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The map label for this gene is dsbC [H]

Identifier: 157372125

GI number: 157372125

Start: 4312111

End: 4312827

Strand: Reverse

Name: dsbC [H]

Synonym: Spro_3891

Alternate gene names: 157372125

Gene position: 4312827-4312111 (Counterclockwise)

Preceding gene: 157372126

Following gene: 157372124

Centisome position: 79.15

GC content: 55.79

Gene sequence:

>717_bases
ATGAAGAAAGGTTTAATGCTGCTCTCTATGCTGGTGGCTTCAGTGACCGGCGCGGCCCATGCCGACGACGCGGCAATTCA
AAAAGCACTTGGCAGCCTGGGCATTCAGCAGGCGGACGTGCAGCCTTCACCGGTGAACGGCCTGAAAACCGTATTGACCG
ATAGCGGCGTGCTGTACGTGACCGAAGACGGCAAACACATTCTGCAAGGCCCGCTGTACGACGTCAGTGGCAAAGAGCCG
GTTAACGTCACCAACCAACTGCTGACCGGCAAGCTGGAAGCGCTGAAAGATCAGATGATCGTCTACAAAGCGCCAAAGCA
GAAACACGTGATCACCGTGTTCACCGACATCACCTGTGGCTATTGCCACAAGCTGCACCAGCAGATGAAAGAATATAACG
ATCTGGGCATTACCGTCCGTTATCTGGCGTTCCCGCGTCAGGGGCTGAATTCCCAGGCCGAAAAAGACATGCAGTCAATC
TGGTGTACCGCCGACAAGGCCAAGGCCTTCGATACCGCCATGAAAGGCGACGCGGTTTCTCCGGCGACCTGTAAAACCGA
CATCAGCAAACACTATGCGCTCGGCGTGCAGTTCGGTATTCAGGGCACCCCGGCGATCATTCTGGAAAACGGCATGATGA
TCCCAGGGTATCAGGGGCCAAAAGAGATGGCCGCCATGCTGGACGCGCATCAGACCGCAACCAAAACCGGTGGTTAA

Upstream 100 bases:

>100_bases
CACACAAATTTACACGCATGTAGCGACCGAAAGACTTAAACAGCTACATCAACAGCACCACCCGCGTGCCTGACATGCCG
GGTTCAAAAGGATTGGAAGA

Downstream 100 bases:

>100_bases
TCGCCGGTGAGCATCAAAACACAACTACGCCGCCGTGCGGCGACGGACGACAGCCATTTGCCAGCCAGCCTGCACCCGCT
GTTGCGCCGTTTATATGCGC

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKKGLMLLSMLVASVTGAAHADDAAIQKALGSLGIQQADVQPSPVNGLKTVLTDSGVLYVTEDGKHILQGPLYDVSGKEP
VNVTNQLLTGKLEALKDQMIVYKAPKQKHVITVFTDITCGYCHKLHQQMKEYNDLGITVRYLAFPRQGLNSQAEKDMQSI
WCTADKAKAFDTAMKGDAVSPATCKTDISKHYALGVQFGIQGTPAIILENGMMIPGYQGPKEMAAMLDAHQTATKTGG

Sequences:

>Translated_238_residues
MKKGLMLLSMLVASVTGAAHADDAAIQKALGSLGIQQADVQPSPVNGLKTVLTDSGVLYVTEDGKHILQGPLYDVSGKEP
VNVTNQLLTGKLEALKDQMIVYKAPKQKHVITVFTDITCGYCHKLHQQMKEYNDLGITVRYLAFPRQGLNSQAEKDMQSI
WCTADKAKAFDTAMKGDAVSPATCKTDISKHYALGVQFGIQGTPAIILENGMMIPGYQGPKEMAAMLDAHQTATKTGG
>Mature_238_residues
MKKGLMLLSMLVASVTGAAHADDAAIQKALGSLGIQQADVQPSPVNGLKTVLTDSGVLYVTEDGKHILQGPLYDVSGKEP
VNVTNQLLTGKLEALKDQMIVYKAPKQKHVITVFTDITCGYCHKLHQQMKEYNDLGITVRYLAFPRQGLNSQAEKDMQSI
WCTADKAKAFDTAMKGDAVSPATCKTDISKHYALGVQFGIQGTPAIILENGMMIPGYQGPKEMAAMLDAHQTATKTGG

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=234, Percent_Identity=66.2393162393162, Blast_Score=344, Evalue=2e-96,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 25581; Mature: 25581

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGLMLLSMLVASVTGAAHADDAAIQKALGSLGIQQADVQPSPVNGLKTVLTDSGVLYV
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEE
TEDGKHILQGPLYDVSGKEPVNVTNQLLTGKLEALKDQMIVYKAPKQKHVITVFTDITCG
ECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCHH
YCHKLHQQMKEYNDLGITVRYLAFPRQGLNSQAEKDMQSIWCTADKAKAFDTAMKGDAVS
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
PATCKTDISKHYALGVQFGIQGTPAIILENGMMIPGYQGPKEMAAMLDAHQTATKTGG
CCHHHHHHHHHHEEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKGLMLLSMLVASVTGAAHADDAAIQKALGSLGIQQADVQPSPVNGLKTVLTDSGVLYV
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEE
TEDGKHILQGPLYDVSGKEPVNVTNQLLTGKLEALKDQMIVYKAPKQKHVITVFTDITCG
ECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCHH
YCHKLHQQMKEYNDLGITVRYLAFPRQGLNSQAEKDMQSIWCTADKAKAFDTAMKGDAVS
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
PATCKTDISKHYALGVQFGIQGTPAIILENGMMIPGYQGPKEMAAMLDAHQTATKTGG
CCHHHHHHHHHHEEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8168497 [H]