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The map label for this gene is mdlA [H]

Identifier: 157372940

GI number: 157372940

Start: 5202687

End: 5203763

Strand: Reverse

Name: mdlA [H]

Synonym: Spro_4708

Alternate gene names: 157372940

Gene position: 5203763-5202687 (Counterclockwise)

Preceding gene: 157372941

Following gene: 157372939

Centisome position: 95.5

GC content: 54.6

Gene sequence:

>1077_bases
ATGGACAAAATAAAACAGGTCAATCTCTATCGAGCCGTATCACCTTTATCTCGCCCTATCGCGGATTCCACTCATTACAT
CAATGAAATTTCCTTTGTGGTTGCCGAAGTGGTGCTGGCCAGTGGCATCACTGGCGAAGGGTATTTGCTTTCTTTCCACT
ATTCGCCCGAGGCCATTGCCGGAGCAATGAAAGATCTCCAACAGTTTGCCGTGGGTTATCACTGTTGGCAGACCGGTAAA
TTCCTGCGGGACGTGGCGGCAGAGCACGAATACTTTGGCCACAACGGTTTGCAGAAGTGGGCGGCGGCAACGCTCAATGT
CGCGATGTGGGACGCATGGGGTAAGACCCTGCAACAGCCGATCTGGAAGATGTTGGGCAACACCGTCGATCGCGTGCCGG
TGTATGGCAGTGGCGGTTGGTTGTCATACAGCGAGGCCGAACTGCTGGAAGAAGTGCTGGAATACCAGGCGCGTGGCTTG
CAGGCCGTGAAGATAAAAGTGGGTTCTCCGGAGGTAGAGCAAGACATCATGCGTTTGCGCAAAGTGCGGGAAGTGGTTGG
CCCCGGGATGAAAATCATGATGGATGCCAATCAGGGGATGACCCTGCCGGATGCGCTGAAGTTATCGACGCAGGCGGCAG
AAATTGGCATCCACTGGTTCGAAGAACCCTTGGTGCATACCGATTTTGACGGCTATCAGCAGTTGCGCCAGAAAACCGGC
ATCGCACTGGCAATGGGCGAGCGGGAATATGACATGGAACCGCTCAAGGCCTTGATCGCCCGTAATGCGCTGGATTTATG
GCAACCGGATCTGATCCGCATCGGCGGCGTTGAACCCTGGCGTGAGTCGGCGATGCTGGCACATGCCCATCACCTGCCGG
TATTACCGCATTACTACAAGGATTATGACGTGCCGCTGCTGTGCACTATCCCCAACCCTTACGGAGCGGAGTCTTTCGAC
TGGATCGACAGCATTATCGATAACCCGATGACCATTGACGGCGGCTACGCTTTTCCGCGCTCTGGTGCAGGCTGGGGCTT
TAATTTCAACCCGGCATCTCTGACAGAAATCAAATAG

Upstream 100 bases:

>100_bases
GGTGTATCGTTGCTTTGCATCGAGGGTTACAGACAGTGAGGTCACTTAGTCGTTTGTTTTAATAGGTTTTTAATTCCTGT
GCCGACTTTGGAGTATGCCA

Downstream 100 bases:

>100_bases
GGACAGGGCGATGAAACAGGACGTTTTAACTCAGTATTTTTCATTACAGGGCCGGACCGGCATTGTTACCGGCGCATCAT
CCGGTATTGGGCGCGGCATT

Product: mandelate racemase/muconate lactonizing protein

Products: NA

Alternate protein names: MR [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MDKIKQVNLYRAVSPLSRPIADSTHYINEISFVVAEVVLASGITGEGYLLSFHYSPEAIAGAMKDLQQFAVGYHCWQTGK
FLRDVAAEHEYFGHNGLQKWAAATLNVAMWDAWGKTLQQPIWKMLGNTVDRVPVYGSGGWLSYSEAELLEEVLEYQARGL
QAVKIKVGSPEVEQDIMRLRKVREVVGPGMKIMMDANQGMTLPDALKLSTQAAEIGIHWFEEPLVHTDFDGYQQLRQKTG
IALAMGEREYDMEPLKALIARNALDLWQPDLIRIGGVEPWRESAMLAHAHHLPVLPHYYKDYDVPLLCTIPNPYGAESFD
WIDSIIDNPMTIDGGYAFPRSGAGWGFNFNPASLTEIK

Sequences:

>Translated_358_residues
MDKIKQVNLYRAVSPLSRPIADSTHYINEISFVVAEVVLASGITGEGYLLSFHYSPEAIAGAMKDLQQFAVGYHCWQTGK
FLRDVAAEHEYFGHNGLQKWAAATLNVAMWDAWGKTLQQPIWKMLGNTVDRVPVYGSGGWLSYSEAELLEEVLEYQARGL
QAVKIKVGSPEVEQDIMRLRKVREVVGPGMKIMMDANQGMTLPDALKLSTQAAEIGIHWFEEPLVHTDFDGYQQLRQKTG
IALAMGEREYDMEPLKALIARNALDLWQPDLIRIGGVEPWRESAMLAHAHHLPVLPHYYKDYDVPLLCTIPNPYGAESFD
WIDSIIDNPMTIDGGYAFPRSGAGWGFNFNPASLTEIK
>Mature_358_residues
MDKIKQVNLYRAVSPLSRPIADSTHYINEISFVVAEVVLASGITGEGYLLSFHYSPEAIAGAMKDLQQFAVGYHCWQTGK
FLRDVAAEHEYFGHNGLQKWAAATLNVAMWDAWGKTLQQPIWKMLGNTVDRVPVYGSGGWLSYSEAELLEEVLEYQARGL
QAVKIKVGSPEVEQDIMRLRKVREVVGPGMKIMMDANQGMTLPDALKLSTQAAEIGIHWFEEPLVHTDFDGYQQLRQKTG
IALAMGEREYDMEPLKALIARNALDLWQPDLIRIGGVEPWRESAMLAHAHHLPVLPHYYKDYDVPLLCTIPNPYGAESFD
WIDSIIDNPMTIDGGYAFPRSGAGWGFNFNPASLTEIK

Specific function: Unknown

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=340, Percent_Identity=25.5882352941176, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI186972148, Length=243, Percent_Identity=27.1604938271605, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI42544117, Length=337, Percent_Identity=24.3323442136499, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI226510960, Length=294, Percent_Identity=25.1700680272109, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI48994953, Length=281, Percent_Identity=23.8434163701068, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR015654
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =5.1.2.2 [H]

Molecular weight: Translated: 40142; Mature: 40142

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIKQVNLYRAVSPLSRPIADSTHYINEISFVVAEVVLASGITGEGYLLSFHYSPEAIA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
GAMKDLQQFAVGYHCWQTGKFLRDVAAEHEYFGHNGLQKWAAATLNVAMWDAWGKTLQQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IWKMLGNTVDRVPVYGSGGWLSYSEAELLEEVLEYQARGLQAVKIKVGSPEVEQDIMRLR
HHHHHCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
KVREVVGPGMKIMMDANQGMTLPDALKLSTQAAEIGIHWFEEPLVHTDFDGYQQLRQKTG
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
IALAMGEREYDMEPLKALIARNALDLWQPDLIRIGGVEPWRESAMLAHAHHLPVLPHYYK
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHC
DYDVPLLCTIPNPYGAESFDWIDSIIDNPMTIDGGYAFPRSGAGWGFNFNPASLTEIK
CCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDKIKQVNLYRAVSPLSRPIADSTHYINEISFVVAEVVLASGITGEGYLLSFHYSPEAIA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
GAMKDLQQFAVGYHCWQTGKFLRDVAAEHEYFGHNGLQKWAAATLNVAMWDAWGKTLQQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IWKMLGNTVDRVPVYGSGGWLSYSEAELLEEVLEYQARGLQAVKIKVGSPEVEQDIMRLR
HHHHHCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
KVREVVGPGMKIMMDANQGMTLPDALKLSTQAAEIGIHWFEEPLVHTDFDGYQQLRQKTG
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
IALAMGEREYDMEPLKALIARNALDLWQPDLIRIGGVEPWRESAMLAHAHHLPVLPHYYK
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHC
DYDVPLLCTIPNPYGAESFDWIDSIIDNPMTIDGGYAFPRSGAGWGFNFNPASLTEIK
CCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2831968; 2271624; 2215699; 1909893; 1892834; 7893689; 7893690 [H]