Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 157373071

GI number: 157373071

Start: 5359460

End: 5360269

Strand: Reverse

Name: mutM [H]

Synonym: Spro_4839

Alternate gene names: 157373071

Gene position: 5360269-5359460 (Counterclockwise)

Preceding gene: 157373072

Following gene: 157373067

Centisome position: 98.37

GC content: 58.02

Gene sequence:

>810_bases
ATGCCTGAATTACCAGAAGTTGAAACCAGCCGCCGCGGTATTGAACCTTACCTGGTTGGCCATAGTATTCAATATGCGGT
GGTACGCAATGCACGCCTGCGCTGGCCGGTCTCCGAGCAAATTCTGGCGTTGAGCGACCAGCCGGTACTCAGCGTACAGC
GTCGCGCCAAGTATTTGCTGATTGAACTGGCTAGCGGCTGGATTATCGTCCATCTGGGGATGTCAGGCAGTCTGCGGATG
TTGGCGGAGGAAACCGAGGCTGGAAAGCACGACCACGTCGATCTGGTGATCAGCAATGGCATGACGCTCCGTTATACCGA
TCCGCGCCGTTTTGGTGCCTGGCTATGGTGTGACGATCTGGCGACCAGCAATGTGCTGGCTCACCTTGGACCGGAACCCT
TGAGTGAAGCCTTTACCGGTGCCTACCTGTACGAAAAATCACGCAACAAGCGGACGCTGATCAAACCCTGGTTGATGGAT
AACAAGCTGGTGGTGGGCGTGGGCAATATCTACGCCAGTGAATCGTTGTTTACCGCCGGGATCCTGCCTGACCGGCCTGC
AGGCTCGCTGAGCAAGGTAGAAGCCGAAGTTTTGGTGGCAACCATTAAGGCGGTATTGCTGCGTTCGATTGAGCAGGGCG
GTACCACGCTGCGTGATTTCCTGCAGTCGGACGGCAAGCCGGGTTATTTTGCGCAGGAACTGCAGGTGTATGGGCGAGCG
GGTGAGCCTTGCCGCGCGTGCGGCACGCCGATCGAGTCCGCCAAGCACGGGCAGCGCAGCACTTTCTTCTGCCCACGCTG
CCAGCGCTGA

Upstream 100 bases:

>100_bases
AAAGAAGCTAAAATTAAATAATTTTAGTGGATTAATAAAAACCCGGCTCAGGCCGGGTTTTTTGCATTCTAAAGGTAGAA
AGCCGACAGGAGAGCGCCAG

Downstream 100 bases:

>100_bases
TTATTGCGCGGCGAGTTTTTCGAACAATGCCTGGGTAACCACTGCCGGCAGGAAAGGGGCGATGTCACCGCCGTGGCGCG
CCACTTCTTTCACCAGCGAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVETSRRGIEPYLVGHSIQYAVVRNARLRWPVSEQILALSDQPVLSVQRRAKYLLIELASGWIIVHLGMSGSLRM
LAEETEAGKHDHVDLVISNGMTLRYTDPRRFGAWLWCDDLATSNVLAHLGPEPLSEAFTGAYLYEKSRNKRTLIKPWLMD
NKLVVGVGNIYASESLFTAGILPDRPAGSLSKVEAEVLVATIKAVLLRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
GEPCRACGTPIESAKHGQRSTFFCPRCQR

Sequences:

>Translated_269_residues
MPELPEVETSRRGIEPYLVGHSIQYAVVRNARLRWPVSEQILALSDQPVLSVQRRAKYLLIELASGWIIVHLGMSGSLRM
LAEETEAGKHDHVDLVISNGMTLRYTDPRRFGAWLWCDDLATSNVLAHLGPEPLSEAFTGAYLYEKSRNKRTLIKPWLMD
NKLVVGVGNIYASESLFTAGILPDRPAGSLSKVEAEVLVATIKAVLLRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
GEPCRACGTPIESAKHGQRSTFFCPRCQR
>Mature_268_residues
PELPEVETSRRGIEPYLVGHSIQYAVVRNARLRWPVSEQILALSDQPVLSVQRRAKYLLIELASGWIIVHLGMSGSLRML
AEETEAGKHDHVDLVISNGMTLRYTDPRRFGAWLWCDDLATSNVLAHLGPEPLSEAFTGAYLYEKSRNKRTLIKPWLMDN
KLVVGVGNIYASESLFTAGILPDRPAGSLSKVEAEVLVATIKAVLLRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRAG
EPCRACGTPIESAKHGQRSTFFCPRCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=269, Percent_Identity=76.5799256505576, Blast_Score=429, Evalue=1e-122,
Organism=Escherichia coli, GI1786932, Length=274, Percent_Identity=24.4525547445255, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 29882; Mature: 29751

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRRGIEPYLVGHSIQYAVVRNARLRWPVSEQILALSDQPVLSVQRRAKYLL
CCCCCCCCHHHCCCCEEEECCCEEEEEEECCEECCCCHHHHEEECCCCHHHHHHHHHEEE
IELASGWIIVHLGMSGSLRMLAEETEAGKHDHVDLVISNGMTLRYTDPRRFGAWLWCDDL
EEECCCEEEEEECCCCCEEHHHHHHCCCCCCCEEEEEECCEEEEEECCHHHCCEEEECCH
ATSNVLAHLGPEPLSEAFTGAYLYEKSRNKRTLIKPWLMDNKLVVGVGNIYASESLFTAG
HHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEECCEECCCEEEEEECCEEECCCEEEEC
ILPDRPAGSLSKVEAEVLVATIKAVLLRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRACGTPIESAKHGQRSTFFCPRCQR
CCCHHHHCCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETSRRGIEPYLVGHSIQYAVVRNARLRWPVSEQILALSDQPVLSVQRRAKYLL
CCCCCCCHHHCCCCEEEECCCEEEEEEECCEECCCCHHHHEEECCCCHHHHHHHHHEEE
IELASGWIIVHLGMSGSLRMLAEETEAGKHDHVDLVISNGMTLRYTDPRRFGAWLWCDDL
EEECCCEEEEEECCCCCEEHHHHHHCCCCCCCEEEEEECCEEEEEECCHHHCCEEEECCH
ATSNVLAHLGPEPLSEAFTGAYLYEKSRNKRTLIKPWLMDNKLVVGVGNIYASESLFTAG
HHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEECCEECCCEEEEEECCEEECCCEEEEC
ILPDRPAGSLSKVEAEVLVATIKAVLLRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRACGTPIESAKHGQRSTFFCPRCQR
CCCHHHHCCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA