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The map label for this gene is shlB [H]

Identifier: 157372714

GI number: 157372714

Start: 4958837

End: 4960513

Strand: Direct

Name: shlB [H]

Synonym: Spro_4481

Alternate gene names: 157372714

Gene position: 4958837-4960513 (Clockwise)

Preceding gene: 157372713

Following gene: 157372715

Centisome position: 91.01

GC content: 57.96

Gene sequence:

>1677_bases
ATGATTAAAAAAACCGTCGCACTGGCGTTGCTGTTCAGCACCGCACTCCCCGCCGCTACCCTGCCGGAAATGGAGCATTT
TTCGCCGATGGGCGAATCACGCCGCGCCCTGCAAGACGGCACGCGTGAAGTGAATCAACAGATAGAACAACGCCGCTACC
GACAGCTTAAACAGCAGCAATTACTGGCAGAACCCGAGCCTGCGACCCCGGCATTACCGCGTTCGGCCCAGTGCCTGCCC
ATCGATGGCGTATATCTGCAAGGCATTACCCTGCTGTCGGCGAAAGATTTGGCGGCGCTCAGCGCACTGCCACCACGTTG
CATCAGCAGTAATGACATCAACCGCCTGGCGCGCGAATTAACCCGTTTATATCTTGATAAAGGCTATATCACCGCCCGCG
TACAGTTTATTCGCCCTAATGCCGAGGGGGAATTAGGGCTGCGGGTGACCGAAGGATTTATCGAGAAAATAGAAGGTGGC
GATCGTTGGGTTAACAGCCAATTATTATTCCCCGGACTGGAAGGTAAGCCGCTGAAATTAACTCAGCTCGATCAGGGATT
GGATCAGGCCAATCGTTTGCAATCGAACAAAACCCGTCTGGATATATTGCCTGGCAGCCAAACCGGTGGCTCCATTATTC
GCTTGCACAACCAACATGCCAAACCCTGGTTGCTGTCTGCCACTCTGGACAATTATGGCCAAAAAAATACCGGCCAGTGG
TTAGCGCGCAGCACGGCAACGCTGGACAGTCCATTCGGCCTGTCGGACTTTGTCAGTCTGAACGTCGCCGGCACGCTGAA
AGACCCATCGCAGCGCTACAACCGCGCCTATACCCTGCTCTATTCCCTGCCCTACGGCGCCTTTACCTTCAGTGGCTTTG
CCAGCTATTCGCAATACATGAACCGCCAGCAGTTGGTGTTCAACAGCTATAAGCTGCACGGCCAGACCCAGCAGTACGGC
CTGCGCGGCGACTATGTGTTTTACCGCGATCGCGATCAAATCAACGCCCTGAGCGGTCAGCTAACCCATAAGCGCATCAA
TAACTATTTCGACACCGTGCGTATCGGCCTCGGCAGCCCGACGCTCAGCCTGTTCGAACTGGGCGTTAATCACCTGCAGA
TCCTGCCTGGCGGGCTTGTCAGCGCCAACCTCAGCGTAGAACAAGGATTGCCGTGGTTTGGGGCCGACAGCCACGGCGGT
GCCGGGCTGCCCGATGCCCAATTCACCAAGGGCAAGCTGTTTGCCAACCTCAACCAACGTTTCACCCTGGCCGGTTCCAG
CTACCAGCTCAGTAACCTGCTTTACGGGCAATACAGCCGCGATCGCCTGCCCGGCGTGGAATGGCTCAGCCTGACCGACC
GCAGCGCGATCCGCGGTTTCAGCCGCAGCACGCTGTCCGGCGATAACGGCTGGTATCTGCAAAATACCCTGTCCCGCAGC
TTCAACCTGGGCCAAAGCATCCTCACCCCGCGCATTGGTGGCGATGTCGGCCGGGTGCTGCCGCGTGACAATCGGCCTTC
GGGCTGGCAAAGCAGCGCAGGTCTGAGTGCCGGCGCCACTCTGCGTTACCAGCGGGCGTCGCTCGACGTCGAAGCCAGCC
GTGGCTGGCTACTGTCCAGTCACGCCATGCCCGACGATCCCGTCCAGGTACTGGCGCGCTTTTCGTACACCTTTTAG

Upstream 100 bases:

>100_bases
TGTGCTTGTCGCTCGCTGTTTCGGGCCGGCCTCTGGCCGTCCGTTTCTTGACCTCATGGATTGAGCAGGCCACCCCGCTG
GCTTCTCATAATGGATTAAA

Downstream 100 bases:

>100_bases
TCAGCGTTTTCTTGCACTACCACAGCGATATATGGAGATACATGGATGAAAAATAATAACTTCAGGCTTTCGGCGGCGGG
TAAGTTGGCCGCTTCACTGG

Product: hemolysin activator HlyB domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MIKKTVALALLFSTALPAATLPEMEHFSPMGESRRALQDGTREVNQQIEQRRYRQLKQQQLLAEPEPATPALPRSAQCLP
IDGVYLQGITLLSAKDLAALSALPPRCISSNDINRLARELTRLYLDKGYITARVQFIRPNAEGELGLRVTEGFIEKIEGG
DRWVNSQLLFPGLEGKPLKLTQLDQGLDQANRLQSNKTRLDILPGSQTGGSIIRLHNQHAKPWLLSATLDNYGQKNTGQW
LARSTATLDSPFGLSDFVSLNVAGTLKDPSQRYNRAYTLLYSLPYGAFTFSGFASYSQYMNRQQLVFNSYKLHGQTQQYG
LRGDYVFYRDRDQINALSGQLTHKRINNYFDTVRIGLGSPTLSLFELGVNHLQILPGGLVSANLSVEQGLPWFGADSHGG
AGLPDAQFTKGKLFANLNQRFTLAGSSYQLSNLLYGQYSRDRLPGVEWLSLTDRSAIRGFSRSTLSGDNGWYLQNTLSRS
FNLGQSILTPRIGGDVGRVLPRDNRPSGWQSSAGLSAGATLRYQRASLDVEASRGWLLSSHAMPDDPVQVLARFSYTF

Sequences:

>Translated_558_residues
MIKKTVALALLFSTALPAATLPEMEHFSPMGESRRALQDGTREVNQQIEQRRYRQLKQQQLLAEPEPATPALPRSAQCLP
IDGVYLQGITLLSAKDLAALSALPPRCISSNDINRLARELTRLYLDKGYITARVQFIRPNAEGELGLRVTEGFIEKIEGG
DRWVNSQLLFPGLEGKPLKLTQLDQGLDQANRLQSNKTRLDILPGSQTGGSIIRLHNQHAKPWLLSATLDNYGQKNTGQW
LARSTATLDSPFGLSDFVSLNVAGTLKDPSQRYNRAYTLLYSLPYGAFTFSGFASYSQYMNRQQLVFNSYKLHGQTQQYG
LRGDYVFYRDRDQINALSGQLTHKRINNYFDTVRIGLGSPTLSLFELGVNHLQILPGGLVSANLSVEQGLPWFGADSHGG
AGLPDAQFTKGKLFANLNQRFTLAGSSYQLSNLLYGQYSRDRLPGVEWLSLTDRSAIRGFSRSTLSGDNGWYLQNTLSRS
FNLGQSILTPRIGGDVGRVLPRDNRPSGWQSSAGLSAGATLRYQRASLDVEASRGWLLSSHAMPDDPVQVLARFSYTF
>Mature_558_residues
MIKKTVALALLFSTALPAATLPEMEHFSPMGESRRALQDGTREVNQQIEQRRYRQLKQQQLLAEPEPATPALPRSAQCLP
IDGVYLQGITLLSAKDLAALSALPPRCISSNDINRLARELTRLYLDKGYITARVQFIRPNAEGELGLRVTEGFIEKIEGG
DRWVNSQLLFPGLEGKPLKLTQLDQGLDQANRLQSNKTRLDILPGSQTGGSIIRLHNQHAKPWLLSATLDNYGQKNTGQW
LARSTATLDSPFGLSDFVSLNVAGTLKDPSQRYNRAYTLLYSLPYGAFTFSGFASYSQYMNRQQLVFNSYKLHGQTQQYG
LRGDYVFYRDRDQINALSGQLTHKRINNYFDTVRIGLGSPTLSLFELGVNHLQILPGGLVSANLSVEQGLPWFGADSHGG
AGLPDAQFTKGKLFANLNQRFTLAGSSYQLSNLLYGQYSRDRLPGVEWLSLTDRSAIRGFSRSTLSGDNGWYLQNTLSRS
FNLGQSILTPRIGGDVGRVLPRDNRPSGWQSSAGLSAGATLRYQRASLDVEASRGWLLSSHAMPDDPVQVLARFSYTF

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 61873; Mature: 61873

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKTVALALLFSTALPAATLPEMEHFSPMGESRRALQDGTREVNQQIEQRRYRQLKQQQ
CCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEPEPATPALPRSAQCLPIDGVYLQGITLLSAKDLAALSALPPRCISSNDINRLAREL
HHCCCCCCCCCCCCCCCEEECCCEEECCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHH
TRLYLDKGYITARVQFIRPNAEGELGLRVTEGFIEKIEGGDRWVNSQLLFPGLEGKPLKL
HHHHHCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHCCCCEEECCEEECCCCCCCCEEH
TQLDQGLDQANRLQSNKTRLDILPGSQTGGSIIRLHNQHAKPWLLSATLDNYGQKNTGQW
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCHH
LARSTATLDSPFGLSDFVSLNVAGTLKDPSQRYNRAYTLLYSLPYGAFTFSGFASYSQYM
HHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHC
NRQQLVFNSYKLHGQTQQYGLRGDYVFYRDRDQINALSGQLTHKRINNYFDTVRIGLGSP
CHHHHHHHHEEECCCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCC
TLSLFELGVNHLQILPGGLVSANLSVEQGLPWFGADSHGGAGLPDAQFTKGKLFANLNQR
HHHHHHHCCCCEEECCCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCE
FTLAGSSYQLSNLLYGQYSRDRLPGVEWLSLTDRSAIRGFSRSTLSGDNGWYLQNTLSRS
EEEECCCEEHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCEEEHHHHHHH
FNLGQSILTPRIGGDVGRVLPRDNRPSGWQSSAGLSAGATLRYQRASLDVEASRGWLLSS
HCCCHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCEEEEC
HAMPDDPVQVLARFSYTF
CCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIKKTVALALLFSTALPAATLPEMEHFSPMGESRRALQDGTREVNQQIEQRRYRQLKQQQ
CCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEPEPATPALPRSAQCLPIDGVYLQGITLLSAKDLAALSALPPRCISSNDINRLAREL
HHCCCCCCCCCCCCCCCEEECCCEEECCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHH
TRLYLDKGYITARVQFIRPNAEGELGLRVTEGFIEKIEGGDRWVNSQLLFPGLEGKPLKL
HHHHHCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHCCCCEEECCEEECCCCCCCCEEH
TQLDQGLDQANRLQSNKTRLDILPGSQTGGSIIRLHNQHAKPWLLSATLDNYGQKNTGQW
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCHH
LARSTATLDSPFGLSDFVSLNVAGTLKDPSQRYNRAYTLLYSLPYGAFTFSGFASYSQYM
HHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHC
NRQQLVFNSYKLHGQTQQYGLRGDYVFYRDRDQINALSGQLTHKRINNYFDTVRIGLGSP
CHHHHHHHHEEECCCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCC
TLSLFELGVNHLQILPGGLVSANLSVEQGLPWFGADSHGGAGLPDAQFTKGKLFANLNQR
HHHHHHHCCCCEEECCCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCE
FTLAGSSYQLSNLLYGQYSRDRLPGVEWLSLTDRSAIRGFSRSTLSGDNGWYLQNTLSRS
EEEECCCEEHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCEEEHHHHHHH
FNLGQSILTPRIGGDVGRVLPRDNRPSGWQSSAGLSAGATLRYQRASLDVEASRGWLLSS
HCCCHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCEEEEC
HAMPDDPVQVLARFSYTF
CCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]