Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 157825858

GI number: 157825858

Start: 712868

End: 714244

Strand: Direct

Name: nuoN [H]

Synonym: A1C_03985

Alternate gene names: 157825858

Gene position: 712868-714244 (Clockwise)

Preceding gene: 157825843

Following gene: 157825862

Centisome position: 57.91

GC content: 31.37

Gene sequence:

>1377_bases
ATGCTACTGCTACTTCCTGAAATAACTTTGACTTTAATAGCACTTTTAGGGCAGTTTTTTGCCGTAATGATCCCAAATAA
AAATAGAATTATTGCTAATATCATTATTTTATTATGTATATTATCAATTTTTCTTACCTTTAAGTACTCAAGCTATGAAG
GAGTATGGCACTCATTTGCTACCGGAATAAGTATCGGTATTAGTAAAAGCATAGTACTGATATTCACTATTATATCCATG
ATTATATACCGTGATTACTCTATTCTTGTTGCTGAGGAATTAAAATTTGAATTTATCACTTTAATATTATTATCGGTTGT
AGGTCTTTTTGTTGCAATCTCATCACGGAATTTTATATTATTATTCTGTGGTATGGAGCTTACTGCTTTAACTTCATATG
CACTTGCAGGATTCAAATTAAATGACATTAAATCCTCGGAAGGTGCTGTAAAATATTTTATCTTAAGTAGTTTAGTTAGT
TGTTTATCATTATTCGGGATTTCTTTTATATACGGATTTGGTGGAAGTCTACAATTTGAGGATATCTTAGATAAACTACA
TAATAATTCTGGGATGAATCTTGGTTTAATAATCGGTATTGTACTATTTTTAAGTAGTATTTTCTTTAAACTCTCAAGTG
TTCCACTCCATTTTTGGGTCCCTGACGTATATGAAGGCTCACCGATTAGTTCGGTTACTTATTTCACCGCTGCCTCCAAA
ATAGGTATGGTTATTGTTGTATTAAATATTAGCAAATTAATTATAGGTAATTACTATCCTATTAACTATAATTTAATAAA
GATAATTGCTATATTATCTATGCTGTTCGGAGCTTTTGGAGCTATTCGTCAAACTTCTCTAAAAAGATTAATGGCTTATA
GTACTATTTTAAATATCGGTTATGTGTTAATTGGCGTTCTTCTGCATAATCAAGAAGGGTATAAAGCAGCTCTACTATAT
ATTCTAATATATGCGGTAGGGAATATAGGTTTTTTTACTTGCTTAATCATGCTGCTCGGTAAAGACGCCGATAAAGCTAG
TTTTAAAACTATACAAGGAATTGCAGAGAACCATCAAACTATAGCTGCCGTAATTAGCATAGTTATGTTTTCGATGATCG
GAATTCCTCCTCTCACAGGATTTTTTGGTAAATATTACCTGTTGCACCAAGCAATTAATCAAGAAGAATTCGCATTAGCT
TATTGTGGTATTTTTACCAGCGTAGTTGCTGCTTTTTATTATCTTAAAGTAGTAAAAGCCATGTATTTTTCTAAAAAGAC
TGAAAGAATTAAGCTACCTACGCAATATGGGCTTTTACTGATTAATTACTTAGTTACAGGCTTCTTGTTGCTTGGTTCAT
TTATTATCGCGTTTTAG

Upstream 100 bases:

>100_bases
ATTGTCGGTAGTATTAAAGTGCAATATTATATATAAGTTTGTTGATAAAAAATGATTTATTTACTAATATCTATATTTCC
ATAAATAATATTAGTTTTAT

Downstream 100 bases:

>100_bases
CCGATGTATACTTCTTATTAACAACACTAGCCGAAGTAATTTTTGCAGGCCTCATAACATTTTCTTTTAGAGTATTTATA
TGTTTTAGATCTTCTTCATC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIIANIIILLCILSIFLTFKYSSYEGVWHSFATGISIGISKSIVLIFTIISM
IIYRDYSILVAEELKFEFITLILLSVVGLFVAISSRNFILLFCGMELTALTSYALAGFKLNDIKSSEGAVKYFILSSLVS
CLSLFGISFIYGFGGSLQFEDILDKLHNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASK
IGMVIVVLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGNIGFFTCLIMLLGKDADKASFKTIQGIAENHQTIAAVISIVMFSMIGIPPLTGFFGKYYLLHQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKTERIKLPTQYGLLLINYLVTGFLLLGSFIIAF

Sequences:

>Translated_458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIIANIIILLCILSIFLTFKYSSYEGVWHSFATGISIGISKSIVLIFTIISM
IIYRDYSILVAEELKFEFITLILLSVVGLFVAISSRNFILLFCGMELTALTSYALAGFKLNDIKSSEGAVKYFILSSLVS
CLSLFGISFIYGFGGSLQFEDILDKLHNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASK
IGMVIVVLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGNIGFFTCLIMLLGKDADKASFKTIQGIAENHQTIAAVISIVMFSMIGIPPLTGFFGKYYLLHQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKTERIKLPTQYGLLLINYLVTGFLLLGSFIIAF
>Mature_458_residues
MLLLLPEITLTLIALLGQFFAVMIPNKNRIIANIIILLCILSIFLTFKYSSYEGVWHSFATGISIGISKSIVLIFTIISM
IIYRDYSILVAEELKFEFITLILLSVVGLFVAISSRNFILLFCGMELTALTSYALAGFKLNDIKSSEGAVKYFILSSLVS
CLSLFGISFIYGFGGSLQFEDILDKLHNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASK
IGMVIVVLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIGYVLIGVLLHNQEGYKAALLY
ILIYAVGNIGFFTCLIMLLGKDADKASFKTIQGIAENHQTIAAVISIVMFSMIGIPPLTGFFGKYYLLHQAINQEEFALA
YCGIFTSVVAAFYYLKVVKAMYFSKKTERIKLPTQYGLLLINYLVTGFLLLGSFIIAF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=323, Percent_Identity=24.1486068111455, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=345, Percent_Identity=31.304347826087, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788614, Length=372, Percent_Identity=22.5806451612903, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788613, Length=343, Percent_Identity=25.0728862973761, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788831, Length=235, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788827, Length=331, Percent_Identity=24.773413897281, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788829, Length=274, Percent_Identity=22.992700729927, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50784; Mature: 50784

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLLPEITLTLIALLGQFFAVMIPNKNRIIANIIILLCILSIFLTFKYSSYEGVWHSFA
CEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TGISIGISKSIVLIFTIISMIIYRDYSILVAEELKFEFITLILLSVVGLFVAISSRNFIL
HHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LFCGMELTALTSYALAGFKLNDIKSSEGAVKYFILSSLVSCLSLFGISFIYGFGGSLQFE
EEECCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DILDKLHNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHH
IGMVIVVLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIG
HCEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLIGVLLHNQEGYKAALLYILIYAVGNIGFFTCLIMLLGKDADKASFKTIQGIAENHQT
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IAAVISIVMFSMIGIPPLTGFFGKYYLLHQAINQEEFALAYCGIFTSVVAAFYYLKVVKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MYFSKKTERIKLPTQYGLLLINYLVTGFLLLGSFIIAF
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLLLPEITLTLIALLGQFFAVMIPNKNRIIANIIILLCILSIFLTFKYSSYEGVWHSFA
CEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TGISIGISKSIVLIFTIISMIIYRDYSILVAEELKFEFITLILLSVVGLFVAISSRNFIL
HHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LFCGMELTALTSYALAGFKLNDIKSSEGAVKYFILSSLVSCLSLFGISFIYGFGGSLQFE
EEECCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DILDKLHNNSGMNLGLIIGIVLFLSSIFFKLSSVPLHFWVPDVYEGSPISSVTYFTAASK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHH
IGMVIVVLNISKLIIGNYYPINYNLIKIIAILSMLFGAFGAIRQTSLKRLMAYSTILNIG
HCEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLIGVLLHNQEGYKAALLYILIYAVGNIGFFTCLIMLLGKDADKASFKTIQGIAENHQT
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IAAVISIVMFSMIGIPPLTGFFGKYYLLHQAINQEEFALAYCGIFTSVVAAFYYLKVVKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MYFSKKTERIKLPTQYGLLLINYLVTGFLLLGSFIIAF
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]