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The map label for this gene is aas [H]

Identifier: 157372065

GI number: 157372065

Start: 4237738

End: 4239891

Strand: Reverse

Name: aas [H]

Synonym: Spro_3830

Alternate gene names: 157372065

Gene position: 4239891-4237738 (Counterclockwise)

Preceding gene: 157372066

Following gene: 157372064

Centisome position: 77.81

GC content: 59.29

Gene sequence:

>2154_bases
ATGATCTTTTCTATACTGCGGGTGCTGTTCCGCCTGCTGTACCGGGTACGTGTCGAGGGCGACGTCCGGCATTTCGAGCA
GCAAAAACTGCTGATTACGCCCAATCATATCTCCTTCCTTGACGGTATTTTGCTGGCGTTGTTTTTGCCGATCAAACCGG
TGTTTGCCGTCTATGCCAGTATTGGCGATCGCTGGTTTATGCGCTGGCTGCGGCCCTATATCGACTTTGTCTCACTCGAC
CCTACCAAACCCATGGCCATCAAACAGCTGGTGCGCACGGTGGAACAGGGCAGGCCGGTAGTGGTGTTTCCCGAAGGGCG
CATAACCGTTACCGGTTCGCTGATGAAGGTTTATGACGGTGCCGCGTTTATCGCCGCCAAATCGGGGGCGACCCTGGTGC
CGATACGGCTCGATGGTGCCGAGTTCAGCCCCTTTGGCCGCATGGCCGGAGTGTTCAAGATCCGCTGGTTCCCGCAGATC
AGCATCCGTATTTTACCGCCGACCTCGCTGCCGATGCCGGTAGCGCCGCGCGCCCGCGATCGCCGAGCATTGGCCGGGGA
TCGGCTGCACCAGATCATGATGCAGGCGCGAATGGATACCCGTGAGCCGCAGACCCTGTTTCAGGCTCTGCTGGCGGCGC
AGCACCGTTATGGCCGCAGCAAGCCGTGTATCGAGGATATTAACTTCAAGGAGGACAGTTACCGCACGCTGACCAAGAAA
GCGCTGGGCGTCAGCCGTATCCTGCAACGTTTTACCGCCGAGGGCGAACATGTCGGTATGTTATTGCCGAACGCGACCAT
CACCGTAGCGGCGATTTTTGGCGCTTCACTGCGCAACCGCATTCCGGCGATGCTCAACTACACCGCCGGTTCCAAAGGCC
TGAAAAGCGCCATGACCGCCGCCAGCCTCAAAACTATCGTCACGTCACGCCAGTTTCTCGAAAAGGGCAAGCTGACCCAT
TTGCCGCAGCAGGTGCCGGAGGCCAACTGGGTGTACCTGGAAGACCTGAAAGATACGGTGACCCTGGCGGACAAGCTGTG
GATCCTGCGCCATCTGTTGCAACCGGCGCGGGCCATGCTGCCGCAGCAACCTGACGATGCGGCGCTGATCCTGTTCACAT
CGGGTTCGGAGGGCAATCCGAAAGGCGTGGTGCATTCCCATGCCAGCCTGTTGGCCAACGTTGAACAGATCCGTACCATC
GCCGATTTCACCCCGCGTGACCGCTTTATGTCATCGCTGCCGCTGTTCCACTCGTTCGGCCTGACGGTCGGGCTGCTGAC
GCCGCTGATGACCGGCAGCCGCATCTTCCTTTACCCCAGCCCGCTGCATTACCGTGTGGTTCCGGAACTGGTGTACGACC
GTAACTGCACCGTGTTGTTCGGCACAGCGACCTTCCTTAATAACTATGCGCGTTTTGCTCACCCGTATGATTTTGCCCGT
TTGCGCTATGTGGTTGCCGGTGCGGAAAAGCTGGCGGACAGCACCAAACAGATTTATCAGGACAAATACGGCATCCGTAT
TCTGGAAGGCTATGGCGTGACTGAATGCGCACCTGTGGTGTCGATCAACGTGCCGCTGGCGGCCAAGGTCGGTACCGTCG
GCCGTATTATGCCGAACATGGAGGCACGGCTGATGAAGGTGCCGGGCATCGATAACGGTGGGCGCCTGCAGTTGAAGGGG
CCTAATATCATGAAAGGTTACCTGCGGGTCGAGCGTCCGGGCGAACTGGAACCCCCGGCGGCCGAGGATGAGCATGGCAA
CCTGCAGCCGGGTTGGTACGACACCGGCGATATTGTCACATTGGACGAGCAGGGTTACTGCGTGATCCGCGGCCGGGTGA
AGCGCTTTGCCAAACTGGCGGGGGAAATGGTCTCGCTGGAAAGCGTTGAACTGCTGGCACAGCGCGTCGCGCCGGAAGCC
CAGCATGCCGCCACGGTTAAAAGCGACAGCAGCAAGGGCGAGGCGCTGGTGCTGTTTACCACCGACGCCGGCATAACCCG
TGAGGCCTTGTTGAAGGTGGCGCGTGAGTTGGGCAGCCCTGAGCTGACGGTGCCGCGTGATATCCGTATTTTGAAAACCT
TACCGGTGCTTGGCAGCGGTAAACCGGACTTTGTGACCCTGCGTAACATGGCTGAACAGCCGGAGATTGCCTGA

Upstream 100 bases:

>100_bases
TGCACCAACCTACGCGGATGCGTAGGTTTTTTTTTGCCTGCCATATAGTATTCTTTTCCCTACAACCATTTACGCTCATC
TTGGCCAAGGGGAGAAGGGC

Downstream 100 bases:

>100_bases
TGAACCCGACGTTACCTACTGATTCACCTTTGCTTTCTCGCAGTATGATTGCCGTAATTTGCGCCCAGTTTCTGTCCGCA
TTCGGTGACAATGCATTGCT

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MIFSILRVLFRLLYRVRVEGDVRHFEQQKLLITPNHISFLDGILLALFLPIKPVFAVYASIGDRWFMRWLRPYIDFVSLD
PTKPMAIKQLVRTVEQGRPVVVFPEGRITVTGSLMKVYDGAAFIAAKSGATLVPIRLDGAEFSPFGRMAGVFKIRWFPQI
SIRILPPTSLPMPVAPRARDRRALAGDRLHQIMMQARMDTREPQTLFQALLAAQHRYGRSKPCIEDINFKEDSYRTLTKK
ALGVSRILQRFTAEGEHVGMLLPNATITVAAIFGASLRNRIPAMLNYTAGSKGLKSAMTAASLKTIVTSRQFLEKGKLTH
LPQQVPEANWVYLEDLKDTVTLADKLWILRHLLQPARAMLPQQPDDAALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHSFGLTVGLLTPLMTGSRIFLYPSPLHYRVVPELVYDRNCTVLFGTATFLNNYARFAHPYDFAR
LRYVVAGAEKLADSTKQIYQDKYGIRILEGYGVTECAPVVSINVPLAAKVGTVGRIMPNMEARLMKVPGIDNGGRLQLKG
PNIMKGYLRVERPGELEPPAAEDEHGNLQPGWYDTGDIVTLDEQGYCVIRGRVKRFAKLAGEMVSLESVELLAQRVAPEA
QHAATVKSDSSKGEALVLFTTDAGITREALLKVARELGSPELTVPRDIRILKTLPVLGSGKPDFVTLRNMAEQPEIA

Sequences:

>Translated_717_residues
MIFSILRVLFRLLYRVRVEGDVRHFEQQKLLITPNHISFLDGILLALFLPIKPVFAVYASIGDRWFMRWLRPYIDFVSLD
PTKPMAIKQLVRTVEQGRPVVVFPEGRITVTGSLMKVYDGAAFIAAKSGATLVPIRLDGAEFSPFGRMAGVFKIRWFPQI
SIRILPPTSLPMPVAPRARDRRALAGDRLHQIMMQARMDTREPQTLFQALLAAQHRYGRSKPCIEDINFKEDSYRTLTKK
ALGVSRILQRFTAEGEHVGMLLPNATITVAAIFGASLRNRIPAMLNYTAGSKGLKSAMTAASLKTIVTSRQFLEKGKLTH
LPQQVPEANWVYLEDLKDTVTLADKLWILRHLLQPARAMLPQQPDDAALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHSFGLTVGLLTPLMTGSRIFLYPSPLHYRVVPELVYDRNCTVLFGTATFLNNYARFAHPYDFAR
LRYVVAGAEKLADSTKQIYQDKYGIRILEGYGVTECAPVVSINVPLAAKVGTVGRIMPNMEARLMKVPGIDNGGRLQLKG
PNIMKGYLRVERPGELEPPAAEDEHGNLQPGWYDTGDIVTLDEQGYCVIRGRVKRFAKLAGEMVSLESVELLAQRVAPEA
QHAATVKSDSSKGEALVLFTTDAGITREALLKVARELGSPELTVPRDIRILKTLPVLGSGKPDFVTLRNMAEQPEIA
>Mature_717_residues
MIFSILRVLFRLLYRVRVEGDVRHFEQQKLLITPNHISFLDGILLALFLPIKPVFAVYASIGDRWFMRWLRPYIDFVSLD
PTKPMAIKQLVRTVEQGRPVVVFPEGRITVTGSLMKVYDGAAFIAAKSGATLVPIRLDGAEFSPFGRMAGVFKIRWFPQI
SIRILPPTSLPMPVAPRARDRRALAGDRLHQIMMQARMDTREPQTLFQALLAAQHRYGRSKPCIEDINFKEDSYRTLTKK
ALGVSRILQRFTAEGEHVGMLLPNATITVAAIFGASLRNRIPAMLNYTAGSKGLKSAMTAASLKTIVTSRQFLEKGKLTH
LPQQVPEANWVYLEDLKDTVTLADKLWILRHLLQPARAMLPQQPDDAALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHSFGLTVGLLTPLMTGSRIFLYPSPLHYRVVPELVYDRNCTVLFGTATFLNNYARFAHPYDFAR
LRYVVAGAEKLADSTKQIYQDKYGIRILEGYGVTECAPVVSINVPLAAKVGTVGRIMPNMEARLMKVPGIDNGGRLQLKG
PNIMKGYLRVERPGELEPPAAEDEHGNLQPGWYDTGDIVTLDEQGYCVIRGRVKRFAKLAGEMVSLESVELLAQRVAPEA
QHAATVKSDSSKGEALVLFTTDAGITREALLKVARELGSPELTVPRDIRILKTLPVLGSGKPDFVTLRNMAEQPEIA

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=530, Percent_Identity=25.2830188679245, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI40807491, Length=415, Percent_Identity=26.9879518072289, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI187761345, Length=406, Percent_Identity=26.1083743842365, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI187761343, Length=406, Percent_Identity=26.1083743842365, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789201, Length=715, Percent_Identity=68.5314685314685, Blast_Score=1042, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=517, Percent_Identity=28.2398452611219, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI145693145, Length=363, Percent_Identity=30.3030303030303, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786810, Length=365, Percent_Identity=23.5616438356164, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=352, Percent_Identity=27.5568181818182, Blast_Score=121, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=366, Percent_Identity=28.6885245901639, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=509, Percent_Identity=23.9685658153242, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=509, Percent_Identity=23.9685658153242, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994690, Length=509, Percent_Identity=23.9685658153242, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17510401, Length=491, Percent_Identity=24.2362525458248, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=493, Percent_Identity=23.5294117647059, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=310, Percent_Identity=28.0645161290323, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=503, Percent_Identity=22.6640159045726, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=401, Percent_Identity=23.9401496259352, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=389, Percent_Identity=23.6503856041131, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=304, Percent_Identity=25.3289473684211, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=25.2124645892351, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320852, Length=412, Percent_Identity=24.5145631067961, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355181, Length=539, Percent_Identity=23.0055658627087, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859661, Length=283, Percent_Identity=27.9151943462898, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581924, Length=468, Percent_Identity=21.1538461538462, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922652, Length=444, Percent_Identity=25.2252252252252, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 79815; Mature: 79815

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFSILRVLFRLLYRVRVEGDVRHFEQQKLLITPNHISFLDGILLALFLPIKPVFAVYAS
CHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
IGDRWFMRWLRPYIDFVSLDPTKPMAIKQLVRTVEQGRPVVVFPEGRITVTGSLMKVYDG
HHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHCC
AAFIAAKSGATLVPIRLDGAEFSPFGRMAGVFKIRWFPQISIRILPPTSLPMPVAPRARD
EEEEEECCCCEEEEEEECCCCCCCHHHHCCEEEEEEECCEEEEEECCCCCCCCCCCCCCC
RRALAGDRLHQIMMQARMDTREPQTLFQALLAAQHRYGRSKPCIEDINFKEDSYRTLTKK
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHH
ALGVSRILQRFTAEGEHVGMLLPNATITVAAIFGASLRNRIPAMLNYTAGSKGLKSAMTA
HHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPQQVPEANWVYLEDLKDTVTLADKLWILRHLLQPARAML
HHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHC
PQQPDDAALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHSFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLLTPLMTGSRIFLYPSPLHYRVVPELVYDRNCTVLFGTATFLNNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLADSTKQIYQDKYGIRILEGYGVTECAPVVSINVPLAAKVGTVGRIMPNM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHCCCC
EARLMKVPGIDNGGRLQLKGPNIMKGYLRVERPGELEPPAAEDEHGNLQPGWYDTGDIVT
CHHEEECCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LDEQGYCVIRGRVKRFAKLAGEMVSLESVELLAQRVAPEAQHAATVKSDSSKGEALVLFT
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCEEEEEE
TDAGITREALLKVARELGSPELTVPRDIRILKTLPVLGSGKPDFVTLRNMAEQPEIA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEHHHHCCCCCCC
>Mature Secondary Structure
MIFSILRVLFRLLYRVRVEGDVRHFEQQKLLITPNHISFLDGILLALFLPIKPVFAVYAS
CHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
IGDRWFMRWLRPYIDFVSLDPTKPMAIKQLVRTVEQGRPVVVFPEGRITVTGSLMKVYDG
HHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHCC
AAFIAAKSGATLVPIRLDGAEFSPFGRMAGVFKIRWFPQISIRILPPTSLPMPVAPRARD
EEEEEECCCCEEEEEEECCCCCCCHHHHCCEEEEEEECCEEEEEECCCCCCCCCCCCCCC
RRALAGDRLHQIMMQARMDTREPQTLFQALLAAQHRYGRSKPCIEDINFKEDSYRTLTKK
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHH
ALGVSRILQRFTAEGEHVGMLLPNATITVAAIFGASLRNRIPAMLNYTAGSKGLKSAMTA
HHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPQQVPEANWVYLEDLKDTVTLADKLWILRHLLQPARAML
HHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHC
PQQPDDAALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHSFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLLTPLMTGSRIFLYPSPLHYRVVPELVYDRNCTVLFGTATFLNNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLADSTKQIYQDKYGIRILEGYGVTECAPVVSINVPLAAKVGTVGRIMPNM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHCCCC
EARLMKVPGIDNGGRLQLKGPNIMKGYLRVERPGELEPPAAEDEHGNLQPGWYDTGDIVT
CHHEEECCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LDEQGYCVIRGRVKRFAKLAGEMVSLESVELLAQRVAPEAQHAATVKSDSSKGEALVLFT
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCEEEEEE
TDAGITREALLKVARELGSPELTVPRDIRILKTLPVLGSGKPDFVTLRNMAEQPEIA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA