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The map label for this gene is aroB

Identifier: 157372836

GI number: 157372836

Start: 5079201

End: 5080301

Strand: Reverse

Name: aroB

Synonym: Spro_4604

Alternate gene names: 157372836

Gene position: 5080301-5079201 (Counterclockwise)

Preceding gene: 157372837

Following gene: 157372835

Centisome position: 93.24

GC content: 56.68

Gene sequence:

>1101_bases
ATGGAGAGAATTACCGTAACGCTTGGGGAGCGCAGCTACCCGATAACCATAGCCGCCGGATTGTTTAACGATCCGGCTTC
TTTTATGCCGCTGAAGGCGGGTGAACAGGTCATGCTGGTCACCAACCAAACCCTGGCGCCACTCTATCTGGACCACGTCC
GGAAGGTGTTGGAGCAGGCAGGCGTCATGGTGGATCAGGTGATTTTGCCTGATGGCGAACAGTATAAATCTCTGGCCGTA
CTCGAGCAGGTGTTCTCGGCACTGTTGGAAAAGCCGCACGGTCGTGATACCACGCTGATTGCCCTTGGGGGCGGCGTGAT
TGGCGATCTTACCGGCTTTGCCGCCGCCTGTTATCAGCGCGGTGTCCGCTTTATTCAGGTCCCTACCACGCTGTTGTCGC
AGGTGGACTCTTCCGTTGGCGGTAAAACCGCCGTCAATCATCCGCTCGGCAAGAACATGATCGGCGCCTTCTATCAACCC
GTTTCTGTGGTGGTTGATCTCGATTGCCTGAAAACCTTACCGGCGCGTGAGCTCTCCTCTGGTTTGGCTGAAGTGATCAA
GTACGGGATTATTCTCGACCACGATTTCTTCGTCTGGCTGGAAAACAATATCGATGCCCTGGTGGCGCTGGATATGCAGG
CTCTGGCCTACTGTATCCGTCGCTGCTGCGAGCTGAAAGCTGAGGTGGTTGCTGCTGACGAACGCGAAAGCGGGCTGCGC
GCGCTGCTGAATCTGGGCCATACTTACGGCCATGCGATCGAAGCCGAAATGGGCTATGGTGTATGGTTGCACGGTGAGGC
CATTGCCGCCGGTATGGTGATGGCGGCAGAAACCGCGCACCGTCTCGGCCAGTTCTCCCGCGAAGATATTGAACGTATTA
AAGCACTGTTGTTGCGCGCCGGTTTACCAGTGTGTGGCCCGCAGGAAATGGCTCCGGGAACTTATCTGCCGCATATGATG
CGCGATAAGAAAGTCCTGGCCGGTGAATTGCGCCTGGTACTGCCGACGGCCATTGGCCAGGCGGAAGTCCGTGGCGGAGT
GGGGCATGATATGGTGCTCGCTTCGATCGCAGCTTGCTTTCCTGACGGAATGTCTAAGTAA

Upstream 100 bases:

>100_bases
AGCAACTGATAGCGGTTTCCGTGTTCGCCACGGCAAATGCGGAAGACTGATTGTGTTCCCCGCGTTGCGGGGATAAACCA
CATTGAGAACTGAGCGCGAC

Downstream 100 bases:

>100_bases
ATCGGACGAAGTAACAGTGGCTTAGCCGCCGTTTACATCTATATTAATTAATGTGCAAAGCATGACTGACGTCGCTTTGC
CATCATCGGGTTAATCTGCC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MERITVTLGERSYPITIAAGLFNDPASFMPLKAGEQVMLVTNQTLAPLYLDHVRKVLEQAGVMVDQVILPDGEQYKSLAV
LEQVFSALLEKPHGRDTTLIALGGGVIGDLTGFAAACYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQP
VSVVVDLDCLKTLPARELSSGLAEVIKYGIILDHDFFVWLENNIDALVALDMQALAYCIRRCCELKAEVVAADERESGLR
ALLNLGHTYGHAIEAEMGYGVWLHGEAIAAGMVMAAETAHRLGQFSREDIERIKALLLRAGLPVCGPQEMAPGTYLPHMM
RDKKVLAGELRLVLPTAIGQAEVRGGVGHDMVLASIAACFPDGMSK

Sequences:

>Translated_366_residues
MERITVTLGERSYPITIAAGLFNDPASFMPLKAGEQVMLVTNQTLAPLYLDHVRKVLEQAGVMVDQVILPDGEQYKSLAV
LEQVFSALLEKPHGRDTTLIALGGGVIGDLTGFAAACYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQP
VSVVVDLDCLKTLPARELSSGLAEVIKYGIILDHDFFVWLENNIDALVALDMQALAYCIRRCCELKAEVVAADERESGLR
ALLNLGHTYGHAIEAEMGYGVWLHGEAIAAGMVMAAETAHRLGQFSREDIERIKALLLRAGLPVCGPQEMAPGTYLPHMM
RDKKVLAGELRLVLPTAIGQAEVRGGVGHDMVLASIAACFPDGMSK
>Mature_366_residues
MERITVTLGERSYPITIAAGLFNDPASFMPLKAGEQVMLVTNQTLAPLYLDHVRKVLEQAGVMVDQVILPDGEQYKSLAV
LEQVFSALLEKPHGRDTTLIALGGGVIGDLTGFAAACYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQP
VSVVVDLDCLKTLPARELSSGLAEVIKYGIILDHDFFVWLENNIDALVALDMQALAYCIRRCCELKAEVVAADERESGLR
ALLNLGHTYGHAIEAEMGYGVWLHGEAIAAGMVMAAETAHRLGQFSREDIERIKALLLRAGLPVCGPQEMAPGTYLPHMM
RDKKVLAGELRLVLPTAIGQAEVRGGVGHDMVLASIAACFPDGMSK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=359, Percent_Identity=82.1727019498607, Blast_Score=590, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6320332, Length=353, Percent_Identity=37.9603399433428, Blast_Score=205, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_SERP5 (A8GKQ7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480825.1
- ProteinModelPortal:   A8GKQ7
- SMR:   A8GKQ7
- STRING:   A8GKQ7
- GeneID:   5605908
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4604
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   SPRO399741:SPRO_4604-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39465; Mature: 39465

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERITVTLGERSYPITIAAGLFNDPASFMPLKAGEQVMLVTNQTLAPLYLDHVRKVLEQA
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
GVMVDQVILPDGEQYKSLAVLEQVFSALLEKPHGRDTTLIALGGGVIGDLTGFAAACYQR
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHC
GVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPVSVVVDLDCLKTLPARELSS
CCEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHEEEHHHHHCCCHHHHHH
GLAEVIKYGIILDHDFFVWLENNIDALVALDMQALAYCIRRCCELKAEVVAADERESGLR
HHHHHHHHCEEECCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLNLGHTYGHAIEAEMGYGVWLHGEAIAAGMVMAAETAHRLGQFSREDIERIKALLLRA
HHHHCCHHHCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GLPVCGPQEMAPGTYLPHMMRDKKVLAGELRLVLPTAIGQAEVRGGVGHDMVLASIAACF
CCCCCCCHHCCCCCCCHHHHHCCHHHHHHHEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
PDGMSK
CCCCCC
>Mature Secondary Structure
MERITVTLGERSYPITIAAGLFNDPASFMPLKAGEQVMLVTNQTLAPLYLDHVRKVLEQA
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
GVMVDQVILPDGEQYKSLAVLEQVFSALLEKPHGRDTTLIALGGGVIGDLTGFAAACYQR
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHC
GVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPVSVVVDLDCLKTLPARELSS
CCEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHEEEHHHHHCCCHHHHHH
GLAEVIKYGIILDHDFFVWLENNIDALVALDMQALAYCIRRCCELKAEVVAADERESGLR
HHHHHHHHCEEECCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLNLGHTYGHAIEAEMGYGVWLHGEAIAAGMVMAAETAHRLGQFSREDIERIKALLLRA
HHHHCCHHHCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GLPVCGPQEMAPGTYLPHMMRDKKVLAGELRLVLPTAIGQAEVRGGVGHDMVLASIAACF
CCCCCCCHHCCCCCCCHHHHHCCHHHHHHHEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
PDGMSK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA