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The map label for this gene is nhaB [H]

Identifier: 157962260

GI number: 157962260

Start: 2983416

End: 2985002

Strand: Direct

Name: nhaB [H]

Synonym: Spea_2439

Alternate gene names: 157962260

Gene position: 2983416-2985002 (Clockwise)

Preceding gene: 157962258

Following gene: 157962261

Centisome position: 57.66

GC content: 43.35

Gene sequence:

>1587_bases
ATGCCTGTGACAATGAGTCGGGCGTTTCTTGATAACTTCTTAGGTAACTCACCGAAGTGGTTCAAAATCGCGATCATATC
GTTCTTAGTGATCAACCCTATCGTGTTTTATTTTAATCCATTCGTAGCGGGTTGGTTGTTAGTTGTTGAGTTTATCTTCA
CCTTAGCTATGGCGCTTAAATGTTACCCGCTGCAACCAGGCGGATTATTAGCGATTGAAGCTGTGGCTATCGGCATGACT
TCGCCGAGCCAAGTGCTACATGAAATTGAAGCAAACCTAGAAGTGGTTCTACTACTGGTCTTTATGGTCGCCGGTATTTA
CTTCATGAAGCAGTTGCTTCTGTTTGTTTTCACCAAAATGATCACTAAAGTACGTTCAAAGATATACGTTTCTTTATTGT
TCTGTATTTCATCAGCATTCCTTTCTGCGTTCTTAGATGCATTAACCGTTATCGCAGTGATTATTACTGTTGCGGTTGGT
TTCTACTCTATTTACCACAAAGTAGCATCAGGAAAGACCTTTGGTGAAAGTCACGACCACACCTCAGATGGCTATCCACA
GCTATGTGAAGAAGAGCTTGAATCATTCAGAGGCTTCTTACGTAACTTGCTTATGCATGCCGGTGTTGGTACTGCATTAG
GTGGTGTTTGCACCATGGTTGGTGAACCACAAAACCTGATTATTGCTGCACAAGCAAACTGGCAGTTCGCTGAATTTGCT
ATTCGCATGTCACCAGTAACTGTGCCTGTATTCTTTGCTGGTATTACAACCTGTTTTTTAGTTGAGAAATTTAAGGTGTT
TGGCTACGGTCAACAGCTACCTGACGCGGTTCATAAAATCCTATCTGATTACGACGCTCATGAAGATGCAAACCGCACCA
AGCACGATAAAGTAAAGCTTCTTATCCAAGCGGTTATTGGTGTTTGGTTAATCGCGGGTCTTGCTCTGCATTTAGCTTCT
GTTGGTCTAATCGGTCTTTCTGTGATTATTCTTGCGACTGCATTTAACGGTATCACTAACGAGCACGCACTAGGTAAAGC
CTTCGAAGAAGCCCTACCATTTACGGCGCTATTAGCGGTATTCTTCGCTATCGTTGCTGTGATTATCGATCAACAGTTAT
TCGCACCTGTTATTCAGTGGGCACTAAGCTATGAAGGTAACACTCAGTTAGTGATCTTCTACATTGCTAACGGTCTGCTT
TCAATGGTGAGCGATAACGTATTCGTAGGTACGGTGTACATTAACGAGGTGAAATCTGCACTACTTAATGGCCAAATCAC
TCGTGATCAGTTCGACCTTCTTGCTGTAGCAATCAACACGGGTACTAACCTACCTTCTGTTGCGACGCCAAATGGTCAGG
CTGCGTTCCTATTCTTACTAACATCTGCTATCGCCCCACTTATCCGTCTTTCTTACGGAAGAATGGTGTGGATGGCGCTG
CCATACACTATCGTACTCTCTATCGTAGGTGTACTTGCGATTCAGTTAGGTGCGCTAGAGCAGATGACACAATACTTCTA
TGACAGTCAAATGTTAATCCATCACTCTGCTCAAGCAGCTGCAGATGGTGTAGTATCATCACATTGA

Upstream 100 bases:

>100_bases
ATCGGCTATTTAAGTCATCAAAAAAGCTTTTACCTTTTCATTATCGCTAGTAGCATACGGTGCAAATTTGTTTGCTACTC
AAATCAATAGAGAGGATTCC

Downstream 100 bases:

>100_bases
TAAGCATTTTGTGAACTATTTAACAAATAGTTAGTCATATAAAACGCCCTATTCAATAGGGCGTTTTTTTTATTTGCAAT
GGAGACAATGTCGTTGAATG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MPVTMSRAFLDNFLGNSPKWFKIAIISFLVINPIVFYFNPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMT
SPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKIYVSLLFCISSAFLSAFLDALTVIAVIITVAVG
FYSIYHKVASGKTFGESHDHTSDGYPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFA
IRMSPVTVPVFFAGITTCFLVEKFKVFGYGQQLPDAVHKILSDYDAHEDANRTKHDKVKLLIQAVIGVWLIAGLALHLAS
VGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDQQLFAPVIQWALSYEGNTQLVIFYIANGLL
SMVSDNVFVGTVYINEVKSALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMAL
PYTIVLSIVGVLAIQLGALEQMTQYFYDSQMLIHHSAQAAADGVVSSH

Sequences:

>Translated_528_residues
MPVTMSRAFLDNFLGNSPKWFKIAIISFLVINPIVFYFNPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMT
SPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKIYVSLLFCISSAFLSAFLDALTVIAVIITVAVG
FYSIYHKVASGKTFGESHDHTSDGYPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFA
IRMSPVTVPVFFAGITTCFLVEKFKVFGYGQQLPDAVHKILSDYDAHEDANRTKHDKVKLLIQAVIGVWLIAGLALHLAS
VGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDQQLFAPVIQWALSYEGNTQLVIFYIANGLL
SMVSDNVFVGTVYINEVKSALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMAL
PYTIVLSIVGVLAIQLGALEQMTQYFYDSQMLIHHSAQAAADGVVSSH
>Mature_527_residues
PVTMSRAFLDNFLGNSPKWFKIAIISFLVINPIVFYFNPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAVAIGMTS
PSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKMITKVRSKIYVSLLFCISSAFLSAFLDALTVIAVIITVAVGF
YSIYHKVASGKTFGESHDHTSDGYPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFAI
RMSPVTVPVFFAGITTCFLVEKFKVFGYGQQLPDAVHKILSDYDAHEDANRTKHDKVKLLIQAVIGVWLIAGLALHLASV
GLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAVFFAIVAVIIDQQLFAPVIQWALSYEGNTQLVIFYIANGLLS
MVSDNVFVGTVYINEVKSALLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMALP
YTIVLSIVGVLAIQLGALEQMTQYFYDSQMLIHHSAQAAADGVVSSH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=507, Percent_Identity=66.0749506903353, Blast_Score=659, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57646; Mature: 57514

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PVTMSRAFLDNFLGNSPKWFKIAIISFLVINPIVFYFNPFVAGWLLVVEFIFTLAMALK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYPLQPGGLLAIEAVAIGMTSPSQVLHEIEANLEVVLLLVFMVAGIYFMKQLLLFVFTKM
CCCCCCCCEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITKVRSKIYVSLLFCISSAFLSAFLDALTVIAVIITVAVGFYSIYHKVASGKTFGESHDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSDGYPQLCEEELESFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFAEFA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
IRMSPVTVPVFFAGITTCFLVEKFKVFGYGQQLPDAVHKILSDYDAHEDANRTKHDKVKL
HEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIQAVIGVWLIAGLALHLASVGLIGLSVIILATAFNGITNEHALGKAFEEALPFTALLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
FFAIVAVIIDQQLFAPVIQWALSYEGNTQLVIFYIANGLLSMVSDNVFVGTVYINEVKSA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCEEEEEEEHHHHHHH
LLNGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLIRLSYGRMVWMAL
HHCCCCCCCHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYTIVLSIVGVLAIQLGALEQMTQYFYDSQMLIHHSAQAAADGVVSSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA