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The map label for this gene is lpxB

Identifier: 157825565

GI number: 157825565

Start: 436733

End: 437908

Strand: Direct

Name: lpxB

Synonym: A1C_02380

Alternate gene names: 157825565

Gene position: 436733-437908 (Clockwise)

Preceding gene: 157825564

Following gene: 157825567

Centisome position: 35.48

GC content: 31.97

Gene sequence:

>1176_bases
ATGACAAAAGTTTACTTTATAGCTGGTGAGACGTCAGGAGATTTTATTGGTGGACGCATAATTCAAAACTTAAAAAGTAA
TAAAGGAGTAGAGTTTACCGGCATCGGCGGTAAATGTATGGAGGAAGCTGGTAACTTTAAAAGCTTATTTCCTATTACTT
GTATAAATTTAATGGGTTTTGTAGAGATTTTGCCTCATATTTTTAATCTTAAAAAATTAATTGATAAAACTGTGCAGGAT
ATCATAAATAGTCAAGCTGATTTATTAATCACCATAGATTCACCGGGGTTTACTTATCGTGTGGCAAAGCAACTAAGAAA
ACTTTTACCAAAGCTGAAAATGATTCATATCGTTGCACCATCAGTTTGGGCATACAAAGATGGTAGAGCAGTAAAATACG
CTAAAATTTATGATTGTTTATTTGCTTTACTACCGTTTGAACCTCCATATTTTACTAAAGTCGGTCTTGACTGTAGATAT
ATAGGTCATCCGATTATGGAGCAAGAGTTTTATAGTGATAAAATAGCTTTACGTGAAGAGTTTAAAATAGACAAGAATGA
GAGAGTTTTATGTGTTACTCTTGGAAGCAGGCAAGGAGAGATTCGAAAGCATTTACCGGTTTTTATTTCTTCTATTGAAG
AAATATTCAAGAGTTGTAATAATCTTAAAGTTATATTTACTCTTGCAAATCCTGCTCATGAGGCAATAATAAAACCGTTT
CTAGAAGATGTTCAGTTTCATTATTTATTTTCAAGTGCGAGACTTAAAGCTTATGCTGTTGCGGATGCAGCTTTAGCAAA
ATCCGGCACCAATACTTTAGAGATAGTAGCTTCCGGTACTCCTATGGTTGTGGCTTATCAAGTTAATCTTATAAGCTTTT
TTATTATAAGGCTATTGATAAAAATCAAATATGTTACGTTGATAAATATTATAGCAGGTAGCGAAATAATTCCGGAATTT
ATCCAATTTAATTGCCGAGCTAGTCTTATTAGCAATACTCTTCAAGAGTTATTATTTAATTCTAAAAAAGCTTATAAGCA
GGTCATAGAAAGTCAAAAAATTTTACAGACATTAGGGCTTAAATCAAATCGATCACCTTCTTATATAGCTGCAGAAATTA
TTAAACAGGAGTTCTTAGAATCTAAAATAAAGTTGTTAAAAGAGAATAGTACTTGA

Upstream 100 bases:

>100_bases
ATTCACGCAACAACATCTCATGAAAGCGGGGATGATAAAACAAGCCATGCAACAAACTATTGCTTTTGTAGGTATAACAG
ATAAATAAAGATTATAAATA

Downstream 100 bases:

>100_bases
ACCGGTGGTCCACAACATTTTCTGAATTACAATAAACATTAATATTAATATAATAACAAAATATATTTCCATGTTTTTTC
TTATAGTATTAATTTGTTTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTKVYFIAGETSGDFIGGRIIQNLKSNKGVEFTGIGGKCMEEAGNFKSLFPITCINLMGFVEILPHIFNLKKLIDKTVQD
IINSQADLLITIDSPGFTYRVAKQLRKLLPKLKMIHIVAPSVWAYKDGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRY
IGHPIMEQEFYSDKIALREEFKIDKNERVLCVTLGSRQGEIRKHLPVFISSIEEIFKSCNNLKVIFTLANPAHEAIIKPF
LEDVQFHYLFSSARLKAYAVADAALAKSGTNTLEIVASGTPMVVAYQVNLISFFIIRLLIKIKYVTLINIIAGSEIIPEF
IQFNCRASLISNTLQELLFNSKKAYKQVIESQKILQTLGLKSNRSPSYIAAEIIKQEFLESKIKLLKENST

Sequences:

>Translated_391_residues
MTKVYFIAGETSGDFIGGRIIQNLKSNKGVEFTGIGGKCMEEAGNFKSLFPITCINLMGFVEILPHIFNLKKLIDKTVQD
IINSQADLLITIDSPGFTYRVAKQLRKLLPKLKMIHIVAPSVWAYKDGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRY
IGHPIMEQEFYSDKIALREEFKIDKNERVLCVTLGSRQGEIRKHLPVFISSIEEIFKSCNNLKVIFTLANPAHEAIIKPF
LEDVQFHYLFSSARLKAYAVADAALAKSGTNTLEIVASGTPMVVAYQVNLISFFIIRLLIKIKYVTLINIIAGSEIIPEF
IQFNCRASLISNTLQELLFNSKKAYKQVIESQKILQTLGLKSNRSPSYIAAEIIKQEFLESKIKLLKENST
>Mature_390_residues
TKVYFIAGETSGDFIGGRIIQNLKSNKGVEFTGIGGKCMEEAGNFKSLFPITCINLMGFVEILPHIFNLKKLIDKTVQDI
INSQADLLITIDSPGFTYRVAKQLRKLLPKLKMIHIVAPSVWAYKDGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRYI
GHPIMEQEFYSDKIALREEFKIDKNERVLCVTLGSRQGEIRKHLPVFISSIEEIFKSCNNLKVIFTLANPAHEAIIKPFL
EDVQFHYLFSSARLKAYAVADAALAKSGTNTLEIVASGTPMVVAYQVNLISFFIIRLLIKIKYVTLINIIAGSEIIPEFI
QFNCRASLISNTLQELLFNSKKAYKQVIESQKILQTLGLKSNRSPSYIAAEIIKQEFLESKIKLLKENST

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=348, Percent_Identity=30.1724137931034, Blast_Score=168, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_RICAH (A8GN02)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493285.1
- ProteinModelPortal:   A8GN02
- STRING:   A8GN02
- GeneID:   5645791
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_02380
- NMPDR:   fig|293614.3.peg.443
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   RAKA293614:A1C_02380-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 44142; Mature: 44010

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVYFIAGETSGDFIGGRIIQNLKSNKGVEFTGIGGKCMEEAGNFKSLFPITCINLMGF
CCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHH
VEILPHIFNLKKLIDKTVQDIINSQADLLITIDSPGFTYRVAKQLRKLLPKLKMIHIVAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECC
SVWAYKDGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRYIGHPIMEQEFYSDKIALREE
CCEEECCCCEEHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
FKIDKNERVLCVTLGSRQGEIRKHLPVFISSIEEIFKSCNNLKVIFTLANPAHEAIIKPF
HCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
LEDVQFHYLFSSARLKAYAVADAALAKSGTNTLEIVASGTPMVVAYQVNLISFFIIRLLI
HHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHH
KIKYVTLINIIAGSEIIPEFIQFNCRASLISNTLQELLFNSKKAYKQVIESQKILQTLGL
HHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
KSNRSPSYIAAEIIKQEFLESKIKLLKENST
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKVYFIAGETSGDFIGGRIIQNLKSNKGVEFTGIGGKCMEEAGNFKSLFPITCINLMGF
CEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHH
VEILPHIFNLKKLIDKTVQDIINSQADLLITIDSPGFTYRVAKQLRKLLPKLKMIHIVAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECC
SVWAYKDGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRYIGHPIMEQEFYSDKIALREE
CCEEECCCCEEHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
FKIDKNERVLCVTLGSRQGEIRKHLPVFISSIEEIFKSCNNLKVIFTLANPAHEAIIKPF
HCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
LEDVQFHYLFSSARLKAYAVADAALAKSGTNTLEIVASGTPMVVAYQVNLISFFIIRLLI
HHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHH
KIKYVTLINIIAGSEIIPEFIQFNCRASLISNTLQELLFNSKKAYKQVIESQKILQTLGL
HHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
KSNRSPSYIAAEIIKQEFLESKIKLLKENST
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA