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The map label for this gene is ppiA [H]

Identifier: 157372821

GI number: 157372821

Start: 5062645

End: 5063214

Strand: Reverse

Name: ppiA [H]

Synonym: Spro_4589

Alternate gene names: 157372821

Gene position: 5063214-5062645 (Counterclockwise)

Preceding gene: 157372826

Following gene: 157372820

Centisome position: 92.92

GC content: 54.21

Gene sequence:

>570_bases
ATGTTCAAACGTACTTTAGTGACCTTCGTTGCGCTGTGTTCCCTGACAGCAATGGCACCTGCCGCGCTCGCCGCCGGTGA
AACTCATGTCATGCTGACTACCTCGGCTGGGAATATCGAATTGGCGCTCGACAGTCAGAAGGCTCCGGTTTCCACCAAGA
ACTTCGTCGACTACGTGAACAGCGGCTATTACAACAACACCATTTTCCACCGTGTGATCCCGGGCTTTATGGTTCAGGGC
GGTGGCTTTACTGCTGATATGCAGCAAAAATCCACCCAGGCACCGATCAAGAACGAAGCGGATAACGGCCTGCGCAACCT
GCGCGGCACCATTTCGATGGCGCGTACCGCTGACAAAGACAGTGCCACCAGCCAGTTTTTCCTCAACGTGGCAGATAACG
CCTTCCTGGATCACGGCCAGCGCGATTTCGGCTATGCGGTATTCGGCAAAGTGGTCAAAGGGATGGACGTGGTAGATAAA
ATCTCCCAGGCACCGACTGGCAACGTCGGTCCGTACCAGAATGTTCCGAGCAAACCTATCGTCATCCTGTCAGCAAAAGT
GCTGCCATAA

Upstream 100 bases:

>100_bases
CTATTAAGTAAATATAGGTAAATGGCTGGCACTCGCAGGTGCAGCTCTTTAGAATCAATGCGCTTTTCCGTTGTTTGTCT
CTTAGAGAAAGGACCCGTTA

Downstream 100 bases:

>100_bases
TGATTTTGCGCCGGCCCCAGGTGGGCCGGCTGCGTTGCTTTCCCCGGAAGCCTTGCCTGCATCACTGTTTTTTCCCCCTT
CACATGCTTTAATCGCCAGC

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MFKRTLVTFVALCSLTAMAPAALAAGETHVMLTTSAGNIELALDSQKAPVSTKNFVDYVNSGYYNNTIFHRVIPGFMVQG
GGFTADMQQKSTQAPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVDK
ISQAPTGNVGPYQNVPSKPIVILSAKVLP

Sequences:

>Translated_189_residues
MFKRTLVTFVALCSLTAMAPAALAAGETHVMLTTSAGNIELALDSQKAPVSTKNFVDYVNSGYYNNTIFHRVIPGFMVQG
GGFTADMQQKSTQAPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVDK
ISQAPTGNVGPYQNVPSKPIVILSAKVLP
>Mature_189_residues
MFKRTLVTFVALCSLTAMAPAALAAGETHVMLTTSAGNIELALDSQKAPVSTKNFVDYVNSGYYNNTIFHRVIPGFMVQG
GGFTADMQQKSTQAPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVDK
ISQAPTGNVGPYQNVPSKPIVILSAKVLP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=126, Percent_Identity=39.6825396825397, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI24308049, Length=160, Percent_Identity=35, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=32.9113924050633, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=32.0754716981132, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=31.2883435582822, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=31.2883435582822, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI22547215, Length=133, Percent_Identity=34.5864661654135, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1789763, Length=190, Percent_Identity=80.5263157894737, Blast_Score=319, Evalue=7e-89,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=54.0372670807453, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=36.6197183098592, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=36.6197183098592, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=162, Percent_Identity=32.7160493827161, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=169, Percent_Identity=34.3195266272189, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=126, Percent_Identity=35.7142857142857, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=196, Percent_Identity=32.6530612244898, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=32.8671328671329, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=166, Percent_Identity=33.1325301204819, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=160, Percent_Identity=35, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321848, Length=135, Percent_Identity=37.037037037037, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=35.4037267080745, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19922912, Length=151, Percent_Identity=36.4238410596026, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=31.9018404907975, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357249, Length=162, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20130249, Length=160, Percent_Identity=33.75, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20252; Mature: 20252

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRTLVTFVALCSLTAMAPAALAAGETHVMLTTSAGNIELALDSQKAPVSTKNFVDYVN
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHH
SGYYNNTIFHRVIPGFMVQGGGFTADMQQKSTQAPIKNEADNGLRNLRGTISMARTADKD
CCCCCCCHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
SATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVDKISQAPTGNVGPYQNVPSKPI
CCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VILSAKVLP
EEEEEECCC
>Mature Secondary Structure
MFKRTLVTFVALCSLTAMAPAALAAGETHVMLTTSAGNIELALDSQKAPVSTKNFVDYVN
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHH
SGYYNNTIFHRVIPGFMVQGGGFTADMQQKSTQAPIKNEADNGLRNLRGTISMARTADKD
CCCCCCCHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
SATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVDKISQAPTGNVGPYQNVPSKPI
CCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VILSAKVLP
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]