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The map label for this gene is ffh [H]

Identifier: 157960876

GI number: 157960876

Start: 1271098

End: 1272471

Strand: Direct

Name: ffh [H]

Synonym: Spea_1048

Alternate gene names: 157960876

Gene position: 1271098-1272471 (Clockwise)

Preceding gene: 157960873

Following gene: 157960877

Centisome position: 24.56

GC content: 47.45

Gene sequence:

>1374_bases
ATGTTTGAGAACTTAACTGACAGATTGTCACGGACTCTGAAAAATATCAGTGGCCGTGGTCGCTTAACGGAAGAAAACGT
TAAGGAAACCTTACGCGAAGTCCGCATGGCTCTTCTTGAGGCCGACGTTGCCTTGCCTGTGGTTCGTGAATTCGTAAATA
GCGTTAAAGAACGCGCTGTTGGACAAGAGGTTTCTAAAAGTCTAAGTCCAGGCCAAGCCTTTATTAAGATCGTTCAAAGC
GAACTTGAAAACGCCATGGGTGAAGCGAACGAAGCTTTGGACCTATCGGCGCAGCCACCAGCTGTTATTATGATGGCGGG
TTTGCAAGGTGCCGGTAAAACTACCAGTGTTGCAAAACTGTCTAAATTCTTGCGTGAGCGCGAAAAGAAATCAGTCCTAG
TTGTATCGGCTGACGTATACCGTCCAGCGGCAATCAAGCAGCTAGAAACCTTAGCCGCAGAAGTTGACGTTCAATTCTTC
CCATCTGACGTTAGCCAAAAGCCAGTCGATATCGCCAATGCTGCGATTGCTCATGCAAAGCTTAAGTTCATTGATGTGGT
CATTGTCGATACTGCAGGTCGTTTGCACGTCGATGAAGCCATGATGGATGAGATTAAAGAGCTTCATGCTGCAGTTAAAC
CGGTTGAGACACTGTTTGTGGTTGATGCCATGACAGGTCAAGATGCGGCCAATACAGCTAAGGCCTTTAATGAAGCGCTA
CCGCTAACCGGTGTGGTACTGACAAAAGTCGATGGTGATGCACGTGGTGGTGCGGCGCTGTCGATTCGTCATATTACCGG
GAAACCAATTAAATTCTTAGGTGTCGGTGAAAAAACTGACGCACTAGAAGCGTTCCACCCAGATCGTGTTGCTTCACGTA
TTCTTGGTATGGGCGATGTGCTTTCTCTTATTGAAGAGGTTGAGCGCGGCGTAGACCAAGAAAAAGCCATGAAGCTTGCG
GCTAAAGTAAAGCAAGGCGGAAATTTTGATTTAGAAGATTTCCGTGAGCAGCTGCAGCAAATGAAAAACATGGGCGGCAT
GATGAACATGATTGAAAAGCTGCCAGGTGTGGGGCAATTACCACCTGAGGCTTTAGCTCAAGTTCAAGATGGCAAGATGA
CAGGGCAGATGGAAGCGATTATCAACTCTATGACCCCAGGTGAGCGCCAACGTCCAGATATCATCAAAGGTTCGCGCAAG
CGCAGAATCGCGATGGGCAGCGGCACACAAATTCAAGATGTGAACCGTTTATTGAAACAGTTTACGCAAATGCAGAAGAT
GATGAAAAAAATGTCATCAAAAGGCGGCATGAAAAAAATGATGCGTGGCATGAGCGGTATGCTCCCACCAGGCATGAAAA
TGCCCGGCCGCTAG

Upstream 100 bases:

>100_bases
CAGTTATAAAAGTTACTTGCGTCATTCTGTAGCATAATATCTGGGCATCGCTATAATACAGCCCCATCAATGTAAATTTT
AAACGGTAAAGAACTGGATA

Downstream 100 bases:

>100_bases
GCATTCTTAATATTCTGCAAAGCTAAATTTACAGACCAGAGTGAATCTCACTCTGGTCTGTTGATCGTTTTAGGTGTAAA
AAACGCCGATTACGGTTGCA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLSKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVDVQFF
PSDVSQKPVDIANAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAAVKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKQGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTPGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR

Sequences:

>Translated_457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLSKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVDVQFF
PSDVSQKPVDIANAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAAVKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKQGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTPGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
>Mature_457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLSKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVDVQFF
PSDVSQKPVDIANAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAAVKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKQGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTPGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=32.5221238938053, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI226371618, Length=354, Percent_Identity=34.7457627118644, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=29.4303797468354, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=29.4303797468354, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=37.5, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788963, Length=457, Percent_Identity=76.8052516411379, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.2075471698113, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=459, Percent_Identity=29.8474945533769, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=35.3488372093023, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=445, Percent_Identity=33.4831460674157, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=210, Percent_Identity=31.4285714285714, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647949, Length=446, Percent_Identity=31.1659192825112, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=33.1818181818182, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49808; Mature: 49808

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVSKSLSPGQAFIKIVQSELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
SKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVDVQFFPSDVSQKPVDIANAAIAHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDEAMMDEIKELHAAVKPVETLFVVDAMTGQDAANTAKAFNEAL
HHEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCHHHH
LSLIEEVERGVDQEKAMKLAAKVKQGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEALAQVQDGKMTGQMEAIINSMTPGERQRPDIIKGSRKRRIAMGSGTQIQDVNRLLKQ
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHH
FTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVSKSLSPGQAFIKIVQSELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
SKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVDVQFFPSDVSQKPVDIANAAIAHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDEAMMDEIKELHAAVKPVETLFVVDAMTGQDAANTAKAFNEAL
HHEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCHHHH
LSLIEEVERGVDQEKAMKLAAKVKQGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEALAQVQDGKMTGQMEAIINSMTPGERQRPDIIKGSRKRRIAMGSGTQIQDVNRLLKQ
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHH
FTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]