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The map label for this gene is fkpA [H]

Identifier: 157372901

GI number: 157372901

Start: 5159591

End: 5160739

Strand: Reverse

Name: fkpA [H]

Synonym: Spro_4669

Alternate gene names: 157372901

Gene position: 5160739-5159591 (Counterclockwise)

Preceding gene: 157372902

Following gene: 157372900

Centisome position: 94.71

GC content: 62.05

Gene sequence:

>1149_bases
ATGAAAAAGTACGCGGAAGGAGCCGCGGCTTTACTGCTGTTGATTGCAGGAGGCAGCGCGTTAGCGGCAGGTAATGCGTC
TGGCGGGGATGACGGCATCCCTGCATTGCTGAAATTTGCCGAGCAACAGCAGGCCGTGCCGGTGGTGGAAAAAGTGCCGC
CGACGCCCCCGCCTGCGGCCAGCAAACCAAAGCCTGCGCCCGTTCCGCGTGGGGATAACGCCCGGCTAGCGGCGTTGAAT
CAGGCGTTACAGCGGCAGGCCGACACTATCCGCCTGTTGGAACAGCAGTTGGCAACTCAGGCTCAACCAACGATGCCGGT
ACCGCTACCCAAGGCTGCACCTGTGGATATCCGGCCGCTGGTGGCGGCGTTAAAAGGCGTTCGCCGGGCCATTGCCACAC
CGCCGGATCTACTTGCCATGGCGGCAGCACTGGCACGGCAGCAGCGGTTGGTCGCGGAGCAAGAGCGGCAATTGCAGCAG
CTCAATCGCCAGCTTCAGCCACCGGAGCTGGTCAGTGTGGCAGATAAACAGGCTTACGCCGCCGGGGTTTCGCTCGGACG
CGACATTCTGCGGCTGCAGGAAGAGAACCGACGGCTGGGGATTGAGGCCGATCGGTCACGCCTGCTGGCGGGTATTGGCG
ATACGTTGGCGGGCAAGCCGCGGCTGGACAACGCCGCTATCGACAGCGCGCTGCAGGCTGCAGACGCTGCATTGCAGCAG
GCCCGGCAGCAACGGCAACAGGACATACGGCAGGATGGCAAAGCCTATCTTGCCGATTTTGCCAAACAGCCGGGGGTACA
AAAGGATGAACTCGGCTTCTATTACCGCGTGGATTACGCCGGCAGTGGGCAGATAGCCGCAGGCGACAATGTCGATATTG
TGGTGCGTGAAAGCCTGCCCGACGGGCAAGTGATCAAGGATATGGAGTTGGCCGGCACGGTGATCTCACAACCCCTGGCA
CAGTACCCGGCGCTGTTCCGCGCAGCCATCGGCAAACTGAACAAACACGGTTCGATGACTCTGGTGGTGCCGGCGGCGCT
GGCCTATGGCGATAAGGGAAGTCCACCCGCCATACCACCTGGGGCCACCATGATTTATACCCTGCGCGTGGCCGATGCGC
TGCCGCAGGACAGGAGCAGGCAAAAGTAA

Upstream 100 bases:

>100_bases
CTATAGACGCACTTTATAAATACAAGACCGAGAAGTTCTGCGCCGACGTTGAACATGAGCTGATGTCCAGTCTGTCCAGC
CGGGTGGAGAGCCTGTAGCC

Downstream 100 bases:

>100_bases
CTCAAGGAGAACGCGATGGCCAAGGTGCCGATAACATATGAAATCAGGAAGTCACATATGCTAAACGTGTTACGAAAACT
GTGTATGGAACGTGCGGCCG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKYAEGAAALLLLIAGGSALAAGNASGGDDGIPALLKFAEQQQAVPVVEKVPPTPPPAASKPKPAPVPRGDNARLAALN
QALQRQADTIRLLEQQLATQAQPTMPVPLPKAAPVDIRPLVAALKGVRRAIATPPDLLAMAAALARQQRLVAEQERQLQQ
LNRQLQPPELVSVADKQAYAAGVSLGRDILRLQEENRRLGIEADRSRLLAGIGDTLAGKPRLDNAAIDSALQAADAALQQ
ARQQRQQDIRQDGKAYLADFAKQPGVQKDELGFYYRVDYAGSGQIAAGDNVDIVVRESLPDGQVIKDMELAGTVISQPLA
QYPALFRAAIGKLNKHGSMTLVVPAALAYGDKGSPPAIPPGATMIYTLRVADALPQDRSRQK

Sequences:

>Translated_382_residues
MKKYAEGAAALLLLIAGGSALAAGNASGGDDGIPALLKFAEQQQAVPVVEKVPPTPPPAASKPKPAPVPRGDNARLAALN
QALQRQADTIRLLEQQLATQAQPTMPVPLPKAAPVDIRPLVAALKGVRRAIATPPDLLAMAAALARQQRLVAEQERQLQQ
LNRQLQPPELVSVADKQAYAAGVSLGRDILRLQEENRRLGIEADRSRLLAGIGDTLAGKPRLDNAAIDSALQAADAALQQ
ARQQRQQDIRQDGKAYLADFAKQPGVQKDELGFYYRVDYAGSGQIAAGDNVDIVVRESLPDGQVIKDMELAGTVISQPLA
QYPALFRAAIGKLNKHGSMTLVVPAALAYGDKGSPPAIPPGATMIYTLRVADALPQDRSRQK
>Mature_382_residues
MKKYAEGAAALLLLIAGGSALAAGNASGGDDGIPALLKFAEQQQAVPVVEKVPPTPPPAASKPKPAPVPRGDNARLAALN
QALQRQADTIRLLEQQLATQAQPTMPVPLPKAAPVDIRPLVAALKGVRRAIATPPDLLAMAAALARQQRLVAEQERQLQQ
LNRQLQPPELVSVADKQAYAAGVSLGRDILRLQEENRRLGIEADRSRLLAGIGDTLAGKPRLDNAAIDSALQAADAALQQ
ARQQRQQDIRQDGKAYLADFAKQPGVQKDELGFYYRVDYAGSGQIAAGDNVDIVVRESLPDGQVIKDMELAGTVISQPLA
QYPALFRAAIGKLNKHGSMTLVVPAALAYGDKGSPPAIPPGATMIYTLRVADALPQDRSRQK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789745, Length=205, Percent_Identity=32.6829268292683, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082390, Length=169, Percent_Identity=30.1775147928994, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 40512; Mature: 40512

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYAEGAAALLLLIAGGSALAAGNASGGDDGIPALLKFAEQQQAVPVVEKVPPTPPPAA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCC
SKPKPAPVPRGDNARLAALNQALQRQADTIRLLEQQLATQAQPTMPVPLPKAAPVDIRPL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
VAALKGVRRAIATPPDLLAMAAALARQQRLVAEQERQLQQLNRQLQPPELVSVADKQAYA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AGVSLGRDILRLQEENRRLGIEADRSRLLAGIGDTLAGKPRLDNAAIDSALQAADAALQQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
ARQQRQQDIRQDGKAYLADFAKQPGVQKDELGFYYRVDYAGSGQIAAGDNVDIVVRESLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCCEECCCCCEEEEECCCC
DGQVIKDMELAGTVISQPLAQYPALFRAAIGKLNKHGSMTLVVPAALAYGDKGSPPAIPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCC
GATMIYTLRVADALPQDRSRQK
CCCEEEEEHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKYAEGAAALLLLIAGGSALAAGNASGGDDGIPALLKFAEQQQAVPVVEKVPPTPPPAA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCC
SKPKPAPVPRGDNARLAALNQALQRQADTIRLLEQQLATQAQPTMPVPLPKAAPVDIRPL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
VAALKGVRRAIATPPDLLAMAAALARQQRLVAEQERQLQQLNRQLQPPELVSVADKQAYA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AGVSLGRDILRLQEENRRLGIEADRSRLLAGIGDTLAGKPRLDNAAIDSALQAADAALQQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
ARQQRQQDIRQDGKAYLADFAKQPGVQKDELGFYYRVDYAGSGQIAAGDNVDIVVRESLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCCEECCCCCEEEEECCCC
DGQVIKDMELAGTVISQPLAQYPALFRAAIGKLNKHGSMTLVVPAALAYGDKGSPPAIPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCC
GATMIYTLRVADALPQDRSRQK
CCCEEEEEHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]