Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 157962313

GI number: 157962313

Start: 3037867

End: 3039105

Strand: Reverse

Name: fabF [H]

Synonym: Spea_2492

Alternate gene names: 157962313

Gene position: 3039105-3037867 (Counterclockwise)

Preceding gene: 157962314

Following gene: 157962312

Centisome position: 58.73

GC content: 47.46

Gene sequence:

>1239_bases
GTGTCTAAACGTCGAGTAGTCATAACGGGCTTAGGCTTAGTTAGCCCTGTGGGAAATACAGTTGACTCTTCTTGGAAAGC
ACTTGTTTCAGGTAAGAGTGGTATTGCACCAATAACCAAATTTGATGCAAGTGAGTTCACAACGCGTTTTAGTGGTTCTG
TTAAAGACTTTGATGTCGAGCAGTACATGTCTCGTAAAGACGCACGTAAGATGGACCTGTTTATTCAGTACGGCATGGCT
GCCGGTATCCAAGCTGTCGAAGACTCAGGTCTTGAGATGGATAAGCTTGATCCTGCACGTGTAGGAACAGCCATTGGTGC
GGGTATGGGCGGTATGCCGCTTATCGAACAAAATCATGCAGCTCTATTAAAGGGTGGCCCTCGCAAGGTATCGCCGTTCT
TTGTTCCAAGCACGATTATCAATATGATAGCTGGACACCTTTCAATTAAATACGGCATGACAGGCCCGAACTTTGCTGTG
ACGACCGCTTGTACTACTGGTGTACACAATATCGGTTTTGCGGCGCGTACCATTGCTTATGGCGATGCAGACGTAATGGT
TGCGGGCGGCGCAGAAGATGTTACTTGCCCATTAGCCGTAGCAGGCTTTGGTTCTGCAAAGGCACTTTCAACACGTAACG
ATGACCCACAAGCGGCAAGTCGCCCTTGGGATAAAGACCGTGATGGTTTTGTTATTGGTGACGGCGCAGGTGTGATGGTT
GTTGAAGAGTACGAGCACGCTAAAGCTCGTGGCGCAACGATCTATGCTGAGTTAGTCGGTTTCGGCATGAGCGGCGATGC
GTTTCATATGACATCACCACCTAGTGATGGTGCTGGCGCGGCTGCTGCTATGGTTAATGCCATTAACGATGCTAAAATTG
GCCGTGAAGAGATTGGTTATATCAATGCTCATGGCACTTCTACTCCTGCTGGTGACAAGGCGGAAGCCGCTGCCGTTAAG
TCAGTATTTGGCGACCATGCCTATGACTTACTTGTGAGCTCAACAAAATCAATGACAGGTCATTTGCTTGGCGCTGCAGG
TTCAGTCGAAGCCATTATCACGATATTGGCACTAAAAGATCAGGTTATTCCACCTACGCTTAACTTGGATAATCCTGATG
AAGGCTGTGATTTAGATTTTGTTGCTCACACTGCTCGCGATTATAAGTTCGATTACGGTCTATGTAATTCGTTTGGCTTT
GGTGGCACCAACGGTTCGCTACTGTTTAAGAAAGTGTAA

Upstream 100 bases:

>100_bases
CCTTTGAAACCGTATTTTCAAAAACAGGGTATAGGTATTGGTAGTTCAACCTCTTTGTAGCTATCATCATTATTCATTTT
TAAAGTAAAAAGGTGACCGC

Downstream 100 bases:

>100_bases
TTAGTTAGTACGCCGAGTTAATTTAAAAGCGCCTAAGGGCGCTTTTTTTGTGGCAGCAAAGACTCGATATTTGAAGTGTT
TCACATAATTTTGAGGTTAT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMA
AGIQAVEDSGLEMDKLDPARVGTAIGAGMGGMPLIEQNHAALLKGGPRKVSPFFVPSTIINMIAGHLSIKYGMTGPNFAV
TTACTTGVHNIGFAARTIAYGDADVMVAGGAEDVTCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKIGREEIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALKDQVIPPTLNLDNPDEGCDLDFVAHTARDYKFDYGLCNSFGF
GGTNGSLLFKKV

Sequences:

>Translated_412_residues
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMA
AGIQAVEDSGLEMDKLDPARVGTAIGAGMGGMPLIEQNHAALLKGGPRKVSPFFVPSTIINMIAGHLSIKYGMTGPNFAV
TTACTTGVHNIGFAARTIAYGDADVMVAGGAEDVTCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKIGREEIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALKDQVIPPTLNLDNPDEGCDLDFVAHTARDYKFDYGLCNSFGF
GGTNGSLLFKKV
>Mature_411_residues
SKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMAA
GIQAVEDSGLEMDKLDPARVGTAIGAGMGGMPLIEQNHAALLKGGPRKVSPFFVPSTIINMIAGHLSIKYGMTGPNFAVT
TACTTGVHNIGFAARTIAYGDADVMVAGGAEDVTCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMVV
EEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKIGREEIGYINAHGTSTPAGDKAEAAAVKS
VFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALKDQVIPPTLNLDNPDEGCDLDFVAHTARDYKFDYGLCNSFGFG
GTNGSLLFKKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=48.3091787439614, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=52.6627218934911, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=23.9336492890995, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=70.4600484261501, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=40, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=41.2621359223301, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=46.2121212121212, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=26.0623229461756, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=349, Percent_Identity=24.3553008595989, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=40, Blast_Score=295, Evalue=8e-81,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=43.1325301204819, Blast_Score=336, Evalue=1e-92,
Organism=Drosophila melanogaster, GI221330659, Length=374, Percent_Identity=25.1336898395722, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920632, Length=374, Percent_Identity=25.1336898395722, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=377, Percent_Identity=24.6684350132626, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42938; Mature: 42807

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVE
CCCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCCCCHH
QYMSRKDARKMDLFIQYGMAAGIQAVEDSGLEMDKLDPARVGTAIGAGMGGMPLIEQNHA
HHHHHHHHHHHHHHEEHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCE
ALLKGGPRKVSPFFVPSTIINMIAGHLSIKYGMTGPNFAVTTACTTGVHNIGFAARTIAY
EEECCCCCCCCCEECHHHHHHHHHHHEEEEECCCCCCEEEEEEHHCCCHHCCCCEEEEEE
GDADVMVAGGAEDVTCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
CCCCEEEECCCCCCCCCEEEECCCCCCEECCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKIGREEIGY
EECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHCCE
INAHGTSTPAGDKAEAAAVKSVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALKD
EECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHEECCCCCHHHHHHHHHHHC
QVIPPTLNLDNPDEGCDLDFVAHTARDYKFDYGLCNSFGFGGTNGSLLFKKV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCEECCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVE
CCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCCCCHH
QYMSRKDARKMDLFIQYGMAAGIQAVEDSGLEMDKLDPARVGTAIGAGMGGMPLIEQNHA
HHHHHHHHHHHHHHEEHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCE
ALLKGGPRKVSPFFVPSTIINMIAGHLSIKYGMTGPNFAVTTACTTGVHNIGFAARTIAY
EEECCCCCCCCCEECHHHHHHHHHHHEEEEECCCCCCEEEEEEHHCCCHHCCCCEEEEEE
GDADVMVAGGAEDVTCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
CCCCEEEECCCCCCCCCEEEECCCCCCEECCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKIGREEIGY
EECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHCCE
INAHGTSTPAGDKAEAAAVKSVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALKD
EECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHEECCCCCHHHHHHHHHHHC
QVIPPTLNLDNPDEGCDLDFVAHTARDYKFDYGLCNSFGFGGTNGSLLFKKV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCEECCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]