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The map label for this gene is hisI [H]

Identifier: 157962284

GI number: 157962284

Start: 3006202

End: 3006840

Strand: Direct

Name: hisI [H]

Synonym: Spea_2463

Alternate gene names: 157962284

Gene position: 3006202-3006840 (Clockwise)

Preceding gene: 157962283

Following gene: 157962285

Centisome position: 58.1

GC content: 45.38

Gene sequence:

>639_bases
ATGACAAGTACCAAGCAAAACCAGCAATACGGCGATCTAATCACTCAATTGGACTGGAAAAAAACAGATGGCCTAGTTCC
TGCTGTCGTACAGAACTTTTTAACCGGTAAAGTCTTGATGTTAGGCTATATGGATAAAGCTGCGTTAGACAAGAGCCTAT
CGACTAAACAAGTCACCTTCTTTAGTCGCAGCAAGCAACGGCTCTGGACCAAGGGGGAAACCTCTGGTAATACGCTTGAA
TTAGTTGCTATCGATATGGACTGTGATAACGACAGCCTGTTAGTACAAGTAATCCCCAACGGGCCGACTTGCCATAAAGG
CACCGAAAGCTGCTGGAAAGATGGCAAGGCTCACAGCTTTATCGATAACCTTACTAGTCTAATTGCATCACGTAAGGGCC
AAGATCCACAGTCGAGCTATACCGCTCACCTGTTTGAGAGAGGCACCAAACGTATCGCCCAAAAAGTCGGCGAGGAAGGC
TTAGAAACTGCGCTAGCCGCTGCGACTAATGATAAGCCAGAGCTGATAGATGAAGCATCGGATCTCATCTACCACCTGTT
GGTGCTGTTAGAAGATCAAGAGTTAAGTATGCAAGATATCAACTTAAACCTGATGAAAAGACACAATAAGGCTAAGTAG

Upstream 100 bases:

>100_bases
GGATCATCGACATTCAGGCGCTAAAGCGGTATCTAAAAGATAAAAATATTGCTGTCCGGATCTAATTCAGTGAGACCTTG
ACCCAAATTAAGGATGTAAC

Downstream 100 bases:

>100_bases
CCGAGTGATAAGGGCGTAAGCTAAATTTACGCCCTTTATTTTTGGGGATAATTAACCCGTCGCAACGATTCATAACAGCA
TAATCTTTCAATTATCCTCC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTSTKQNQQYGDLITQLDWKKTDGLVPAVVQNFLTGKVLMLGYMDKAALDKSLSTKQVTFFSRSKQRLWTKGETSGNTLE
LVAIDMDCDNDSLLVQVIPNGPTCHKGTESCWKDGKAHSFIDNLTSLIASRKGQDPQSSYTAHLFERGTKRIAQKVGEEG
LETALAAATNDKPELIDEASDLIYHLLVLLEDQELSMQDINLNLMKRHNKAK

Sequences:

>Translated_212_residues
MTSTKQNQQYGDLITQLDWKKTDGLVPAVVQNFLTGKVLMLGYMDKAALDKSLSTKQVTFFSRSKQRLWTKGETSGNTLE
LVAIDMDCDNDSLLVQVIPNGPTCHKGTESCWKDGKAHSFIDNLTSLIASRKGQDPQSSYTAHLFERGTKRIAQKVGEEG
LETALAAATNDKPELIDEASDLIYHLLVLLEDQELSMQDINLNLMKRHNKAK
>Mature_211_residues
TSTKQNQQYGDLITQLDWKKTDGLVPAVVQNFLTGKVLMLGYMDKAALDKSLSTKQVTFFSRSKQRLWTKGETSGNTLEL
VAIDMDCDNDSLLVQVIPNGPTCHKGTESCWKDGKAHSFIDNLTSLIASRKGQDPQSSYTAHLFERGTKRIAQKVGEEGL
ETALAAATNDKPELIDEASDLIYHLLVLLEDQELSMQDINLNLMKRHNKAK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=63.0769230769231, Blast_Score=250, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6319819, Length=200, Percent_Identity=33, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23616; Mature: 23485

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTKQNQQYGDLITQLDWKKTDGLVPAVVQNFLTGKVLMLGYMDKAALDKSLSTKQVTF
CCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH
FSRSKQRLWTKGETSGNTLELVAIDMDCDNDSLLVQVIPNGPTCHKGTESCWKDGKAHSF
HHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHH
IDNLTSLIASRKGQDPQSSYTAHLFERGTKRIAQKVGEEGLETALAAATNDKPELIDEAS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DLIYHLLVLLEDQELSMQDINLNLMKRHNKAK
HHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCC
>Mature Secondary Structure 
TSTKQNQQYGDLITQLDWKKTDGLVPAVVQNFLTGKVLMLGYMDKAALDKSLSTKQVTF
CCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH
FSRSKQRLWTKGETSGNTLELVAIDMDCDNDSLLVQVIPNGPTCHKGTESCWKDGKAHSF
HHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHH
IDNLTSLIASRKGQDPQSSYTAHLFERGTKRIAQKVGEEGLETALAAATNDKPELIDEAS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DLIYHLLVLLEDQELSMQDINLNLMKRHNKAK
HHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]