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The map label for this gene is lysS

Identifier: 157372123

GI number: 157372123

Start: 4307579

End: 4309096

Strand: Reverse

Name: lysS

Synonym: Spro_3888

Alternate gene names: 157372123

Gene position: 4309096-4307579 (Counterclockwise)

Preceding gene: 157372124

Following gene: 157372122

Centisome position: 79.08

GC content: 56.06

Gene sequence:

>1518_bases
ATGTCTGAGCAACAACCACAAGGCGCCGAACAGGCGCTGGATCTCAATAACGAGTTGCAGTCACGCCGTGAAAAACTGGC
TGCGCTGCGCGAGAACGGCATTGCGTTCCCGAATGATTTCCGTCGCGACACCACGTCCGACAAGCTGCACGCTGCGTACG
GCGATAAAGACAACGAAGAGCTGGAAGCACTGGGTGTAGAAGTCACCGTTGCCGGCCGTATGATGACCCGTCGTATCATG
GGCAAGGCATCCTTTGTCACGCTGCAAGACGTTGGTGGCCGCATCCAGTTGTACGTCGCCCGCGACGATCTGGCGGAAGG
CGTTTACAACGAAGAATTCAAGAAGTGGGACCTGGGTGACATCCTTGGCGCACGCGGTAAGCTGTTCAAAACCAAGACCG
GCGAGCTGTCTATCCACTGCACCGAACTGCGCCTGCTGACCAAGGCCCTGCGCCCGCTGCCGGACAAGTTCCACGGCCTG
GCCGATCAGGAAACCCGCTATCGTCAGCGTTACCTGGATCTGATTGCCAACGACGAATCGCGCAAGACCTTCCAGGTGCG
TTCTCAGATCATGGCGGCGATGCGTAACTTCATGGTGGAACGCGGCTTCATGGAAGTCGAAACCCCTATGATGCAGGTGA
TCCCGGGTGGTGCTTCTGCTCGTCCATTCGTGACTCACCACAATGCGCTGGACATCGATATGTATCTGCGTATTGCCCCA
GAGCTGTACCTGAAGCGTCTGGTGGTAGGTGGCTTCGAGCGCGTGTTCGAAATCAACCGTAACTTCCGTAACGAAGGCGT
TTCTCCGCGTCATAACCCAGAGTTCACCATGATGGAACTCTATATGGCTTACGCGGATTACAAAGATCTGATCGAACTGA
CCGAGTCGCTGTTCCGCACCCTGACCCAGAACGTGCTGGGTAATACTCAGGTGCAGTACGGTGATGAAGTGTTCGACTTC
GGCAAGCCGTTCGTGAAGCTGACCATGACCGAGGCGATCAAAAAATACCGTCCGGAAACCGATCTGGCTGACCTGGCTGA
TATGGGTAAAGCGGTGGCTATCGCTGAATCCATCGGCATCAAGGTTGAGAAGAGCTGGGGTCTGGGCCGCGTAGTGACCG
AGATCTTCGAAGAAGTGGCGGAAAGCCATCTGATTCAGCCGACTTTCATCACTGAATACCCGGCCGAAGTTTCACCGCTG
GCGCGCCGTAACGACGTTAACCCGGAAATCACTGACCGCTTTGAGTTCTTCATCGGCGGCCGTGAAATCGGCAACGGCTT
CTCCGAGCTGAATGACGCAGAAGACCAGGCGCAGCGTTTTGCTGACCAGGCTAATGCGAAAGACGCAGGTGATGACGAAG
CCATGTTCTACGACGAAGACTACGTCACCGCGCTGGAGCACGGCCTGCCACCAACCGCAGGTCTGGGCATCGGTATCGAC
CGTATGGTGATGCTGTTCACTAACAGCCACACCATTCGCGACGTGATTCTGTTCCCGGCAATGCGCCCACAGAAATAA

Upstream 100 bases:

>100_bases
GCGCACTAACGTTGAAACGCGCAACACGCAGGCCGTATTAGATGGCGACCTGGATAAATTCATTGAGGCAAGTTTGAAAG
CCGGGTTATAAGGAACAGAA

Downstream 100 bases:

>100_bases
CTTCGCAGTAATGAATATCAACCGGCGCAGGTCTCTGTGCCGGTTTTTTTTCGTCTGAGGGGGAAGGTGAGGGGATGTTG
CGGCTAACTGCTTAAAACAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSEQQPQGAEQALDLNNELQSRREKLAALRENGIAFPNDFRRDTTSDKLHAAYGDKDNEELEALGVEVTVAGRMMTRRIM
GKASFVTLQDVGGRIQLYVARDDLAEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGL
ADQETRYRQRYLDLIANDESRKTFQVRSQIMAAMRNFMVERGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAP
ELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIELTESLFRTLTQNVLGNTQVQYGDEVFDF
GKPFVKLTMTEAIKKYRPETDLADLADMGKAVAIAESIGIKVEKSWGLGRVVTEIFEEVAESHLIQPTFITEYPAEVSPL
ARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQANAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGID
RMVMLFTNSHTIRDVILFPAMRPQK

Sequences:

>Translated_505_residues
MSEQQPQGAEQALDLNNELQSRREKLAALRENGIAFPNDFRRDTTSDKLHAAYGDKDNEELEALGVEVTVAGRMMTRRIM
GKASFVTLQDVGGRIQLYVARDDLAEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGL
ADQETRYRQRYLDLIANDESRKTFQVRSQIMAAMRNFMVERGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAP
ELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIELTESLFRTLTQNVLGNTQVQYGDEVFDF
GKPFVKLTMTEAIKKYRPETDLADLADMGKAVAIAESIGIKVEKSWGLGRVVTEIFEEVAESHLIQPTFITEYPAEVSPL
ARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQANAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGID
RMVMLFTNSHTIRDVILFPAMRPQK
>Mature_504_residues
SEQQPQGAEQALDLNNELQSRREKLAALRENGIAFPNDFRRDTTSDKLHAAYGDKDNEELEALGVEVTVAGRMMTRRIMG
KASFVTLQDVGGRIQLYVARDDLAEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLA
DQETRYRQRYLDLIANDESRKTFQVRSQIMAAMRNFMVERGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPE
LYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIELTESLFRTLTQNVLGNTQVQYGDEVFDFG
KPFVKLTMTEAIKKYRPETDLADLADMGKAVAIAESIGIKVEKSWGLGRVVTEIFEEVAESHLIQPTFITEYPAEVSPLA
RRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQANAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDR
MVMLFTNSHTIRDVILFPAMRPQK

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=515, Percent_Identity=43.1067961165049, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI194272210, Length=512, Percent_Identity=42.96875, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI45439306, Length=463, Percent_Identity=25.0539956803456, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI40789249, Length=312, Percent_Identity=25.9615384615385, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789256, Length=505, Percent_Identity=87.3267326732673, Blast_Score=919, Evalue=0.0,
Organism=Escherichia coli, GI1790571, Length=505, Percent_Identity=85.1485148514851, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI87082379, Length=322, Percent_Identity=30.4347826086957, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1788173, Length=311, Percent_Identity=28.6173633440514, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17535925, Length=453, Percent_Identity=42.1633554083885, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17535927, Length=453, Percent_Identity=42.1633554083885, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71994340, Length=453, Percent_Identity=42.1633554083885, Blast_Score=354, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI17551876, Length=354, Percent_Identity=28.2485875706215, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566633, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320242, Length=514, Percent_Identity=40.272373540856, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=30.1255230125523, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323011, Length=543, Percent_Identity=26.5193370165746, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321807, Length=470, Percent_Identity=24.0425531914894, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640849, Length=485, Percent_Identity=42.0618556701031, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640851, Length=485, Percent_Identity=42.0618556701031, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17136276, Length=464, Percent_Identity=23.7068965517241, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24584738, Length=218, Percent_Identity=27.9816513761468, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYK_SERP5 (A8GIP4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480112.1
- ProteinModelPortal:   A8GIP4
- SMR:   A8GIP4
- STRING:   A8GIP4
- GeneID:   5602986
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3888
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- ProtClustDB:   PRK00484
- BioCyc:   SPRO399741:SPRO_3888-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 57345; Mature: 57214

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQQPQGAEQALDLNNELQSRREKLAALRENGIAFPNDFRRDTTSDKLHAAYGDKDNEE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEECCCCCCCCH
LEALGVEVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLAEGVYNEEFKKWDLGD
HHHHCEEEEEHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCHHHCCHHHHHHHCCCHHH
ILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDES
HHCCCCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCC
RKTFQVRSQIMAAMRNFMVERGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAP
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCCCCCCCCEEECCCCEEHHHHHHHHH
ELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIELTESLFRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQNVLGNTQVQYGDEVFDFGKPFVKLTMTEAIKKYRPETDLADLADMGKAVAIAESIGI
HHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCE
KVEKSWGLGRVVTEIFEEVAESHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHCCCCCCCHHHHHHHEECC
REIGNGFSELNDAEDQAQRFADQANAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGID
HHHCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCHH
RMVMLFTNSHTIRDVILFPAMRPQK
HEEEEEECCCHHHHHHEECCCCCCC
>Mature Secondary Structure 
SEQQPQGAEQALDLNNELQSRREKLAALRENGIAFPNDFRRDTTSDKLHAAYGDKDNEE
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEECCCCCCCCH
LEALGVEVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLAEGVYNEEFKKWDLGD
HHHHCEEEEEHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCHHHCCHHHHHHHCCCHHH
ILGARGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDES
HHCCCCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCC
RKTFQVRSQIMAAMRNFMVERGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAP
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCCCCCCCCEEECCCCEEHHHHHHHHH
ELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIELTESLFRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQNVLGNTQVQYGDEVFDFGKPFVKLTMTEAIKKYRPETDLADLADMGKAVAIAESIGI
HHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCE
KVEKSWGLGRVVTEIFEEVAESHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHCCCCCCCHHHHHHHEECC
REIGNGFSELNDAEDQAQRFADQANAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGID
HHHCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCHH
RMVMLFTNSHTIRDVILFPAMRPQK
HEEEEEECCCHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA