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The map label for this gene is cysG [H]

Identifier: 157961632

GI number: 157961632

Start: 2208785

End: 2209759

Strand: Direct

Name: cysG [H]

Synonym: Spea_1808

Alternate gene names: 157961632

Gene position: 2208785-2209759 (Clockwise)

Preceding gene: 157961631

Following gene: 157961633

Centisome position: 42.69

GC content: 46.87

Gene sequence:

>975_bases
ATGCAGAAAAAACAGATTGTCTCTGAAAAAATCACAACTGCAGTTAACACCCTGAGAGTTTGTCGCAGTATTACTCAGGT
TAATGATTTTCCCTTGTCGCAGTTAAGCCACAATAGGGGAGTTAACACACCTGATAGGGCTCTGCATCAAACGGTAAAAA
TTGTCGGAGCAGGTTGTGGAGACATTGATTTGCTGACCATAAAAGCGGCGCAGGCGATTATGGATGCCGATGAAGTGGTG
TATGACAATTTAGTCAGCGAAGATATTTTGAGTTTAGCCAGTGATAGTTGTGGCCTGCATTACATGGGGAAACGCTGTAA
CCAGAAAAGTAGCTCACAGAGCGCAATCAATAATAAACTTTATCAATTGGCGATGACTGGCGCTAACGTAGTGCGGTTAA
AAGGTGGGGATCCTAATGTTTTTGGCCGTGGCAGCGAAGAAGCACTTTTCCTTGCCAAACATGGCGTTAAAAGTGAGTTT
ATTGCCGGGGTCACCGCAGCTTTGGGCTGCGCGGCTAGCGCAGGTGTTCCGCTGACTCACAGAGAGGTGGCCCGCAGCGT
TACGTTTGTTACTGGTAGAACCTGCGATGATTCGGCCCAGCATTGGCAACGCTTGTTAGCGGCGCAGAGCACCTTGGTAT
TTTACATGGGTAAAGAAAGAGCTGCAGATATATCCACTAGCTTGTTAAAGGCTGGAGCAGAGTCTTCCACCCCCGTGGCT
TTTATCAGCGAAGGTGCACGGGCTACCCAATCGACTATTTATGGTGAAATCGAGTGCATGGCAAGCCTTGCAGCTAATAT
TACCGCTCAAGGCCCCACTTTAATCGTTATAGGCGATGTGGTTAATATTGCTCAAGAGATAGCCCATTCACTCGCCCAAA
CACTGGCTCTGGAACCAAGAAGAGAATTTCCCTTTACTAATGACAACTCGGTTATTCAGCACTTAACGGATCATGCAGAG
TGTGTCTATGGATAA

Upstream 100 bases:

>100_bases
CAACATTCTGCTTTTGAACCCCCAAGTGATTTCGAAACCCAAGCTGCTGTTGATGAGCAAACTACTTTTGATACACAAGC
AAAAAAAGAAGAGGTGCGTA

Downstream 100 bases:

>100_bases
AATAAAAGCGATAGAAGAGCCGTTTGTGCCAATAAGCCAAAATTTAAGTGCTGACTCCTCTAACGTTAGCGTCTCTCAAA
TTGGGAGTATGGACGCAGTT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQKKQIVSEKITTAVNTLRVCRSITQVNDFPLSQLSHNRGVNTPDRALHQTVKIVGAGCGDIDLLTIKAAQAIMDADEVV
YDNLVSEDILSLASDSCGLHYMGKRCNQKSSSQSAINNKLYQLAMTGANVVRLKGGDPNVFGRGSEEALFLAKHGVKSEF
IAGVTAALGCAASAGVPLTHREVARSVTFVTGRTCDDSAQHWQRLLAAQSTLVFYMGKERAADISTSLLKAGAESSTPVA
FISEGARATQSTIYGEIECMASLAANITAQGPTLIVIGDVVNIAQEIAHSLAQTLALEPRREFPFTNDNSVIQHLTDHAE
CVYG

Sequences:

>Translated_324_residues
MQKKQIVSEKITTAVNTLRVCRSITQVNDFPLSQLSHNRGVNTPDRALHQTVKIVGAGCGDIDLLTIKAAQAIMDADEVV
YDNLVSEDILSLASDSCGLHYMGKRCNQKSSSQSAINNKLYQLAMTGANVVRLKGGDPNVFGRGSEEALFLAKHGVKSEF
IAGVTAALGCAASAGVPLTHREVARSVTFVTGRTCDDSAQHWQRLLAAQSTLVFYMGKERAADISTSLLKAGAESSTPVA
FISEGARATQSTIYGEIECMASLAANITAQGPTLIVIGDVVNIAQEIAHSLAQTLALEPRREFPFTNDNSVIQHLTDHAE
CVYG
>Mature_324_residues
MQKKQIVSEKITTAVNTLRVCRSITQVNDFPLSQLSHNRGVNTPDRALHQTVKIVGAGCGDIDLLTIKAAQAIMDADEVV
YDNLVSEDILSLASDSCGLHYMGKRCNQKSSSQSAINNKLYQLAMTGANVVRLKGGDPNVFGRGSEEALFLAKHGVKSEF
IAGVTAALGCAASAGVPLTHREVARSVTFVTGRTCDDSAQHWQRLLAAQSTLVFYMGKERAADISTSLLKAGAESSTPVA
FISEGARATQSTIYGEIECMASLAANITAQGPTLIVIGDVVNIAQEIAHSLAQTLALEPRREFPFTNDNSVIQHLTDHAE
CVYG

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=236, Percent_Identity=42.7966101694915, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322922, Length=231, Percent_Identity=30.7359307359307, Blast_Score=115, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 34594; Mature: 34594

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKQIVSEKITTAVNTLRVCRSITQVNDFPLSQLSHNRGVNTPDRALHQTVKIVGAGCG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
DIDLLTIKAAQAIMDADEVVYDNLVSEDILSLASDSCGLHYMGKRCNQKSSSQSAINNKL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
YQLAMTGANVVRLKGGDPNVFGRGSEEALFLAKHGVKSEFIAGVTAALGCAASAGVPLTH
HHHEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
REVARSVTFVTGRTCDDSAQHWQRLLAAQSTLVFYMGKERAADISTSLLKAGAESSTPVA
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCEE
FISEGARATQSTIYGEIECMASLAANITAQGPTLIVIGDVVNIAQEIAHSLAQTLALEPR
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
REFPFTNDNSVIQHLTDHAECVYG
CCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKKQIVSEKITTAVNTLRVCRSITQVNDFPLSQLSHNRGVNTPDRALHQTVKIVGAGCG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
DIDLLTIKAAQAIMDADEVVYDNLVSEDILSLASDSCGLHYMGKRCNQKSSSQSAINNKL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
YQLAMTGANVVRLKGGDPNVFGRGSEEALFLAKHGVKSEFIAGVTAALGCAASAGVPLTH
HHHEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
REVARSVTFVTGRTCDDSAQHWQRLLAAQSTLVFYMGKERAADISTSLLKAGAESSTPVA
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCEE
FISEGARATQSTIYGEIECMASLAANITAQGPTLIVIGDVVNIAQEIAHSLAQTLALEPR
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
REFPFTNDNSVIQHLTDHAECVYG
CCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA