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The map label for this gene is trpS [H]

Identifier: 157372831

GI number: 157372831

Start: 5074516

End: 5075520

Strand: Reverse

Name: trpS [H]

Synonym: Spro_4599

Alternate gene names: 157372831

Gene position: 5075520-5074516 (Counterclockwise)

Preceding gene: 157372832

Following gene: 157372826

Centisome position: 93.15

GC content: 56.42

Gene sequence:

>1005_bases
ATGAGTAAGCCCATCGTATTTAGCGGCGCGCAACCGTCCGGTGAACTGACCATTGGCAACTACATGGGTGCACTGCGTCA
GTGGGAAAAAATGCAGGATGATTACGACTGCATCTACTGCATCGTTGACCTGCATGCGATCACCGTACGTCAGGATGCAG
AAAAATTGCGTAAGGCCACGCTCGATACGCTGGCGCTGTATCTGGCCTGTGGTATCGATCCGCAAAAAAGCACCATCTTC
GTGCAGTCGCACGTACCGGAACACACGCAGCTGAGCTGGGTGTTGAACTGCTACACCTATTTCGGCGAACTGAGCCGCAT
GACCCAGTTCAAGGACAAATCCACTCGTTATGCAGAGAACATCAACGCCGGCCTGTTCAGCTACCCGGTATTGATGGCGG
CGGATATCCTGCTGTACCAGACCAACCAGGTGCCGGTCGGCGAAGACCAGAAACAGCATCTGGAGTTGAGCCGTGACATC
GGTCAGCGTTTCAACGCGCTGTACGGTGACGTGTTCAAAGTGCCTGAGCCGTTTATTCCCAAGTCCGGCGCCCGCGTGAT
GTCGCTGCAAGAGCCGACCAAGAAGATGTCCAAGTCGGACGATAACCGTAATAACGTGATCGGCCTGCTGGAAGATCCGA
AAGCGGTGGCTAAAAAGATCAAACGCGCGATGACCGACTCGGAAGAGCCGCCAGTGGTGCGTTATGACGTGGTGAACAAG
GCGGGGGTATCCAACCTGTTGGATATTCTCTCCGGCGTGACCGGCAAGAGCATCCCTCAGTTGGAAGCCGAGTTTGAAGG
GCAGATGTACGGCCACCTGAAAGGCGCCGTCGCTGACGCGGTATCCGGCATGCTGGGTGAGCTGCAGGAGCGCTATCATC
GTTTCCGTAATGACGAGGCCCTGCTGCAGCAAGTGATGCGTGATGGCGCTGCCAAGGCCCGTGCACGAGCTCAGGAAACG
CTGGCGAAGGTTTACCAGGCGGTGGGCTTTGTTTCCCCGCAGTGA

Upstream 100 bases:

>100_bases
AGGCCATTGCCCTGAGCCATCCCGACCGCGTGTTGGAGCGCTTTGCCGATTTGTTGCCCGCTCTTGGGCTGTCATCTTTA
GAGAATCAGGAAATTTAAAC

Downstream 100 bases:

>100_bases
AGCTCCGAGCAAAAAGAAAAGCGGCCACTGGCCGCTTTTTTTACGTCTGTATCAGGCCATTTGCGCCAGTGGTTGCGACG
GCTCCTGGCTTGAGAACCAG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSKPIVFSGAQPSGELTIGNYMGALRQWEKMQDDYDCIYCIVDLHAITVRQDAEKLRKATLDTLALYLACGIDPQKSTIF
VQSHVPEHTQLSWVLNCYTYFGELSRMTQFKDKSTRYAENINAGLFSYPVLMAADILLYQTNQVPVGEDQKQHLELSRDI
GQRFNALYGDVFKVPEPFIPKSGARVMSLQEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDSEEPPVVRYDVVNK
AGVSNLLDILSGVTGKSIPQLEAEFEGQMYGHLKGAVADAVSGMLGELQERYHRFRNDEALLQQVMRDGAAKARARAQET
LAKVYQAVGFVSPQ

Sequences:

>Translated_334_residues
MSKPIVFSGAQPSGELTIGNYMGALRQWEKMQDDYDCIYCIVDLHAITVRQDAEKLRKATLDTLALYLACGIDPQKSTIF
VQSHVPEHTQLSWVLNCYTYFGELSRMTQFKDKSTRYAENINAGLFSYPVLMAADILLYQTNQVPVGEDQKQHLELSRDI
GQRFNALYGDVFKVPEPFIPKSGARVMSLQEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDSEEPPVVRYDVVNK
AGVSNLLDILSGVTGKSIPQLEAEFEGQMYGHLKGAVADAVSGMLGELQERYHRFRNDEALLQQVMRDGAAKARARAQET
LAKVYQAVGFVSPQ
>Mature_333_residues
SKPIVFSGAQPSGELTIGNYMGALRQWEKMQDDYDCIYCIVDLHAITVRQDAEKLRKATLDTLALYLACGIDPQKSTIFV
QSHVPEHTQLSWVLNCYTYFGELSRMTQFKDKSTRYAENINAGLFSYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIG
QRFNALYGDVFKVPEPFIPKSGARVMSLQEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDSEEPPVVRYDVVNKA
GVSNLLDILSGVTGKSIPQLEAEFEGQMYGHLKGAVADAVSGMLGELQERYHRFRNDEALLQQVMRDGAAKARARAQETL
AKVYQAVGFVSPQ

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=43.5045317220544, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=53.6312849162011, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1789786, Length=332, Percent_Identity=87.3493975903614, Blast_Score=615, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=34.4311377245509, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=34.4311377245509, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320474, Length=349, Percent_Identity=40.6876790830946, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24666151, Length=327, Percent_Identity=41.5902140672783, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37348; Mature: 37217

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPIVFSGAQPSGELTIGNYMGALRQWEKMQDDYDCIYCIVDLHAITVRQDAEKLRKAT
CCCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LDTLALYLACGIDPQKSTIFVQSHVPEHTQLSWVLNCYTYFGELSRMTQFKDKSTRYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFSYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIGQRFNALYGDVFKVPEPFIP
CCCCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KSGARVMSLQEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDSEEPPVVRYDVVNK
CCCCEEEEHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCC
AGVSNLLDILSGVTGKSIPQLEAEFEGQMYGHLKGAVADAVSGMLGELQERYHRFRNDEA
CCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLQQVMRDGAAKARARAQETLAKVYQAVGFVSPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPIVFSGAQPSGELTIGNYMGALRQWEKMQDDYDCIYCIVDLHAITVRQDAEKLRKAT
CCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LDTLALYLACGIDPQKSTIFVQSHVPEHTQLSWVLNCYTYFGELSRMTQFKDKSTRYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFSYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIGQRFNALYGDVFKVPEPFIP
CCCCHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KSGARVMSLQEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDSEEPPVVRYDVVNK
CCCCEEEEHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCC
AGVSNLLDILSGVTGKSIPQLEAEFEGQMYGHLKGAVADAVSGMLGELQERYHRFRNDEA
CCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLQQVMRDGAAKARARAQETLAKVYQAVGFVSPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]