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The map label for this gene is sbcB [H]

Identifier: 157962308

GI number: 157962308

Start: 3033204

End: 3034616

Strand: Direct

Name: sbcB [H]

Synonym: Spea_2487

Alternate gene names: 157962308

Gene position: 3033204-3034616 (Clockwise)

Preceding gene: 157962305

Following gene: 157962309

Centisome position: 58.62

GC content: 43.31

Gene sequence:

>1413_bases
ATGTCTACCAATAACCAACCCACCCTCTTCTGGCACGATTATGAAACCTTCGGCGCCAATCCAGCGAAAGACAGGCCTTC
TCAATTTGCTGGTGTGCGCACAGATATGGACCTTAATATCATTGGTGAGCCAGAAACCTTTTATTGTAAGCTCGCGAATG
ATTATTTACCGTCGCCTGAAGCTATTCTGATCACAGGTATTACTCCGCAACTTGCTAACTTAAAAGGTATGCCTGAAGCC
GAGTTCATGGACAAGATTAATAGCCTCTTTAGTCAGCCTAAGACTTGTGTGGTTGGTTACAACTCATTGCGCTTTGATGA
TGAAGTGTCGCGCTACGGTTTTTATCGTAACTTTATCGACCCTTATGCCCGTGAGTGGCAAAACGGCAACAGCCGCTGGG
ATATTATCGATCTAGTGCGTGCCTGCTACGCCTTTAGACCTGAAGGCATAAACTGGCCAGAGAAAGAAGATGGCTCGCCA
AGCTTTAAGCTTGAGCAGCTTACCGTGGCCAATGGCTTAAGCCATGAAAAAGCCCATGATGCGATGTCTGATGTATATGC
CACTATTGATATGGCAAAGCTAATTAAATCAGTACAGCCAAAACTGTTTGATTATTACTTTAGCCTTAGACTAAAACAGC
AAGTCTCTAAACTTATCGATGTGCTAGAGATGAAGCCACTCGTTCATGTCAGCTCTAAAATTAGTGCGCTTAATGGTTGC
ACTACAATCATTGCGCCTGTGGCCTATCACTCCACCAATAAAAATGCCGTTATTTGCGTTAATCTTGCCATGGATGTCAC
ACCGCTGATTGAGTTAAGTGTCGAAGAGATCCGTGAGCGTATGTATACCCGTCGCAGTGATTTAGCGCCTGATGAGTTGC
CTATTGGGTTAAAGCAAATCCATATCAATAAGAGTCCATTTATTGCAGCGGCTAATACGTTAACTGACGAAAATGCAGCA
AGACTCGATTTTGATAAGGCCTTTGCCAGAGCACAGTACAAAAAGCTTAAGCAGCACCCTGAATTACGCGAAAAATTGGT
TGCGGTATTTGATGTAGAGCATGAAGGCAAAACGGTTGACCCCGATCAGGCCCTATATAGTGGTGGCTTCTTTAGCAGTG
CCGACAAGGCAAAGATTGAGATCATTCGTCATACACAACCCCGTAATCTCGCAGCGTTAGAACTTGATTTTGATGACCAG
CGACTTTCTGAAATGTTATTTAGATATCGCGCACGTAATTATCCAGAAACGCTCGATGATAGTGAGCAGTATCGCTGGCG
TGAGTTTTGTCAAACTAGACTTAATGACCCTGATTACATCATTCGTTTAGAAAACTTGCTTGAAGAGACCGAGCAAGACG
AATCTAAGCAAAAATTATTACAGGCTTTATGTCATTATCTTAGAAACCTATAA

Upstream 100 bases:

>100_bases
ACTCAAGCAAATAGCCTAATCAAAGCGAACGAACTAAGACATTCAAATCACTCAAGTGCTATGATAGGCGTAATTATTAT
TTGTGATAGCCACTCAATAT

Downstream 100 bases:

>100_bases
GCTTTATAGGTGGCAACTGAGATCTTCGTCTCGTTCTAGGTGTAACAAGGTTACTAGAATGATACTTCATTAGTGTTAAT
AAAAGGAAATAGCATATGCA

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSTNNQPTLFWHDYETFGANPAKDRPSQFAGVRTDMDLNIIGEPETFYCKLANDYLPSPEAILITGITPQLANLKGMPEA
EFMDKINSLFSQPKTCVVGYNSLRFDDEVSRYGFYRNFIDPYAREWQNGNSRWDIIDLVRACYAFRPEGINWPEKEDGSP
SFKLEQLTVANGLSHEKAHDAMSDVYATIDMAKLIKSVQPKLFDYYFSLRLKQQVSKLIDVLEMKPLVHVSSKISALNGC
TTIIAPVAYHSTNKNAVICVNLAMDVTPLIELSVEEIRERMYTRRSDLAPDELPIGLKQIHINKSPFIAAANTLTDENAA
RLDFDKAFARAQYKKLKQHPELREKLVAVFDVEHEGKTVDPDQALYSGGFFSSADKAKIEIIRHTQPRNLAALELDFDDQ
RLSEMLFRYRARNYPETLDDSEQYRWREFCQTRLNDPDYIIRLENLLEETEQDESKQKLLQALCHYLRNL

Sequences:

>Translated_470_residues
MSTNNQPTLFWHDYETFGANPAKDRPSQFAGVRTDMDLNIIGEPETFYCKLANDYLPSPEAILITGITPQLANLKGMPEA
EFMDKINSLFSQPKTCVVGYNSLRFDDEVSRYGFYRNFIDPYAREWQNGNSRWDIIDLVRACYAFRPEGINWPEKEDGSP
SFKLEQLTVANGLSHEKAHDAMSDVYATIDMAKLIKSVQPKLFDYYFSLRLKQQVSKLIDVLEMKPLVHVSSKISALNGC
TTIIAPVAYHSTNKNAVICVNLAMDVTPLIELSVEEIRERMYTRRSDLAPDELPIGLKQIHINKSPFIAAANTLTDENAA
RLDFDKAFARAQYKKLKQHPELREKLVAVFDVEHEGKTVDPDQALYSGGFFSSADKAKIEIIRHTQPRNLAALELDFDDQ
RLSEMLFRYRARNYPETLDDSEQYRWREFCQTRLNDPDYIIRLENLLEETEQDESKQKLLQALCHYLRNL
>Mature_469_residues
STNNQPTLFWHDYETFGANPAKDRPSQFAGVRTDMDLNIIGEPETFYCKLANDYLPSPEAILITGITPQLANLKGMPEAE
FMDKINSLFSQPKTCVVGYNSLRFDDEVSRYGFYRNFIDPYAREWQNGNSRWDIIDLVRACYAFRPEGINWPEKEDGSPS
FKLEQLTVANGLSHEKAHDAMSDVYATIDMAKLIKSVQPKLFDYYFSLRLKQQVSKLIDVLEMKPLVHVSSKISALNGCT
TIIAPVAYHSTNKNAVICVNLAMDVTPLIELSVEEIRERMYTRRSDLAPDELPIGLKQIHINKSPFIAAANTLTDENAAR
LDFDKAFARAQYKKLKQHPELREKLVAVFDVEHEGKTVDPDQALYSGGFFSSADKAKIEIIRHTQPRNLAALELDFDDQR
LSEMLFRYRARNYPETLDDSEQYRWREFCQTRLNDPDYIIRLENLLEETEQDESKQKLLQALCHYLRNL

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=466, Percent_Identity=53.862660944206, Blast_Score=510, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54096; Mature: 53965

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNNQPTLFWHDYETFGANPAKDRPSQFAGVRTDMDLNIIGEPETFYCKLANDYLPSPE
CCCCCCCEEEEECHHHCCCCCCCCCCHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCCC
AILITGITPQLANLKGMPEAEFMDKINSLFSQPKTCVVGYNSLRFDDEVSRYGFYRNFID
EEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
PYAREWQNGNSRWDIIDLVRACYAFRPEGINWPEKEDGSPSFKLEQLTVANGLSHEKAHD
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHH
AMSDVYATIDMAKLIKSVQPKLFDYYFSLRLKQQVSKLIDVLEMKPLVHVSSKISALNGC
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCH
TTIIAPVAYHSTNKNAVICVNLAMDVTPLIELSVEEIRERMYTRRSDLAPDELPIGLKQI
HHHHHHHHEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
HINKSPFIAAANTLTDENAARLDFDKAFARAQYKKLKQHPELREKLVAVFDVEHEGKTVD
EECCCCCEEEECCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCC
PDQALYSGGFFSSADKAKIEIIRHTQPRNLAALELDFDDQRLSEMLFRYRARNYPETLDD
HHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCC
SEQYRWREFCQTRLNDPDYIIRLENLLEETEQDESKQKLLQALCHYLRNL
CHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STNNQPTLFWHDYETFGANPAKDRPSQFAGVRTDMDLNIIGEPETFYCKLANDYLPSPE
CCCCCCEEEEECHHHCCCCCCCCCCHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCCC
AILITGITPQLANLKGMPEAEFMDKINSLFSQPKTCVVGYNSLRFDDEVSRYGFYRNFID
EEEEECCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
PYAREWQNGNSRWDIIDLVRACYAFRPEGINWPEKEDGSPSFKLEQLTVANGLSHEKAHD
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHH
AMSDVYATIDMAKLIKSVQPKLFDYYFSLRLKQQVSKLIDVLEMKPLVHVSSKISALNGC
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCH
TTIIAPVAYHSTNKNAVICVNLAMDVTPLIELSVEEIRERMYTRRSDLAPDELPIGLKQI
HHHHHHHHEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
HINKSPFIAAANTLTDENAARLDFDKAFARAQYKKLKQHPELREKLVAVFDVEHEGKTVD
EECCCCCEEEECCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCC
PDQALYSGGFFSSADKAKIEIIRHTQPRNLAALELDFDDQRLSEMLFRYRARNYPETLDD
HHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCC
SEQYRWREFCQTRLNDPDYIIRLENLLEETEQDESKQKLLQALCHYLRNL
CHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]