Definition Rickettsia akari str. Hartford, complete genome.
Accession NC_009881
Length 1,231,060

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The map label for this gene is pbpC [H]

Identifier: 157825388

GI number: 157825388

Start: 264225

End: 266579

Strand: Reverse

Name: pbpC [H]

Synonym: A1C_01410

Alternate gene names: 157825388

Gene position: 266579-264225 (Counterclockwise)

Preceding gene: 157825397

Following gene: 157825387

Centisome position: 21.65

GC content: 33.25

Gene sequence:

>2355_bases
TTGACTATCAAAACCAAATTACTTTTTATTACAATCAGCGGCATTATAATATTATATTTTGCTATTCCTCCTGCTCCATT
GCTTAAAGACATAAGCTTCTCACAAAGAGTATTTGACCGAAGCGGCGAGTTAATGCGTATTTCGCTTTCTAAAGACGATA
AATATAGAATATTCACTCCTATACGTGAAATACCAGCAAGTTTTATAGAAGCAGTATTGTTATATGAAGATAGGCATTTT
TATAAACATTGCGGCATTAACCCAATTTCTTTAGCCAAAGCTTTTTATTATACTTATTTACAGAATAATCGTAAAATAGG
CGGCTCTACTATAACAATGCAAATAGCACGTTTAAGATATGGGATAAACTCTTCTACTATTCTTGGTAAAATCCATCAAA
TCATTAAAGCTATTCATGTAGAGCTACATTATTCAAAAAATGAAATCCTAGAAGCTTATCTAAACCTAGTGCCTTACGGT
AGTAATATTGAAGGGATAACAGCCAGCAGTTATATTTATTTCAATCGTGACCTAAAAGATTTAAATTTGCTCGATATTCT
AAGCCTTGCAGTAATCCCACAAAATCCTCTTAAAAGAGGCGGGAATGATATGAATATTTTTCAAGCGCGTAAATATCTAT
TTACTGAGTGGCTAACTACTCACCCACAAGATATTATTTATAATAAGTTAATTAGTTTGCCGATTAAATTTAATCAAAAT
AAAAATCTTCCTTTTATAGCACCGCATTTCACTTTAGATATCCTGGCAAATAATGATAGTCCTATTATACGTACTACTAT
AGATAAGAATTTGCAAACTACTATAGAAAAGCAGGTGCAGCTATATATTAATAACCTGAAAAAATACGGCATTAATAATG
CTTCCGTAATTCTTATTGATTTTACTACTATGGAAGTGCTTGCAAGCGTTGGTTCAGGTGATTTTTTTAATAACGATATT
TGCGGACAGATTAACGGCACTAAAAGCCATCGATCTCCAGGCTCCGCTTTAAAACCATTTGTCTATGCACTTAGTTTTGA
TCAATCGCTAATACATCCGTTAACTTTACTAAAGGATACACCTACTTACTACGATCATTATAAACCGGAAAATTTTGATA
GCAGATTTACAGGAGGATTAAGTGTCAGAGAATCATTAATAAGGAGCCGCAACGTACCTGTAATATTTCTGGCGTCTAAG
TTAAAAAATCCGAATTTTTATGAGTTCTTACAACAAGCAAAAATTAGTGGCTTACAAAAACCTGAACATTACGGCTTATC
TATAGTACTCGGCACAGCAGAAATTACTCTTGAAGAGTTAACTACTCTTTATGCTATGCTTGCTAATTTCGGTACTTATA
AACCGCTTAGGAAAATGCTTTCTACGTCATTACACGGAGAAGCACAACGAGGGCGCGGCACTCTAGAACAAAATAATACA
AACTCTACTAGATTGCCACGCTCCGAGCAAATGCTCGCAACAACAATGATATCCCCCGAAGCAAGCTATTTAACTCTTGA
TATTATAAAAGATACAACTCGTCCTATTACCTATAACAATACAAAGCATAACTTACCGATTTATTGGAAAACAGGTACTT
CTAGCTCATTTAGAGACGCACTGAGTATAGGAATATTCAGCAAATACGTACTTGCCGTTTGGGTTGGAGATTTCAAAGGG
CAAACTCACGGAACATTTACAGGTAATATTTCTGCGGCCCCTTTATTCTTTAATATTATAGAATCAATAGCCGAGCCAAA
TAAAGATAAGGATTTAATCCTTTCAAAAATTAATAAACTAAATATTACTAAAGTAAAAGTTTGTGCAGATACGGGAGATA
TCGATAACGATATGTGTCCACTTAAAGCAGAATCCTTATTTATTAAAGGCAAATCACCGATAAAACAATCCGGTATTTAT
AGAAAAATGTTGATAGATTTAAAAACCGGTATGCCTGCTTGCCACTTTATTCAAGGACAAACAGAATATAAAACCGTAAA
TTTATGGCCGGCAGATATGATTTCGGTTTACCAAAAAGCAGGAATACATATATTACCGAAACCGATACCCACAAACCATT
GCAATAGGTTGATAAATTGGCATCATCAGAAACCTAAAATTATATATCCGTTAAGAAATTCCATACATTCAATTAAAGAT
AGTGATAATATTACTTTTAGTGCGATTAGCGATAATAAAACCAATAACATTTTTTGGTTTGTAGATAATGAATTAATAGC
AACCGCAAAATCAAACGAACCTGTAATATGGAAAGCAAAAACCGGTGAATTTATTATTAGAGCTATCAGTGATAGCGGAG
AAAACGACAGTATAAAAATTTATATTAAAGAATAA

Upstream 100 bases:

>100_bases
TACATATTTGATAAAATAAGTATATAAAAATAAGTTTTTTATATACTTTACTGGCTTTCCCGCCTACGCGGGAATGACAT
TAAACTATAAGGTATATACT

Downstream 100 bases:

>100_bases
ATTAGTGGTTATATATGAAATCTACAATGCCCACAGAACTTGATATTAAATCTTTAACATAAGAAGAAACTGCTCTTGAT
TCTTTAAAAAAGAAAATATT

Product: bifunctional penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MTIKTKLLFITISGIIILYFAIPPAPLLKDISFSQRVFDRSGELMRISLSKDDKYRIFTPIREIPASFIEAVLLYEDRHF
YKHCGINPISLAKAFYYTYLQNNRKIGGSTITMQIARLRYGINSSTILGKIHQIIKAIHVELHYSKNEILEAYLNLVPYG
SNIEGITASSYIYFNRDLKDLNLLDILSLAVIPQNPLKRGGNDMNIFQARKYLFTEWLTTHPQDIIYNKLISLPIKFNQN
KNLPFIAPHFTLDILANNDSPIIRTTIDKNLQTTIEKQVQLYINNLKKYGINNASVILIDFTTMEVLASVGSGDFFNNDI
CGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDHYKPENFDSRFTGGLSVRESLIRSRNVPVIFLASK
LKNPNFYEFLQQAKISGLQKPEHYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKMLSTSLHGEAQRGRGTLEQNNT
NSTRLPRSEQMLATTMISPEASYLTLDIIKDTTRPITYNNTKHNLPIYWKTGTSSSFRDALSIGIFSKYVLAVWVGDFKG
QTHGTFTGNISAAPLFFNIIESIAEPNKDKDLILSKINKLNITKVKVCADTGDIDNDMCPLKAESLFIKGKSPIKQSGIY
RKMLIDLKTGMPACHFIQGQTEYKTVNLWPADMISVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIYPLRNSIHSIKD
SDNITFSAISDNKTNNIFWFVDNELIATAKSNEPVIWKAKTGEFIIRAISDSGENDSIKIYIKE

Sequences:

>Translated_784_residues
MTIKTKLLFITISGIIILYFAIPPAPLLKDISFSQRVFDRSGELMRISLSKDDKYRIFTPIREIPASFIEAVLLYEDRHF
YKHCGINPISLAKAFYYTYLQNNRKIGGSTITMQIARLRYGINSSTILGKIHQIIKAIHVELHYSKNEILEAYLNLVPYG
SNIEGITASSYIYFNRDLKDLNLLDILSLAVIPQNPLKRGGNDMNIFQARKYLFTEWLTTHPQDIIYNKLISLPIKFNQN
KNLPFIAPHFTLDILANNDSPIIRTTIDKNLQTTIEKQVQLYINNLKKYGINNASVILIDFTTMEVLASVGSGDFFNNDI
CGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDHYKPENFDSRFTGGLSVRESLIRSRNVPVIFLASK
LKNPNFYEFLQQAKISGLQKPEHYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKMLSTSLHGEAQRGRGTLEQNNT
NSTRLPRSEQMLATTMISPEASYLTLDIIKDTTRPITYNNTKHNLPIYWKTGTSSSFRDALSIGIFSKYVLAVWVGDFKG
QTHGTFTGNISAAPLFFNIIESIAEPNKDKDLILSKINKLNITKVKVCADTGDIDNDMCPLKAESLFIKGKSPIKQSGIY
RKMLIDLKTGMPACHFIQGQTEYKTVNLWPADMISVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIYPLRNSIHSIKD
SDNITFSAISDNKTNNIFWFVDNELIATAKSNEPVIWKAKTGEFIIRAISDSGENDSIKIYIKE
>Mature_783_residues
TIKTKLLFITISGIIILYFAIPPAPLLKDISFSQRVFDRSGELMRISLSKDDKYRIFTPIREIPASFIEAVLLYEDRHFY
KHCGINPISLAKAFYYTYLQNNRKIGGSTITMQIARLRYGINSSTILGKIHQIIKAIHVELHYSKNEILEAYLNLVPYGS
NIEGITASSYIYFNRDLKDLNLLDILSLAVIPQNPLKRGGNDMNIFQARKYLFTEWLTTHPQDIIYNKLISLPIKFNQNK
NLPFIAPHFTLDILANNDSPIIRTTIDKNLQTTIEKQVQLYINNLKKYGINNASVILIDFTTMEVLASVGSGDFFNNDIC
GQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDTPTYYDHYKPENFDSRFTGGLSVRESLIRSRNVPVIFLASKL
KNPNFYEFLQQAKISGLQKPEHYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKMLSTSLHGEAQRGRGTLEQNNTN
STRLPRSEQMLATTMISPEASYLTLDIIKDTTRPITYNNTKHNLPIYWKTGTSSSFRDALSIGIFSKYVLAVWVGDFKGQ
THGTFTGNISAAPLFFNIIESIAEPNKDKDLILSKINKLNITKVKVCADTGDIDNDMCPLKAESLFIKGKSPIKQSGIYR
KMLIDLKTGMPACHFIQGQTEYKTVNLWPADMISVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIYPLRNSIHSIKDS
DNITFSAISDNKTNNIFWFVDNELIATAKSNEPVIWKAKTGEFIIRAISDSGENDSIKIYIKE

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=817, Percent_Identity=26.5605875152999, Blast_Score=282, Evalue=6e-77,
Organism=Escherichia coli, GI1786343, Length=544, Percent_Identity=25, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082258, Length=321, Percent_Identity=25.5451713395639, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1789601, Length=138, Percent_Identity=29.7101449275362, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 88858; Mature: 88726

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKTKLLFITISGIIILYFAIPPAPLLKDISFSQRVFDRSGELMRISLSKDDKYRIFTP
CCEEEEEEEEECCCEEEEEECCCCHHHHHCCCHHHHHHCCCCCEEEEEECCCCCEEEECC
IREIPASFIEAVLLYEDRHFYKHCGINPISLAKAFYYTYLQNNRKIGGSTITMQIARLRY
HHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHC
GINSSTILGKIHQIIKAIHVELHYSKNEILEAYLNLVPYGSNIEGITASSYIYFNRDLKD
CCCCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHCCCCCCCCCEEECEEEEEECCCCC
LNLLDILSLAVIPQNPLKRGGNDMNIFQARKYLFTEWLTTHPQDIIYNKLISLPIKFNQN
CCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCC
KNLPFIAPHFTLDILANNDSPIIRTTIDKNLQTTIEKQVQLYINNLKKYGINNASVILID
CCCCEEECCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
FTTMEVLASVGSGDFFNNDICGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDT
EHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCEEEEEECCHHHHHHHHHHCCC
PTYYDHYKPENFDSRFTGGLSVRESLIRSRNVPVIFLASKLKNPNFYEFLQQAKISGLQK
CCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PEHYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKMLSTSLHGEAQRGRGTLEQNNT
CCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCC
NSTRLPRSEQMLATTMISPEASYLTLDIIKDTTRPITYNNTKHNLPIYWKTGTSSSFRDA
CCCCCCCCHHHHHHEEECCCCCEEEEEEECCCCCCEEECCCCCCCEEEEECCCCCHHHHH
LSIGIFSKYVLAVWVGDFKGQTHGTFTGNISAAPLFFNIIESIAEPNKDKDLILSKINKL
HHHHHHHHEEHEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC
NITKVKVCADTGDIDNDMCPLKAESLFIKGKSPIKQSGIYRKMLIDLKTGMPACHFIQGQ
CCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHCCCCEEEEECCC
TEYKTVNLWPADMISVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIYPLRNSIHSIKD
CCEEEEEECHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHCCC
SDNITFSAISDNKTNNIFWFVDNELIATAKSNEPVIWKAKTGEFIIRAISDSGENDSIKI
CCCEEEEEECCCCCCEEEEEECCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCEEEE
YIKE
EEEC
>Mature Secondary Structure 
TIKTKLLFITISGIIILYFAIPPAPLLKDISFSQRVFDRSGELMRISLSKDDKYRIFTP
CEEEEEEEEECCCEEEEEECCCCHHHHHCCCHHHHHHCCCCCEEEEEECCCCCEEEECC
IREIPASFIEAVLLYEDRHFYKHCGINPISLAKAFYYTYLQNNRKIGGSTITMQIARLRY
HHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHC
GINSSTILGKIHQIIKAIHVELHYSKNEILEAYLNLVPYGSNIEGITASSYIYFNRDLKD
CCCCHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHCCCCCCCCCEEECEEEEEECCCCC
LNLLDILSLAVIPQNPLKRGGNDMNIFQARKYLFTEWLTTHPQDIIYNKLISLPIKFNQN
CCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCC
KNLPFIAPHFTLDILANNDSPIIRTTIDKNLQTTIEKQVQLYINNLKKYGINNASVILID
CCCCEEECCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
FTTMEVLASVGSGDFFNNDICGQINGTKSHRSPGSALKPFVYALSFDQSLIHPLTLLKDT
EHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCEEEEEECCHHHHHHHHHHCCC
PTYYDHYKPENFDSRFTGGLSVRESLIRSRNVPVIFLASKLKNPNFYEFLQQAKISGLQK
CCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
PEHYGLSIVLGTAEITLEELTTLYAMLANFGTYKPLRKMLSTSLHGEAQRGRGTLEQNNT
CCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCC
NSTRLPRSEQMLATTMISPEASYLTLDIIKDTTRPITYNNTKHNLPIYWKTGTSSSFRDA
CCCCCCCCHHHHHHEEECCCCCEEEEEEECCCCCCEEECCCCCCCEEEEECCCCCHHHHH
LSIGIFSKYVLAVWVGDFKGQTHGTFTGNISAAPLFFNIIESIAEPNKDKDLILSKINKL
HHHHHHHHEEHEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC
NITKVKVCADTGDIDNDMCPLKAESLFIKGKSPIKQSGIYRKMLIDLKTGMPACHFIQGQ
CCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHCCCCEEEEECCC
TEYKTVNLWPADMISVYQKAGIHILPKPIPTNHCNRLINWHHQKPKIIYPLRNSIHSIKD
CCEEEEEECHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHCCC
SDNITFSAISDNKTNNIFWFVDNELIATAKSNEPVIWKAKTGEFIIRAISDSGENDSIKI
CCCEEEEEECCCCCCEEEEEECCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCEEEE
YIKE
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]