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The map label for this gene is ldcC [H]

Identifier: 157372008

GI number: 157372008

Start: 4168707

End: 4170851

Strand: Reverse

Name: ldcC [H]

Synonym: Spro_3773

Alternate gene names: 157372008

Gene position: 4170851-4168707 (Counterclockwise)

Preceding gene: 157372009

Following gene: 157372006

Centisome position: 76.55

GC content: 54.5

Gene sequence:

>2145_bases
TTGAATATCATCGCGATCATGAGCCCAGCGGGCGTTTATTACAAAGACGAGCCGATCCGCGAGCTTCACACCGCACTGGC
TGCAATGGATTTCCAACTGGTCTATCCGAAAAACAGCGGCGATCTGTTAAAACTGGTCGAAGCCAACGCGCGCATTTGTG
GGGTGATTTTTGACTGGGACGACTACAGTCTGGAGCTGTGCAGCGATATCAATGAGTTGAATGAATATCTGCCGTTGTAT
GCCTTCATCAACACCCATTCCACCTTCGACGTCAGCCTGCATGAAATGCGCATGGCGCTGTATTTCTTTGAGTACGCTCT
AAATGCGGCGGATGATATTGCACAGCGTATTCAGCAGTACACCGCCGAATACATAGATACCATTACGCCTCCTTTGACCA
AGGCGCTGTTCAACTATGTGCGCGAAGGGAAATACACTTTCTGTACTCCAGGCCATATGGCCGGCACTGCCTTTCAGAAA
AGCCCGGTCGGCTGTCTGTTTTACGACTTTTTTGGTGCCAACACGCTAAAAGCAGATGTCTCGATCTCTGTGACAGAACT
GGGATCGCTGCTGGATCACACCGGCCCACATCTGGAAGCCGAGGAGTATATTGCCCGTACCTTTAACGCCGAGCAGAGTT
ATCTGGTGACTAACGGCACCTCCACCGCCAACAAGATAGTCGGAATGTATTCGGCGCCGACCGGTAGCACGGTATTGATT
GACCGCAACTGCCATAAATCCTTATGCCATTTGCTGATGATGAGCGATATCGTGCCTATCTACCTGCGTCCGCTGCGTAA
TGCCTATGGCATTCTCGGTGGTATTCCGCAGCATGAATTTACTCGCGAGAGCATTGCCGGCCGGGTCGCGGCAACGGCTA
ACGCCAGTTGGCCGGTACATGCGGTGATCACCAACTCCACTTATGACGGTTTGTTGTACAACACCGACTACATCAAACAG
ACGCTGGACGTACCCTCAATTCACTTTGATTCGGCCTGGGTGCCCTATACCAACTTCCATCCCATTTACGACGGCAAGAG
CGGTATGAGCGGCGAGCGCACGCCCGGCAAGGTTATCTACGAAACCCAGTCTACGCACAAGCTGCTGGCGGCGTTTTCGC
AGGCTTCAATGATTCACATTAAGGGTGACTACGACGAAAGCACCTTTAACGAAGCCTATATGATGCACACCACCACCTCG
CCGAATTACGGCATCGTAGCATCGATGGAGACTGCCGCAGCCATGCTGCGCGGCAATCCGGGGCGGCGATTGATAAATCG
CTCGGTGGAGCGCGCACTGCATTTCCGCCGTGAGGTACAGCGGCTGCGAGAGGAGAGCGATAGCTGGTTCTTCGACATCT
GGCAGCCGGAGGAGATCGACGAGGCGCAGTGTTGGCCGCTGAACCCGGATGATAATTGGCACGGTTTCGGCAACACCGAC
AGCAACCACATGTACCTCGATCCGATCAAGGTCACTATCCTGACGCCGGGCATGAATGAACTGGGCATGCTGGAAGAGAG
CGGGATACCGGCGGCGCTGGTGGCGAAGTATCTGGACGAACGCGGTATCGTAGTGGAAAAAACCGGGCCTTATAACCTGT
TATTCCTGTTCAGCATCGGCATCGATAAAACCAAGGCGATGAGTCTGCTGCGCGGTCTGACCGATTTTAAACGCGCTTAC
GATCTCAACCTGCGGGTGAAGAACATGCTGCCGGATCTGTTCGCGGAAGATCCGGATTTCTACCGCAATATGCGCATTCA
GGATCTGGCGGCCGGGATCCACAGTTTAATCTGTCGGCACGATCTGCCGGGGCTGATGCAGCGGGCGTTTGACGTGCTGC
CTGAAATGAAACTGACGCCGCACCAGATGTTCCAGCAACAGGTGCGCGGCAACGTAGAAACCTGCGAGCTGGATCAGTTG
GTCGGCAAGGTGGCGGCCAACATGATCCTGCCTTATCCGCCAGGGGTACCACTGGTGATGCCGGGCGAGATGATCACCGA
AGAGAGCCGTGCAGTGCTGGATTTCCTGCTGATGCTGTGCTCGATCGGCGAGCGTTACCCGGGCTTTGAAACCGATATCC
ACGGCGCGAAACTGACCGAGGACGGGCGTTATCTGGTGAAGGTGCTGAAAATGCCGCTGGCTTAA

Upstream 100 bases:

>100_bases
CGGTTTTTTTTTGGCTGACGAAAAGGGGGGCTTTGGGGTACACAGCACGGTTTTTTCATGTTGTTATAGACGATTGGTGG
TTAACTGACAGGAGCAGCCG

Downstream 100 bases:

>100_bases
GCAAATTCTCGGCAAATCAGGTTCACGCTGCTTGCCGGCAACGGTTCCTGCGTCAGGCCGCAAAATGGTTGGCCATCCTG
CCGTTGGTGATAGCGGCAGC

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MNIIAIMSPAGVYYKDEPIRELHTALAAMDFQLVYPKNSGDLLKLVEANARICGVIFDWDDYSLELCSDINELNEYLPLY
AFINTHSTFDVSLHEMRMALYFFEYALNAADDIAQRIQQYTAEYIDTITPPLTKALFNYVREGKYTFCTPGHMAGTAFQK
SPVGCLFYDFFGANTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFNAEQSYLVTNGTSTANKIVGMYSAPTGSTVLI
DRNCHKSLCHLLMMSDIVPIYLRPLRNAYGILGGIPQHEFTRESIAGRVAATANASWPVHAVITNSTYDGLLYNTDYIKQ
TLDVPSIHFDSAWVPYTNFHPIYDGKSGMSGERTPGKVIYETQSTHKLLAAFSQASMIHIKGDYDESTFNEAYMMHTTTS
PNYGIVASMETAAAMLRGNPGRRLINRSVERALHFRREVQRLREESDSWFFDIWQPEEIDEAQCWPLNPDDNWHGFGNTD
SNHMYLDPIKVTILTPGMNELGMLEESGIPAALVAKYLDERGIVVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPDLFAEDPDFYRNMRIQDLAAGIHSLICRHDLPGLMQRAFDVLPEMKLTPHQMFQQQVRGNVETCELDQL
VGKVAANMILPYPPGVPLVMPGEMITEESRAVLDFLLMLCSIGERYPGFETDIHGAKLTEDGRYLVKVLKMPLA

Sequences:

>Translated_714_residues
MNIIAIMSPAGVYYKDEPIRELHTALAAMDFQLVYPKNSGDLLKLVEANARICGVIFDWDDYSLELCSDINELNEYLPLY
AFINTHSTFDVSLHEMRMALYFFEYALNAADDIAQRIQQYTAEYIDTITPPLTKALFNYVREGKYTFCTPGHMAGTAFQK
SPVGCLFYDFFGANTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFNAEQSYLVTNGTSTANKIVGMYSAPTGSTVLI
DRNCHKSLCHLLMMSDIVPIYLRPLRNAYGILGGIPQHEFTRESIAGRVAATANASWPVHAVITNSTYDGLLYNTDYIKQ
TLDVPSIHFDSAWVPYTNFHPIYDGKSGMSGERTPGKVIYETQSTHKLLAAFSQASMIHIKGDYDESTFNEAYMMHTTTS
PNYGIVASMETAAAMLRGNPGRRLINRSVERALHFRREVQRLREESDSWFFDIWQPEEIDEAQCWPLNPDDNWHGFGNTD
SNHMYLDPIKVTILTPGMNELGMLEESGIPAALVAKYLDERGIVVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPDLFAEDPDFYRNMRIQDLAAGIHSLICRHDLPGLMQRAFDVLPEMKLTPHQMFQQQVRGNVETCELDQL
VGKVAANMILPYPPGVPLVMPGEMITEESRAVLDFLLMLCSIGERYPGFETDIHGAKLTEDGRYLVKVLKMPLA
>Mature_714_residues
MNIIAIMSPAGVYYKDEPIRELHTALAAMDFQLVYPKNSGDLLKLVEANARICGVIFDWDDYSLELCSDINELNEYLPLY
AFINTHSTFDVSLHEMRMALYFFEYALNAADDIAQRIQQYTAEYIDTITPPLTKALFNYVREGKYTFCTPGHMAGTAFQK
SPVGCLFYDFFGANTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFNAEQSYLVTNGTSTANKIVGMYSAPTGSTVLI
DRNCHKSLCHLLMMSDIVPIYLRPLRNAYGILGGIPQHEFTRESIAGRVAATANASWPVHAVITNSTYDGLLYNTDYIKQ
TLDVPSIHFDSAWVPYTNFHPIYDGKSGMSGERTPGKVIYETQSTHKLLAAFSQASMIHIKGDYDESTFNEAYMMHTTTS
PNYGIVASMETAAAMLRGNPGRRLINRSVERALHFRREVQRLREESDSWFFDIWQPEEIDEAQCWPLNPDDNWHGFGNTD
SNHMYLDPIKVTILTPGMNELGMLEESGIPAALVAKYLDERGIVVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPDLFAEDPDFYRNMRIQDLAAGIHSLICRHDLPGLMQRAFDVLPEMKLTPHQMFQQQVRGNVETCELDQL
VGKVAANMILPYPPGVPLVMPGEMITEESRAVLDFLLMLCSIGERYPGFETDIHGAKLTEDGRYLVKVLKMPLA

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=711, Percent_Identity=79.887482419128, Blast_Score=1232, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=710, Percent_Identity=74.2253521126761, Blast_Score=1140, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=34.5578231292517, Blast_Score=454, Evalue=1e-128,
Organism=Escherichia coli, GI87082193, Length=610, Percent_Identity=33.2786885245902, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1786909, Length=692, Percent_Identity=31.3583815028902, Blast_Score=305, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80424; Mature: 80424

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMSPAGVYYKDEPIRELHTALAAMDFQLVYPKNSGDLLKLVEANARICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCEEHEEECCCEEEEEEECCC
DYSLELCSDINELNEYLPLYAFINTHSTFDVSLHEMRMALYFFEYALNAADDIAQRIQQY
CCHHHHHHHHHHHHHHCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TAEYIDTITPPLTKALFNYVREGKYTFCTPGHMAGTAFQKSPVGCLFYDFFGANTLKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEHHCCCEEEECC
SISVTELGSLLDHTGPHLEAEEYIARTFNAEQSYLVTNGTSTANKIVGMYSAPTGSTVLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLCHLLMMSDIVPIYLRPLRNAYGILGGIPQHEFTRESIAGRVAATANASWPVH
ECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCEE
AVITNSTYDGLLYNTDYIKQTLDVPSIHFDSAWVPYTNFHPIYDGKSGMSGERTPGKVIY
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ETQSTHKLLAAFSQASMIHIKGDYDESTFNEAYMMHTTTSPNYGIVASMETAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GRRLINRSVERALHFRREVQRLREESDSWFFDIWQPEEIDEAQCWPLNPDDNWHGFGNTD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
SNHMYLDPIKVTILTPGMNELGMLEESGIPAALVAKYLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
IDKTKAMSLLRGLTDFKRAYDLNLRVKNMLPDLFAEDPDFYRNMRIQDLAAGIHSLICRH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHC
DLPGLMQRAFDVLPEMKLTPHQMFQQQVRGNVETCELDQLVGKVAANMILPYPPGVPLVM
CCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEECCCCCCCEEE
PGEMITEESRAVLDFLLMLCSIGERYPGFETDIHGAKLTEDGRYLVKVLKMPLA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNIIAIMSPAGVYYKDEPIRELHTALAAMDFQLVYPKNSGDLLKLVEANARICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCEEHEEECCCEEEEEEECCC
DYSLELCSDINELNEYLPLYAFINTHSTFDVSLHEMRMALYFFEYALNAADDIAQRIQQY
CCHHHHHHHHHHHHHHCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TAEYIDTITPPLTKALFNYVREGKYTFCTPGHMAGTAFQKSPVGCLFYDFFGANTLKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEHHCCCEEEECC
SISVTELGSLLDHTGPHLEAEEYIARTFNAEQSYLVTNGTSTANKIVGMYSAPTGSTVLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLCHLLMMSDIVPIYLRPLRNAYGILGGIPQHEFTRESIAGRVAATANASWPVH
ECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCEE
AVITNSTYDGLLYNTDYIKQTLDVPSIHFDSAWVPYTNFHPIYDGKSGMSGERTPGKVIY
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ETQSTHKLLAAFSQASMIHIKGDYDESTFNEAYMMHTTTSPNYGIVASMETAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GRRLINRSVERALHFRREVQRLREESDSWFFDIWQPEEIDEAQCWPLNPDDNWHGFGNTD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
SNHMYLDPIKVTILTPGMNELGMLEESGIPAALVAKYLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
IDKTKAMSLLRGLTDFKRAYDLNLRVKNMLPDLFAEDPDFYRNMRIQDLAAGIHSLICRH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHC
DLPGLMQRAFDVLPEMKLTPHQMFQQQVRGNVETCELDQLVGKVAANMILPYPPGVPLVM
CCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEECCCCCCCEEE
PGEMITEESRAVLDFLLMLCSIGERYPGFETDIHGAKLTEDGRYLVKVLKMPLA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]