Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 157372852

GI number: 157372852

Start: 5095420

End: 5096799

Strand: Reverse

Name: envZ [H]

Synonym: Spro_4620

Alternate gene names: 157372852

Gene position: 5096799-5095420 (Counterclockwise)

Preceding gene: 157372853

Following gene: 157372844

Centisome position: 93.54

GC content: 57.1

Gene sequence:

>1380_bases
ATGAGACGATTACGCTTTTCACCGCGTAGCTCGTTTGCCCGAACCCTGCTATTGATCGTCACCTTGCTGTTCGTCAGCCT
GGTGACGACCTATCTGGTGGTGCTGAACTTCGCCATCCTGCCCAGTTTGCAGCAGTTCAACAAGGTATTGGCCTACGAAG
TTCGTATGCTGATGACCGATAAGCTGCAGCTGGAGGATGGGACCTTACTGGAGGTGCCGCCGGCGTTCCGTCGTGAAATC
TATCGCGAACTGGGGATTTCTCTCTACACCAACTCGGCGGCGGAGGAGAGCGGTCTGCGCTGGGCGCAGCACTATCAATT
CCTCAGCCAGCAAATGGCTCAGCAGCTCGGTGGGCCAACCGACGTCCGGGTAGAAGTGAACAAAAACTCACCGGTGGTGT
GGCTGAAGACCTGGCTGCAGCCGGATATCTGGGTGCGCGTTCCGCTGACTGAGATTCACCAGGGCGATTTCTCGCCGCTG
TTCCGTTATACCCTGGCAATTATGCTGTTGGCGATAGGCGGTGCCTGGCTGTTTATTCGTATCCAAAACCGCCCGCTGGT
GGAGCTGGAGCATGCGGCTCTGCAGGTCGGCAAGGGTATTATTCCGCCGCCGTTGCGTGAGTATGGCGCATCTGAAGTAC
GTTCGGTAACGCGGGCCTTTAATCAGATGGCATCGGGCGTTAAGCAACTGGCGGATGACCGCACGCTGCTGATGGCCGGC
GTCAGCCACGACCTGCGCACACCGCTGACGCGCATCCGTCTGGCAACCGAGATGATGAGTGCCGAAGACGGCTATCTGGC
GGAGTCGATCAATAAAGACATTGAAGAGTGCAATGCCATCATTGAGCAGTTTATTGACTATCTGCGCACCGGCCAGGAGA
TGCAGACCGAGTTAAGCGATCTGAATGGCATTCTGGGTGAAGTGGTTGCGGCCGAGAGTGGCTATGAGCGGGTTATCGAA
ACTGCCATGGCACCGGGTGAACTGATGATGAATGTGCATCCGCTGTCGATCAAGCGTGCGGCGGCGAATATGGTGGTGAA
TGCGGCACGTTACGGCAACGGCTGGATCAAAGTCAGTAGTGGCCGTGAGCTGCAGCGCGGCTGGTTCCAGGTGGAAGACG
ACGGCCCGGGCATTAAACCGGAAGAGTTGAAACATCTGCTGCAGCCGTTTGTCCGTGGCGACAGCGCACGCAGCACCAGC
GGAACCGGGCTTGGCCTGGCTATCGTACAGCGTATTATTGATGGTCATCACGGCGCTTTGGATATTGGCACCAGCGAACG
CGGCGGGTTGTTGATCAGGGCTTATATTCCGTTGCCGATGGAAAAGAAAGAGTCGGCCAACGGGCATCAGGCAGTGAAAG
ACAGCGCCAAACTCCCCTGA

Upstream 100 bases:

>100_bases
CTCGTCTGCGTCGTATGGTTGAGGAAGATCCTGCGCATCCACGTTATATCCAGACCGTTTGGGGTCTTGGCTACGTCTTC
GTCCCGGACGGCAGCAAGGC

Downstream 100 bases:

>100_bases
CAGCGAAGCTGCCCTGTCAGGGTTTTCTGCTCATGACGTAATATTCCGCCGCTTCTTCATGCAGACGCCGACCGGTGCTG
GCTTGCCAGGGGTCGATTAA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTLLEVPPAFRREI
YRELGISLYTNSAAEESGLRWAQHYQFLSQQMAQQLGGPTDVRVEVNKNSPVVWLKTWLQPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGIIPPPLREYGASEVRSVTRAFNQMASGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSAEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMQTELSDLNGILGEVVAAESGYERVIE
TAMAPGELMMNVHPLSIKRAAANMVVNAARYGNGWIKVSSGRELQRGWFQVEDDGPGIKPEELKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDGHHGALDIGTSERGGLLIRAYIPLPMEKKESANGHQAVKDSAKLP

Sequences:

>Translated_459_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTLLEVPPAFRREI
YRELGISLYTNSAAEESGLRWAQHYQFLSQQMAQQLGGPTDVRVEVNKNSPVVWLKTWLQPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGIIPPPLREYGASEVRSVTRAFNQMASGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSAEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMQTELSDLNGILGEVVAAESGYERVIE
TAMAPGELMMNVHPLSIKRAAANMVVNAARYGNGWIKVSSGRELQRGWFQVEDDGPGIKPEELKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDGHHGALDIGTSERGGLLIRAYIPLPMEKKESANGHQAVKDSAKLP
>Mature_459_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTLLEVPPAFRREI
YRELGISLYTNSAAEESGLRWAQHYQFLSQQMAQQLGGPTDVRVEVNKNSPVVWLKTWLQPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVELEHAALQVGKGIIPPPLREYGASEVRSVTRAFNQMASGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSAEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMQTELSDLNGILGEVVAAESGYERVIE
TAMAPGELMMNVHPLSIKRAAANMVVNAARYGNGWIKVSSGRELQRGWFQVEDDGPGIKPEELKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDGHHGALDIGTSERGGLLIRAYIPLPMEKKESANGHQAVKDSAKLP

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=444, Percent_Identity=86.7117117117117, Blast_Score=801, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=275, Percent_Identity=32, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=29.5620437956204, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=29.4573643410853, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=27.1551724137931, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=252, Percent_Identity=26.984126984127, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=24.3986254295533, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=245, Percent_Identity=26.1224489795918, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=243, Percent_Identity=26.3374485596708, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=22.2727272727273, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=26.5384615384615, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51228; Mature: 51228

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQLEDGTLLEVPPAFRREIYRELGISLYTNSAAEESGLRWAQHYQFLSQQMAQQLGGPT
CEEECCCCEEECCHHHHHHHHHHHCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVRVEVNKNSPVVWLKTWLQPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGIIPPPLREYGASEVRSVTRAFNQMASGVKQLADDRTLLMAG
ECCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VSHDLRTPLTRIRLATEMMSAEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMQTELSD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LNGILGEVVAAESGYERVIETAMAPGELMMNVHPLSIKRAAANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCHHHHHHHHHHHHHHHCCCCCEEEECC
GRELQRGWFQVEDDGPGIKPEELKHLLQPFVRGDSARSTSGTGLGLAIVQRIIDGHHGAL
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
DIGTSERGGLLIRAYIPLPMEKKESANGHQAVKDSAKLP
ECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQLEDGTLLEVPPAFRREIYRELGISLYTNSAAEESGLRWAQHYQFLSQQMAQQLGGPT
CEEECCCCEEECCHHHHHHHHHHHCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVRVEVNKNSPVVWLKTWLQPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGIIPPPLREYGASEVRSVTRAFNQMASGVKQLADDRTLLMAG
ECCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VSHDLRTPLTRIRLATEMMSAEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMQTELSD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LNGILGEVVAAESGYERVIETAMAPGELMMNVHPLSIKRAAANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCHHHHHHHHHHHHHHHCCCCCEEEECC
GRELQRGWFQVEDDGPGIKPEELKHLLQPFVRGDSARSTSGTGLGLAIVQRIIDGHHGAL
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
DIGTSERGGLLIRAYIPLPMEKKESANGHQAVKDSAKLP
ECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]