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The map label for this gene is panF [H]

Identifier: 157372653

GI number: 157372653

Start: 4893140

End: 4894585

Strand: Direct

Name: panF [H]

Synonym: Spro_4420

Alternate gene names: 157372653

Gene position: 4893140-4894585 (Clockwise)

Preceding gene: 157372652

Following gene: 157372654

Centisome position: 89.8

GC content: 58.51

Gene sequence:

>1446_bases
ATGCAAACTGAAGTTATTTTGCCGCTGGTTGCCTATCTGCTGCTGGTATTTGGGCTGTCGGTTTACGCCTACAGTCGGCG
TCAGACCGGTAATTTCCTCAGCGAATACTTCCTGGGTAGCCGATCGATGGGTGGCTTTGTGCTGGCGATGACGCTGACCG
CAACCTATATCAGCGCCAGTTCGTTTATCGGTGGCCCCGGTGCCGCCTATAAATATGGCCTTGGTTGGGTGTTGTTGGCG
ATGATCCAACTGCCCGCCGTATGGTTATCGCTCGGTGTGCTGGGCAAGAAATTCGCCATTCTGGCGCGCCGCTACAACGC
CATCACCTTAAACGACATGCTGTACGGGCGCTATCAAAGCCGCCTGTTGGTCTGGCTAGCCAGTCTCAGTTTGTTGGTGG
CGTTCCTGGGGGCCATGACGGTGCAGTTTATCGGCGGCGCACGCCTGCTGGAAACCGCTGCCGGCATCCCTTACGACACC
GGCCTGCTGATCTTTGGCGTCAGCATCGCGCTGTATACCGCCTTTGGCGGCTTTCGTGCCAGCGTGCTGAACGATGCCAT
GCAGGGCCTGGTCATGTTGATCGGCACCGTGCTGTTGCTGGTGGCGGTGATCCACGCCGCTGGCGGCCTGCACAGCGCGG
TGGACAAACTCCACCAAATTGACCCGGCGCTGGTGTCCCCCCAGGGCGGTGAACAGATCCTCAGCCTGCCATTTATGGCC
TCGTTTTGGATCCTGGTGTGCTTTGGCGTGATAGGCCTGCCGCATACTGCGGTGCGCTGCATCTCTTACAAAGACAGCAA
AGCGGTACACCGCGGCATCATCCTCGGTACCATGGTAGTGGCAGTGCTGATGTTCGGTATGCATCTGGCCGGTGCGCTGG
GCCGCGCGGTGTTGCCGGATCTGAAGATCCCCGATCAGGTGATCCCGACGCTGATGATCACCGTGCTGCCGCCGTATGCT
GCCGGCATCTTCCTGGCAGCACCGATGGCGGCCATCATGTCGACCATTAATGCCCAACTGCTGCAGTCTTCCGCCACTAT
TATTAAAGATCTCTACCTTGGCGTACGGCCGCAGCAGATGCAGAACGAACGCTTGATCAAACGCTTTTCCAGCCTGACCA
CCTTGATCCTCGGGCTTTTGGTGCTGCTGGCGGCATGGCGTCCGCCGGAAATGATCATCTGGCTAAACCTGCTGGCGTTC
GGCGGCCTGGAGGCGGTATTCCTGTGGCCGCTGGTGCTGGGCCTGTACTGGGAACGCGCCAACGCACAGGGAGCGCTTAG
CTCAATGGTGACGGGTGCGGTATGCTATACGCTATTGGCCAGTTTTAATCTGCAACTGGCGGGGCTGCACCCTATCGTGC
CTTCACTGCTGCTTAGCCTGCTGGCATTTTATATCGGTAACCTCGTCGGCGAAAAACGCCGGACGGCGTCATCATTACCC
TCTTAA

Upstream 100 bases:

>100_bases
TGGTTCGAAATGGCCTGCTTATTGGTACCACTGCTGTTTATCGGCCTGTGTTGGCTGATGGTACGCGGCATATTCCGTGA
TATTTCACTGGAGGACGGCG

Downstream 100 bases:

>100_bases
AAGAGAATTGTTATGCCTTGGATCCAACTCAAACTGAACACCACCGGCAGCCAGGCAGAAGACCTGAGCGACGCGCTGGT
TGAAAGCGGCGCAGTATCGG

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MQTEVILPLVAYLLLVFGLSVYAYSRRQTGNFLSEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAITLNDMLYGRYQSRLLVWLASLSLLVAFLGAMTVQFIGGARLLETAAGIPYDT
GLLIFGVSIALYTAFGGFRASVLNDAMQGLVMLIGTVLLLVAVIHAAGGLHSAVDKLHQIDPALVSPQGGEQILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRGIILGTMVVAVLMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPYA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLGVRPQQMQNERLIKRFSSLTTLILGLLVLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAQGALSSMVTGAVCYTLLASFNLQLAGLHPIVPSLLLSLLAFYIGNLVGEKRRTASSLP
S

Sequences:

>Translated_481_residues
MQTEVILPLVAYLLLVFGLSVYAYSRRQTGNFLSEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAITLNDMLYGRYQSRLLVWLASLSLLVAFLGAMTVQFIGGARLLETAAGIPYDT
GLLIFGVSIALYTAFGGFRASVLNDAMQGLVMLIGTVLLLVAVIHAAGGLHSAVDKLHQIDPALVSPQGGEQILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRGIILGTMVVAVLMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPYA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLGVRPQQMQNERLIKRFSSLTTLILGLLVLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAQGALSSMVTGAVCYTLLASFNLQLAGLHPIVPSLLLSLLAFYIGNLVGEKRRTASSLP
S
>Mature_481_residues
MQTEVILPLVAYLLLVFGLSVYAYSRRQTGNFLSEYFLGSRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAITLNDMLYGRYQSRLLVWLASLSLLVAFLGAMTVQFIGGARLLETAAGIPYDT
GLLIFGVSIALYTAFGGFRASVLNDAMQGLVMLIGTVLLLVAVIHAAGGLHSAVDKLHQIDPALVSPQGGEQILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRGIILGTMVVAVLMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPYA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLGVRPQQMQNERLIKRFSSLTTLILGLLVLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAQGALSSMVTGAVCYTLLASFNLQLAGLHPIVPSLLLSLLAFYIGNLVGEKRRTASSLP
S

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=488, Percent_Identity=28.6885245901639, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI14140236, Length=475, Percent_Identity=24, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4507033, Length=410, Percent_Identity=26.0975609756098, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=23.8900634249471, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI109659836, Length=512, Percent_Identity=24.21875, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI157671931, Length=435, Percent_Identity=20.6896551724138, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI110835708, Length=493, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87082237, Length=481, Percent_Identity=81.4968814968815, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=491, Percent_Identity=27.9022403258656, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790113, Length=461, Percent_Identity=23.4273318872017, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790503, Length=449, Percent_Identity=21.6035634743875, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573698, Length=447, Percent_Identity=23.489932885906, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51724; Mature: 51724

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]