Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 157372992

GI number: 157372992

Start: 5265291

End: 5266937

Strand: Reverse

Name: ilvG [H]

Synonym: Spro_4760

Alternate gene names: 157372992

Gene position: 5266937-5265291 (Counterclockwise)

Preceding gene: 157372993

Following gene: 157372991

Centisome position: 96.66

GC content: 60.11

Gene sequence:

>1647_bases
ATGAACGGGGCTCAGTGGGTAGTACAAGCATTGCGTGCACAGGGAGTTGATACGGTTTTCGGCTACCCGGGTGGCGCAAT
CATGCCGGTCTACGATGCATTGTATGACGGTGGGGTGGAACACCTGCTGTGCCGCCACGAGCAAGGCGCCGCGATGGCTG
CCATTGGTTATGCCCGTTCAACCGGCAAGGTGGGCGTTTGTATCGCCACTTCCGGCCCCGGCGCCACCAACCTGATCACC
GGCCTGGCCGATGCGCTGCTGGATTCTGTTCCGCTGGTAGCGATCACCGGTCAGGTAGGCTCCGCACTGATTGGCACCGA
TGCCTTTCAGGAGATCGATGTCCTCGGCCTGTCGCTGGCCTGCACCAAACACAGCTTCCTGGTGGAATCACTGGATGCGC
TGCCGGGCATCATGGCGGAAGCCTTCGCCATCGCCAGCAGCGGTCGTCCTGGCCCGGTGCTGATCGATATCCCGAAAGAC
ATCCAACTGGCGCACGGCGAATTACACCCGCACCTAATGCCGGTAGAGGAAGAACTGCACTACCCGGCAGCGGAGCTGGC
GCAGGCCGCCGAATTGCTGTCGCAGGCGCACAAGCCGATGCTGTACGTCGGCGGCGGTGTGGGCATGGCGCAGGCGGTAC
CGGCGCTGCGAGAGTTCATCGCGGTGACCCAAATGCCCAACGTTGCCACGCTGAAAGGGCTGGGCGCACCGGACGCTGAG
AAGCCGTACTACCTCGGTATGCTGGGAATGCACGGCACCAAGGCCGCCAACCTGGCGGTGCAGGAGTGCGATTTGTTGAT
TGCCGTTGGCGCGCGTTTTGACGATCGCGTAACCGGTAAACTGAATGCTTTCGCCCCGCATGCCAAGGTGATCCACATGG
ATATCGACCCGGCGGAAATGAGCAAGTTGCGCCAGGCGCACGTGGCGTTGCAGGGCGATTTGAAAGCCTTGTTACCGGCG
TTGCAGCAGCCGTTGAAGATCGCCGCCTGGCAGCAGCGAGTGGTTGAACTGAAAGAAACCCATACCTGGCGTTACGACCA
TCCAGGCCAGCCGATCTACGCGCCGCTGTTGTTGAAGCAGCTGTCCGAGCGCAAGCCGGCCAACAGCGTGATCACCACCG
ACGTGGGCCAGCACCAGATGTGGACCGCGCAGCACATGACCTTTGAACGCCCGGAGAATTTCATCACCTCCAGCGGTTTG
GGCACCATGGGTTTTGGTGTGCCGGCCGCGGTTGGCGCCCAGATGGCCCGCCCGGAGGATACGGTGGTCTGCGTATCGGG
CGACGGTTCTTTCATGATGAATGTGCAGGAGCTGGGCACCATCAAACGCAAACAGTTACCGCTGAAAATCGTTTTGCTGG
ATAACCAGCGTTTGGGGATGGTTCGTCAGTGGCAGCAACTGTTTTTTGACGGGCGTTACAGCGAAACCAATCTCTCCGAT
AACCCCGATTTCCTGATGTTGGCCAATGCCTTTGGCATCCCCGGCCAGCGTATCACCCGCAAAGACCAGGTAGCAGACGC
GCTCGACGCCTTATTCAACAGCGAAGGGCCTTACATGCTGCACGTGTCGATCGATGAGCTTGAAAACGTCTGGCCGCTGG
TGCCGCCGGGTGCCGGTAACGAAACCATGTTGGAGAAAATATCATGA

Upstream 100 bases:

>100_bases
CCGGGGGTTTTTTATTGGCAAGAGAAAAGTGAAACGAGGATAACAATATGAATAACAGAACAAAATCCTGCAGTTGTCGA
AGTAAGGCGGGGAAATAACT

Downstream 100 bases:

>100_bases
TGCAGCATCAACTCTCGATCCAGGCCCGTTTTCGCCCTGAAATGTTAGAGCGCGTATTGCGTGTCGTGCGTCATCGTGGC
TTTCAGGTTTGTGCTATGAA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNGAQWVVQALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKVGVCIATSGPGATNLIT
GLADALLDSVPLVAITGQVGSALIGTDAFQEIDVLGLSLACTKHSFLVESLDALPGIMAEAFAIASSGRPGPVLIDIPKD
IQLAHGELHPHLMPVEEELHYPAAELAQAAELLSQAHKPMLYVGGGVGMAQAVPALREFIAVTQMPNVATLKGLGAPDAE
KPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNAFAPHAKVIHMDIDPAEMSKLRQAHVALQGDLKALLPA
LQQPLKIAAWQQRVVELKETHTWRYDHPGQPIYAPLLLKQLSERKPANSVITTDVGQHQMWTAQHMTFERPENFITSSGL
GTMGFGVPAAVGAQMARPEDTVVCVSGDGSFMMNVQELGTIKRKQLPLKIVLLDNQRLGMVRQWQQLFFDGRYSETNLSD
NPDFLMLANAFGIPGQRITRKDQVADALDALFNSEGPYMLHVSIDELENVWPLVPPGAGNETMLEKIS

Sequences:

>Translated_548_residues
MNGAQWVVQALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKVGVCIATSGPGATNLIT
GLADALLDSVPLVAITGQVGSALIGTDAFQEIDVLGLSLACTKHSFLVESLDALPGIMAEAFAIASSGRPGPVLIDIPKD
IQLAHGELHPHLMPVEEELHYPAAELAQAAELLSQAHKPMLYVGGGVGMAQAVPALREFIAVTQMPNVATLKGLGAPDAE
KPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNAFAPHAKVIHMDIDPAEMSKLRQAHVALQGDLKALLPA
LQQPLKIAAWQQRVVELKETHTWRYDHPGQPIYAPLLLKQLSERKPANSVITTDVGQHQMWTAQHMTFERPENFITSSGL
GTMGFGVPAAVGAQMARPEDTVVCVSGDGSFMMNVQELGTIKRKQLPLKIVLLDNQRLGMVRQWQQLFFDGRYSETNLSD
NPDFLMLANAFGIPGQRITRKDQVADALDALFNSEGPYMLHVSIDELENVWPLVPPGAGNETMLEKIS
>Mature_548_residues
MNGAQWVVQALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKVGVCIATSGPGATNLIT
GLADALLDSVPLVAITGQVGSALIGTDAFQEIDVLGLSLACTKHSFLVESLDALPGIMAEAFAIASSGRPGPVLIDIPKD
IQLAHGELHPHLMPVEEELHYPAAELAQAAELLSQAHKPMLYVGGGVGMAQAVPALREFIAVTQMPNVATLKGLGAPDAE
KPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNAFAPHAKVIHMDIDPAEMSKLRQAHVALQGDLKALLPA
LQQPLKIAAWQQRVVELKETHTWRYDHPGQPIYAPLLLKQLSERKPANSVITTDVGQHQMWTAQHMTFERPENFITSSGL
GTMGFGVPAAVGAQMARPEDTVVCVSGDGSFMMNVQELGTIKRKQLPLKIVLLDNQRLGMVRQWQQLFFDGRYSETNLSD
NPDFLMLANAFGIPGQRITRKDQVADALDALFNSEGPYMLHVSIDELENVWPLVPPGAGNETMLEKIS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=561, Percent_Identity=24.2424242424242, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI21361361, Length=503, Percent_Identity=25.4473161033797, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1790104, Length=552, Percent_Identity=46.0144927536232, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI87081685, Length=565, Percent_Identity=43.0088495575221, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=29.5373665480427, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1787096, Length=550, Percent_Identity=29.4545454545455, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788716, Length=565, Percent_Identity=26.3716814159292, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=552, Percent_Identity=28.0797101449275, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17531299, Length=552, Percent_Identity=28.0797101449275, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=504, Percent_Identity=23.8095238095238, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=575, Percent_Identity=43.6521739130435, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6320816, Length=493, Percent_Identity=23.1237322515213, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320588, Length=567, Percent_Identity=20.1058201058201, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=513, Percent_Identity=23.5867446393762, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323163, Length=522, Percent_Identity=23.5632183908046, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922626, Length=557, Percent_Identity=27.1095152603232, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 58889; Mature: 58889

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQWVVQALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCC
TGKVGVCIATSGPGATNLITGLADALLDSVPLVAITGQVGSALIGTDAFQEIDVLGLSLA
CCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCEEEE
CTKHSFLVESLDALPGIMAEAFAIASSGRPGPVLIDIPKDIQLAHGELHPHLMPVEEELH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCCCHHHHC
YPAAELAQAAELLSQAHKPMLYVGGGVGMAQAVPALREFIAVTQMPNVATLKGLGAPDAE
CCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
KPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNAFAPHAKVIHMDIDPAEM
CCEEEEEECCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
SKLRQAHVALQGDLKALLPALQQPLKIAAWQQRVVELKETHTWRYDHPGQPIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LSERKPANSVITTDVGQHQMWTAQHMTFERPENFITSSGLGTMGFGVPAAVGAQMARPED
HHHCCCCCCEEEECCCCCCEEHHHCCCHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCC
TVVCVSGDGSFMMNVQELGTIKRKQLPLKIVLLDNQRLGMVRQWQQLFFDGRYSETNLSD
CEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
NPDFLMLANAFGIPGQRITRKDQVADALDALFNSEGPYMLHVSIDELENVWPLVPPGAGN
CCCEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCC
ETMLEKIS
HHHHHHCC
>Mature Secondary Structure
MNGAQWVVQALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCC
TGKVGVCIATSGPGATNLITGLADALLDSVPLVAITGQVGSALIGTDAFQEIDVLGLSLA
CCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCEEEE
CTKHSFLVESLDALPGIMAEAFAIASSGRPGPVLIDIPKDIQLAHGELHPHLMPVEEELH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCCCHHHHC
YPAAELAQAAELLSQAHKPMLYVGGGVGMAQAVPALREFIAVTQMPNVATLKGLGAPDAE
CCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCC
KPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNAFAPHAKVIHMDIDPAEM
CCEEEEEECCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
SKLRQAHVALQGDLKALLPALQQPLKIAAWQQRVVELKETHTWRYDHPGQPIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LSERKPANSVITTDVGQHQMWTAQHMTFERPENFITSSGLGTMGFGVPAAVGAQMARPED
HHHCCCCCCEEEECCCCCCEEHHHCCCHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCC
TVVCVSGDGSFMMNVQELGTIKRKQLPLKIVLLDNQRLGMVRQWQQLFFDGRYSETNLSD
CEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
NPDFLMLANAFGIPGQRITRKDQVADALDALFNSEGPYMLHVSIDELENVWPLVPPGAGN
CCCEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCC
ETMLEKIS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]