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The map label for this gene is argH [H]

Identifier: 157373010

GI number: 157373010

Start: 5292764

End: 5294137

Strand: Reverse

Name: argH [H]

Synonym: Spro_4778

Alternate gene names: 157373010

Gene position: 5294137-5292764 (Counterclockwise)

Preceding gene: 157373011

Following gene: 157373007

Centisome position: 97.16

GC content: 58.08

Gene sequence:

>1374_bases
ATGGCACTTTGGGGCGGACGGTTCAGTCAGGCGGCAGATCAGCGGTTCAAACAATTAAACGATTCTCTGCGCTTCGATTA
TCGCCTGGCGGAACAGGACATTGTGGGTTCGGTGGCCTGGTCGAAAGCGCTGGTCACCGTCAACGTATTGACGGCAGCCG
AGCAGCAGCAGCTTGAGCAGGCGTTGAACGGGCTGTTGGCAGAAGTGCAGGCCGATCCGCAGGCGATTGTCAGCAGCGAT
GCAGAAGATATTCACAGTTGGGTGGAGCAGAAGCTGATCGACCAAGTCGGCGATTTGGGCAAAAAACTGCACACCGGCCG
TAGCCGTAACGATCAGGTCGCGACCGATCTGAAATTGTGGTGCAAACAGCAGATCGGCGAACTGCATCAGGCCATCGTGC
AGCTGCAACAGGCGCTGGTGGAAACTGCCGAAGCCAATCAAGACGCGGTAATGCCGGGCTATACTCACCTGCAGCGTGCG
CAGCCGGTGACCTTTGCCCACTGGTGCTTGGCCTATGTGGAAATGCTGGCGCGTGACGAAAGCCGTTTGCAGGACACGCT
GAAGCGCCTGGACGTCAGCCCATTGGGCAGCGGTGCGCTGGCCGGCACCGCCTACCCGATCGACCGTGAACAACTGGCCG
GTTGGCTGGGCTTTGCTTCGGCCACCCGTAATAGTCTGGACAGCGTTTCCGACCGTGACCACGTGCTGGAGCTGTTATCC
AATGCTTCTATCAGCATGGTGCACCTGTCGCGCTTTGCCGAAGACCTGATTTTCTTCAACAGTGGCGAAGCAGCCTTTGT
CGATCTGTCTGACCGTGTGACTTCCGGCTCCTCGCTGATGCCGCAAAAGAAAAACCCGGATGCACTGGAGCTGATCCGTG
GCAAATGTGGCCGCGTGCAGGGTGCATTGACCGGTATGATGATGACGTTGAAAGGCCTGCCGTTGGCATATAACAAAGAC
ATGCAGGAAGACAAGGAAGGGCTGTTCGACGCGCTTGATACCTGGATGGATTGCCTGCAGATGGCTGCGCTGGTGCTGGA
TGGTATCCAGGTGAAACGTCCGCGCTGTAAAGAAGCGGCGGAGCAGGGCTACGCCAACTCGACCGAACTGGCGGACTATC
TGGTCGCCAAAGGCGTGCCGTTCCGTGAGGCGCACCATATCGTCGGTGAAGCGGTAGTGGAAGCCATTCGTCAGGGCAAG
GCGCTGGAAGCCCTGCCGTTGACTGATTTGCAGAAATTCAGCGCAGTGATTGGTGACGATGTGTACCCGATCCTGGCATT
GCAGTCTTGCCTGGATAAGCGCTCGGCCAAAGGCGGCGTTTCTCCTCAGCAGGTCGCCAGCGCGATCGCCGCAGCGAAAC
AACGCTTGGCTTAA

Upstream 100 bases:

>100_bases
CTGAACGAGATCAAGAACAAGTAACTTATTAATTATTCGGCGTGACTTGATAGGGGCGCAGCGTGCTGCGCCCCTATTCG
CATAAAATCAGGAGTAAGGT

Downstream 100 bases:

>100_bases
TTAGGTTACTCAGTATCAAGGGCGCAGTTCATAGGCAGAACTGCGCCCTTTGTTTTTAGAAAGATTACTCGCCCGGGCAG
CGCTGGCAGCGTTCCGCCTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MALWGGRFSQAADQRFKQLNDSLRFDYRLAEQDIVGSVAWSKALVTVNVLTAAEQQQLEQALNGLLAEVQADPQAIVSSD
AEDIHSWVEQKLIDQVGDLGKKLHTGRSRNDQVATDLKLWCKQQIGELHQAIVQLQQALVETAEANQDAVMPGYTHLQRA
QPVTFAHWCLAYVEMLARDESRLQDTLKRLDVSPLGSGALAGTAYPIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
NASISMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKD
MQEDKEGLFDALDTWMDCLQMAALVLDGIQVKRPRCKEAAEQGYANSTELADYLVAKGVPFREAHHIVGEAVVEAIRQGK
ALEALPLTDLQKFSAVIGDDVYPILALQSCLDKRSAKGGVSPQQVASAIAAAKQRLA

Sequences:

>Translated_457_residues
MALWGGRFSQAADQRFKQLNDSLRFDYRLAEQDIVGSVAWSKALVTVNVLTAAEQQQLEQALNGLLAEVQADPQAIVSSD
AEDIHSWVEQKLIDQVGDLGKKLHTGRSRNDQVATDLKLWCKQQIGELHQAIVQLQQALVETAEANQDAVMPGYTHLQRA
QPVTFAHWCLAYVEMLARDESRLQDTLKRLDVSPLGSGALAGTAYPIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
NASISMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKD
MQEDKEGLFDALDTWMDCLQMAALVLDGIQVKRPRCKEAAEQGYANSTELADYLVAKGVPFREAHHIVGEAVVEAIRQGK
ALEALPLTDLQKFSAVIGDDVYPILALQSCLDKRSAKGGVSPQQVASAIAAAKQRLA
>Mature_456_residues
ALWGGRFSQAADQRFKQLNDSLRFDYRLAEQDIVGSVAWSKALVTVNVLTAAEQQQLEQALNGLLAEVQADPQAIVSSDA
EDIHSWVEQKLIDQVGDLGKKLHTGRSRNDQVATDLKLWCKQQIGELHQAIVQLQQALVETAEANQDAVMPGYTHLQRAQ
PVTFAHWCLAYVEMLARDESRLQDTLKRLDVSPLGSGALAGTAYPIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSN
ASISMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDM
QEDKEGLFDALDTWMDCLQMAALVLDGIQVKRPRCKEAAEQGYANSTELADYLVAKGVPFREAHHIVGEAVVEAIRQGKA
LEALPLTDLQKFSAVIGDDVYPILALQSCLDKRSAKGGVSPQQVASAIAAAKQRLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=445, Percent_Identity=46.2921348314607, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=445, Percent_Identity=46.2921348314607, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=445, Percent_Identity=43.8202247191011, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI68303547, Length=445, Percent_Identity=43.3707865168539, Blast_Score=336, Evalue=2e-92,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=87.746170678337, Blast_Score=820, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=44.4201312910284, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=43.141592920354, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=43.141592920354, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49969; Mature: 49838

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALWGGRFSQAADQRFKQLNDSLRFDYRLAEQDIVGSVAWSKALVTVNVLTAAEQQQLEQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNGLLAEVQADPQAIVSSDAEDIHSWVEQKLIDQVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKQQIGELHQAIVQLQQALVETAEANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCH
SRLQDTLKRLDVSPLGSGALAGTAYPIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
NASISMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQ
CCCHHHHHHHHHHHHHHEECCCCEEEEECHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWMDCLQMAALVLDGIQVKRPRCKEAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHH
EQGYANSTELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEALPLTDLQKFSAVIGDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
VYPILALQSCLDKRSAKGGVSPQQVASAIAAAKQRLA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA