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The map label for this gene is entC [H]

Identifier: 157371658

GI number: 157371658

Start: 3785776

End: 3786984

Strand: Reverse

Name: entC [H]

Synonym: Spro_3421

Alternate gene names: 157371658

Gene position: 3786984-3785776 (Counterclockwise)

Preceding gene: 157371660

Following gene: 157371657

Centisome position: 69.5

GC content: 59.06

Gene sequence:

>1209_bases
ATGAGCGTTACACTAAACAGTACCGGGCAGAAGAAGCCGCAAAGCAAGGATAGCGAACAAGCTGCTGCAAATGTGTCGCC
GACCTCCGGCTTTTTCTTTACCTCTCCTTTCCGTAGCCTGAGCACCCAAGGCTGCTTTGCTAAAATCACGATGCCGGCCC
ATAACGGGGACCAGCTTAACGGCGAGTTCCAGCAGGCGGCACAACATGCTTTTGCCGAAGCGAAACTGGCGGGGGTTAAA
AACCCGGTTCTGTGCGGCGCGATCCCGTTTGATACTCATCAGCCCTCCGCTCTGTTTATTCCCCAGCAAACCCAATGGTT
TGAGCGCGATGCCTTTCTGGCTGGCGTAACTTCCCCGCAGGACGCGTTGCCGGAAATTATCCGCCAAAATGAAGTGCCTG
CCCAACAACCCTTTATGCAGATGGTGGCGGATGCGGTGGAAGCGACCCGCGGCGACCAGTTGGATAAAGTGGTGTTGTCG
CGCCTGCTGGAGATTGAAACGCGTGAGCCGGTAGACCGCCAGGCGTTGATGGCGCGGATCATCGCCCAGAATCCTCATGG
TTTCCACTTCCATGTCCCGCTGGAACAAGGGGCATTGCTGGGGGCCAGCCCGGAATTGCTGCTACGTAAATCCGGCGCGC
AGTTCTACTCCAATCCGCTGGCCGGTTCTGCCCGTCGTGATGCCGATCCGCAGCGGGATCTGGAAGTCAGCCAGCAGCTG
TTGGTGTCCGAAAAAGATCGCTATGAGCACCAGTTTGTCACCGAAGGCATGCGGCAGGTACTGGCCGAGCGCTGCCGCTA
TCTGAATATTCCCACCGTGCCTGAATTATTGAGCACCACCACGCTGTGGCACCTGTCCACGCCTATCGACGGTGAAGCCG
CCAGCCGCGCTGAAAATGCGCTGTCGCTGGCCTGCCTGCTGCACCCGACACCGGCGCTGTGCGGTACCCCGACCGCGTTG
GCGCATCAGGTGATCAAGCAGTTGGAGCCGTTCGATCGCGGCCTGTTTGGCGGCATCGTCGGCTGGTGTGACGCCGAAGG
CAACGGTGAGTGGGTAGTGACCATCCGCTGCGGCACGGTGCAGGGCAATCAGGTGCGACTGTTTGCCGGTGCCGGCATTG
TGCAAGACTCTTCGCCGGAATCCGAATGGCATGAAACCGGCACCAAACTCAGTACCATTTCGCGGGCGTTTGGCCTGAAC
CAAGGATAG

Upstream 100 bases:

>100_bases
TATTGACATAGCATATTCACGAGGGTAATTTAACGCGATTCAATACAAATGATAATCATTATTATACAGGTTATTGTTCA
TGATACGAAAGGGAGCACCG

Downstream 100 bases:

>100_bases
ACATTCTGATGACCATTGCTTTTACCCCCTGGCCTGAGGCGTTAGCCCATCGCTATCGCGAACGCGGCTATTGGACCGAC
CGGCCCCTGACCGACATCAT

Product: isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSVTLNSTGQKKPQSKDSEQAAANVSPTSGFFFTSPFRSLSTQGCFAKITMPAHNGDQLNGEFQQAAQHAFAEAKLAGVK
NPVLCGAIPFDTHQPSALFIPQQTQWFERDAFLAGVTSPQDALPEIIRQNEVPAQQPFMQMVADAVEATRGDQLDKVVLS
RLLEIETREPVDRQALMARIIAQNPHGFHFHVPLEQGALLGASPELLLRKSGAQFYSNPLAGSARRDADPQRDLEVSQQL
LVSEKDRYEHQFVTEGMRQVLAERCRYLNIPTVPELLSTTTLWHLSTPIDGEAASRAENALSLACLLHPTPALCGTPTAL
AHQVIKQLEPFDRGLFGGIVGWCDAEGNGEWVVTIRCGTVQGNQVRLFAGAGIVQDSSPESEWHETGTKLSTISRAFGLN
QG

Sequences:

>Translated_402_residues
MSVTLNSTGQKKPQSKDSEQAAANVSPTSGFFFTSPFRSLSTQGCFAKITMPAHNGDQLNGEFQQAAQHAFAEAKLAGVK
NPVLCGAIPFDTHQPSALFIPQQTQWFERDAFLAGVTSPQDALPEIIRQNEVPAQQPFMQMVADAVEATRGDQLDKVVLS
RLLEIETREPVDRQALMARIIAQNPHGFHFHVPLEQGALLGASPELLLRKSGAQFYSNPLAGSARRDADPQRDLEVSQQL
LVSEKDRYEHQFVTEGMRQVLAERCRYLNIPTVPELLSTTTLWHLSTPIDGEAASRAENALSLACLLHPTPALCGTPTAL
AHQVIKQLEPFDRGLFGGIVGWCDAEGNGEWVVTIRCGTVQGNQVRLFAGAGIVQDSSPESEWHETGTKLSTISRAFGLN
QG
>Mature_401_residues
SVTLNSTGQKKPQSKDSEQAAANVSPTSGFFFTSPFRSLSTQGCFAKITMPAHNGDQLNGEFQQAAQHAFAEAKLAGVKN
PVLCGAIPFDTHQPSALFIPQQTQWFERDAFLAGVTSPQDALPEIIRQNEVPAQQPFMQMVADAVEATRGDQLDKVVLSR
LLEIETREPVDRQALMARIIAQNPHGFHFHVPLEQGALLGASPELLLRKSGAQFYSNPLAGSARRDADPQRDLEVSQQLL
VSEKDRYEHQFVTEGMRQVLAERCRYLNIPTVPELLSTTTLWHLSTPIDGEAASRAENALSLACLLHPTPALCGTPTALA
HQVIKQLEPFDRGLFGGIVGWCDAEGNGEWVVTIRCGTVQGNQVRLFAGAGIVQDSSPESEWHETGTKLSTISRAFGLNQ
G

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786809, Length=390, Percent_Identity=55.6410256410256, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=31.6981132075472, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788114, Length=209, Percent_Identity=31.5789473684211, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787518, Length=265, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=222, Percent_Identity=28.8288288288288, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 43819; Mature: 43688

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLNSTGQKKPQSKDSEQAAANVSPTSGFFFTSPFRSLSTQGCFAKITMPAHNGDQLN
CEEEECCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHCCCCCEEEEEECCCCCCCCC
GEFQQAAQHAFAEAKLAGVKNPVLCGAIPFDTHQPSALFIPQQTQWFERDAFLAGVTSPQ
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHEECCCCCH
DALPEIIRQNEVPAQQPFMQMVADAVEATRGDQLDKVVLSRLLEIETREPVDRQALMARI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IAQNPHGFHFHVPLEQGALLGASPELLLRKSGAQFYSNPLAGSARRDADPQRDLEVSQQL
HHCCCCCEEEEEEHHCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHH
LVSEKDRYEHQFVTEGMRQVLAERCRYLNIPTVPELLSTTTLWHLSTPIDGEAASRAENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHH
LSLACLLHPTPALCGTPTALAHQVIKQLEPFDRGLFGGIVGWCDAEGNGEWVVTIRCGTV
HEEEEEECCCCCCCCCHHHHHHHHHHHHCHHHCHHHHHHEEEEECCCCCCEEEEEEECCC
QGNQVRLFAGAGIVQDSSPESEWHETGTKLSTISRAFGLNQG
CCCEEEEEECCCEECCCCCCHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVTLNSTGQKKPQSKDSEQAAANVSPTSGFFFTSPFRSLSTQGCFAKITMPAHNGDQLN
EEEECCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHCCCCCEEEEEECCCCCCCCC
GEFQQAAQHAFAEAKLAGVKNPVLCGAIPFDTHQPSALFIPQQTQWFERDAFLAGVTSPQ
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHEECCCCCH
DALPEIIRQNEVPAQQPFMQMVADAVEATRGDQLDKVVLSRLLEIETREPVDRQALMARI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IAQNPHGFHFHVPLEQGALLGASPELLLRKSGAQFYSNPLAGSARRDADPQRDLEVSQQL
HHCCCCCEEEEEEHHCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHH
LVSEKDRYEHQFVTEGMRQVLAERCRYLNIPTVPELLSTTTLWHLSTPIDGEAASRAENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHH
LSLACLLHPTPALCGTPTALAHQVIKQLEPFDRGLFGGIVGWCDAEGNGEWVVTIRCGTV
HEEEEEECCCCCCCCCHHHHHHHHHHHHCHHHCHHHHHHEEEEECCCCCCEEEEEEECCC
QGNQVRLFAGAGIVQDSSPESEWHETGTKLSTISRAFGLNQG
CCCEEEEEECCCEECCCCCCHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]