGTTAAACAGCT
TAAAGGTCCGATTCTTTGTTTAGTTGGCCCGCCAGGTGTGGGTAAGACTTCATTGGGTCAGTCAATCGCGAAGGCGACGG
GCCGTAAGTATGTGCGTGTGGCATTAGGTGGTGTACGTGATGAAGCGGAGATCCGTGGTCACCGTCGTACCTATATCGGT
TCTATGCCTGGTAAAGTCATCCAAAAGATGTCGAAAGTTGGTGTGAAAAACCCGTTATTCCTGCTTGATGAAATCGACAA
GATGAGCAGTGATATGCGTGGCGATCCGGCTTCAGCTTTGCTTGAGGTGTTAGATCCTGAACAAAACTCAGCATTTAGCG
ATCACTACATGGAAGTCGATTACGACCTATCTGATGTAATGTTTGTGGCAACGTCTAACTCGATGAATATTCCAGGTCCT
TTACTAGACCGTATGGAAGTGATCCGCTTATCGGGTTATACCGAAGATGAAAAGCTTAATATTGCTAAGCAACACTTGTT
GCCGAAGCAGATTGAGCGTAATGGTCTAAAAGCGAAAGAAGTGACAGTAGATGATAGTGCCATTATCGGTATTATTCGTT
ACTACACCCGTGAAGCGGGCGTGCGTGCGCTTGAGCGTGAATTGTCGAAGATCTGCCGTAAAGTGGTTAAACAAATCTTG
CTTGATAAGACGATTAAGCATATTGAAGTTAACCAAGACAACCTTAAGTCATTCCTTGGCGTGCAGCGTTGTGATTACGG
TAAGGCTGAATCGAACAATCAGATTGGTCAAGTTACCGGTCTTGCGTGGACAGAAGTCGGCGGTGACTTACTGACTATCG
AAGCAACATCAGTTCCTGGTAAAGGTAAGCTAACCTACACCGGCTCACTTGGCGATGTGATGCAAGAGTCGATTCAAGCG
GCGATGACAGTTGTTCGTGCGCGTGCTGAGCAGCTTGGTATTAACCCAGACTTTTACGAGAAGCGTGATATTCACGTTCA
CGTACCAGAAGGGGCGACTCCAAAAGATGGTCCATCTGCTGGTGCAGCAATGTGTACAGCGCTTGTATCTAGCTTAACGG
GTAACCCTGTTCGTGCCGATGTGGCAATGACAGGTGAAATTACCCTACGAGGCGAAGTGTTACCGATTGGTGGATTGAAG
GAAAAACTGTTGGCTGCCCATCGTGGTGGTACGAAAGTTGTTCTAATTCCAAAAGAAAATGAACGTGACTTGGAAGAAAT
TCCGCAAAACGTCATTGCCGATCTGAAAATTTATCCAGTTAAATGGGTTGATGAAGTGCTTAAGTTGGCGTTAGAGCGAC
CAGTTGAAGGCTTCGAAGTAGTAGAAAACGTGGACTAA

Upstream 100 bases:

>100_bases
CCTTTTTTATGCAGTTCTCCAATTTATTTATTTTCGCCATTGAAACCTATTTAATCATCCCAATATACTCATAAGTAATC
ATAAAAAACGGAATCGAGCT

Downstream 100 bases:

>100_bases
CGCAATAAATTGCAGGATTGCCTTAAAAAAACAGTAAAAAGGGCTTACCTTAGTATAAAGCTGTGGTAGCCTAAGTCTGT
GGAGAGTCAGTCGCTCCAGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMDQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQL
LKLPDGTVKVLVEGGQRVCIDNYIEQEDIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKE
LGDIDESHDEFESLAKKIEEAQMPAEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVL
DTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKTIKHIEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD

Sequences:

>Translated_785_residues
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMDQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQL
LKLPDGTVKVLVEGGQRVCIDNYIEQEDIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGID
EAARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKE
LGDIDESHDEFESLAKKIEEAQMPAEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVL
DTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIG
SMPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQIL
LDKTIKHIEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQA
AMTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD
>Mature_784_residues
TLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMDQGKQIILVAQRDAELDDPTSDDIFDVGTVASILQLL
KLPDGTVKVLVEGGQRVCIDNYIEQEDIFQATAHYLESEPLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDIDESHDEFESLAKKIEEAQMPAEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVSVPWHKRSKIKRDLAKAQDVLD
TDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAGVRALERELSKICRKVVKQILL
DKTIKHIEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTGLAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINPDFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEVVENVD

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=666, Percent_Identity=42.042042042042, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=41.025641025641, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=81.3060179257362, Blast_Score=1291, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=40.5819295558959, Blast_Score=487, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=39.8148148148148, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=843, Percent_Identity=35.5871886120996, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=43.5483870967742, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=43.5483870967742, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87484; Mature: 87353

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMDQGKQIILVAQRDAEL
CCCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPTSDDIFDVGTVASILQLLKLPDGTVKVLVEGGQRVCIDNYIEQEDIFQATAHYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHCCHHHHHHHHHHHHCCC
PLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIDESHDEFESLAKKIEEAQMPAEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVS
HCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHKRSKIKRDLAKAQDVLDTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMSKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKTIKHIEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCHHEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCHHHH
VENVD
HHCCC
>Mature Secondary Structure 
TLERDARIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLEKAMDQGKQIILVAQRDAEL
CCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPTSDDIFDVGTVASILQLLKLPDGTVKVLVEGGQRVCIDNYIEQEDIFQATAHYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHCCHHHHHHHHHHHHCCC
PLSEKEEEVLVRSAVGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDK
CCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHH
QSVLEMVNVSERIEYLMAMMESEIDLLQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIDESHDEFESLAKKIEEAQMPAEAKEKASAELNKLKMMSPMSAEATVVRSYVEWMVS
HCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
VPWHKRSKIKRDLAKAQDVLDTDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMSKVGVKNPLF
CHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYMEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQIERNGLKAKEVTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VRALERELSKICRKVVKQILLDKTIKHIEVNQDNLKSFLGVQRCDYGKAESNNQIGQVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCHHEEC
LAWTEVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINPDFYE
EEHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRADVAMTGEITLRGEVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECEEEEECEEEECCCHH
EKLLAAHRGGTKVVLIPKENERDLEEIPQNVIADLKIYPVKWVDEVLKLALERPVEGFEV
HHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCHHHH
VENVD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]