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The map label for this gene is dapA [H]

Identifier: 157371746

GI number: 157371746

Start: 3885061

End: 3885942

Strand: Reverse

Name: dapA [H]

Synonym: Spro_3509

Alternate gene names: 157371746

Gene position: 3885942-3885061 (Counterclockwise)

Preceding gene: 157371749

Following gene: 157371745

Centisome position: 71.32

GC content: 54.76

Gene sequence:

>882_bases
ATGTTTACGGGAAGTATAGTTGCACTGGTTACGCCGATGGACGACACAGGTGCTGTCGATCGCGCGAGCCTAAAAAAATT
GATTGATTATCATGTAGCCAGTGGAACTGCGGCCATCGTTTCCGTAGGGACTACCGGCGAGTCTGCAACGCTTGCCCATG
ACGAGCACGTTGACGTGGTATTGCAGACGCTGGAACTGGCCGCAGGCCGTATTCCGGTGATCGCCGGTACCGGCGCCAAC
GCCACCGCCGAAGCCATTTCGCTGACCCAGCGCTTCGAAAATAGCGGCGTAGTGGGTTGCCTGACGGTCACGCCTTACTA
CAATAAACCGACTCAGGAAGGGCTGTATCAGCACTTCAAGGCCATTGCCGAAAGCACCGCACTGCCACAAATCCTCTATA
ACGTGCCTTCTCGCACCGGGTGTGACATGCTGCCGCCGACGATTGCGCGCCTGGCAAAAATCAAGAATATTGTTGCTGTT
AAAGAGGCAACAGGGAACTTAAGTCGTGTAAGTCAGATCCAAGTGCTGGTTGATGATGAAGATTTCATTTTGCTGAGCGG
CGATGACGCCAGCGGTCTGGATTTCATGCAACTGGGTGGCAAGGGCGTGATTTCCGTGACGGCCAACGTGGCCGCACGTG
AAATGGCGCAACTTTGCGCGCTGGCAGCACAGGGCAACTTTGCTGAGGCACGCCGCTTAAATCAACGCTTGATGCCGTTG
CATCAGGATTTGTTTGTAGAAGCAAACCCAATTCCGGTGAAATGGGCCTGTAAGGCATTGGGATTGATGGCAACCGATAC
GATGCGTCTGCCTATGACGCCGTTGACCGACGCTGCCCGTCCGGTAGTGGAACGCGCGTTGAAAAGCGCCGGTTTGCTGT
AA

Upstream 100 bases:

>100_bases
AAAAAAACCGCCTGCCAAGCGCTTACAACACCGTTGTTTGCTTGCTTTTGGATAGGCAGCAAAAGTACCATGAGTGACTT
GTTTGTGGAGGGGACGGCCA

Downstream 100 bases:

>100_bases
CTCTAAGGGAAATTTGATGGTTTATTCATTGCAAAAGTCGACGGTAGCAAAAGTCGTGGGTATTTCGCTGGTTATGATGC
TGGTCGGTTGTACCACCGAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFTGSIVALVTPMDDTGAVDRASLKKLIDYHVASGTAAIVSVGTTGESATLAHDEHVDVVLQTLELAAGRIPVIAGTGAN
ATAEAISLTQRFENSGVVGCLTVTPYYNKPTQEGLYQHFKAIAESTALPQILYNVPSRTGCDMLPPTIARLAKIKNIVAV
KEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANVAAREMAQLCALAAQGNFAEARRLNQRLMPL
HQDLFVEANPIPVKWACKALGLMATDTMRLPMTPLTDAARPVVERALKSAGLL

Sequences:

>Translated_293_residues
MFTGSIVALVTPMDDTGAVDRASLKKLIDYHVASGTAAIVSVGTTGESATLAHDEHVDVVLQTLELAAGRIPVIAGTGAN
ATAEAISLTQRFENSGVVGCLTVTPYYNKPTQEGLYQHFKAIAESTALPQILYNVPSRTGCDMLPPTIARLAKIKNIVAV
KEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANVAAREMAQLCALAAQGNFAEARRLNQRLMPL
HQDLFVEANPIPVKWACKALGLMATDTMRLPMTPLTDAARPVVERALKSAGLL
>Mature_293_residues
MFTGSIVALVTPMDDTGAVDRASLKKLIDYHVASGTAAIVSVGTTGESATLAHDEHVDVVLQTLELAAGRIPVIAGTGAN
ATAEAISLTQRFENSGVVGCLTVTPYYNKPTQEGLYQHFKAIAESTALPQILYNVPSRTGCDMLPPTIARLAKIKNIVAV
KEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANVAAREMAQLCALAAQGNFAEARRLNQRLMPL
HQDLFVEANPIPVKWACKALGLMATDTMRLPMTPLTDAARPVVERALKSAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=232, Percent_Identity=26.2931034482759, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=80.5460750853242, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=27.4247491638796, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=28.9795918367347, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789620, Length=235, Percent_Identity=29.7872340425532, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31010; Mature: 31010

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGSIVALVTPMDDTGAVDRASLKKLIDYHVASGTAAIVSVGTTGESATLAHDEHVDVV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCHHHHHH
LQTLELAAGRIPVIAGTGANATAEAISLTQRFENSGVVGCLTVTPYYNKPTQEGLYQHFK
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
AIAESTALPQILYNVPSRTGCDMLPPTIARLAKIKNIVAVKEATGNLSRVSQIQVLVDDE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEHHCCCCHHHEEEEEEEECCC
DFILLSGDDASGLDFMQLGGKGVISVTANVAAREMAQLCALAAQGNFAEARRLNQRLMPL
CEEEEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
HQDLFVEANPIPVKWACKALGLMATDTMRLPMTPLTDAARPVVERALKSAGLL
CHHHEEECCCCCHHHHHHHHHHHEECCEECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGSIVALVTPMDDTGAVDRASLKKLIDYHVASGTAAIVSVGTTGESATLAHDEHVDVV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCHHHHHH
LQTLELAAGRIPVIAGTGANATAEAISLTQRFENSGVVGCLTVTPYYNKPTQEGLYQHFK
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
AIAESTALPQILYNVPSRTGCDMLPPTIARLAKIKNIVAVKEATGNLSRVSQIQVLVDDE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEHHCCCCHHHEEEEEEEECCC
DFILLSGDDASGLDFMQLGGKGVISVTANVAAREMAQLCALAAQGNFAEARRLNQRLMPL
CEEEEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
HQDLFVEANPIPVKWACKALGLMATDTMRLPMTPLTDAARPVVERALKSAGLL
CHHHEEECCCCCHHHHHHHHHHHEECCEECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA