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The map label for this gene is holC [H]

Identifier: 157960730

GI number: 157960730

Start: 1103072

End: 1103563

Strand: Reverse

Name: holC [H]

Synonym: Spea_0902

Alternate gene names: 157960730

Gene position: 1103563-1103072 (Counterclockwise)

Preceding gene: 157960733

Following gene: 157960729

Centisome position: 21.33

GC content: 46.34

Gene sequence:

>492_bases
ATGTCGCCAAGTCAGTCTCAAGCTCAGTTTTATCTGATGCCAAAGGATGCACTGCAAGCATCTAACGCGCCCAAATCGGC
ACTTGAGCAAGTGTATTTGCTTGCCTGCCAATTGGCGCAGCGAGCCTTTGCCACTCAGCAACTGGTCTACGTTCATTGCC
AAGATCAACAGCAAGCTTATGCGATTGATGAACTCTTATGGCAATTTGAGCCACAATCTTTTGTGCCCCACAACCTTAAA
GGTGAAGGTACATTAGGCGGCGCGCCGGTAGAAATTGGCTTTGACAGACTTGGAGCCAACAAAAAACGTCATCTTCTGAT
TAATCTTGCAGACCAAGTGCCGCAATTTGCGGTAAACTTTGGACAGATTATCGATTTCGTTGCTAACGACGATAGCCATA
AAGCGATTGCTCGCGATCGCTACAGACAGTATCGCGCACTTGGGATAGCTCTAACGACCCAAGATATAGCAACACAACCT
ATTAATTTTTAG

Upstream 100 bases:

>100_bases
TCTGAGCGACTTTTAGTGTAAAATCCTCTCTTTCGTCAGCCAAAAGCCGAAGCAATAGCAAACTATCTCTTCGAGCTGGT
CTTCAAGCAGGTTTTTAAGC

Downstream 100 bases:

>100_bases
TTTGAGATAAACACGCCCCATGGAAAAAACATATAACCCGCAGTCTATAGAACAGTCTCTCTACCAAAACTGGGAAGAGA
AAGGTTACTTCAAGCCACAC

Product: DNA polymerase III chi subunit HolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSPSQSQAQFYLMPKDALQASNAPKSALEQVYLLACQLAQRAFATQQLVYVHCQDQQQAYAIDELLWQFEPQSFVPHNLK
GEGTLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALTTQDIATQP
INF

Sequences:

>Translated_163_residues
MSPSQSQAQFYLMPKDALQASNAPKSALEQVYLLACQLAQRAFATQQLVYVHCQDQQQAYAIDELLWQFEPQSFVPHNLK
GEGTLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALTTQDIATQP
INF
>Mature_162_residues
SPSQSQAQFYLMPKDALQASNAPKSALEQVYLLACQLAQRAFATQQLVYVHCQDQQQAYAIDELLWQFEPQSFVPHNLKG
EGTLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALTTQDIATQPI
NF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=147, Percent_Identity=41.4965986394558, Blast_Score=120, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 18250; Mature: 18119

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSQSQAQFYLMPKDALQASNAPKSALEQVYLLACQLAQRAFATQQLVYVHCQDQQQAY
CCCCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHH
AIDELLWQFEPQSFVPHNLKGEGTLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCCEEEEEEEHHHHHHHHHHH
GQIIDFVANDDSHKAIARDRYRQYRALGIALTTQDIATQPINF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECHHHCCCCCCC
>Mature Secondary Structure 
SPSQSQAQFYLMPKDALQASNAPKSALEQVYLLACQLAQRAFATQQLVYVHCQDQQQAY
CCCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHH
AIDELLWQFEPQSFVPHNLKGEGTLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCCEEEEEEEHHHHHHHHHHH
GQIIDFVANDDSHKAIARDRYRQYRALGIALTTQDIATQPINF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8389364; 8246893; 7610040; 9278503; 2670557; 8505305; 1575709 [H]