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The map label for this gene is f1pep1 [H]

Identifier: 157962390

GI number: 157962390

Start: 3127371

End: 3129527

Strand: Reverse

Name: f1pep1 [H]

Synonym: Spea_2569

Alternate gene names: 157962390

Gene position: 3129527-3127371 (Counterclockwise)

Preceding gene: 157962391

Following gene: 157962389

Centisome position: 60.48

GC content: 42.98

Gene sequence:

>2157_bases
ATGCGAATTCATTCGATACTAACTAAAAATCACTTGTTAGCTATAGGCTTAGGCATAGCTGTAGTGGGTTGCCAGTCACA
ACCAGTACAAGATAATACAACAAATACCATTACGAAAAGTCAAGACAGTGTTATTGAAACGATACACGGTGTTCAGGTTG
CCGACCCTTATCGCTATTTAGAAGTTGAATCAGATAAAACTAAAAAATGGGTAAGTGAACAGCAGAAAGCGGGCCACGAA
TATCTCGCTAATATCGAAAATAAGCAGGCGATTGTTGATCGTATTACTGAGCTTTGGAATTTTGAGAAGATTTCTGCACC
GTTTGAAAAGGGTGATAACACATTTTATTACCGTAATGATGGATTACAGGCGCAGTCAGTTCTTTATGTAACAGCTGCAG
ATGGTCAGGCTAAAATTGCGCTAGATCCTAATCGTTTTTCTGATGACGGCACCGTTGCTTTATCTGGTGTATCTGTAAGC
GATGACGGTAAAACACTGGCTTATGGTGTCTCTAAATCGGGTTCTGATTGGCAGGCATGGCACTTTATTGATGTCGCGAC
GGGTAACAAGCTGACCGATGAGCTGGATTGGATTAAGTTTTCAAGTGCAGTTTGGAGCAGCGATAACAACGGTGTCTATT
ATGCCCGTTATGATGCCCCAGAAGGTGGTAACGCACTTGCTGACGTTAACTTTAACCAAAAAGTCTACTTCCACAAGATT
GGTACAAGTCAAAGTGAAGATACTTTAGTCTATGAAAGACCTCAGAATAAAGATTGGGGTTTTGGTATAGAGGTGTCAGA
GAAGGGCGATTACTTGTTGCTTTATATCTCTCAAGGAACCGATAGTCGCAACCGATTCTTTTATAAGTCGCTTATTGAAC
CACAAGCTCAAGTCGTTGAGTTGATCCCCGATCTTGAAGCTGAATACCAGTTTATCGGCAACGATGATTCAATATTCTAC
TTTAAAACCGACTATAACGCGCCAAACGGTAAAGTTATTGCGGTCGATGTAAACAATAGCGCCAAAGATAATTGGAAAAC
GATTATTCCAGAGCTAAAAGATCCGATCAGCAGCATAAAGATTATTAACGACCATTTTGTGGTGAGTTATCTGCATGACG
TTTTAGGCAAGCTAACGGTTTACAATATGAATGGCGATAAGCGCCAAGACGTGACTTTACCAGGTAAAGGTAAGATTGCA
GGCCCTTACGGCAAGCGCAGTAAAGATTACTTCTACTATGTTTTCAACAGCTACACTCAGCCTCAAACGACCTACAAGTT
TGATTTTAACACTGGTGAGTCGACCGTTTATTCAAAACCAGACATCTCTTTCGACCCAAGTGATTATATTTCTGAGCAGG
TTTTTTATAGCAGCAAAGATGGCACGAAAGTGCCAATGATGATCTCTTATAAGAAAGGCATTAAAAAAGATGGCCAAAAC
CCTACGCTGCTGTATGCCTATGGTGGTTTCGCTATTTCACTGACACCACGCTTTAGCCCTGCCAATATTGCTTGGATGGA
TATGGGCGGCGTGTATGCGGTGCCTAATCTTCGTGGTGGAGCCGAATATGGTGAAAGCTGGCATCAGGCGGGTATGTTCG
ATAAAAAGCAGAACGTATTTGATGATTACTATGCTGCTGCAGAGTACTTAATAGAGCAAGATTATACTAACTCTTCTAAG
TTAGGTGCCTATGGTCGCAGTAATGGTGGCTTATTGATGGGCGCGACATTGACTCAGCGCCCAGAGCTATTTGCCGCGGT
ACTGCCTGCTGTTGGTGTATTGGATATGTTACGTTTCCAAAAGTTCACTATTGGATGGGCTTGGACCAGTGAATATGGCA
GTGCTGATAATGCCGAACAATTCCCTGCACTCTATGCTTATTCGCCATACCACAACCTTAAAGCTCAAGCCTACCCCGCG
ACTATGGTGATGACAGCCGACCACGACGACCGTGTTGTACCACTGCATAGCTTTAAGTTTGGCGCCTTGATGCAAGAGAA
ACAGCAAGGTGATGCGCCGGTAATTATGCGTATTGAGTCGAAGGCTGGCCATGGCGCAGGTAAGCCGACCTCAATGAAGA
TTGATGAGTTTGCCGATATTTATAGTTTCCTTTGGCATAACTTTGGACTTCAGGTGCCAGCTAAAATAGCCAAATAA

Upstream 100 bases:

>100_bases
TGAAGAAGGGTTAGGGACAAAATAAGATTATCTAATTACAAAAACCTAACTACATGAACAGAAGGCTCATTAAATAGAGT
CAGTTTATCAGGGGTAAAAA

Downstream 100 bases:

>100_bases
GGCAGTTTAAATCTCTTGAAAAGGAAGCTTCGGCTTCCTTTTTTATGGGCGAAATAAAATGTGCTGCTTGCTTTAAGCGC
GGCGTACTCATTGCTAGGGC

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MRIHSILTKNHLLAIGLGIAVVGCQSQPVQDNTTNTITKSQDSVIETIHGVQVADPYRYLEVESDKTKKWVSEQQKAGHE
YLANIENKQAIVDRITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVTAADGQAKIALDPNRFSDDGTVALSGVSVS
DDGKTLAYGVSKSGSDWQAWHFIDVATGNKLTDELDWIKFSSAVWSSDNNGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTSQSEDTLVYERPQNKDWGFGIEVSEKGDYLLLYISQGTDSRNRFFYKSLIEPQAQVVELIPDLEAEYQFIGNDDSIFY
FKTDYNAPNGKVIAVDVNNSAKDNWKTIIPELKDPISSIKIINDHFVVSYLHDVLGKLTVYNMNGDKRQDVTLPGKGKIA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFNTGESTVYSKPDISFDPSDYISEQVFYSSKDGTKVPMMISYKKGIKKDGQN
PTLLYAYGGFAISLTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEQDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKAQAYPA
TMVMTADHDDRVVPLHSFKFGALMQEKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIAK

Sequences:

>Translated_718_residues
MRIHSILTKNHLLAIGLGIAVVGCQSQPVQDNTTNTITKSQDSVIETIHGVQVADPYRYLEVESDKTKKWVSEQQKAGHE
YLANIENKQAIVDRITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVTAADGQAKIALDPNRFSDDGTVALSGVSVS
DDGKTLAYGVSKSGSDWQAWHFIDVATGNKLTDELDWIKFSSAVWSSDNNGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTSQSEDTLVYERPQNKDWGFGIEVSEKGDYLLLYISQGTDSRNRFFYKSLIEPQAQVVELIPDLEAEYQFIGNDDSIFY
FKTDYNAPNGKVIAVDVNNSAKDNWKTIIPELKDPISSIKIINDHFVVSYLHDVLGKLTVYNMNGDKRQDVTLPGKGKIA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFNTGESTVYSKPDISFDPSDYISEQVFYSSKDGTKVPMMISYKKGIKKDGQN
PTLLYAYGGFAISLTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEQDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKAQAYPA
TMVMTADHDDRVVPLHSFKFGALMQEKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIAK
>Mature_718_residues
MRIHSILTKNHLLAIGLGIAVVGCQSQPVQDNTTNTITKSQDSVIETIHGVQVADPYRYLEVESDKTKKWVSEQQKAGHE
YLANIENKQAIVDRITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVTAADGQAKIALDPNRFSDDGTVALSGVSVS
DDGKTLAYGVSKSGSDWQAWHFIDVATGNKLTDELDWIKFSSAVWSSDNNGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTSQSEDTLVYERPQNKDWGFGIEVSEKGDYLLLYISQGTDSRNRFFYKSLIEPQAQVVELIPDLEAEYQFIGNDDSIFY
FKTDYNAPNGKVIAVDVNNSAKDNWKTIIPELKDPISSIKIINDHFVVSYLHDVLGKLTVYNMNGDKRQDVTLPGKGKIA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFNTGESTVYSKPDISFDPSDYISEQVFYSSKDGTKVPMMISYKKGIKKDGQN
PTLLYAYGGFAISLTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEQDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKAQAYPA
TMVMTADHDDRVVPLHSFKFGALMQEKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIAK

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=688, Percent_Identity=41.5697674418605, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI284172438, Length=358, Percent_Identity=26.2569832402235, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI284172431, Length=358, Percent_Identity=26.2569832402235, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI284172420, Length=355, Percent_Identity=25.9154929577465, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI284172413, Length=355, Percent_Identity=25.9154929577465, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI70778815, Length=355, Percent_Identity=25.9154929577465, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI108860686, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI108860692, Length=203, Percent_Identity=31.5270935960591, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI1788150, Length=684, Percent_Identity=25.1461988304094, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24583414, Length=706, Percent_Identity=42.3512747875354, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221510989, Length=687, Percent_Identity=40.4657933042213, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 80367; Mature: 80367

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHSILTKNHLLAIGLGIAVVGCQSQPVQDNTTNTITKSQDSVIETIHGVQVADPYRYL
CCCHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCEECCHHHHHHHHCCCEEECCEEEE
EVESDKTKKWVSEQQKAGHEYLANIENKQAIVDRITELWNFEKISAPFEKGDNTFYYRND
EECCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCHHHCCCHHCCCCEEEEECC
GLQAQSVLYVTAADGQAKIALDPNRFSDDGTVALSGVSVSDDGKTLAYGVSKSGSDWQAW
CCCEEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEE
HFIDVATGNKLTDELDWIKFSSAVWSSDNNGVYYARYDAPEGGNALADVNFNQKVYFHKI
EEEEECCCCCCCCCHHHEEECCEEECCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEC
GTSQSEDTLVYERPQNKDWGFGIEVSEKGDYLLLYISQGTDSRNRFFYKSLIEPQAQVVE
CCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHH
LIPDLEAEYQFIGNDDSIFYFKTDYNAPNGKVIAVDVNNSAKDNWKTIIPELKDPISSIK
HHCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHEE
IINDHFVVSYLHDVLGKLTVYNMNGDKRQDVTLPGKGKIAGPYGKRSKDYFYYVFNSYTQ
EECCHHHHHHHHHHHCCEEEEECCCCCCCEEECCCCCCEECCCCCCCCCEEEEEEECCCC
PQTTYKFDFNTGESTVYSKPDISFDPSDYISEQVFYSSKDGTKVPMMISYKKGIKKDGQN
CCEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHEEECCCCCCCCEEEEECCCCCCCCCC
PTLLYAYGGFAISLTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVF
CEEEEEECCEEEEEECCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
DDYYAAAEYLIEQDYTNSSKLGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKAQAYPATMVMTADHDDRVVPLHSFKF
EEEEEEEEECCCCCCCCHHHCCEEEEECCCCCCCCEECCEEEEEEECCCCCEEEECCCCH
GALMQEKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIAK
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure
MRIHSILTKNHLLAIGLGIAVVGCQSQPVQDNTTNTITKSQDSVIETIHGVQVADPYRYL
CCCHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCEECCHHHHHHHHCCCEEECCEEEE
EVESDKTKKWVSEQQKAGHEYLANIENKQAIVDRITELWNFEKISAPFEKGDNTFYYRND
EECCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCHHHCCCHHCCCCEEEEECC
GLQAQSVLYVTAADGQAKIALDPNRFSDDGTVALSGVSVSDDGKTLAYGVSKSGSDWQAW
CCCEEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEE
HFIDVATGNKLTDELDWIKFSSAVWSSDNNGVYYARYDAPEGGNALADVNFNQKVYFHKI
EEEEECCCCCCCCCHHHEEECCEEECCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEC
GTSQSEDTLVYERPQNKDWGFGIEVSEKGDYLLLYISQGTDSRNRFFYKSLIEPQAQVVE
CCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHH
LIPDLEAEYQFIGNDDSIFYFKTDYNAPNGKVIAVDVNNSAKDNWKTIIPELKDPISSIK
HHCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHEE
IINDHFVVSYLHDVLGKLTVYNMNGDKRQDVTLPGKGKIAGPYGKRSKDYFYYVFNSYTQ
EECCHHHHHHHHHHHCCEEEEECCCCCCCEEECCCCCCEECCCCCCCCCEEEEEEECCCC
PQTTYKFDFNTGESTVYSKPDISFDPSDYISEQVFYSSKDGTKVPMMISYKKGIKKDGQN
CCEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHEEECCCCCCCCEEEEECCCCCCCCCC
PTLLYAYGGFAISLTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVF
CEEEEEECCEEEEEECCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
DDYYAAAEYLIEQDYTNSSKLGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKAQAYPATMVMTADHDDRVVPLHSFKF
EEEEEEEEECCCCCCCCHHHCCEEEEECCCCCCCCEECCEEEEEEECCCCCEEEECCCCH
GALMQEKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIAK
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]