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The map label for this gene is grxA [H]

Identifier: 157962381

GI number: 157962381

Start: 3117970

End: 3118236

Strand: Direct

Name: grxA [H]

Synonym: Spea_2560

Alternate gene names: 157962381

Gene position: 3117970-3118236 (Clockwise)

Preceding gene: 157962380

Following gene: 157962392

Centisome position: 60.26

GC content: 39.7

Gene sequence:

>267_bases
ATGTTTGTTGTAATTTTCGGTCGTCCAGGTTGTCCTTATTGTGTTCGTGCTGTACAAGTTGCCGAGCAACTCACAGAAAA
GCGCGATGATTTTAAATTTAAGTACGTAGACATTCATGCTGAAGGGATCAGTAAAGCTGATCTAGAAAAAACAGTAGGTA
AGCCAGTTGAAACTGTGCCACAAATCTTTGTTGATCAAGTACACGTTGGTGGTTGTACTGAGTTTGTACAATACGTAAGT
GACAACGAATTAATGCCAGCTGCATAA

Upstream 100 bases:

>100_bases
GTAAAAATCAGTAAATCGATTAACACGAATTTAAATATCGATTAGAACAATTGCAATCGCTATGATATAAAGTGTTCAAG
CTAAAACTGAGGAAGCTATC

Downstream 100 bases:

>100_bases
GTAAAATGTTCAGATCATCATAAAAAAGGAGGCCAAGGCCTCCTTTTTTGCGTTAGATAGACTAAAGCACGTACTTCATT
GAAAATATCACTCGATTTAA

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1 [H]

Number of amino acids: Translated: 88; Mature: 88

Protein sequence:

>88_residues
MFVVIFGRPGCPYCVRAVQVAEQLTEKRDDFKFKYVDIHAEGISKADLEKTVGKPVETVPQIFVDQVHVGGCTEFVQYVS
DNELMPAA

Sequences:

>Translated_88_residues
MFVVIFGRPGCPYCVRAVQVAEQLTEKRDDFKFKYVDIHAEGISKADLEKTVGKPVETVPQIFVDQVHVGGCTEFVQYVS
DNELMPAA
>Mature_88_residues
MFVVIFGRPGCPYCVRAVQVAEQLTEKRDDFKFKYVDIHAEGISKADLEKTVGKPVETVPQIFVDQVHVGGCTEFVQYVS
DNELMPAA

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=82, Percent_Identity=64.6341463414634, Blast_Score=120, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9836; Mature: 9836

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVIFGRPGCPYCVRAVQVAEQLTEKRDDFKFKYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQVHVGGCTEFVQYVSDNELMPAA
HHHHHHCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFVVIFGRPGCPYCVRAVQVAEQLTEKRDDFKFKYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQVHVGGCTEFVQYVSDNELMPAA
HHHHHHCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]