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The map label for this gene is phlB [H]

Identifier: 157371915

GI number: 157371915

Start: 4073266

End: 4074021

Strand: Reverse

Name: phlB [H]

Synonym: Spro_3680

Alternate gene names: 157371915

Gene position: 4074021-4073266 (Counterclockwise)

Preceding gene: 157371916

Following gene: 157371913

Centisome position: 74.77

GC content: 60.45

Gene sequence:

>756_bases
ATGCCTGACAGGCGGCGCGTGCGGCAGACGTTGATTATCGCCATGCTGGCGTTGGTTGCGATCGCCGGTTTGCTGATTAT
GGCTAAGGAGCAACAGATGAATCAGGATATCTCTCCGTTCAACGGACGTGGCAATGCAGCGCTGGCTCAGGCGGTAGCGC
GCGGTGATGTACAGGGTATTGCCGAACAGGCCACACAGGGGCGTCTGAACGAGCAGGGTGAGCGTCAGGTCACTTTGCCG
CAGTGGGCAATACTGGCGCAGCAACCGCAAAGTCTGGCCTTACTGCTGGAGCTGGGAGCTGATGCTTCCACTCCGGGTCT
GGATGGCAACAGCGCGCTGCATACCGCAGCGGCGGTGCAGGACCCGCAGTATTTGCGGCTGTTGCTGGAGCAGGGGGGAG
CAGTTAACCCACGTAATGCGGTAACCGGCGCCACACCCTTGGCGACTGCCGTGTTGGCCGGGCGGGAAGAGCAACTGCGG
TTGCTGTTGGTCTCCGGGGCGGACGTCACGCTGAGCGATCGGCTGGGCGATACGCCTTTGCACATAGCGGCAAAAACCAA
CGCGCCGCAGTTGGCGCTGATGCTGTTGCAGGCGGGGGCGGATGCCAAGGCCCGCAATCAGCAGGGAGTGACCTTCCAGT
TCTATTTCTCACAAACGCCAGCGTCGTTGCAGAGTGAAGAAATGCGTGAGGGTTATCGTCAACTGAATGCCTGGCTGAAA
GCCCATCAGCAGGCAACGCATTACGCGCAGCAGTAA

Upstream 100 bases:

>100_bases
TGGCGGCCGAGCAAACATGTGGATCGCAGCCTGACCGCGCACGGAATCGATAAGGTCATCAGTTCGATGGCGGAGCAAAA
GCCATGGGAGATCAAGGCCA

Downstream 100 bases:

>100_bases
GCGGGCATAAAAAAACCGCCTTCAGGTTAATGGAGGCGGTTTTTATTCACTACGGCAGCATTACTTCGCGCCGTTGCTCT
CAGGTTTGGCCTTCGGCTGG

Product: ankyrin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MPDRRRVRQTLIIAMLALVAIAGLLIMAKEQQMNQDISPFNGRGNAALAQAVARGDVQGIAEQATQGRLNEQGERQVTLP
QWAILAQQPQSLALLLELGADASTPGLDGNSALHTAAAVQDPQYLRLLLEQGGAVNPRNAVTGATPLATAVLAGREEQLR
LLLVSGADVTLSDRLGDTPLHIAAKTNAPQLALMLLQAGADAKARNQQGVTFQFYFSQTPASLQSEEMREGYRQLNAWLK
AHQQATHYAQQ

Sequences:

>Translated_251_residues
MPDRRRVRQTLIIAMLALVAIAGLLIMAKEQQMNQDISPFNGRGNAALAQAVARGDVQGIAEQATQGRLNEQGERQVTLP
QWAILAQQPQSLALLLELGADASTPGLDGNSALHTAAAVQDPQYLRLLLEQGGAVNPRNAVTGATPLATAVLAGREEQLR
LLLVSGADVTLSDRLGDTPLHIAAKTNAPQLALMLLQAGADAKARNQQGVTFQFYFSQTPASLQSEEMREGYRQLNAWLK
AHQQATHYAQQ
>Mature_250_residues
PDRRRVRQTLIIAMLALVAIAGLLIMAKEQQMNQDISPFNGRGNAALAQAVARGDVQGIAEQATQGRLNEQGERQVTLPQ
WAILAQQPQSLALLLELGADASTPGLDGNSALHTAAAVQDPQYLRLLLEQGGAVNPRNAVTGATPLATAVLAGREEQLRL
LLVSGADVTLSDRLGDTPLHIAAKTNAPQLALMLLQAGADAKARNQQGVTFQFYFSQTPASLQSEEMREGYRQLNAWLKA
HQQATHYAQQ

Specific function: Cell-protective protein that neutralizes the intracellular lysis capacity of phospholipase A1 through a direct interaction with the enzyme [H]

COG id: COG0666

COG function: function code R; FOG: Ankyrin repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 ANK repeats [H]

Homologues:

Organism=Homo sapiens, GI7705748, Length=140, Percent_Identity=35, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI163914396, Length=125, Percent_Identity=36, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI96975023, Length=177, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI153792284, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI239747114, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI310124281, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4506217, Length=104, Percent_Identity=37.5, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI28605137, Length=104, Percent_Identity=37.5, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002110
- InterPro:   IPR020683 [H]

Pfam domain/function: PF00023 Ank [H]

EC number: NA

Molecular weight: Translated: 26970; Mature: 26839

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50088 ANK_REPEAT ; PS50297 ANK_REP_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRRRVRQTLIIAMLALVAIAGLLIMAKEQQMNQDISPFNGRGNAALAQAVARGDVQGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AEQATQGRLNEQGERQVTLPQWAILAQQPQSLALLLELGADASTPGLDGNSALHTAAAVQ
HHHHHHCCCCCCCCCEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
DPQYLRLLLEQGGAVNPRNAVTGATPLATAVLAGREEQLRLLLVSGADVTLSDRLGDTPL
CHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEEEECCCEEECCCCCCCCE
HIAAKTNAPQLALMLLQAGADAKARNQQGVTFQFYFSQTPASLQSEEMREGYRQLNAWLK
EEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AHQQATHYAQQ
HHHHHHHHCCC
>Mature Secondary Structure 
PDRRRVRQTLIIAMLALVAIAGLLIMAKEQQMNQDISPFNGRGNAALAQAVARGDVQGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AEQATQGRLNEQGERQVTLPQWAILAQQPQSLALLLELGADASTPGLDGNSALHTAAAVQ
HHHHHHCCCCCCCCCEECCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
DPQYLRLLLEQGGAVNPRNAVTGATPLATAVLAGREEQLRLLLVSGADVTLSDRLGDTPL
CHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEEEECCCEEECCCCCCCCE
HIAAKTNAPQLALMLLQAGADAKARNQQGVTFQFYFSQTPASLQSEEMREGYRQLNAWLK
EEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AHQQATHYAQQ
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3056919; 8316077 [H]