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The map label for this gene is 157962025

Identifier: 157962025

GI number: 157962025

Start: 2673302

End: 2674417

Strand: Direct

Name: 157962025

Synonym: Spea_2204

Alternate gene names: NA

Gene position: 2673302-2674417 (Clockwise)

Preceding gene: 157962024

Following gene: 157962026

Centisome position: 51.66

GC content: 41.94

Gene sequence:

>1116_bases
ATGTTTATTCACAAATGTGAACGTGTAGATGAAAATCTTGCGATTCAATTTTCTAATAATAATGAAGCAAACTTCAGTTT
ATTTTGGTTAAGAGATCACAGTACCGATCAGTCCAGCCTTAACCCAGATACATTACAACGAGATGTTGAAACCTTTTCCT
TACCGACAGTGCCACAGGTAGAACAGTTCCAGATTATCAATAACGGCGCTCAACTGCGCATTCATTGGCTAGATGGTGAT
CTAGTCAGCGAGTTTGATGCTAGCTTTCTTTTTAATATGGCCTGTACGCCAGTTAATGACCCCTCATATCAGTTATGGGC
TAACGAGCTACAAAACCAAGTCCCAGATTTTGATTTTGAACAGGTAACCGCTAACGATGCTGCTTTTTTGCCAGTATTAG
AAAGTATGGATCGGTATGGTTTAGTGACATTTTCAGGCATGCCTTCAAATATGGAAGCGACCAAAAAGTTACTCAATCAA
GTCGGGTATATCCGAGATACCGTATTTGGTAGTTTATGGGACTTTTCTAATAATGGCGCTCATAGTGACAGTGCCTATAC
CAGTGTGGGGATTGGGCTACATACCGACAGTACATATACACTTGACCCGCCAGGCTTACAGTTATTGCATTGTTTGGCCT
TCGACGGCGAAGGGGCCTTTAACCAATTTGCCGATGGCTTTAAAGTTGCTCAAACCATTAAAAATGAAGACCCTGCCGCT
TATGAGACTCTGAGCAAGATTAAGGTGCCTGCCCATTATATTGAGCCCGGCATCCAATTAAGAGGCCAGCATGAGGTTGT
GCGCGAAGATATTAATGGCCAGTTTGAACAAATTTGTTTTAATAACTTTGATCGCAGTCCCTTTATGCTAAGTGCTAGTG
AGCAAAAGGCTTTTTATCATGCTTATGGCCTGTTTCAACGTTTAATTAACGACCCTAAATATCAGGTGAACTTTCAATTA
CAACCAGGACGTGCGGTATGGTTTGATAATTGGCGTGTTCTTCATGCGCGTAGCGCTTTTAGCGGCTTCCGACATCTTGC
CGGCGGCTACACTAATCGAGAAGATTACATAAGTAAAAAGCTAACCTTAAAAGGGAAAACACCATGGCAGGAGTAA

Upstream 100 bases:

>100_bases
AGCACTTGATAATCTTAAATCGTCGATGCTATGGTGGTTAATTGTTACCACTTTGTTGTGTCAGCTGTTATTTAACAGAT
TGACTTAGGGTTCTATTTTT

Downstream 100 bases:

>100_bases
TCGATTTACGCAGTGATACCGTCACGCAGCCTTGCCAGAACATGCGCGCGTTAATGGCATCAGCCGAAACGGGTGATGAT
GTTTATGGTGAAGATCCTAG

Product: trimethyllysine dioxygenase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MFIHKCERVDENLAIQFSNNNEANFSLFWLRDHSTDQSSLNPDTLQRDVETFSLPTVPQVEQFQIINNGAQLRIHWLDGD
LVSEFDASFLFNMACTPVNDPSYQLWANELQNQVPDFDFEQVTANDAAFLPVLESMDRYGLVTFSGMPSNMEATKKLLNQ
VGYIRDTVFGSLWDFSNNGAHSDSAYTSVGIGLHTDSTYTLDPPGLQLLHCLAFDGEGAFNQFADGFKVAQTIKNEDPAA
YETLSKIKVPAHYIEPGIQLRGQHEVVREDINGQFEQICFNNFDRSPFMLSASEQKAFYHAYGLFQRLINDPKYQVNFQL
QPGRAVWFDNWRVLHARSAFSGFRHLAGGYTNREDYISKKLTLKGKTPWQE

Sequences:

>Translated_371_residues
MFIHKCERVDENLAIQFSNNNEANFSLFWLRDHSTDQSSLNPDTLQRDVETFSLPTVPQVEQFQIINNGAQLRIHWLDGD
LVSEFDASFLFNMACTPVNDPSYQLWANELQNQVPDFDFEQVTANDAAFLPVLESMDRYGLVTFSGMPSNMEATKKLLNQ
VGYIRDTVFGSLWDFSNNGAHSDSAYTSVGIGLHTDSTYTLDPPGLQLLHCLAFDGEGAFNQFADGFKVAQTIKNEDPAA
YETLSKIKVPAHYIEPGIQLRGQHEVVREDINGQFEQICFNNFDRSPFMLSASEQKAFYHAYGLFQRLINDPKYQVNFQL
QPGRAVWFDNWRVLHARSAFSGFRHLAGGYTNREDYISKKLTLKGKTPWQE
>Mature_371_residues
MFIHKCERVDENLAIQFSNNNEANFSLFWLRDHSTDQSSLNPDTLQRDVETFSLPTVPQVEQFQIINNGAQLRIHWLDGD
LVSEFDASFLFNMACTPVNDPSYQLWANELQNQVPDFDFEQVTANDAAFLPVLESMDRYGLVTFSGMPSNMEATKKLLNQ
VGYIRDTVFGSLWDFSNNGAHSDSAYTSVGIGLHTDSTYTLDPPGLQLLHCLAFDGEGAFNQFADGFKVAQTIKNEDPAA
YETLSKIKVPAHYIEPGIQLRGQHEVVREDINGQFEQICFNNFDRSPFMLSASEQKAFYHAYGLFQRLINDPKYQVNFQL
QPGRAVWFDNWRVLHARSAFSGFRHLAGGYTNREDYISKKLTLKGKTPWQE

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI8922625, Length=350, Percent_Identity=29.1428571428571, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4502369, Length=386, Percent_Identity=26.9430051813472, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI296317249, Length=241, Percent_Identity=30.2904564315353, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71992672, Length=387, Percent_Identity=30.749354005168, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17534641, Length=404, Percent_Identity=25.990099009901, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321766, Length=377, Percent_Identity=27.3209549071618, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648401, Length=346, Percent_Identity=33.5260115606936, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24639015, Length=376, Percent_Identity=27.6595744680851, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI221329931, Length=370, Percent_Identity=25.4054054054054, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922166, Length=371, Percent_Identity=24.7978436657682, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR010376
- InterPro:   IPR003819 [H]

Pfam domain/function: PF06155 DUF971; PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 42288; Mature: 42288

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIHKCERVDENLAIQFSNNNEANFSLFWLRDHSTDQSSLNPDTLQRDVETFSLPTVPQV
CCCCCHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCC
EQFQIINNGAQLRIHWLDGDLVSEFDASFLFNMACTPVNDPSYQLWANELQNQVPDFDFE
HHEEEECCCCEEEEEEECCHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCHH
QVTANDAAFLPVLESMDRYGLVTFSGMPSNMEATKKLLNQVGYIRDTVFGSLWDFSNNGA
HHCCCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HSDSAYTSVGIGLHTDSTYTLDPPGLQLLHCLAFDGEGAFNQFADGFKVAQTIKNEDPAA
CCCCCCEEEEEEEECCCEEEECCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHH
YETLSKIKVPAHYIEPGIQLRGQHEVVREDINGQFEQICFNNFDRSPFMLSASEQKAFYH
HHHHHHHCCCHHHHCCCCEECCCHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCHHHHH
AYGLFQRLINDPKYQVNFQLQPGRAVWFDNWRVLHARSAFSGFRHLAGGYTNREDYISKK
HHHHHHHHHCCCCEEEEEEECCCCEEEECCEEEEEHHHHHHHHHHHHCCCCCHHHHHCEE
LTLKGKTPWQE
EEECCCCCCCC
>Mature Secondary Structure
MFIHKCERVDENLAIQFSNNNEANFSLFWLRDHSTDQSSLNPDTLQRDVETFSLPTVPQV
CCCCCHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCC
EQFQIINNGAQLRIHWLDGDLVSEFDASFLFNMACTPVNDPSYQLWANELQNQVPDFDFE
HHEEEECCCCEEEEEEECCHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCHH
QVTANDAAFLPVLESMDRYGLVTFSGMPSNMEATKKLLNQVGYIRDTVFGSLWDFSNNGA
HHCCCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HSDSAYTSVGIGLHTDSTYTLDPPGLQLLHCLAFDGEGAFNQFADGFKVAQTIKNEDPAA
CCCCCCEEEEEEEECCCEEEECCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHH
YETLSKIKVPAHYIEPGIQLRGQHEVVREDINGQFEQICFNNFDRSPFMLSASEQKAFYH
HHHHHHHCCCHHHHCCCCEECCCHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCHHHHH
AYGLFQRLINDPKYQVNFQLQPGRAVWFDNWRVLHARSAFSGFRHLAGGYTNREDYISKK
HHHHHHHHHCCCCEEEEEEECCCCEEEECCEEEEEHHHHHHHHHHHHCCCCCHHHHHCEE
LTLKGKTPWQE
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504802 [H]