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The map label for this gene is pepA2 [H]

Identifier: 157960738

GI number: 157960738

Start: 1114869

End: 1116377

Strand: Reverse

Name: pepA2 [H]

Synonym: Spea_0910

Alternate gene names: 157960738

Gene position: 1116377-1114869 (Counterclockwise)

Preceding gene: 157960741

Following gene: 157960737

Centisome position: 21.57

GC content: 48.97

Gene sequence:

>1509_bases
ATGGAGTTTAGCGTAAAGAGCGGTAGTCCAGAGAAACAACGCTCAGCTTGTATCGTCGTAGGTGTATACGAACCTAGACG
CTTGTCCGGTATTGCCGAACAGTTAGATAAAATCAGTGAAGGCTATATTAGCAACTTACTTCGTCGTGGCGACTTGGAAG
GTAAGCCTGGACAGATGTTGTTGCTTCATCATGTACCCAACGTGCTTAGCGAGCGTGTTTTACTCGTTGGCTGTGGTAAA
GAGCGCGAGCTTGATGAACGCCAATATAAGCAGATCATCACTAAAACCATCAACACCTTGAATGAAACAGGTTCAATGGA
AGCGGTTTGTTTCCTTACTGAGCTGCATGTCAAAGGGCGCGACACCTACTGGAAAGTACGTGAAGCCGTAGAAACCACAC
AGAATAGCCTTTACTGCTTCGACGCACTGAAAACACGTAAAGGTGAAACTCGTCGCCCACTACGCAAATTAGTATTTAAT
GTACCGACTCGCCGTGAGCTCACGGTTGGCGAGCGCGCCATCGAGCACGGTATGGCGGTTTCTGCTGGTATGCACCTTTG
CCGCGACGTGGCAAACATGCCACCAAATATCTGTAATCCTGCTTACCTGGCGTCCCAAGCGCGCCAAATAGCCGAAAACA
CAGAAAACCTAACGGTGACCACTCTCGGTGAAGAGCAGATGGAAGCCTTAGGCATGAACTCATACCTAGCTGTAGGTCGT
GGTAGCCATAATGAGTCAGTCATGACCATCATGGAATACAAGGGCGCAGTCGATAATACTGAAAAGCCTATTGTTCTAGT
GGGTAAAGGCCTTACATTCGACTCGGGTGGTATTTCACTCAAGCCTGGCGAAGCCATGGATGAGATGAAGTACGACATGG
GCGGCGCAGCTGGCGTTATTGGCACCATGAAAGCCTTATGTCAGATGCAACTGCCGCTCAATGTTATCGGTATCTTGGCT
GGCTGTGAAAACATGCCATCAAGCAATGCGTATCGCCCAGGTGATATTCTAACGACCATGTCAGGCCAAACTGTAGAAGT
GTTAAACACAGATGCTGAAGGTCGCCTGGTGTTGTGTGACGTTCTAACTTATGTAGAACGCTTCGATCCTGAACTGGTTG
TCGATACAGCAACCCTAACTGGTGCTTGTGTTATCGCATTAGGTAAGCATGCATCGGGCTTGTTCTCAGGCCATAACCCA
CTTGCACACGAGCTATTAAATGCCGGTGAACAAAGTGGTGACCGCGCATGGCGCATGCCGCTATGGGATGAGTATCAAGA
GCACTTAGAAAGCCCATTTGCCGATATGACCAACCTAGGCGGTCGTGCAGCAGGGTCGATTACCGCAGCTTGCTTCCTAT
CTCGCTTTACTAAGAAGTATAACTGGGCGCATCTTGATGTAGCTGGTACGGCTTGGAATAGCGGTGCAAACAAAGGCTCG
ACGGGTCGTCCAGTACCTTTGTTAACTCAGTTCCTAATTAACAAAGCTGGCGTCGAACAAGGCGAATAG

Upstream 100 bases:

>100_bases
AAGAAAGTTCTTGAGTGAGCCATATCTTTGCCCTTTTTGGGCACAAGCAGACATTATCTAATAAATAATAAAATTTGTCT
TTAAGAATCTAGGAGAGCTC

Downstream 100 bases:

>100_bases
CCCTGCTAGATACCCTTGCTAAAGTTAATGCTAGAAAGCTAATATTAGAGAGTTAATATTAGCTAGCTGGCGCATAAAGG
CTAAACCACTGATTATATAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 2; LAP 2; Leucyl aminopeptidase 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYCFDALKTRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQIAENTENLTVTTLGEEQMEALGMNSYLAVGR
GSHNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKALCQMQLPLNVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFTKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINKAGVEQGE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYCFDALKTRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQIAENTENLTVTTLGEEQMEALGMNSYLAVGR
GSHNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKALCQMQLPLNVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFTKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINKAGVEQGE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVREAVETTQNSLYCFDALKTRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQIAENTENLTVTTLGEEQMEALGMNSYLAVGR
GSHNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKALCQMQLPLNVIGILA
GCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNP
LAHELLNAGEQSGDRAWRMPLWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFTKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINKAGVEQGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=490, Percent_Identity=33.6734693877551, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI47155554, Length=363, Percent_Identity=28.6501377410468, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=76.3052208835341, Blast_Score=805, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=309, Percent_Identity=40.7766990291262, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=288, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=459, Percent_Identity=27.0152505446623, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20129969, Length=522, Percent_Identity=29.6934865900383, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21355725, Length=323, Percent_Identity=33.7461300309598, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24661038, Length=323, Percent_Identity=34.0557275541796, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161077148, Length=501, Percent_Identity=29.1417165668663, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI20130057, Length=501, Percent_Identity=29.1417165668663, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI21355645, Length=506, Percent_Identity=29.4466403162055, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662223, Length=506, Percent_Identity=29.4466403162055, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662227, Length=508, Percent_Identity=28.9370078740157, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20129963, Length=507, Percent_Identity=28.5996055226824, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922386, Length=498, Percent_Identity=29.1164658634538, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=32.9861111111111, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=32.9861111111111, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=32.9861111111111, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24646701, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646703, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358201, Length=246, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54816; Mature: 54816

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCC
DTYWKVREAVETTQNSLYCFDALKTRKGETRRPLRKLVFNVPTRRELTVGERAIEHGMAV
CHHHHHHHHHHHHCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHH
SAGMHLCRDVANMPPNICNPAYLASQARQIAENTENLTVTTLGEEQMEALGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEECC
GSHNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCCEEEHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHHCCCCHHHH
GTMKALCQMQLPLNVIGILAGCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFTKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINKAGVEQGE
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCC
DTYWKVREAVETTQNSLYCFDALKTRKGETRRPLRKLVFNVPTRRELTVGERAIEHGMAV
CHHHHHHHHHHHHCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHH
SAGMHLCRDVANMPPNICNPAYLASQARQIAENTENLTVTTLGEEQMEALGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEECC
GSHNESVMTIMEYKGAVDNTEKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCCEEEHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHHCCCCHHHH
GTMKALCQMQLPLNVIGILAGCENMPSSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSGHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQEHLESPFADMTNLGGRAAGSITAACFLSRFTKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINKAGVEQGE
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]